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Investigation of Interaction of Bismarck Brown Y- Palladium Complex with AS1411 G-quadruplex Aptamer

Year 2022, Volume: 4 Issue: 2, 116 - 122, 29.12.2022

Esra Bağda Rümeysa Durak Efkan Bağda Didem Duman Ebubekir Ayhan

https://doi.org/10.51435/turkjac.1203081
Cited By: 1

Abstract

Artan metabolik aktivite ve metastaz, kanser hücrelerinin ana ve en bilinen özellikleridir. Hücrelerin artan aktivitesi, G-dörtlü yapıların oluşumunda artışa neden olur. G-quadruplex'in çeşitli ligandlarla stabilizasyonu veya destabilizasyonu, hücre proliferasyonunda bozulmalara neden olabilir. Dolayısıyla, bu ikincil yapının stabilizasyonu veya destabilizasyonu önemli antikanser ilaç hedefleridir. Bu çalışmada, Bismarck kahverengi Y-Pd kompleksi, kolay, tek aşamalı bir karıştırma yöntemiyle oluşturulmuştur. Kompleksin spektral özellikleri ve stokiyometrisi, Uv-vis spektrofotometrik olarak araştırıldı. 1:2, Bismarck Brown Y-Pd kompleksinin AS1411 G-dörtlü yapı ile etkileşimi spektrofotometrik titrasyon ile araştırıldı. Bağlanma sabitleri hesaplandı ve 4.38 (±1.96) x104 M-1 olarak bulundu. Kompleksin G-dörtlü konformasyon üzerindeki etkisi CD spektroskopisi ile araştırıldı. Etkileşimlerin varlığı, yüksek hassasiyetli LED kaynaklı floresan dedektör Qsep100 kapiler jel elektroforez sistemi kullanılarak DNA polimeraz durdurma testi ile desteklenmiştir.

Keywords

G-quadruplex DNA As1411 Bismarck brown Y Palladium CD spectroscopy capillary gel electrophoresis

Project Number

2209-A -application number 1919B012006417

References

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  • C. Schiliro, B.L. Firestein, Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation, Cells, 10(5), 2021, 1056. https://doi.org/10.3390/cells10051056
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  • M.A. Khan, M. Tania, J. Fu, Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics, Drug Discov Today, 24(12), 2019, 2315–2322. https://doi.org/10.1016/j.drudis.2019.09.007
  • T. Das, D. Panda, P. Saha, J. Dash, Small molecule driven stabilization of promoter G-quadruplexes and transcriptional regulation of c-MYC, Bioconjugate Chem, 29(8), 2018, 2636–2645. https://doi.org/10.1021/acs.bioconjchem.8b00338
  • E. Bağda, E. Bağda, The recent studies about the interaction of phthalocyanines with DNA, Turkish Anal Chem, 3(1), 2021, 9–18. https://doi.org/10.51435/turkjac.938781
  • L. Hassani, Z. Fazeli, E. Safaei, H. Rastegar, M. Akbari, A spectroscopic investigation of the interaction between c-MYC DNA and tetrapyridinoporphyrazinatozinc (II), J Biol Phys, 40(3), 2014, 275–283. 10.1007/s10867-014-9348-x
  • D. Bhattacharyya, G. Mirihana Arachchilage, S. Basu, Metal cations in G-quadruplex folding and stability, Front Chem, 4, 2016, 38. https://doi.org/10.3389/fchem.2016.00038
  • Q. Li, J.F. Xiang, H. Zhang, Y.L. Tang, Searching drug-like anti-cancer compound (s) based on G-quadruplex ligands, Curr Pharm Design, 18(14), 2012, 1973–1983. 10.2174/138161212799958369
  • Z. Shen, K.A. Mulholland, Y. Zheng, C. Wu, Binding of anticancer drug daunomycin to a TGGGGT G-quadruplex DNA probed by all-atom molecular dynamics simulations: Additional pure groove binding mode and implications on designing more selective G-quadruplex ligands, Mol Model, 23(9), 2017, 1–11. 10.1007/s00894-017-3417-6
  • A. Awadasseid, X. Ma, Y. Wu, W. Zhang, G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy, Biomed Pharmacother, 139, 2021, 111550. 10.1016/j.biopha.2021.111550
  • Q. Cao, Y. Li, E. Freisinger, P.Z. Qin, R.K. Sigel, Z.W. Mao, G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs, Inorg Chem Front, 4(1), 2017, 10–32. https://doi.org/10.1039/C6QI00300A
  • R. Yazdian-Robati, P. Bayat, F. Oroojalian, M. Zargari, M. Ramezani, S.M. Taghdisi, K. Abnous, Therapeutic applications of AS1411 aptamer, an update review. Int Biol Macromol, 155, 2020, 1420–1431. 10.1016/j.ijbiomac.2019.11.118
  • J. Carvalho, J.L. Mergny, G.F. Salgado, J.A. Queiroz, C. Cruz, G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies, Trends Mol Med, 26(9), 2020, 848–861. 10.1016/j.molmed.2020.05.002
  • J. Figueiredo, J. Lopes-Nunes, J. Carvalho, F. Antunes, M. Ribeiro, M.P.C. Campello, A. Paulo; A. Paiva, G.F. Salgado, J.A. Queiroz, J.L. Mergny, C. Cruz, AS1411 derivatives as carriers of G-quadruplex ligands for cervical cancer cells, Int Pharm, 568, 2019, 118511. 10.1016/j.ijpharm.2019.118511
  • E. Krieg, M.M. Bastings, P. Besenius, B. Rybtchinski, Supramolecular polymers in aqueous media, Chem Rev, 116(4), 2016, 2414–2477. https://doi.org/10.1021/acs.chemrev.5b00369
  • Y. Liu, J. Li, M. Chen, X. Chen, N. Zheng, Palladium-based nanomaterials for cancer imaging and therapy, Theranostics, 10(22), 2020, 10057. https://doi.org/10.7150%2Fthno.45990
  • E. Bağda, E. Bağda, A. Kocak, M. Durmuş, Investigation of Binding behaviour of a water-soluble gallium (III) phthalocyanine with double-stranded and G-quadruplex DNA via experimental and computational methods, Mol Struct, 1240, 2021, 130536. https://doi.org/10.1016/j.molstruc.2021.130536
  • H. Han, L.H. Hurley, M. Salazar, A DNA polymerase stop assay for G-quadruplex-interactive compounds, Nucleic acids research, 27(2), 1999, 537–542. https://doi.org/10.1093/nar/27.2.537
  • A. Dey, K. Pandav, M. Nath, R. Barthwal, R. Prasad, Binding characterization of anthraquinone derivatives by stabilizing G-quadruplex DNA leads to an anticancerous activity, Mol Ther-Nucl Acids, 2022. https://doi.org/10.1016/j.omtn.2022.11.008
  • H.J. Lipps, D. Rhodes, G-quadruplex structures: in vivo evidence and function. Trends Cell Biol, 19(8), 2009. 414–422. https://doi.org/10.1016/j.tcb.2009.05.002
  • S.M. Haider, S. Neidle, G.N. Parkinson, A structural analysis of G-quadruplex/ligand interactions. Biochimie, 93(8), 2011, 1239–1251. https://doi.org/10.1016/j.biochi.2011.05.012
  • H. Li, Y. Tang, S. Lei, Z. You, T. Yang, S. Wang, A Spectroscopic Study of the Interaction Between the Bismarck Brown R–Eu (III) Complex and DNA, Appl Spectrosc, 85(4), 2018, 791–799. https://doi.org/10.1007/s10812-018-0720-7
  • J. Alzeer, B.R. Vummidi, P.J. Roth, N.W. Luedtke, Guanidinium‐modified phthalocyanines as high‐affinity G‐Quadruplex fluorescent probes and transcriptional regulators, Angew Chem Int Edit, 48(49), 2009, 9362–9365. https://doi.org/10.1002/anie.200903685
  • A.K. Jain, V.V. Reddy, A. Paul, and S. Bhattacharya, Synthesis and evaluation of a novel class of G-quadruplex-stabilizing small molecules based on the 1, 3-phenylene-bis (piperazinyl benzimidazole) system, Biochemistry, 48(45), 2009, 10693–10704. https://doi.org/10.1021/bi9003815
  • Z. Bagheri, B. Ranjbar, H. Latifi, M.I. Zibaii, T.T Moghadam, A. Azizi, Spectral properties and thermal stability of AS1411 G-quadruplex, Int Biol Macromol, 72, 2015, 806–811. https://doi.org/10.1016/j.ijbiomac.2014.09.016

Year 2022, Volume: 4 Issue: 2, 116 - 122, 29.12.2022

Esra Bağda Rümeysa Durak Efkan Bağda Didem Duman Ebubekir Ayhan

https://doi.org/10.51435/turkjac.1203081
Cited By: 1

Abstract

Keywords

G-quadruplex DNA As1411 Bismarck brown Y Palladium CD spectroscopy capillary gel electrophoresis

Supporting Institution

TÜBİTAK

Project Number

2209-A -application number 1919B012006417

References

  • [World Health Organization, WHO report on cancer: setting priorities, investing wisely and providing care for all, (2020).
  • C. Schiliro, B.L. Firestein, Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation, Cells, 10(5), 2021, 1056. https://doi.org/10.3390/cells10051056
  • A.R. Yadav, S.K. Mohite, Cancer-A silent killer: An overview, Asian Pharm Res, 10(3), 2020, 213–216. 10.5958/2231-5691.2020.00036.2
  • M.A. Khan, M. Tania, J. Fu, Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics, Drug Discov Today, 24(12), 2019, 2315–2322. https://doi.org/10.1016/j.drudis.2019.09.007
  • T. Das, D. Panda, P. Saha, J. Dash, Small molecule driven stabilization of promoter G-quadruplexes and transcriptional regulation of c-MYC, Bioconjugate Chem, 29(8), 2018, 2636–2645. https://doi.org/10.1021/acs.bioconjchem.8b00338
  • E. Bağda, E. Bağda, The recent studies about the interaction of phthalocyanines with DNA, Turkish Anal Chem, 3(1), 2021, 9–18. https://doi.org/10.51435/turkjac.938781
  • L. Hassani, Z. Fazeli, E. Safaei, H. Rastegar, M. Akbari, A spectroscopic investigation of the interaction between c-MYC DNA and tetrapyridinoporphyrazinatozinc (II), J Biol Phys, 40(3), 2014, 275–283. 10.1007/s10867-014-9348-x
  • D. Bhattacharyya, G. Mirihana Arachchilage, S. Basu, Metal cations in G-quadruplex folding and stability, Front Chem, 4, 2016, 38. https://doi.org/10.3389/fchem.2016.00038
  • Q. Li, J.F. Xiang, H. Zhang, Y.L. Tang, Searching drug-like anti-cancer compound (s) based on G-quadruplex ligands, Curr Pharm Design, 18(14), 2012, 1973–1983. 10.2174/138161212799958369
  • Z. Shen, K.A. Mulholland, Y. Zheng, C. Wu, Binding of anticancer drug daunomycin to a TGGGGT G-quadruplex DNA probed by all-atom molecular dynamics simulations: Additional pure groove binding mode and implications on designing more selective G-quadruplex ligands, Mol Model, 23(9), 2017, 1–11. 10.1007/s00894-017-3417-6
  • A. Awadasseid, X. Ma, Y. Wu, W. Zhang, G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy, Biomed Pharmacother, 139, 2021, 111550. 10.1016/j.biopha.2021.111550
  • Q. Cao, Y. Li, E. Freisinger, P.Z. Qin, R.K. Sigel, Z.W. Mao, G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs, Inorg Chem Front, 4(1), 2017, 10–32. https://doi.org/10.1039/C6QI00300A
  • R. Yazdian-Robati, P. Bayat, F. Oroojalian, M. Zargari, M. Ramezani, S.M. Taghdisi, K. Abnous, Therapeutic applications of AS1411 aptamer, an update review. Int Biol Macromol, 155, 2020, 1420–1431. 10.1016/j.ijbiomac.2019.11.118
  • J. Carvalho, J.L. Mergny, G.F. Salgado, J.A. Queiroz, C. Cruz, G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies, Trends Mol Med, 26(9), 2020, 848–861. 10.1016/j.molmed.2020.05.002
  • J. Figueiredo, J. Lopes-Nunes, J. Carvalho, F. Antunes, M. Ribeiro, M.P.C. Campello, A. Paulo; A. Paiva, G.F. Salgado, J.A. Queiroz, J.L. Mergny, C. Cruz, AS1411 derivatives as carriers of G-quadruplex ligands for cervical cancer cells, Int Pharm, 568, 2019, 118511. 10.1016/j.ijpharm.2019.118511
  • E. Krieg, M.M. Bastings, P. Besenius, B. Rybtchinski, Supramolecular polymers in aqueous media, Chem Rev, 116(4), 2016, 2414–2477. https://doi.org/10.1021/acs.chemrev.5b00369
  • Y. Liu, J. Li, M. Chen, X. Chen, N. Zheng, Palladium-based nanomaterials for cancer imaging and therapy, Theranostics, 10(22), 2020, 10057. https://doi.org/10.7150%2Fthno.45990
  • E. Bağda, E. Bağda, A. Kocak, M. Durmuş, Investigation of Binding behaviour of a water-soluble gallium (III) phthalocyanine with double-stranded and G-quadruplex DNA via experimental and computational methods, Mol Struct, 1240, 2021, 130536. https://doi.org/10.1016/j.molstruc.2021.130536
  • H. Han, L.H. Hurley, M. Salazar, A DNA polymerase stop assay for G-quadruplex-interactive compounds, Nucleic acids research, 27(2), 1999, 537–542. https://doi.org/10.1093/nar/27.2.537
  • A. Dey, K. Pandav, M. Nath, R. Barthwal, R. Prasad, Binding characterization of anthraquinone derivatives by stabilizing G-quadruplex DNA leads to an anticancerous activity, Mol Ther-Nucl Acids, 2022. https://doi.org/10.1016/j.omtn.2022.11.008
  • H.J. Lipps, D. Rhodes, G-quadruplex structures: in vivo evidence and function. Trends Cell Biol, 19(8), 2009. 414–422. https://doi.org/10.1016/j.tcb.2009.05.002
  • S.M. Haider, S. Neidle, G.N. Parkinson, A structural analysis of G-quadruplex/ligand interactions. Biochimie, 93(8), 2011, 1239–1251. https://doi.org/10.1016/j.biochi.2011.05.012
  • H. Li, Y. Tang, S. Lei, Z. You, T. Yang, S. Wang, A Spectroscopic Study of the Interaction Between the Bismarck Brown R–Eu (III) Complex and DNA, Appl Spectrosc, 85(4), 2018, 791–799. https://doi.org/10.1007/s10812-018-0720-7
  • J. Alzeer, B.R. Vummidi, P.J. Roth, N.W. Luedtke, Guanidinium‐modified phthalocyanines as high‐affinity G‐Quadruplex fluorescent probes and transcriptional regulators, Angew Chem Int Edit, 48(49), 2009, 9362–9365. https://doi.org/10.1002/anie.200903685
  • A.K. Jain, V.V. Reddy, A. Paul, and S. Bhattacharya, Synthesis and evaluation of a novel class of G-quadruplex-stabilizing small molecules based on the 1, 3-phenylene-bis (piperazinyl benzimidazole) system, Biochemistry, 48(45), 2009, 10693–10704. https://doi.org/10.1021/bi9003815
  • Z. Bagheri, B. Ranjbar, H. Latifi, M.I. Zibaii, T.T Moghadam, A. Azizi, Spectral properties and thermal stability of AS1411 G-quadruplex, Int Biol Macromol, 72, 2015, 806–811. https://doi.org/10.1016/j.ijbiomac.2014.09.016
There are 26 citations in total.

Details

Primary Language English
Subjects Analytical Chemistry
Journal Section Research Articles
Authors

Esra Bağda 0000-0003-1900-4944

Rümeysa Durak 0000-0001-8345-3248

Efkan Bağda 0000-0002-3925-3430

Didem Duman 0000-0002-0900-0336

Ebubekir Ayhan 0000-0002-5371-8425

Project Number 2209-A -application number 1919B012006417
Early Pub Date December 23, 2022
Publication Date December 29, 2022
Submission Date November 12, 2022
Acceptance Date November 30, 2022
Published in Issue Year 2022 Volume: 4 Issue: 2

Cite

APA Bağda, E., Durak, R., Bağda, E., Duman, D., et al. (2022). Investigation of Interaction of Bismarck Brown Y- Palladium Complex with AS1411 G-quadruplex Aptamer. Turkish Journal of Analytical Chemistry, 4(2), 116-122. https://doi.org/10.51435/turkjac.1203081
AMA Bağda E, Durak R, Bağda E, Duman D, Ayhan E. Investigation of Interaction of Bismarck Brown Y- Palladium Complex with AS1411 G-quadruplex Aptamer. TurkJAC. December 2022;4(2):116-122. doi:10.51435/turkjac.1203081
Chicago Bağda, Esra, Rümeysa Durak, Efkan Bağda, Didem Duman, and Ebubekir Ayhan. “Investigation of Interaction of Bismarck Brown Y- Palladium Complex With AS1411 G-Quadruplex Aptamer”. Turkish Journal of Analytical Chemistry 4, no. 2 (December 2022): 116-22. https://doi.org/10.51435/turkjac.1203081.
EndNote Bağda E, Durak R, Bağda E, Duman D, Ayhan E (December 1, 2022) Investigation of Interaction of Bismarck Brown Y- Palladium Complex with AS1411 G-quadruplex Aptamer. Turkish Journal of Analytical Chemistry 4 2 116–122.
IEEE E. Bağda, R. Durak, E. Bağda, D. Duman, and E. Ayhan, “Investigation of Interaction of Bismarck Brown Y- Palladium Complex with AS1411 G-quadruplex Aptamer”, TurkJAC, vol. 4, no. 2, pp. 116–122, 2022, doi: 10.51435/turkjac.1203081.
ISNAD Bağda, Esra et al. “Investigation of Interaction of Bismarck Brown Y- Palladium Complex With AS1411 G-Quadruplex Aptamer”. Turkish Journal of Analytical Chemistry 4/2 (December 2022), 116-122. https://doi.org/10.51435/turkjac.1203081.
JAMA Bağda E, Durak R, Bağda E, Duman D, Ayhan E. Investigation of Interaction of Bismarck Brown Y- Palladium Complex with AS1411 G-quadruplex Aptamer. TurkJAC. 2022;4:116–122.
MLA Bağda, Esra et al. “Investigation of Interaction of Bismarck Brown Y- Palladium Complex With AS1411 G-Quadruplex Aptamer”. Turkish Journal of Analytical Chemistry, vol. 4, no. 2, 2022, pp. 116-22, doi:10.51435/turkjac.1203081.
Vancouver Bağda E, Durak R, Bağda E, Duman D, Ayhan E. Investigation of Interaction of Bismarck Brown Y- Palladium Complex with AS1411 G-quadruplex Aptamer. TurkJAC. 2022;4(2):116-22.

Cited By

Thermodynamic and structural investigation of the interaction of quaternized 2,3‐octakis‐[(2‐mercaptopyridine)phthalocyaninato] copper (II) sulfate (CuPc) with parallel and hybrid type G‐quadruplex
Journal of Molecular Recognition
https://doi.org/10.1002/jmr.3072
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