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Helikobakter pylori İnfeksiyonunun Endoskopik, Patolojik ve Laboratuvar Bulguları ile Değerlendirilmesi

Year 2022, Volume: 13 Issue: 2, 202 - 206, 30.06.2022
https://doi.org/10.18663/tjcl.1067301

Abstract

Amaç: Helicobacter pylori, gastrointestinal sistemdeki en yaygın bakteridir. Bağırsak metaplazisi, displazi, mide kanseri
ve atrofik gastrit gelişiminde rol oynadığı bilinmektedir. H. pylori enfeksiyonunun demir eksikliği, B vitamini eksikliği gibi
birçok hastalıkla ilişkili olduğu düşünülmüştür… Çalışmamızda endoskopik inceleme yapılan hastaların endoskopik,
patolojik ve laboratuvar (hemogram ve demir değerleri) bulguları açısından değerlendirmeyi amaçladık.
Gereç ve yöntemler: Ekim 2020 - Temmuz 2021 tarihleri arasında gastrointestinal sistem şikayetleri nedeniyle endoskopik
muayene ve laboratuvar tetkiki istenen 322 hasta çalışmaya dahil edildi.
Bulgular: Çalışmamızda; 152 H. pylori negatif vaka ve 170 Helicobacter pylori pozitif vaka tespit edildi. Helicobacter pylori
negatif (HP-) grubunda erkek sayısı 50, kadın sayısı 102 idi. HP+ grubunda erkek sayısı 61, kadın sayısı 109 idi (P=0,6387).
(HP-) grubundaki yaş ortalaması 51,48 ± 1,260 idi. HP+ grubunda ortalama yaş 48,29 ± 1,215 (P=0.0700) idi. HP- grubunda
HGB değeri 13,66 ± 0.1249, HP+ grubunda 13,95 ± 0,1359 (P=0,1194) bulundu. Ortalama MCV değeri HP- grubunda 85,74 ±
0,4877, HP+ grubunda 85,69 ± 0,5860 (P=0,9505) olarak bulundu. HP- grubunda ortalama Ferritin değeri 38,71 ± 2,979, HP+
grubunda 44,38 ± 3,195 (P=0,1983) idi. Ayrıca HP- grubunda 31, HP+ grubunda 54 Pangastrit vakası tespit edildi (p=0,0208).
Sonuç: Çalışmamızda; HP enfeksiyonunun endoskopik, laboratuvar ve patolojik bulguları incelendiğinde, HP enfeksiyonu
ile yaş, cinsiyet, HGB, MCV ve Ferritin değerleri arasında anlamlı bir ilişki bulunmadı. Gastritli olgularda Antral gastrit ve
Atrofik gastrit ile negatif korelasyon bulunmazken, pangastrit ile HP arasında anlamlı korelasyon bulundu (p=0.0208).

Supporting Institution

Herhangi bir kurum desteği yoktur.

Project Number

yok

References

  • 1. Graham DY, Malaty HM, Evans DG, Evans DJ Jr., Klein PD, Adam E. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status. Gastroenterology 1991; 100: 1495-501.
  • 2. Lehours P, Yilmaz O. Epidemiology Helicobacter pylori infection. Helicobacter 2007; 12 : 1-3.
  • 3. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984; 1: 13115.
  • 4. Schirer WH, Schoengold RJ, Baker JT, et al. Development of FlexSure HP-an immunochromatographic method to detect antibodies against Helicobacter pylori. Clin Chem 1998; 44: 293-8.
  • 5. Kikuchi S, Wada O, Nakajima T, et al. Serum antiHelicobacter pylori antibody and gastric carcinoma among young adults. Cancer 1995; 75: 2789-93.
  • 6. Craanen ME, Dekker W, Blok P, Ferwerda J, Tytgat GN. Intestinal metaplasia and Helicobacter pylori: an endoscopic bioptic study of the gastric antrum. Gut 1992; 33: 16-20.
  • 7. Everhart JE. Recent developments in the epidemiology of Helicobacter pylori. Gastroenterology Clinics of North America 2000; 29: 559-79.
  • 8. Coyne D. Iron indices: what do they really mean? Kidney Int Suppl 2006: S4-8.
  • 9. Milman N, Rosenstock S, Andersen L, Jorgensen T, Bonnevie O. Serum ferritin, hemoglobin, and Helicobacter pylori infection: a seroepidemiologic survey comprising 2794 Danish adults. Gastroenterology 1998; 115: 268-74.
  • 10. Şengül D, Şengül İ. Helikobakter Pilori Sıklığı ve Lokasyon, Altı Adet Yaş Grubu ve Anatomik Pilot Bölge Bazlı 50 Yaş Sınır Değerlendirmesinin, Histopatolojik Helikobakter Pilori Kolonizasyon Derecesi ile İlişkileri. Med J Bakirkoy 2018; 14: 381-8.
  • 11. World Gastroenterology Organisation. WGO Practice Guideline: Helicobacter pylori in Developing Countri¬es. 2005.
  • 12. Megraud F. Epidemiology of Helicobacter pylori infection: Helicobacter pylori. Gastroenterology Clin Nort America 1993; 22: 73-88.
  • 13. The Eurogast Study Group. Epidemioloji of and risk faktor for Helicobacter pylori infection among 3194 asemptomatic subject in populations. GUT 1993; 34: 1672-6.
  • 14. Selek MB, Bektöre B, Atik TK, Özyurt M. Üçüncü basamak bir hastanede dispeptik yakınmaları olan hastaların dışkı örnekle¬rinde Helicobacter pylori antijen pozitifliğinin değerlendiril¬mesi. Dicle Med J 2013; 40: 574-8.
  • 15. Erçetin C, Dural AC, Yiğitbaş H, Yavuz E, Çelebi F, Borucu İ, Özcan TB, Alış H. Helikobakter pylori infeksiyonunun endoskopik, patolojik ve laboratuvar bulguları açısından değerlendirilmesi. İKSSTD 2021; 13: 25-30.
  • 16. Cardenas VM, Mulla ZD, Ortiz M, Graham DY. Iron deficiency and Helicobacter pylori infection in the United States. Am J Epidemiol 2006; 163: 127-34.
  • 17. Park SA, Lee HW, Hong MH, Choi YW, Choe YH, Ahn BY, et al. Comparative proteomic analysis of Helicobacter pylori strains associated with iron deficiency anemia. Proteomics 2006; 6: 1319-28.
  • 18. Erdem ME, Keçici S, Akın S, ve ark. Demir eksikliği anemisi ile helikobakter pilori arasındaki ilişki. Eur Arch Med Res 2014; 30: 82-5.
  • 19. Nalbant A, Aydın A. Helicobakter pylori enfeksiyonunun D vitamini, hemogram parametreleri ve kan grubu ile ilişkisi. The Turkish Journal of Academic Gastroenterology 2017;16: 01-05.
  • 20. Hershko C, Ianculovich M, Souroujon M. A hematologist’s view of unexplained iron deficiency anemia in males: impact of Helicobacter pylori eradication. Blood Cells Mol Dis 2007; 38: 45-53.
  • 21. Zuberi BF, Afsar S, Qadeer R, Baloch I, Quraishy MS, Kumar A, Akhtar N. Hemogolbin, ferritin, vitamin B12 and halicobacter pylori infection: a study in patients who underwent upper gi endoscopy at civil hospital karachi. J Coll Physicians Surg Pak. 2007; 17: 546-9.
  • 22. Gisbert JP, Calvet X. Review article: Helicobacter pylori-negative duodenal ulcer disease. Aliment Pharmacol Ther 2009; 30: 791-815.
  • 23. Kuipers EJ, Uyterlinde AM, Peña AS, et al. Long-term sequelae of Helicobacter pylori gastritis. Lancet 1995; 345: 1525-8.

Evaluation of Helicobacter pylori Infection with Endoscopic, Pathological, and Laboratory Findings

Year 2022, Volume: 13 Issue: 2, 202 - 206, 30.06.2022
https://doi.org/10.18663/tjcl.1067301

Abstract

Aim: Helicobacter pylori, the most common bacterial infestation in the gastrointestinal tract. It is known to role in the
development of intestinal metaplasia, dysplasia, gastric cancer, and atrophic gastritis. H. pylori infection has been thought to be
related with many diseases such as iron deficiency, vitamin b deficiency…In our study, we aimed to evaluate the patients who
underwent endoscopic examination in terms of endoscopic, pathological and laboratory (Hemogram and iron values) findings.
Material and Methods: Between October 2020 and July 2021, 322 patients who were requested endoscopic examination
and laboratory examination due to gastrointestinal system complaints were included in the study.
Results: In our study; 152 H. pylori negative cases and 170 Helicobacter pylori positive cases were detected. Helicobacter pylori
negative (HP-) group, the number of men was 50 and the number of women was 102. In the HP+ group, the number of men was
61 and the number of women was 109 (P=0.6387). The mean age in the (HP-) group was 51.48 ± 1.260. The mean age in the HP+
group was 48.29 ± 1.215 (P=0.0700). HGB value in the HP- group was 13.66 ± 0.1249, and in the HP+ group, it was found 13.95
± 0.1359 (P=0.1194). The mean MCV value was found to be 85.74 ± 0.4877 in the HP- group, and 85.69 ± 0.5860 (P=0.9505) in
the HP+ group. The mean Ferritin value in the HP- group was 38.71 ± 2.979, and 44.38 ± 3.195 (P=0.1983) in the HP+ group. In
addition, 31 cases with Pangastritis in the HP- group and 54 cases in the HP+ group were detected (p=0.0208).
Conclusion: In our study; the endoscopic, laboratory and pathological findings of HP infection were examined, no
significant relationship was found between age, gender, HGB, MCV and Ferritin values with HP infection. There is no
negative correlation with Antral gastritis and Atrophic gastritis in gastritis cases, a significant correlation was found
between pangastritis and HP (p=0.0208)

Project Number

yok

References

  • 1. Graham DY, Malaty HM, Evans DG, Evans DJ Jr., Klein PD, Adam E. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status. Gastroenterology 1991; 100: 1495-501.
  • 2. Lehours P, Yilmaz O. Epidemiology Helicobacter pylori infection. Helicobacter 2007; 12 : 1-3.
  • 3. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984; 1: 13115.
  • 4. Schirer WH, Schoengold RJ, Baker JT, et al. Development of FlexSure HP-an immunochromatographic method to detect antibodies against Helicobacter pylori. Clin Chem 1998; 44: 293-8.
  • 5. Kikuchi S, Wada O, Nakajima T, et al. Serum antiHelicobacter pylori antibody and gastric carcinoma among young adults. Cancer 1995; 75: 2789-93.
  • 6. Craanen ME, Dekker W, Blok P, Ferwerda J, Tytgat GN. Intestinal metaplasia and Helicobacter pylori: an endoscopic bioptic study of the gastric antrum. Gut 1992; 33: 16-20.
  • 7. Everhart JE. Recent developments in the epidemiology of Helicobacter pylori. Gastroenterology Clinics of North America 2000; 29: 559-79.
  • 8. Coyne D. Iron indices: what do they really mean? Kidney Int Suppl 2006: S4-8.
  • 9. Milman N, Rosenstock S, Andersen L, Jorgensen T, Bonnevie O. Serum ferritin, hemoglobin, and Helicobacter pylori infection: a seroepidemiologic survey comprising 2794 Danish adults. Gastroenterology 1998; 115: 268-74.
  • 10. Şengül D, Şengül İ. Helikobakter Pilori Sıklığı ve Lokasyon, Altı Adet Yaş Grubu ve Anatomik Pilot Bölge Bazlı 50 Yaş Sınır Değerlendirmesinin, Histopatolojik Helikobakter Pilori Kolonizasyon Derecesi ile İlişkileri. Med J Bakirkoy 2018; 14: 381-8.
  • 11. World Gastroenterology Organisation. WGO Practice Guideline: Helicobacter pylori in Developing Countri¬es. 2005.
  • 12. Megraud F. Epidemiology of Helicobacter pylori infection: Helicobacter pylori. Gastroenterology Clin Nort America 1993; 22: 73-88.
  • 13. The Eurogast Study Group. Epidemioloji of and risk faktor for Helicobacter pylori infection among 3194 asemptomatic subject in populations. GUT 1993; 34: 1672-6.
  • 14. Selek MB, Bektöre B, Atik TK, Özyurt M. Üçüncü basamak bir hastanede dispeptik yakınmaları olan hastaların dışkı örnekle¬rinde Helicobacter pylori antijen pozitifliğinin değerlendiril¬mesi. Dicle Med J 2013; 40: 574-8.
  • 15. Erçetin C, Dural AC, Yiğitbaş H, Yavuz E, Çelebi F, Borucu İ, Özcan TB, Alış H. Helikobakter pylori infeksiyonunun endoskopik, patolojik ve laboratuvar bulguları açısından değerlendirilmesi. İKSSTD 2021; 13: 25-30.
  • 16. Cardenas VM, Mulla ZD, Ortiz M, Graham DY. Iron deficiency and Helicobacter pylori infection in the United States. Am J Epidemiol 2006; 163: 127-34.
  • 17. Park SA, Lee HW, Hong MH, Choi YW, Choe YH, Ahn BY, et al. Comparative proteomic analysis of Helicobacter pylori strains associated with iron deficiency anemia. Proteomics 2006; 6: 1319-28.
  • 18. Erdem ME, Keçici S, Akın S, ve ark. Demir eksikliği anemisi ile helikobakter pilori arasındaki ilişki. Eur Arch Med Res 2014; 30: 82-5.
  • 19. Nalbant A, Aydın A. Helicobakter pylori enfeksiyonunun D vitamini, hemogram parametreleri ve kan grubu ile ilişkisi. The Turkish Journal of Academic Gastroenterology 2017;16: 01-05.
  • 20. Hershko C, Ianculovich M, Souroujon M. A hematologist’s view of unexplained iron deficiency anemia in males: impact of Helicobacter pylori eradication. Blood Cells Mol Dis 2007; 38: 45-53.
  • 21. Zuberi BF, Afsar S, Qadeer R, Baloch I, Quraishy MS, Kumar A, Akhtar N. Hemogolbin, ferritin, vitamin B12 and halicobacter pylori infection: a study in patients who underwent upper gi endoscopy at civil hospital karachi. J Coll Physicians Surg Pak. 2007; 17: 546-9.
  • 22. Gisbert JP, Calvet X. Review article: Helicobacter pylori-negative duodenal ulcer disease. Aliment Pharmacol Ther 2009; 30: 791-815.
  • 23. Kuipers EJ, Uyterlinde AM, Peña AS, et al. Long-term sequelae of Helicobacter pylori gastritis. Lancet 1995; 345: 1525-8.
There are 23 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Orıgınal Artıcle
Authors

Mehmet Alperen Avcı 0000-0003-3911-2686

Merve Nergis Fidan This is me 0000-0002-7213-6156

İsmail Oskay Kaya

Project Number yok
Publication Date June 30, 2022
Published in Issue Year 2022 Volume: 13 Issue: 2

Cite

APA Avcı, M. A., Fidan, M. N., & Kaya, İ. O. (2022). Evaluation of Helicobacter pylori Infection with Endoscopic, Pathological, and Laboratory Findings. Turkish Journal of Clinics and Laboratory, 13(2), 202-206. https://doi.org/10.18663/tjcl.1067301
AMA Avcı MA, Fidan MN, Kaya İO. Evaluation of Helicobacter pylori Infection with Endoscopic, Pathological, and Laboratory Findings. TJCL. June 2022;13(2):202-206. doi:10.18663/tjcl.1067301
Chicago Avcı, Mehmet Alperen, Merve Nergis Fidan, and İsmail Oskay Kaya. “Evaluation of Helicobacter Pylori Infection With Endoscopic, Pathological, and Laboratory Findings”. Turkish Journal of Clinics and Laboratory 13, no. 2 (June 2022): 202-6. https://doi.org/10.18663/tjcl.1067301.
EndNote Avcı MA, Fidan MN, Kaya İO (June 1, 2022) Evaluation of Helicobacter pylori Infection with Endoscopic, Pathological, and Laboratory Findings. Turkish Journal of Clinics and Laboratory 13 2 202–206.
IEEE M. A. Avcı, M. N. Fidan, and İ. O. Kaya, “Evaluation of Helicobacter pylori Infection with Endoscopic, Pathological, and Laboratory Findings”, TJCL, vol. 13, no. 2, pp. 202–206, 2022, doi: 10.18663/tjcl.1067301.
ISNAD Avcı, Mehmet Alperen et al. “Evaluation of Helicobacter Pylori Infection With Endoscopic, Pathological, and Laboratory Findings”. Turkish Journal of Clinics and Laboratory 13/2 (June 2022), 202-206. https://doi.org/10.18663/tjcl.1067301.
JAMA Avcı MA, Fidan MN, Kaya İO. Evaluation of Helicobacter pylori Infection with Endoscopic, Pathological, and Laboratory Findings. TJCL. 2022;13:202–206.
MLA Avcı, Mehmet Alperen et al. “Evaluation of Helicobacter Pylori Infection With Endoscopic, Pathological, and Laboratory Findings”. Turkish Journal of Clinics and Laboratory, vol. 13, no. 2, 2022, pp. 202-6, doi:10.18663/tjcl.1067301.
Vancouver Avcı MA, Fidan MN, Kaya İO. Evaluation of Helicobacter pylori Infection with Endoscopic, Pathological, and Laboratory Findings. TJCL. 2022;13(2):202-6.


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