Case Report
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Asymptomatic ovarian metastasis of malignant melanoma in an adolescent

Year 2023, Volume: 23 Issue: 3, 74 - 77, 28.12.2023
https://doi.org/10.59215/trsgo.1234122

Abstract

Malignant Melanoma (MM) is a tumor with an extremely poor prognosis and is very rare in adolescents. The prognosis of the disease in this population is different from that of adults. The condition can be diagnosed at a metastatic stage. Gynecological metastases of MMs often occur in the endometrium. More rarely, metastases can be detected in the ovaries. Although it is rare in adolescents, MM cases should be evaluated regarding ovarian metastases. It should be noted that adolescents can be asymptomatic no matter how large the mass is. This case report presents a case with a primary melanoma lesion in the leg and a metastatic ovarian mass detected in imaging studies performed five months after the initial diagnosis. The mass detected in the ovary in the case was removed by salphingoopherectomy. The diagnosis of metastasis was confirmed by immunohistochemical staining. Sentinel lymph node biopsy was performed concurrently with oophorectomy. Malignant melanomas may rarely metastasize gynecologically. Metastases should be considered in the differential diagnosis of adnexal mass in patients with melanoma, and the treatment plan should be arranged accordingly.

References

  • Paradela S, Fonseca E, Pita-Fernández S, Kantrow SM, Diwan AH, Herzog C, et al. Prognostic factors for melanoma in children and adolescents: A clinicopathologic, single-center study of 137 patients. Cancer. 2010;116(18):4334–44.
  • Al-Himdani S, Naderi N, Whitaker IS, Jones NW. An 18-year Study of Malignant Melanoma in Childhood and Adolescence. Plast Reconstr Surg - Glob Open. 2019;7(8)
  • Simeone S, Laterza MM, Scaravilli G, Capuano S, Serao M, Orabona P, et al. Malignant melanoma metastasizing to the uterus in a patient with atypical postmenopause metrorrhagia. Minerva Ginecol. 2009;61(1):77–80.
  • Lorimer PD, White RL, Walsh K, Han Y, Kirks RC, Symanowski J, et al. Pediatric and Adolescent Melanoma: A National Cancer Data Base Update. Ann Surg Oncol. 2016;23(12):4058–66.
  • Bartenstein DW, Kelleher CM, Friedmann AM, Duncan LM, Tsao H, Sober AJ, et al. Contrasting features of childhood and adolescent melanomas. Pediatr Dermatol. 2018;35(3):354–60.
  • Moselhi M, Spencer J, Lane G. Malignant melanoma metastatic to the ovary: Presentation and radiological characteristics. Gynecol Oncol. 1998;69(2):165–8.
  • Lange JR, Palis BE, Chang DC, Soong SJ, Balch CM. Melanoma in children and teenagers: An analysis of patients from the National Cancer Data Base. J Clin Oncol. 2007;25(11):1363–8.
  • Young KZ, Fossum SL, Lowe L, Else T, Fecher LA, Demirci H, et al. An adolescent with uveal melanoma and BAP1 tumor predisposition syndrome. JAAD Case Reports. 2020;6(6):563–6.
  • Enomoto LM, Levine EA, Shen P, Votanopoulos KI. Role of Surgery for Metastatic Melanoma. Vol. 100, Surgical Clinics of North America. 2020. p. 127–39.

Adölesanda asemptomatik ovaryan malign melanom

Year 2023, Volume: 23 Issue: 3, 74 - 77, 28.12.2023
https://doi.org/10.59215/trsgo.1234122

Abstract

Malign Melanom (MM), son derece kötü prognoza sahip bir tümördür ve adölesanlarda çok nadir görülür. Bu popülasyonda hastalığın prognozu yetişkinlerden farklıdır. Durum metastatik evrede teşhis edilebilir. MM’lerin jinekolojik metastazları sıklıkla endometriyumda meydana gelir. Daha nadiren yumurtalıklarda metastazlar saptanabilir. Adölesanlarda nadir görülmesine rağmen MM olguları over metastazları açısından değerlendirilmelidir. Unutulmamalıdır ki, kitle ne kadar büyük olursa olsun adölesanlarda asemptomatik olabilir. Bu olgu sunumunda bacakta primer melanom lezyonu ve ilk tanıdan beş ay sonra yapılan görüntüleme tetkiklerinde metastatik over kitlesi saptanan bir olgu sunulmaktadır. Olguda overde saptanan kitle salfingooferektomi ile çıkarılıp metastaz tanısı immünohistokimyasal boyama ile doğrulandı. Ooferektomi ile eş zamanlı olarak sentinel lenf nodu biyopsisi yapıldı. Malign melanomlar nadiren jinekolojik olarak metastaz yapabilirler. Melanomlu hastalarda adneksiyal kitle ayırıcı tanısında metastazlar da düşünülmeli ve tedavi planı buna göre düzenlenmelidir.

References

  • Paradela S, Fonseca E, Pita-Fernández S, Kantrow SM, Diwan AH, Herzog C, et al. Prognostic factors for melanoma in children and adolescents: A clinicopathologic, single-center study of 137 patients. Cancer. 2010;116(18):4334–44.
  • Al-Himdani S, Naderi N, Whitaker IS, Jones NW. An 18-year Study of Malignant Melanoma in Childhood and Adolescence. Plast Reconstr Surg - Glob Open. 2019;7(8)
  • Simeone S, Laterza MM, Scaravilli G, Capuano S, Serao M, Orabona P, et al. Malignant melanoma metastasizing to the uterus in a patient with atypical postmenopause metrorrhagia. Minerva Ginecol. 2009;61(1):77–80.
  • Lorimer PD, White RL, Walsh K, Han Y, Kirks RC, Symanowski J, et al. Pediatric and Adolescent Melanoma: A National Cancer Data Base Update. Ann Surg Oncol. 2016;23(12):4058–66.
  • Bartenstein DW, Kelleher CM, Friedmann AM, Duncan LM, Tsao H, Sober AJ, et al. Contrasting features of childhood and adolescent melanomas. Pediatr Dermatol. 2018;35(3):354–60.
  • Moselhi M, Spencer J, Lane G. Malignant melanoma metastatic to the ovary: Presentation and radiological characteristics. Gynecol Oncol. 1998;69(2):165–8.
  • Lange JR, Palis BE, Chang DC, Soong SJ, Balch CM. Melanoma in children and teenagers: An analysis of patients from the National Cancer Data Base. J Clin Oncol. 2007;25(11):1363–8.
  • Young KZ, Fossum SL, Lowe L, Else T, Fecher LA, Demirci H, et al. An adolescent with uveal melanoma and BAP1 tumor predisposition syndrome. JAAD Case Reports. 2020;6(6):563–6.
  • Enomoto LM, Levine EA, Shen P, Votanopoulos KI. Role of Surgery for Metastatic Melanoma. Vol. 100, Surgical Clinics of North America. 2020. p. 127–39.
There are 9 citations in total.

Details

Primary Language English
Subjects Surgery
Journal Section Case Report
Authors

Sevtap Seyfettinoğlu 0000-0001-8607-6628

Sevda Baş 0000-0001-8559-7536

Mehmet Narin 0000-0002-8145-9053

Emin Kapı 0000-0003-2037-6219

Mehtap Eroğlu 0000-0001-8483-5985

Berna Bozkurt Duman 0000-0003-0295-6295

Publication Date December 28, 2023
Submission Date January 14, 2023
Published in Issue Year 2023 Volume: 23 Issue: 3

Cite

APA Seyfettinoğlu, S., Baş, S., Narin, M., Kapı, E., et al. (2023). Asymptomatic ovarian metastasis of malignant melanoma in an adolescent. Türk Jinekolojik Onkoloji Dergisi, 23(3), 74-77. https://doi.org/10.59215/trsgo.1234122
AMA Seyfettinoğlu S, Baş S, Narin M, Kapı E, Eroğlu M, Bozkurt Duman B. Asymptomatic ovarian metastasis of malignant melanoma in an adolescent. TRSGO Dergisi. December 2023;23(3):74-77. doi:10.59215/trsgo.1234122
Chicago Seyfettinoğlu, Sevtap, Sevda Baş, Mehmet Narin, Emin Kapı, Mehtap Eroğlu, and Berna Bozkurt Duman. “Asymptomatic Ovarian Metastasis of Malignant Melanoma in an Adolescent”. Türk Jinekolojik Onkoloji Dergisi 23, no. 3 (December 2023): 74-77. https://doi.org/10.59215/trsgo.1234122.
EndNote Seyfettinoğlu S, Baş S, Narin M, Kapı E, Eroğlu M, Bozkurt Duman B (December 1, 2023) Asymptomatic ovarian metastasis of malignant melanoma in an adolescent. Türk Jinekolojik Onkoloji Dergisi 23 3 74–77.
IEEE S. Seyfettinoğlu, S. Baş, M. Narin, E. Kapı, M. Eroğlu, and B. Bozkurt Duman, “Asymptomatic ovarian metastasis of malignant melanoma in an adolescent”, TRSGO Dergisi, vol. 23, no. 3, pp. 74–77, 2023, doi: 10.59215/trsgo.1234122.
ISNAD Seyfettinoğlu, Sevtap et al. “Asymptomatic Ovarian Metastasis of Malignant Melanoma in an Adolescent”. Türk Jinekolojik Onkoloji Dergisi 23/3 (December 2023), 74-77. https://doi.org/10.59215/trsgo.1234122.
JAMA Seyfettinoğlu S, Baş S, Narin M, Kapı E, Eroğlu M, Bozkurt Duman B. Asymptomatic ovarian metastasis of malignant melanoma in an adolescent. TRSGO Dergisi. 2023;23:74–77.
MLA Seyfettinoğlu, Sevtap et al. “Asymptomatic Ovarian Metastasis of Malignant Melanoma in an Adolescent”. Türk Jinekolojik Onkoloji Dergisi, vol. 23, no. 3, 2023, pp. 74-77, doi:10.59215/trsgo.1234122.
Vancouver Seyfettinoğlu S, Baş S, Narin M, Kapı E, Eroğlu M, Bozkurt Duman B. Asymptomatic ovarian metastasis of malignant melanoma in an adolescent. TRSGO Dergisi. 2023;23(3):74-7.