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The Effect of Acupuncture and Diet on Serum Leptin and Nesfatin-1 Levels in Overweight/Obese Individuals

Year 2023, Volume: 17 Issue: 3 - Turkish Journal of Family Medicine and Primary Care, 370 - 380, 20.09.2023

Tevhid Aydın Ruhuşen Kutlu Hayriye Baltaoğlu Alp İbrahim Kılınc

https://doi.org/10.21763/tjfmpc.1270587

Abstract

Acupuncture applications and diet are frequently used in obesity treatment. We aimed to investigate the changes in serum leptin and nesfatin-1 levels measured before and after acupuncture and diet in overweight/obese individuals in the presented study. This interventional study was carried out on 90 overweight/obese patients. Participants were divided into three groups: Group 1 (Acupuncture), Group 2 (Diet), and Group 3 (Those who did not take any attempts to lose weight- control group). Serum leptin and nesfatin-1 levels were measured before and after the intervention.
The 30th days leptin values were significantly decreased in the acupuncture group (p=0.040) while they were significantly increased in the control group (p=0.039). It was detected that the nesfatin-1 values were significantly increased in both acupuncture (p=0.032) and diet groups (p=0.017). Also, body weights significantly decreased both in acupuncture (p=0.032) and diet groups (p<0.001). Our results support the effects of acupuncture treatment on appetite hormones. Further research on the mechanisms of endogenous and exogenous actions of the recently discovered hormones, leptin and nesfatin-1, are needed.

Keywords

Acupuncture Diet Leptin Nesfatin-1 Obesity

Supporting Institution

Acknowledgments: We wish to thank the Necmettin Erbakan University Scientific Research Coordination Center for the financial support to this study.

Project Number

Research number: 171518018 (2017).

Thanks

Acknowledgments: We wish to thank the Necmettin Erbakan University Scientific Research Coordination Center for the financial support to this study. Research number: 171518018 (2017). We thank to all of the participants.

References

  • 1. Turkish Endocrine and Metabolism Association, Obesity Diagnosis and Treatment Guide [Internet]. 2018 [cited 2018 Nov 03]; Available from: http://temd.org.tr/admin/uploads/tbl_kilavuz/20180516162841-2018-05 16tbl_kilavuz162840.pdf.
  • 2. Webber L, Divajeva D, Marsh T, McPherson K, Brown M, Galea G et al. The future burden of obesity-related diseases in the 53 WHO European-Region countries and the impact of effective interventions: a modelling study. BMJ Open. 2014;4(7):e004787. doi: 10.1136/bmjopen-2014-004787
  • 3. Satman I, Yilmaz T, Sengül A, Salman S, Salman F, Uygur S et al. Population-based study of diabetes and risk characteristics in Turkey: results of the Turkish diabetes epidemiology study (TURDEP). Diabetes Care 2002;25(9):1551-1556.
  • 4. Satman I, Omer B, Tutuncu Y, Kalaca S, Gedik S, Dinccag N et al. Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. Eur J Epidemiol 2013;28(2):169-180.
  • 5. Darbandi M, Darbandi S, Owji AA, Mokarram P, Mobarhan MG, Fardaei M et al. Auricular or body acupuncture: which one is more effective in reducing abdominal fat mass in Iranian men with obesity: a randomized clinical trial. J Diabetes Metab Disord. 2014;13(1):92. doi: 10.1186/s40200-014-0092-3. eCollection 2014.
  • 6. National Institutes of Health Consensus Development Conference Statement. Acupuncture. NIH Consensus Statement 1997 Nov 3-5; 15(5):134. http://consensus.nih.gov/1997/1997Acupuncture107html. Accessed date: 03.11.2019.
  • 7. Hamann A, Matthaei S. Regulation of energy balance by leptin. Exp Clin Endocrinol Diabetes. 1996;104(4):293-300. doi: 10.1055/s-0029-1211457.
  • 8. Oh-I S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006;443(7112):709-712. doi: 10.1038/nature05162. Epub 2006 Oct 1.
  • 9. Park HD, Song MH, Myoung HS, Lee KJ. A new acupuncture point detection using the impedance measurement system based on ANF and phase-space-method. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:2572-2574.
  • 10. Sun Q, Xu Y. Simple obesity and obesity hyperlipemia treated with otoacupoint pellet pressure and body acupuncture. J Tradit Chin Med 1993;13(1):22-26.
  • 11. Cabioglu MT, Ergene N. Changes in serum leptin and beta endorphin levels with weight loss by electroacupuncture and diet restriction in obesity treatment. Am J Chin Med. 2006;34(1):1-11.
  • 12. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;1;334(5):292-295.
  • 13. Carlson JJ, Turpin AA, Wiebke G, Hunt SC, Adams TD. Pre-and post-prandial appetite hormone levels in normal weight and severely obese women. Nutr Metab (Lond). 2009;6:32.
  • 14. Weigle DS, Duell PB, Connor WE, Steiner RA, Soules MR, Kuijper JL. Effect of fasting refeeding and dietary fat restriction on plasma leptin levels. J Clin Endocrinol Metab 1997;82:561-565.
  • 15. Ozkan Y, Timurkan ES, Aydin S, Sahin I, Timurkan M, Citil C, et al. Acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 peptide changes related to the body mass index. Int J Endocrinol 2013;2013:236085. doi: 10.1155/2013/236085.
  • 16. Anwar GM, Yamamah G, Ibrahim A, El-Lebedy D, Farid TM, Mahmoud R. Nesfatin-1 in childhood and adolescent obesity and its as sociation with food intake, body composition and insulin resistance. Regul Pept. 2014;188:21-24.
  • 17. Tsuchiya T, Shimizu H, Yamada M, Osaki A, Oh-I S, Ariyama Y, et al. Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males. J Clin Endocrinol (Oxf). 2010;73(4):484-490. doi: 10.1111/j.1365-2265.2010.03835.x.
  • 18. Deniz R, Gurates B, Aydin S, Celik H, Sahin I, Baykus Y, et al. Nesfatin-1 and other hormone alterations in polycystic ovary syndrome. Endocrine 2012;42(3):694-699.
  • 19. Sengul O, Dilbaz B, Halıcı Z, Ferah I, Cadırcı E, Yılmaz F. Decreased serum nesfatin-1 levels in endometriosis. Eur J Obstet Gynecol Reprod Biol. 2014;177:34-37.
  • 20. Guo Y, Xing M. Sun W, Yuan X, Dai H, Ding H. Plasma nesfatin-1 level in obese patients after acupuncture: a randomised controlled trial. Acupunct Med 2014;32(4):313–317.
  • 21. Kara H, (2014). Diyet Yapan Obez Bireylerde Leptin, Grelin, Nesfatin 1, Obestatin Biyokimyasal Parametreleri ile Kilo Verme Arasındaki İlişki. Balıkesir Üniversitesi. Sağlık Bilimleri Enstitüsü. Tıbbi Biyokimya Anabilim Dalı Yüksek Lisans Tezi, Balıkesir.
  • 22. Cabioglu MT, Ergene N. Electroacupuncture therapy for weight loss reduces serum total cholesterol, triglycerides, and LDL cholesterol levels in obese women. Am J Chin Med. 2005;33(4):525-533.

Aşırı Kilolu/Obez Bireylerde Akupunktur Ve Diyetin Serum Leptin Ve Nesfatin-1 Düzeylerine Etkisi

Year 2023, Volume: 17 Issue: 3 - Turkish Journal of Family Medicine and Primary Care, 370 - 380, 20.09.2023

Tevhid Aydın Ruhuşen Kutlu Hayriye Baltaoğlu Alp İbrahim Kılınc

https://doi.org/10.21763/tjfmpc.1270587

Abstract

Akupunktur uygulamaları ve diyet obezite tedavisinde sıklıkla kullanılmaktadır. Sunulan çalışmada aşırı kilolu ve/veya obez bireylerde akupunktur ve diyet öncesi/sonrasında ölçülen serum leptin ve nesfatin-1 düzeylerindeki değişiklikleri araştırmayı amaçladık. Bu müdahele çalışması 90 kilolu/obez hasta üzerinde yapıldı. Katılımcılar üç gruba ayrıldı: Grup 1 (Akupunktur), Grup 2 (Diyet) ve Grup 3 (Kilo vermek için herhangi bir girişimde bulunmamış olanlar- kontrol grubu). Müdahale öncesi ve sonrası serum leptin ve nesfatin-1 düzeyleri ölçüldü. Akupunktur grubunda 30. gün leptin değerleri anlamlı olarak azaldı (p=0.040), 3. grupta ise anlamlı olarak arttı (p=0.039). Nesfatin-1 değerlerinin hem akupunktur (p=0.032), hem de diyet (p=0.017) gruplarında anlamlı olarak arttığı saptandı. Ayrıca vücut ağırlıkları hem akupunktur (p=0.032) hem de diyet gruplarında (p<0.001) anlamlı olarak azaldı. Sonuçlarımız akupunktur tedavisinin iştah hormonları üzerindeki etkilerini desteklemektedir. Yakın zamanda keşfedilen leptin ve nesfatin-1 hormonlarının endojen ve ekzojen etkilerinin mekanizmaları hakkında daha fazla araştırmaya ihtiyaç vardır.

Keywords

Akupunktur Diyet Leptin Obezite. Nesfatin-1

Project Number

Research number: 171518018 (2017).

References

  • 1. Turkish Endocrine and Metabolism Association, Obesity Diagnosis and Treatment Guide [Internet]. 2018 [cited 2018 Nov 03]; Available from: http://temd.org.tr/admin/uploads/tbl_kilavuz/20180516162841-2018-05 16tbl_kilavuz162840.pdf.
  • 2. Webber L, Divajeva D, Marsh T, McPherson K, Brown M, Galea G et al. The future burden of obesity-related diseases in the 53 WHO European-Region countries and the impact of effective interventions: a modelling study. BMJ Open. 2014;4(7):e004787. doi: 10.1136/bmjopen-2014-004787
  • 3. Satman I, Yilmaz T, Sengül A, Salman S, Salman F, Uygur S et al. Population-based study of diabetes and risk characteristics in Turkey: results of the Turkish diabetes epidemiology study (TURDEP). Diabetes Care 2002;25(9):1551-1556.
  • 4. Satman I, Omer B, Tutuncu Y, Kalaca S, Gedik S, Dinccag N et al. Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. Eur J Epidemiol 2013;28(2):169-180.
  • 5. Darbandi M, Darbandi S, Owji AA, Mokarram P, Mobarhan MG, Fardaei M et al. Auricular or body acupuncture: which one is more effective in reducing abdominal fat mass in Iranian men with obesity: a randomized clinical trial. J Diabetes Metab Disord. 2014;13(1):92. doi: 10.1186/s40200-014-0092-3. eCollection 2014.
  • 6. National Institutes of Health Consensus Development Conference Statement. Acupuncture. NIH Consensus Statement 1997 Nov 3-5; 15(5):134. http://consensus.nih.gov/1997/1997Acupuncture107html. Accessed date: 03.11.2019.
  • 7. Hamann A, Matthaei S. Regulation of energy balance by leptin. Exp Clin Endocrinol Diabetes. 1996;104(4):293-300. doi: 10.1055/s-0029-1211457.
  • 8. Oh-I S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006;443(7112):709-712. doi: 10.1038/nature05162. Epub 2006 Oct 1.
  • 9. Park HD, Song MH, Myoung HS, Lee KJ. A new acupuncture point detection using the impedance measurement system based on ANF and phase-space-method. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:2572-2574.
  • 10. Sun Q, Xu Y. Simple obesity and obesity hyperlipemia treated with otoacupoint pellet pressure and body acupuncture. J Tradit Chin Med 1993;13(1):22-26.
  • 11. Cabioglu MT, Ergene N. Changes in serum leptin and beta endorphin levels with weight loss by electroacupuncture and diet restriction in obesity treatment. Am J Chin Med. 2006;34(1):1-11.
  • 12. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;1;334(5):292-295.
  • 13. Carlson JJ, Turpin AA, Wiebke G, Hunt SC, Adams TD. Pre-and post-prandial appetite hormone levels in normal weight and severely obese women. Nutr Metab (Lond). 2009;6:32.
  • 14. Weigle DS, Duell PB, Connor WE, Steiner RA, Soules MR, Kuijper JL. Effect of fasting refeeding and dietary fat restriction on plasma leptin levels. J Clin Endocrinol Metab 1997;82:561-565.
  • 15. Ozkan Y, Timurkan ES, Aydin S, Sahin I, Timurkan M, Citil C, et al. Acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 peptide changes related to the body mass index. Int J Endocrinol 2013;2013:236085. doi: 10.1155/2013/236085.
  • 16. Anwar GM, Yamamah G, Ibrahim A, El-Lebedy D, Farid TM, Mahmoud R. Nesfatin-1 in childhood and adolescent obesity and its as sociation with food intake, body composition and insulin resistance. Regul Pept. 2014;188:21-24.
  • 17. Tsuchiya T, Shimizu H, Yamada M, Osaki A, Oh-I S, Ariyama Y, et al. Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males. J Clin Endocrinol (Oxf). 2010;73(4):484-490. doi: 10.1111/j.1365-2265.2010.03835.x.
  • 18. Deniz R, Gurates B, Aydin S, Celik H, Sahin I, Baykus Y, et al. Nesfatin-1 and other hormone alterations in polycystic ovary syndrome. Endocrine 2012;42(3):694-699.
  • 19. Sengul O, Dilbaz B, Halıcı Z, Ferah I, Cadırcı E, Yılmaz F. Decreased serum nesfatin-1 levels in endometriosis. Eur J Obstet Gynecol Reprod Biol. 2014;177:34-37.
  • 20. Guo Y, Xing M. Sun W, Yuan X, Dai H, Ding H. Plasma nesfatin-1 level in obese patients after acupuncture: a randomised controlled trial. Acupunct Med 2014;32(4):313–317.
  • 21. Kara H, (2014). Diyet Yapan Obez Bireylerde Leptin, Grelin, Nesfatin 1, Obestatin Biyokimyasal Parametreleri ile Kilo Verme Arasındaki İlişki. Balıkesir Üniversitesi. Sağlık Bilimleri Enstitüsü. Tıbbi Biyokimya Anabilim Dalı Yüksek Lisans Tezi, Balıkesir.
  • 22. Cabioglu MT, Ergene N. Electroacupuncture therapy for weight loss reduces serum total cholesterol, triglycerides, and LDL cholesterol levels in obese women. Am J Chin Med. 2005;33(4):525-533.
There are 22 citations in total.

Details

Primary Language English
Subjects Family Medicine
Journal Section Orijinal Articles
Authors

Tevhid Aydın 0000-0003-4109-6347

Ruhuşen Kutlu 0000-0002-8502-0232

Hayriye Baltaoğlu Alp 0000-0002-7262-2234

İbrahim Kılınc 0000-0002-7729-7557

Project Number Research number: 171518018 (2017).
Early Pub Date September 16, 2023
Publication Date September 20, 2023
Submission Date March 25, 2023
Published in Issue Year 2023 Volume: 17 Issue: 3 - Turkish Journal of Family Medicine and Primary Care

Cite

Vancouver Aydın T, Kutlu R, Baltaoğlu Alp H, Kılınc İ. The Effect of Acupuncture and Diet on Serum Leptin and Nesfatin-1 Levels in Overweight/Obese Individuals. TJFMPC. 2023;17(3):370-8.
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English or Turkish manuscripts from authors with new knowledge to contribute to understanding and improving health and primary care are welcome.