Research Article
BibTex RIS Cite

The Effect of Coenzyme Q10 on Vestibular Compensation Process after Unilateral Labyrinthectomy in Rats Using Behavioral Tests

Year 2022, Volume: 32 Issue: 1, 5 - 12, 10.03.2022
https://doi.org/10.26650/Tr-ENT.2021.1016110

Abstract

Objective: To determine the effect of coenzyme Q10 on the vestibular compensation process after unilateral labyrinthectomy.

Material and Methods: Thirty Wistar rats were randomly assigned to 3 equal groups: the negative control group, the experimental group and the control group. Labyrinthectomy surgeries were performed in all 3 groups. After the labyrinthectomy, findings such as nystagmus with its fast phase directed to the undamaged side, deviation of the head to the side operated on, impairment in walking, and decreased tonus of the extensor muscles on the same side were observed.

Results: The values of Group EG and Group CG were somewhat higher than those of Group NCG in terms of the degree of head tilt, but there was no statistically significant difference among the three groups. Although Group EG and Group CG were found to differ statistically significantly from Group NCG on certain days in terms of postural deficit values and nystagmus, this significance remained limited to those particular days.

Conclusion: The effect of CoQ10 on the vestibular compensation process was limited may be due to its limited dose, short duration of administration, and the limited number of rats. We believe that the effects of CoQ10 on the vestibular compensation process after labyrinthectomy should not be neglected. Despite the fact that we administered it at limited doses for a short term on a limited number of rats, CoQ10 should be used in larger samples, in higher doses, and for a longer time because CoQ10 has positive, though limited effects, on the vestibular compensation process

References

  • 1. De La Cruz A, Borne Teufert K, Berliner KI. Transmastoid labyrinthectomy versus translabyrinthine vestibular nerve section: dose cutting the vestibular nerve a make a difference in outcome? Otol Neurotol 2007;28(6):801-8. google scholar
  • 2. Nadol NB, McKenna MJ. Labyrinthectomy in surgery of the Ear and Temporal Bone 2nd edition. Nadol JB, McKenna MJ(Eds.), 2005 Lippincott Williams &Wilkins, pp.367-73. google scholar
  • 3. Koç C. Kulak Burun Boğaz Hastalıkları ve Baş -Boyun Cerrahisi. İkinci Baskı, Türkiye Güneş Tıp Kitapevleri; 2019, 307-32. google scholar
  • 4. Rangan U, Bulkley GB. Prospects for treatment of free radical-mediated tissue injury. Br Med Bull 1993;49(3):700-18. google scholar
  • 5. Yalçın AS. Antioksidanlar. Klinik Gelişim, (Serbest Radikaller ve Antioksidanlar Özel Sayısı) 1998;11:342-6. google scholar
  • 6. Bonakdar RA, Guarneri E. Coenzyme Q10. Am Fam Physician 2005;72(6):1065-70. google scholar
  • 7. Miles MV. The uptake and distribution of coenzyme Q10. Mitochondrion 2007;7(Suppl):S72- google scholar
  • 8. Oztay F, Ergin B, Ustunova S, Balci H, Kapucu A, Caner M, et al. Effects of Coenzyme Q10 on the Heart Ultrastructure and Nitric Oxide Synthase during Hyperthyroidism. Chin J Physiol 2007; 50(5):217-24. google scholar
  • 9. Khan, M, Gross J, Haupt H, Jainz A, Niklowitz P, Scherer H, et al. A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium. Otolaryngol Head Neck Surg 2007;136(1):72-7. google scholar
  • 10. Fetoni AR, Eramo SL, Rolesi R, Troiani D, Paludetti G. Antioxidant treatment with coenzyme Q-ter in prevention of gentamycin ototoxicity in an animal model. Acta Otorhinolaryngol Ital 2012;32(2):103-10. google scholar
  • 11. Fetoni AR, Troıanı D, Eramo SL, Rolesı R, Troiani GP. Efficacy of routes of administration for Coenzyme Q10 formulation in noise - induced hearing loss:Systemic versus transtympanic modality. Acta Otolaryngol 2012;132(4):391-9. google scholar
  • 12. Kumar A, Kaur H, Devi P, Mohan V. Role of coenzyme Q10 in cardiac disease, hypertension and Meniere-like syndrome. Pharmacol Ther 2009;124:259-68. google scholar
  • 13. Akyıldız AN. Kulak Hastalıkları ve Mikrocerrahisi. Ankara: Bilimsel Tıp Yayınevi, 1998. google scholar
  • 14. Günther L, Beck R, Xiong G, Potschka H , Jahn K, Bartenstein P et al. N-Acetyl-L Leucine Accelerates Vestibular Compensation after Unilateral Labyrinthectomy by Action in the Cerebellum and Thalamus. PLoS ONE 2015;10(3):e0120891. doi:10.1371/journal. pone.0120891. google scholar
  • 15. Bailey BJ, Johnson TJ. Baş-Boyun Cerrahisi Otolarengoloji. Dördüncü Baskı, Türkiye Güneş Tıp Kitapevleri; 2011, 2295-342. google scholar
  • 16. Lee KJ. Essential Otolaryngology Baş ve Boyun Cerrahisi. Dokuzuncu Baskı, Türkiye Güneş Tıp Kitapevleri; 2012, 502-11. google scholar
  • 17. Ris L, de Waele C, Serafin M, Vidal PP, Godaux E. Neuronal activity in the ipsilateral vestibular nucleus following unilateral labyrinthectomy in the alert guinea pig. J Neurophysiol 1995;74(5):2087-99. google scholar
  • 18. Fetter M, Zee DS. Recovery from unilateral labyrinthectomy in rhesus monkey. J Neurophysiol 1988;59(2):370-93. google scholar
  • 19. Flohr H, Burt A, Will U, Ammelburg R. Vestibular compensation: A paradigm for lesion-induced neural plasticity. Fortschritte der ZoologielProgress in Zoology. BandNol. 37. Rahmann (Ed.): Fundamentals of Memory Formation: Neuronsi Plasticity and Brain Function. Gustav Fischer Verlag • Stuttgart • New York • 1989, p. 243. google scholar
  • 20. Smith PF, Curthoys IS. Neuronal activity in the ipsilateral medial vestibular nucleus of the guinea pig following unilateral labyrinthectomy. Brain Res 1988;444(2):308-19. google scholar
  • 21. Smith PF, Darlington CL. Can vestibular compensation be enhanced by drug treatment? A review of recent evidence. J Vestib Res 1994;4(3):169-79. google scholar
  • 22. Leau O, Ducrot R. Action de l’acetylleucine sur le vertige experimental de la souris [Action of acetylleucine on experimental vertigo in mice]. C R Seances Soc Biol Fil 1957;151(7):1365-7. google scholar
  • 23. Neuzil E, Ravaine S, Cousse H. La N-acetyl-DL-leucine, medicament symptomatique de vertigineux. Bull Soc Pharm Bordeaux 2002;141:15-38. google scholar
  • 24. Park JS, Jeong HS. Effects of nitric oxide on the vestibular functional recovery after unilateral labyrinthectomy. Jpn J Pharmacol 2000;84(4):425-30. google scholar
  • 25. Elmberger PG, Kalen A, Brunk UT, Dallner G. Discharge of newly-synthesized dolichol and ubiquinone with lipoproteins to rat liver perfusate and to the bile. Lipids 1989;24(11):919-30. google scholar
  • 26. Bentinger M, Dallner G, Chojnacki T, Swiezewska E. Distribution and breakdown of labeled coenzyme Q10 in rat. Free Radic Biol Med 2003;34(5):563-75. google scholar
  • 27. Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007;7(Suppl):S78-88. google scholar
Year 2022, Volume: 32 Issue: 1, 5 - 12, 10.03.2022
https://doi.org/10.26650/Tr-ENT.2021.1016110

Abstract

References

  • 1. De La Cruz A, Borne Teufert K, Berliner KI. Transmastoid labyrinthectomy versus translabyrinthine vestibular nerve section: dose cutting the vestibular nerve a make a difference in outcome? Otol Neurotol 2007;28(6):801-8. google scholar
  • 2. Nadol NB, McKenna MJ. Labyrinthectomy in surgery of the Ear and Temporal Bone 2nd edition. Nadol JB, McKenna MJ(Eds.), 2005 Lippincott Williams &Wilkins, pp.367-73. google scholar
  • 3. Koç C. Kulak Burun Boğaz Hastalıkları ve Baş -Boyun Cerrahisi. İkinci Baskı, Türkiye Güneş Tıp Kitapevleri; 2019, 307-32. google scholar
  • 4. Rangan U, Bulkley GB. Prospects for treatment of free radical-mediated tissue injury. Br Med Bull 1993;49(3):700-18. google scholar
  • 5. Yalçın AS. Antioksidanlar. Klinik Gelişim, (Serbest Radikaller ve Antioksidanlar Özel Sayısı) 1998;11:342-6. google scholar
  • 6. Bonakdar RA, Guarneri E. Coenzyme Q10. Am Fam Physician 2005;72(6):1065-70. google scholar
  • 7. Miles MV. The uptake and distribution of coenzyme Q10. Mitochondrion 2007;7(Suppl):S72- google scholar
  • 8. Oztay F, Ergin B, Ustunova S, Balci H, Kapucu A, Caner M, et al. Effects of Coenzyme Q10 on the Heart Ultrastructure and Nitric Oxide Synthase during Hyperthyroidism. Chin J Physiol 2007; 50(5):217-24. google scholar
  • 9. Khan, M, Gross J, Haupt H, Jainz A, Niklowitz P, Scherer H, et al. A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium. Otolaryngol Head Neck Surg 2007;136(1):72-7. google scholar
  • 10. Fetoni AR, Eramo SL, Rolesi R, Troiani D, Paludetti G. Antioxidant treatment with coenzyme Q-ter in prevention of gentamycin ototoxicity in an animal model. Acta Otorhinolaryngol Ital 2012;32(2):103-10. google scholar
  • 11. Fetoni AR, Troıanı D, Eramo SL, Rolesı R, Troiani GP. Efficacy of routes of administration for Coenzyme Q10 formulation in noise - induced hearing loss:Systemic versus transtympanic modality. Acta Otolaryngol 2012;132(4):391-9. google scholar
  • 12. Kumar A, Kaur H, Devi P, Mohan V. Role of coenzyme Q10 in cardiac disease, hypertension and Meniere-like syndrome. Pharmacol Ther 2009;124:259-68. google scholar
  • 13. Akyıldız AN. Kulak Hastalıkları ve Mikrocerrahisi. Ankara: Bilimsel Tıp Yayınevi, 1998. google scholar
  • 14. Günther L, Beck R, Xiong G, Potschka H , Jahn K, Bartenstein P et al. N-Acetyl-L Leucine Accelerates Vestibular Compensation after Unilateral Labyrinthectomy by Action in the Cerebellum and Thalamus. PLoS ONE 2015;10(3):e0120891. doi:10.1371/journal. pone.0120891. google scholar
  • 15. Bailey BJ, Johnson TJ. Baş-Boyun Cerrahisi Otolarengoloji. Dördüncü Baskı, Türkiye Güneş Tıp Kitapevleri; 2011, 2295-342. google scholar
  • 16. Lee KJ. Essential Otolaryngology Baş ve Boyun Cerrahisi. Dokuzuncu Baskı, Türkiye Güneş Tıp Kitapevleri; 2012, 502-11. google scholar
  • 17. Ris L, de Waele C, Serafin M, Vidal PP, Godaux E. Neuronal activity in the ipsilateral vestibular nucleus following unilateral labyrinthectomy in the alert guinea pig. J Neurophysiol 1995;74(5):2087-99. google scholar
  • 18. Fetter M, Zee DS. Recovery from unilateral labyrinthectomy in rhesus monkey. J Neurophysiol 1988;59(2):370-93. google scholar
  • 19. Flohr H, Burt A, Will U, Ammelburg R. Vestibular compensation: A paradigm for lesion-induced neural plasticity. Fortschritte der ZoologielProgress in Zoology. BandNol. 37. Rahmann (Ed.): Fundamentals of Memory Formation: Neuronsi Plasticity and Brain Function. Gustav Fischer Verlag • Stuttgart • New York • 1989, p. 243. google scholar
  • 20. Smith PF, Curthoys IS. Neuronal activity in the ipsilateral medial vestibular nucleus of the guinea pig following unilateral labyrinthectomy. Brain Res 1988;444(2):308-19. google scholar
  • 21. Smith PF, Darlington CL. Can vestibular compensation be enhanced by drug treatment? A review of recent evidence. J Vestib Res 1994;4(3):169-79. google scholar
  • 22. Leau O, Ducrot R. Action de l’acetylleucine sur le vertige experimental de la souris [Action of acetylleucine on experimental vertigo in mice]. C R Seances Soc Biol Fil 1957;151(7):1365-7. google scholar
  • 23. Neuzil E, Ravaine S, Cousse H. La N-acetyl-DL-leucine, medicament symptomatique de vertigineux. Bull Soc Pharm Bordeaux 2002;141:15-38. google scholar
  • 24. Park JS, Jeong HS. Effects of nitric oxide on the vestibular functional recovery after unilateral labyrinthectomy. Jpn J Pharmacol 2000;84(4):425-30. google scholar
  • 25. Elmberger PG, Kalen A, Brunk UT, Dallner G. Discharge of newly-synthesized dolichol and ubiquinone with lipoproteins to rat liver perfusate and to the bile. Lipids 1989;24(11):919-30. google scholar
  • 26. Bentinger M, Dallner G, Chojnacki T, Swiezewska E. Distribution and breakdown of labeled coenzyme Q10 in rat. Free Radic Biol Med 2003;34(5):563-75. google scholar
  • 27. Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007;7(Suppl):S78-88. google scholar
There are 27 citations in total.

Details

Primary Language English
Subjects Otorhinolaryngology
Journal Section Research Article
Authors

Ayşe Çeçen 0000-0001-6255-6125

Rıfat Karlı

Asude Ünal This is me 0000-0003-0282-8277

Publication Date March 10, 2022
Submission Date October 29, 2021
Published in Issue Year 2022 Volume: 32 Issue: 1

Cite

APA Çeçen, A., Karlı, R., & Ünal, A. (2022). The Effect of Coenzyme Q10 on Vestibular Compensation Process after Unilateral Labyrinthectomy in Rats Using Behavioral Tests. The Turkish Journal of Ear Nose and Throat, 32(1), 5-12. https://doi.org/10.26650/Tr-ENT.2021.1016110
AMA Çeçen A, Karlı R, Ünal A. The Effect of Coenzyme Q10 on Vestibular Compensation Process after Unilateral Labyrinthectomy in Rats Using Behavioral Tests. Tr-ENT. March 2022;32(1):5-12. doi:10.26650/Tr-ENT.2021.1016110
Chicago Çeçen, Ayşe, Rıfat Karlı, and Asude Ünal. “The Effect of Coenzyme Q10 on Vestibular Compensation Process After Unilateral Labyrinthectomy in Rats Using Behavioral Tests”. The Turkish Journal of Ear Nose and Throat 32, no. 1 (March 2022): 5-12. https://doi.org/10.26650/Tr-ENT.2021.1016110.
EndNote Çeçen A, Karlı R, Ünal A (March 1, 2022) The Effect of Coenzyme Q10 on Vestibular Compensation Process after Unilateral Labyrinthectomy in Rats Using Behavioral Tests. The Turkish Journal of Ear Nose and Throat 32 1 5–12.
IEEE A. Çeçen, R. Karlı, and A. Ünal, “The Effect of Coenzyme Q10 on Vestibular Compensation Process after Unilateral Labyrinthectomy in Rats Using Behavioral Tests”, Tr-ENT, vol. 32, no. 1, pp. 5–12, 2022, doi: 10.26650/Tr-ENT.2021.1016110.
ISNAD Çeçen, Ayşe et al. “The Effect of Coenzyme Q10 on Vestibular Compensation Process After Unilateral Labyrinthectomy in Rats Using Behavioral Tests”. The Turkish Journal of Ear Nose and Throat 32/1 (March 2022), 5-12. https://doi.org/10.26650/Tr-ENT.2021.1016110.
JAMA Çeçen A, Karlı R, Ünal A. The Effect of Coenzyme Q10 on Vestibular Compensation Process after Unilateral Labyrinthectomy in Rats Using Behavioral Tests. Tr-ENT. 2022;32:5–12.
MLA Çeçen, Ayşe et al. “The Effect of Coenzyme Q10 on Vestibular Compensation Process After Unilateral Labyrinthectomy in Rats Using Behavioral Tests”. The Turkish Journal of Ear Nose and Throat, vol. 32, no. 1, 2022, pp. 5-12, doi:10.26650/Tr-ENT.2021.1016110.
Vancouver Çeçen A, Karlı R, Ünal A. The Effect of Coenzyme Q10 on Vestibular Compensation Process after Unilateral Labyrinthectomy in Rats Using Behavioral Tests. Tr-ENT. 2022;32(1):5-12.