Abstract
Obezite vücut yağ dengesinin bozulması ile karakterize olan küresel bir sağlık sorunudur. Bu sorunla mücadelede yeni bakış açıları
kazanabilmek için obezite gelişimi ve ilerlemesi ile ilgili biyokimyasal, fizyolojik vb. süreçleri anlamaya yönelik çeşitli araştırmalar
yapılmaktadır. Tokluk hormonu olarak adlandırılan leptin, iştah metabolizmasından bağışıklık sistemine birçok yaşamsal faaliyette
görevli olmakla beraber enerji homeostazında da etkilidir. Vücut ağırlığının düzenlenmesinde büyük rol oynayan leptin hormonunun
sinyalizasyonundaki ya da bileşenlerindeki genetik bozukluklar leptin direncine dolayısıyla da obeziteye neden olabilmektedir. Bunun
yanı sıra bağırsak mikrobiyotasının da obezite, insülin direnci, gibi pek çok metabolik bozukluğunda patogenezinde olası katkıları
araştırılmaktadır. Bağırsak mikrobiyotası; besin sindirimi ve emilimi, çeşitli iştah hormonları veya peptitlerinin salgılanmasının
düzenlenmesi gibi birçok metabolik olaydan sorumludur ve mikrobiyotadaki bozukluklar da obezite için risk faktörüdür. Ayrıca bağırsak
mikrobiyotasının leptin ile bağlantılı olduğu bunun da obezite üzerinde etkili olabileceği yapılan çalışmalarla desteklenmektedir. Bu
derleme obezitenin etiyolojisinde mikrobiyota ve leptin hormonunun rolüne dikkat çekebilmek amacıyla araştırılan güncel bilgiler
doğrultusunda hazırlanmıştır. Araştırma hakemli dergilerde yayınlanan ve PubMed, Web of Science ve Google Scholar’da taranan
yayınlardan derlenmiştir. Bu amaçla leptin, bağırsak mikrobiyotası, obezite, leptin direnci anahtar kelimeleri birlikte kullanılmış ve bu
çalışmada araştırma makalelerine yer verilmiştir.
References
- 1. Xu Y, Wang N, Tan HY, Li S, Zhang C, Zhang Z, Feng Y. Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKα/STAT3 signaling in diet-induced obesity. Theranostics. 2020;10(24):11302-11323.
- 2. Benbaibeche H, Bounihi A, Koceir EA. Leptin level as a biomarker of uncontrolled eating in obesity and overweight. Ir J Med Sci. 2021;190(1):155-161.
- 3. Keleş V, Büyükgüzel K, Büyükgüzel E. Leptin ve Metabolik Düzenlemedeki Rolü. Türkiye Diyabet ve Obezite Dergisi. 2018; 2(1): 17-22
- 4. Dornbush S, Aeddula NR. Physiology, Leptin. 2021 Apr 20. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan.
- 5. Ahima RS. HDAC6 inhibition overcomes leptin resistance in obesity. Nat Metab. 2022 Jan 17. doi: 10.1038/s42255-021- 00500-w. Epub ahead of print.
- 6. Enriori, P. J.,Evans, A. E., Sinnayah, P., &Cowley, M. A., Leptin resistance and obesity. Obesity. 2006;14(S8):254S-258S.
- 7. Yetkin İ, Yetiş H, Kayahan Satış N. Bağırsak Mikrobiyotasının İnsülin Direnci, Diabetes Mellitus ve Obezite ile İlişkisi. Türkiye Diyabet ve Obezite Dergisi. 2018; 2(1):1-8.
- 8. Aksoyalp Z Ş, Nacitarhan C. Diabetes Mellitus’ta Mikrobiyotanın Rolü ve Hedeflenmesi. Türkiye Diyabet ve Obezite Dergisi. 2021; 5(1): 51-58.
- 9. Durmaz, B. Bağırsak mikrobiyotası ve obezite ile ilişkisi. Turkish Bulletin of Hygiene & Experimental Biology/Türk Hijyen ve Deneysel Biyoloji, 2019; 76(3).
- 10. Baothman, O. A.,Zamzami, M. A., Taher, I., Abubaker, J., & Abu-Farha, M., The role of gut microbiota in thedevelopment of obesity and diabetes. Lipids in health and disease. 2016;15(1):1-8.
- 11. Amabebe, E., Robert, F. O., Agbalalah, T., &Orubu, E. S., Microbial dysbiosis-induce dobesity: role of gut microbiota in homoeostasis of energy metabolism. British Journal of Nutrition. 2020; 123(10): 1127-1137
- 12. Münzberg, H.,&Morrison, C. D., Structure, production and signaling of leptin. Metabolism. 2015; 64(1): 13-23.
- 13. Tiaka, E. K.,Manolakis, A. C., Kapsoritakis, A. N., & Potamianos, S. P., Unraveling the link between leptin, ghrelin and different types of colitis. Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology. 2011; 24(1):20.
- 14. Gruzdeva, O.,Borodkina, D., Uchasova, E., Dyleva, Y. ve Barbarash, O., Leptin resistance: underlying mechanisms and diagnosis. Diabetes, metabolic syndrome and obesity: targets and treatment. 2019; 12: 191.
- 15. Guo, X., Roberts, M. R., Becker, S. M., Podd, B., Zhang, Y., Chua, S. C., Petri, W. A., Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica. Mucosalimmunology. 2011; 4(3): 294- 303.
- 16. Mackey-Lawrence, N. M., Petri, W. A., Leptin and mucosal immunity. Mucosal immunology. 2012; 5(5): 472-479.
- 17. Dominique M, Breton J, Guérin C, Bole-Feysot C, Lambert G, Déchelotte P, Fetissov S. Effects of Macronutrients on the In Vitro Production of ClpB, a Bacterial Mimetic Protein of α-MSH and Its Possible Role in Satiety Signaling. Nutrients. 2019 Sep 5;11(9):2115.
- 18. Bhaskaran, S.,Pharaoh, G., Ranjit, R., Murphy, A., Matsuzaki, S., Nair, B. C., Deepa, S. S., Loss of mitochondrial protease ClpP protects mice from diet‐induce dobesity and insulinre sistance. EMBO reports. 2018; 19(3):e45009.
- 19. Bargut TC, Silva-e-Silva AC, Souza-Mello V, Mandarim-de- Lacerda CA, Aguila MB. Mice fed fish oil diet and upregulation of brown adipose tissue thermogenic markers. Eur J Nutr. 2016 Feb;55(1):159-69.
- 20. Chakraborti, CK., New-found link between microbiota and obesity. World journal of gastrointestinal pathophysiology. 2015; 6(4): 110.
- 21. Park, H. K., &Ahima, R. S., Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism. 2015; 64(1): 24-34.
- 22. MyersJr, M. G.,Leibel, R. L., Seeley, R. J., &Schwartz, M. W., Obesity and leptin resistance: distinguishing cause from effect. Trends in Endocrinology&Metabolism. 2010; 21(11):643-651.
- 23. Cennet, A. K., Bir Adipositokin Üyesi: Leptin. SDÜ Tıp Fakültesi Dergisi. 2016;23(1).
- 24. Gomes, A. C.,Hoffmann, C., &Mota, J. F., The human gut microbiota: Metabolism and perspective in obesity. Gut microbes. 2018; 9(4):308-325.
- 25. Palmas V, Pisanu S, Madau V, Casula E, Deledda A, Cusano R, Uva P, Vascellari S, Loviselli A, Manzin A, Velluzzi F. Gut microbiota markers associated with obesity and overweight in Italian adults. Sci Rep. 2021;11(1):5532.
- 26. Yuan X, Chen R, McCormick KL, Zhang Y, Lin X, Yang X. The role of the gut microbiota on the metabolic status of obese children. Microb Cell Fact. 2021;20(1):53.
- 27. Saad MJ, Santos A, Prada PO. Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance. Physiology (Bethesda). 2016 Jul;31(4):283-93.
- 28. Cani, P. D.,Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., .&Burcelin, R., Metabolic endotoxemiainitiates obesity and insulin resistance. Diabetes. 2007; 56(7):1761- 1772.
- 29. Klancic, T.,&Reimer, R. A., Gut microbiota and obesity: Impact of antibiotics and prebiotics and potential for musculoskeleta lhealth. Journal of sport and health science. 2020; 9(2): 110- 118.
- 30. Cuevas-Sierra, A.,Ramos-Lopez, O., Riezu-Boj, J. I., Milagro, F. I., &Martinez, J. A., Diet, gut microbiota, and obesity: links with host genetics and epigenetics and potential applications. Advances in Nutrition. 2019; 10(suppl_1): S17-S30.
- 31. Yao, H., Fan, C., Fan, X., Lu, Y., Wang, Y., Wang, R., &Qi, K., Effects of gut microbiota on leptin expressionand body weigh tarelessened by high-fat diet in mice. British Journal of Nutrition. 2020; 124(4):396-406.
Abstract
Obesity is a global health problem characterized by the deterioration of body fat balance. In order to gain new perspectives in the
contend with this problem, various researches are carried out to understand the biochemical, physiological, etc. processes related
to the development and progression of obesity. Leptin, called the satiety hormone, is involved in many vital activities from appetite
metabolism to the immune system and is also effective in energy homeostasis. Genetic defects in the signaling or components of the
leptin hormone, which plays a major role in the regulation of body weight, may cause leptin resistance and thus obesity. In addition,
possible contributions of intestinal microbiota to the pathogenesis of many metabolic disorders such as obesity, insulin resistance are
being investigated. Intestinal microbiota; it is responsible for many metabolic events such as food digestion and absorption, regulation of
secretion of various appetite hormones or peptides, and disorders in the microbiota are also risk factors for obesity. It is also supported
by studies that the intestinal microbiota is associated with leptin, which may have an effect on obesity. This review has been prepared in
line with current information researched in order to draw attention to the microbiota and the role of leptin hormone in the etiology of
obesity. The research was compiled from publications published in peer-reviewed journals and scanned in PubMed, Web of Science, and
Google Scholar. For this purpose, the keywords leptin, intestinal microbiota, obesity, leptin resistance were used together and research
articles were included in this study.
References
- 1. Xu Y, Wang N, Tan HY, Li S, Zhang C, Zhang Z, Feng Y. Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKα/STAT3 signaling in diet-induced obesity. Theranostics. 2020;10(24):11302-11323.
- 2. Benbaibeche H, Bounihi A, Koceir EA. Leptin level as a biomarker of uncontrolled eating in obesity and overweight. Ir J Med Sci. 2021;190(1):155-161.
- 3. Keleş V, Büyükgüzel K, Büyükgüzel E. Leptin ve Metabolik Düzenlemedeki Rolü. Türkiye Diyabet ve Obezite Dergisi. 2018; 2(1): 17-22
- 4. Dornbush S, Aeddula NR. Physiology, Leptin. 2021 Apr 20. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan.
- 5. Ahima RS. HDAC6 inhibition overcomes leptin resistance in obesity. Nat Metab. 2022 Jan 17. doi: 10.1038/s42255-021- 00500-w. Epub ahead of print.
- 6. Enriori, P. J.,Evans, A. E., Sinnayah, P., &Cowley, M. A., Leptin resistance and obesity. Obesity. 2006;14(S8):254S-258S.
- 7. Yetkin İ, Yetiş H, Kayahan Satış N. Bağırsak Mikrobiyotasının İnsülin Direnci, Diabetes Mellitus ve Obezite ile İlişkisi. Türkiye Diyabet ve Obezite Dergisi. 2018; 2(1):1-8.
- 8. Aksoyalp Z Ş, Nacitarhan C. Diabetes Mellitus’ta Mikrobiyotanın Rolü ve Hedeflenmesi. Türkiye Diyabet ve Obezite Dergisi. 2021; 5(1): 51-58.
- 9. Durmaz, B. Bağırsak mikrobiyotası ve obezite ile ilişkisi. Turkish Bulletin of Hygiene & Experimental Biology/Türk Hijyen ve Deneysel Biyoloji, 2019; 76(3).
- 10. Baothman, O. A.,Zamzami, M. A., Taher, I., Abubaker, J., & Abu-Farha, M., The role of gut microbiota in thedevelopment of obesity and diabetes. Lipids in health and disease. 2016;15(1):1-8.
- 11. Amabebe, E., Robert, F. O., Agbalalah, T., &Orubu, E. S., Microbial dysbiosis-induce dobesity: role of gut microbiota in homoeostasis of energy metabolism. British Journal of Nutrition. 2020; 123(10): 1127-1137
- 12. Münzberg, H.,&Morrison, C. D., Structure, production and signaling of leptin. Metabolism. 2015; 64(1): 13-23.
- 13. Tiaka, E. K.,Manolakis, A. C., Kapsoritakis, A. N., & Potamianos, S. P., Unraveling the link between leptin, ghrelin and different types of colitis. Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology. 2011; 24(1):20.
- 14. Gruzdeva, O.,Borodkina, D., Uchasova, E., Dyleva, Y. ve Barbarash, O., Leptin resistance: underlying mechanisms and diagnosis. Diabetes, metabolic syndrome and obesity: targets and treatment. 2019; 12: 191.
- 15. Guo, X., Roberts, M. R., Becker, S. M., Podd, B., Zhang, Y., Chua, S. C., Petri, W. A., Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica. Mucosalimmunology. 2011; 4(3): 294- 303.
- 16. Mackey-Lawrence, N. M., Petri, W. A., Leptin and mucosal immunity. Mucosal immunology. 2012; 5(5): 472-479.
- 17. Dominique M, Breton J, Guérin C, Bole-Feysot C, Lambert G, Déchelotte P, Fetissov S. Effects of Macronutrients on the In Vitro Production of ClpB, a Bacterial Mimetic Protein of α-MSH and Its Possible Role in Satiety Signaling. Nutrients. 2019 Sep 5;11(9):2115.
- 18. Bhaskaran, S.,Pharaoh, G., Ranjit, R., Murphy, A., Matsuzaki, S., Nair, B. C., Deepa, S. S., Loss of mitochondrial protease ClpP protects mice from diet‐induce dobesity and insulinre sistance. EMBO reports. 2018; 19(3):e45009.
- 19. Bargut TC, Silva-e-Silva AC, Souza-Mello V, Mandarim-de- Lacerda CA, Aguila MB. Mice fed fish oil diet and upregulation of brown adipose tissue thermogenic markers. Eur J Nutr. 2016 Feb;55(1):159-69.
- 20. Chakraborti, CK., New-found link between microbiota and obesity. World journal of gastrointestinal pathophysiology. 2015; 6(4): 110.
- 21. Park, H. K., &Ahima, R. S., Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism. 2015; 64(1): 24-34.
- 22. MyersJr, M. G.,Leibel, R. L., Seeley, R. J., &Schwartz, M. W., Obesity and leptin resistance: distinguishing cause from effect. Trends in Endocrinology&Metabolism. 2010; 21(11):643-651.
- 23. Cennet, A. K., Bir Adipositokin Üyesi: Leptin. SDÜ Tıp Fakültesi Dergisi. 2016;23(1).
- 24. Gomes, A. C.,Hoffmann, C., &Mota, J. F., The human gut microbiota: Metabolism and perspective in obesity. Gut microbes. 2018; 9(4):308-325.
- 25. Palmas V, Pisanu S, Madau V, Casula E, Deledda A, Cusano R, Uva P, Vascellari S, Loviselli A, Manzin A, Velluzzi F. Gut microbiota markers associated with obesity and overweight in Italian adults. Sci Rep. 2021;11(1):5532.
- 26. Yuan X, Chen R, McCormick KL, Zhang Y, Lin X, Yang X. The role of the gut microbiota on the metabolic status of obese children. Microb Cell Fact. 2021;20(1):53.
- 27. Saad MJ, Santos A, Prada PO. Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance. Physiology (Bethesda). 2016 Jul;31(4):283-93.
- 28. Cani, P. D.,Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., .&Burcelin, R., Metabolic endotoxemiainitiates obesity and insulin resistance. Diabetes. 2007; 56(7):1761- 1772.
- 29. Klancic, T.,&Reimer, R. A., Gut microbiota and obesity: Impact of antibiotics and prebiotics and potential for musculoskeleta lhealth. Journal of sport and health science. 2020; 9(2): 110- 118.
- 30. Cuevas-Sierra, A.,Ramos-Lopez, O., Riezu-Boj, J. I., Milagro, F. I., &Martinez, J. A., Diet, gut microbiota, and obesity: links with host genetics and epigenetics and potential applications. Advances in Nutrition. 2019; 10(suppl_1): S17-S30.
- 31. Yao, H., Fan, C., Fan, X., Lu, Y., Wang, Y., Wang, R., &Qi, K., Effects of gut microbiota on leptin expressionand body weigh tarelessened by high-fat diet in mice. British Journal of Nutrition. 2020; 124(4):396-406.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Collection |
| Authors | |
| Publication Date | April 30, 2022 |
| Acceptance Date | January 23, 2022 |
| Published in Issue | Year 2022 Volume: 6 Issue: 1 |
