Case Report
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A newborn presented with cholestasis and diagnosed with congenital pituitary hormone deficiency

Year 2017, Volume: 48 Issue: 2, 63 - 66, 01.06.2017

ELİF Özalkaya Arzu Akdağ ESRA Deniz Papatya Sevilay Topçuoğlu

https://doi.org/10.16948/zktipb.266110

Abstract

An infrequent reason of neonatal cholestasis is congenital pituitary hormone deficiency. Clinical manifestations of cholestasis and hypoglycaemia in the neonatal period. Gestational week 37, 3700 grams, girl baby born with cesarean sectioning. Hypoglicemia symptoms developed at postnatal first and cholestasis at postnatal third week. Multiple pituitary hormone deficiency was identified.  Cholestasis symptoms recovered with growth hormone therapy. Congenital pituitary hormone deficiency should be kept in mind in the newborns with hypoglicemia and cholestasis. 

Keywords

cholestasis newborn hormone pituitary

References

  • References
  • 1. Braslavsky D, Keselman A, Galoppo M, Lezama C, Chiesa A, Galoppo C et.al. Neonatal cholestasis in congenital pituitary hormone deficiency and isolated hypocortisolism: characterization of liver dysfunction and follow-up. Arq Bras Endocrinol Metab. 2011;55:622-627
  • 2. Choo-Kang LR, Sun CJ, Counts DR. Clinical case seminar. Cholestasis and hypoglycemia: manifestations of congenital anterior hypopituitarism. J Clin Endocrinol Metab. 1996;81:2786-2789.
  • 3. Leblanc A, Odievre M, Hadchouel M, Gendrel D, Chaussain JL, Rappaport R. Neonatal cholestasis and hypoglycemia: possible role of cortisol deficiency. J Pediatr. 1981;99:577-580
  • 4.De Salvo D, Pohl JF, Wilson DP, Byrant W, Easley D, Greene J. et.al. Cholestasis secondary to panhyopituitarism in an infant. J Natl Med Assoc 2008;100:342-344.
  • 5. Bauman JW, Chang BS, HallBauman JW, Chang BS, Hall FR. The effects of adrenalectomy and hypophysectomy on bile flow in the rats. Acta Endocrinol. 1966;52:404.
  • 6. Karnsakul W, Sawathiparnich P, Nimkarn S, Likitmaskul S, Santiprabhob J, Aanpreung P. Anterior pituitary hormone effects on hepatic functions in infants with congenital hypopituitarism. Annals of Hepathology. 2007;6:97-103.

Neonatal kolestaz ile başvuran, konjenital hipofiz hormon eksikliği tanılı yenidoğan olgusu

Year 2017, Volume: 48 Issue: 2, 63 - 66, 01.06.2017

ELİF Özalkaya Arzu Akdağ ESRA Deniz Papatya Sevilay Topçuoğlu

https://doi.org/10.16948/zktipb.266110

Abstract

Konjenital hipofiz hormon
eksikliği neonatal kolestazın sık olmayan nedenidir.  Yenidoğan döneminde klinik bulguları kolestaz
ve hipoglisemidir. Sezeryan ile, 37 haftalık, 3700 gr doğan kız bebekte postnatal
birinci hafta hipoglisemi, 3. haftada kolestaz bulguları gelişti. Çoklu hipofiz hormon eksikliği saptandı. Büyüme hormonu tedavisi ile kolestaz bulguları düzeldi. Konjenital
hipofiz hormon eksikliği,  hipoglisemi ve
kolestazı olan yenidoğanlarda ayırıcı tanıda akılda tutulmalıdır. 

Keywords

kolestaz hipofiz hormon yenidoğan

References

  • References
  • 1. Braslavsky D, Keselman A, Galoppo M, Lezama C, Chiesa A, Galoppo C et.al. Neonatal cholestasis in congenital pituitary hormone deficiency and isolated hypocortisolism: characterization of liver dysfunction and follow-up. Arq Bras Endocrinol Metab. 2011;55:622-627
  • 2. Choo-Kang LR, Sun CJ, Counts DR. Clinical case seminar. Cholestasis and hypoglycemia: manifestations of congenital anterior hypopituitarism. J Clin Endocrinol Metab. 1996;81:2786-2789.
  • 3. Leblanc A, Odievre M, Hadchouel M, Gendrel D, Chaussain JL, Rappaport R. Neonatal cholestasis and hypoglycemia: possible role of cortisol deficiency. J Pediatr. 1981;99:577-580
  • 4.De Salvo D, Pohl JF, Wilson DP, Byrant W, Easley D, Greene J. et.al. Cholestasis secondary to panhyopituitarism in an infant. J Natl Med Assoc 2008;100:342-344.
  • 5. Bauman JW, Chang BS, HallBauman JW, Chang BS, Hall FR. The effects of adrenalectomy and hypophysectomy on bile flow in the rats. Acta Endocrinol. 1966;52:404.
  • 6. Karnsakul W, Sawathiparnich P, Nimkarn S, Likitmaskul S, Santiprabhob J, Aanpreung P. Anterior pituitary hormone effects on hepatic functions in infants with congenital hypopituitarism. Annals of Hepathology. 2007;6:97-103.
There are 7 citations in total.

Details

Subjects Health Care Administration
Journal Section Case Report
Authors

ELİF Özalkaya

Arzu Akdağ This is me

ESRA Deniz Papatya This is me

Sevilay Topçuoğlu This is me

Publication Date June 1, 2017
Published in Issue Year 2017 Volume: 48 Issue: 2

Cite

APA Özalkaya, E., Akdağ, A., Deniz Papatya, E., Topçuoğlu, S. (2017). Neonatal kolestaz ile başvuran, konjenital hipofiz hormon eksikliği tanılı yenidoğan olgusu. Zeynep Kamil Tıp Bülteni, 48(2), 63-66. https://doi.org/10.16948/zktipb.266110
AMA Özalkaya E, Akdağ A, Deniz Papatya E, Topçuoğlu S. Neonatal kolestaz ile başvuran, konjenital hipofiz hormon eksikliği tanılı yenidoğan olgusu. Zeynep Kamil Tıp Bülteni. June 2017;48(2):63-66. doi:10.16948/zktipb.266110
Chicago Özalkaya, ELİF, Arzu Akdağ, ESRA Deniz Papatya, and Sevilay Topçuoğlu. “Neonatal Kolestaz Ile başvuran, Konjenital Hipofiz Hormon eksikliği tanılı yenidoğan Olgusu”. Zeynep Kamil Tıp Bülteni 48, no. 2 (June 2017): 63-66. https://doi.org/10.16948/zktipb.266110.
EndNote Özalkaya E, Akdağ A, Deniz Papatya E, Topçuoğlu S (June 1, 2017) Neonatal kolestaz ile başvuran, konjenital hipofiz hormon eksikliği tanılı yenidoğan olgusu. Zeynep Kamil Tıp Bülteni 48 2 63–66.
IEEE E. Özalkaya, A. Akdağ, E. Deniz Papatya, and S. Topçuoğlu, “Neonatal kolestaz ile başvuran, konjenital hipofiz hormon eksikliği tanılı yenidoğan olgusu”, Zeynep Kamil Tıp Bülteni, vol. 48, no. 2, pp. 63–66, 2017, doi: 10.16948/zktipb.266110.
ISNAD Özalkaya, ELİF et al. “Neonatal Kolestaz Ile başvuran, Konjenital Hipofiz Hormon eksikliği tanılı yenidoğan Olgusu”. Zeynep Kamil Tıp Bülteni 48/2 (June 2017), 63-66. https://doi.org/10.16948/zktipb.266110.
JAMA Özalkaya E, Akdağ A, Deniz Papatya E, Topçuoğlu S. Neonatal kolestaz ile başvuran, konjenital hipofiz hormon eksikliği tanılı yenidoğan olgusu. Zeynep Kamil Tıp Bülteni. 2017;48:63–66.
MLA Özalkaya, ELİF et al. “Neonatal Kolestaz Ile başvuran, Konjenital Hipofiz Hormon eksikliği tanılı yenidoğan Olgusu”. Zeynep Kamil Tıp Bülteni, vol. 48, no. 2, 2017, pp. 63-66, doi:10.16948/zktipb.266110.
Vancouver Özalkaya E, Akdağ A, Deniz Papatya E, Topçuoğlu S. Neonatal kolestaz ile başvuran, konjenital hipofiz hormon eksikliği tanılı yenidoğan olgusu. Zeynep Kamil Tıp Bülteni. 2017;48(2):63-6.
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