Araştırma Makalesi
Yıl 2024,
Cilt: 3 Sayı: 1, 312 - 319, 29.03.2024
Öz
Kaynakça
- 1. Bowyer L. The confidential enquiry into maternal and Child health (CEMACH). Saving mothers’ lives: reviewing maternal deaths to make motherhood safer 2003–2005. The seventh report of the confidential enquiries into maternal deaths in the UK. SAGE Publications Sage UK: London, England; 2008.
- 2. Duley L, editor The global impact of pre-eclampsia and eclampsia. Seminars in perinatology; 2009: Elsevier.
- 3. Ananth CV, Savitz DA, Bowes Jr WA. Hypertensive disorders of pregnancy and stillbirth in North Carolina, 1988 to 1991. Acta obstetricia et gynecologica Scandinavica. 1995;74(10):788-93.
- 4. Steegers EA, Von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre-eclampsia. The Lancet. 2010;376(9741):631-44.
- 5. Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2013;170(1):1-7.
- 6. Moran P, Baylis PH, Lindheimer MD, Davison JM. Glomerular ultrafiltration in normal and preeclamptic pregnancy. J Am Soc Nephrol. 2003;14(3):648-52.
- 7. Hladunewich MA, Schaefer F. Proteinuria in special populations: pregnant women and children. Advances in chronic kidney disease. 2011;18(4):267-72.
- 8. Conrad KP, Stillman IE, Lindheimer MD. The kidney in normal pregnancy and preeclampsia. Chesley's hypertensive disorders in pregnancy: Elsevier; 2015. p. 335-77.
- 9. Obstetricians ACo, Gynecologists. Task force on hypertension in pregnancy. Hypertension in pregnancy Report of the American College of Obstetricians and Gynecologists’ task force on hypertension in pregnancy Obstet Gynecol. 2013;122(5):1122-31.
- 10. Morikawa M, Yamada T, Minakami H. Outcome of pregnancy in patients with isolated proteinuria. Current Opinion in Obstetrics and Gynecology. 2009;21(6):491-5.
- 11. Masuyama H, Suwaki N, Nakatsukasa H, Masumoto A, Tateishi Y, Hiramatrsu Y. Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis. American journal of obstetrics and gynecology. 2006;194(2):551-6.
- 12. Yamada T, Obata-Yasuoka M, Hamada H, Baba Y, Ohkuchi A, Yasuda S, et al. Isolated gestational proteinuria preceding the diagnosis of preeclampsia - an observational study. Acta Obstet Gynecol Scand. 2016;95(9):1048-54.
- 13. Akaishi R, Yamada T, Morikawa M, Nishida R, Minakami H. Clinical features of isolated gestational proteinuria progressing to pre-eclampsia: retrospective observational study. BMJ Open. 2014;4(4):e004870.
- 14. Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin Summary, Number 222. Obstet Gynecol. 2020;135(6):1492-5.
- 15. Conde‐Agudelo, A. and J.M. Belizán, Risk factors for pre‐eclampsia in a large cohort of Latin American and Caribbean women. BJOG: An International Journal of Obstetrics &Gynaecology, 2000.107(1): p. 75-83.
- 16. Walker, J.J., Pre-eclampsia. The Lancet, 2000. 356(9237): p. 1260-1265.
- 17. Ananth, C.V. and O. Basso, Impact of pregnancy-induced hypertension on stillbirth and neonatal mortality in first and higher order births: a population-based study.Epidemiology (Cambridge, Mass.), 2010. 21(1): p. 118.
- 18. McDonald, S., C. Best, and K. Lam, The recurrence risk of severe de novo pre‐eclampsia in singleton pregnancies: a population‐based cohort. BJOG: An International Journal of Obstetrics &Gynaecology, 2009. 116(12): p. 1578-1584.
- 19. Hladunewich MA, Schaefer F. Proteinuria in special populations: pregnant women and children. Adv Chronic Kidney Dis. 2011;18(4):267-72.
- 20. Magee L, Pels A, Helewa M, Rey E, Von Dadelszen PJPH. Canadian Hypertensive Disorders of Pregnancy (HDP) Working Group. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy. 2014;4(2):105-45.
- 21. Health NIf, Excellence C. NICE clinical guideline 107: hypertension in pregnancy: the management of hypertensive disorders during pregnancy. 2010.
- 22. Ekiz A, Kaya B, Polat I, Avci ME, Ozkose B, Kicik Caliskan R, et al. The outcome of pregnancy with new onset proteinuria without hypertension: retrospective observational study. 2016;29(11):1765-9.
- 23. Maynard SE, Min J-Y, Merchan J, Lim K-H, Li J, Mondal S, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. 2003;111(5):649-58.
- 24. Rana S, Karumanchi SA, Lindheimer MDJH. Angiogenic factors in diagnosis, management, and research in preeclampsia. 2014;63(2):198-202.
- 25. Steegers EA, Von Dadelszen P, Duvekot JJ, Pijnenborg RJTL. Pre-eclampsia. 2010;376(9741):631-44.
- 26. Rana S, Schnettler WT, Powe C, Wenger J, Salahuddin S, Cerdeira AS, et al. Clinical characterization and outcomes of preeclampsia with normal angiogenic profile. 2013;32(2):189-201.
- 27. Venkatesha S, Toporsian M, Lam C, Hanai J-i, Mammoto T, Kim YM, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. 2006;12(6):642-9.
- 28. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. 2006;355(10):992-1005.
- 29. Yamada T, Obata‐Yasuoka M, Hamada H, Baba Y, Ohkuchi A, Yasuda S, et al. Isolated gestational proteinuria preceding the diagnosis of preeclampsia–an observational study. 2016;95(9):1048-54.
- 30. Erkenekli K, Iskender C, Oztas E, Özgü-Erdinç AS, Yucel A, Uygur DJHip. Clinical, but not laboratory features are predictive of risk of subsequent development of preeclampsia in patients with isolated proteinuria after midgestation. 2015;34(4):495-505.
- 31. Morikawa M, Yamada T, Yamada T, Cho K, Yamada H, Sakuragi N, et al. Pregnancy outcome of women who developed proteinuria in the absence of hypertension after mid-gestation. 2008;36(5):419-24.
- 32. Akaishi R, Yamada T, Morikawa M, Nishida R, Minakami HJBo. Clinical features of isolated gestational proteinuria progressing to pre-eclampsia: retrospective observational study. 2014;4(4):e004870.
- 33. Macdonald-Wallis C, Lawlor DA, Heron J, Fraser A, Nelson SM, Tilling KJPO. Relationships of risk factors for pre-eclampsia with patterns of occurrence of isolated gestational proteinuria during normal term pregnancy. 2011;6(7).
- 34. Vatten LJ, Skjærven RJEhd. Offspring sex and pregnancy outcome by length of gestation. 2004;76(1):47-54.
- 35. Reynolds SA, Roberts JM, Bodnar LM, Haggerty CL, Youk AO, Catov JMJGm. Newborns of preeclamptic women show evidence of sex-specific disparity in fetal growth. 2012;9(6):424-35.
The Relationship of Cases with Isolated Proteinuria in Pregnancy with Maternal and Perinatal Outcomes
Öz
Introductıon: There are a limited number of studies in the literature on the obstetric consequences of isolated gestational proteinuria (IGP) disease and the progression of preeclampsia (PE). It has been stated that gestational proteinuria may be a risk factor for PE. With this study, we aimed to determine the risk factors for the development of PE in cases with isolated proteinuria during pregnancy and to compare the maternal and perinatal outcomes of the cases.
Methods: The study was designed as a retrospective cross-sectional study. Pregnant women over the 20th gestational week and diagnosed with proteinuria by 24 hour urine analysis were included in the study. Patients who were diagnosed with gestational proteinuria and did not develop PE during their follow up were classified as IGP and patients who developed PE.
Results: The average time between the detection of proteinuria and the development of PE was calculated as 16 days. Week of gestation at delivery(p<.001)and the time between proteinurine detection and delivery(p=.002) were significantly lower in the PE group. In 52 of 185 patients with gestational proteinuria in total, proteinuria was detected an average of 32w 5d, and increased blood pressure and development of PE occured at an average of 35 weeks of gestation. NB intensive care requirement, preterm delivery and IUGR rates were found to be significantly higher in the group with PE. Ceserean delivery rate in IGP was calculated as 54.14%,ceserean delivery rate in PE was 78.85%. A significant correlation was found between the history of preeclampsia in the development of preeclampsia in IGP patients(OR: 11,000 (1,199-100,883), p=0.034) and increased urine proteinuria(OR: 1,0001 (1,000-1,001),p=0.007).
Conclusion: Patients who have had preeclampsia before and who have a high 24 hour urine value are more likely to return to PE. IGP has a more benign prognosis in terms of maternal and fetal compared to PE.
Anahtar Kelimeler
Isolated gestational proteinuria Preeclampsia Maternal and Perinatal Outcomes
Kaynakça
- 1. Bowyer L. The confidential enquiry into maternal and Child health (CEMACH). Saving mothers’ lives: reviewing maternal deaths to make motherhood safer 2003–2005. The seventh report of the confidential enquiries into maternal deaths in the UK. SAGE Publications Sage UK: London, England; 2008.
- 2. Duley L, editor The global impact of pre-eclampsia and eclampsia. Seminars in perinatology; 2009: Elsevier.
- 3. Ananth CV, Savitz DA, Bowes Jr WA. Hypertensive disorders of pregnancy and stillbirth in North Carolina, 1988 to 1991. Acta obstetricia et gynecologica Scandinavica. 1995;74(10):788-93.
- 4. Steegers EA, Von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre-eclampsia. The Lancet. 2010;376(9741):631-44.
- 5. Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2013;170(1):1-7.
- 6. Moran P, Baylis PH, Lindheimer MD, Davison JM. Glomerular ultrafiltration in normal and preeclamptic pregnancy. J Am Soc Nephrol. 2003;14(3):648-52.
- 7. Hladunewich MA, Schaefer F. Proteinuria in special populations: pregnant women and children. Advances in chronic kidney disease. 2011;18(4):267-72.
- 8. Conrad KP, Stillman IE, Lindheimer MD. The kidney in normal pregnancy and preeclampsia. Chesley's hypertensive disorders in pregnancy: Elsevier; 2015. p. 335-77.
- 9. Obstetricians ACo, Gynecologists. Task force on hypertension in pregnancy. Hypertension in pregnancy Report of the American College of Obstetricians and Gynecologists’ task force on hypertension in pregnancy Obstet Gynecol. 2013;122(5):1122-31.
- 10. Morikawa M, Yamada T, Minakami H. Outcome of pregnancy in patients with isolated proteinuria. Current Opinion in Obstetrics and Gynecology. 2009;21(6):491-5.
- 11. Masuyama H, Suwaki N, Nakatsukasa H, Masumoto A, Tateishi Y, Hiramatrsu Y. Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis. American journal of obstetrics and gynecology. 2006;194(2):551-6.
- 12. Yamada T, Obata-Yasuoka M, Hamada H, Baba Y, Ohkuchi A, Yasuda S, et al. Isolated gestational proteinuria preceding the diagnosis of preeclampsia - an observational study. Acta Obstet Gynecol Scand. 2016;95(9):1048-54.
- 13. Akaishi R, Yamada T, Morikawa M, Nishida R, Minakami H. Clinical features of isolated gestational proteinuria progressing to pre-eclampsia: retrospective observational study. BMJ Open. 2014;4(4):e004870.
- 14. Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin Summary, Number 222. Obstet Gynecol. 2020;135(6):1492-5.
- 15. Conde‐Agudelo, A. and J.M. Belizán, Risk factors for pre‐eclampsia in a large cohort of Latin American and Caribbean women. BJOG: An International Journal of Obstetrics &Gynaecology, 2000.107(1): p. 75-83.
- 16. Walker, J.J., Pre-eclampsia. The Lancet, 2000. 356(9237): p. 1260-1265.
- 17. Ananth, C.V. and O. Basso, Impact of pregnancy-induced hypertension on stillbirth and neonatal mortality in first and higher order births: a population-based study.Epidemiology (Cambridge, Mass.), 2010. 21(1): p. 118.
- 18. McDonald, S., C. Best, and K. Lam, The recurrence risk of severe de novo pre‐eclampsia in singleton pregnancies: a population‐based cohort. BJOG: An International Journal of Obstetrics &Gynaecology, 2009. 116(12): p. 1578-1584.
- 19. Hladunewich MA, Schaefer F. Proteinuria in special populations: pregnant women and children. Adv Chronic Kidney Dis. 2011;18(4):267-72.
- 20. Magee L, Pels A, Helewa M, Rey E, Von Dadelszen PJPH. Canadian Hypertensive Disorders of Pregnancy (HDP) Working Group. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy. 2014;4(2):105-45.
- 21. Health NIf, Excellence C. NICE clinical guideline 107: hypertension in pregnancy: the management of hypertensive disorders during pregnancy. 2010.
- 22. Ekiz A, Kaya B, Polat I, Avci ME, Ozkose B, Kicik Caliskan R, et al. The outcome of pregnancy with new onset proteinuria without hypertension: retrospective observational study. 2016;29(11):1765-9.
- 23. Maynard SE, Min J-Y, Merchan J, Lim K-H, Li J, Mondal S, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. 2003;111(5):649-58.
- 24. Rana S, Karumanchi SA, Lindheimer MDJH. Angiogenic factors in diagnosis, management, and research in preeclampsia. 2014;63(2):198-202.
- 25. Steegers EA, Von Dadelszen P, Duvekot JJ, Pijnenborg RJTL. Pre-eclampsia. 2010;376(9741):631-44.
- 26. Rana S, Schnettler WT, Powe C, Wenger J, Salahuddin S, Cerdeira AS, et al. Clinical characterization and outcomes of preeclampsia with normal angiogenic profile. 2013;32(2):189-201.
- 27. Venkatesha S, Toporsian M, Lam C, Hanai J-i, Mammoto T, Kim YM, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. 2006;12(6):642-9.
- 28. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. 2006;355(10):992-1005.
- 29. Yamada T, Obata‐Yasuoka M, Hamada H, Baba Y, Ohkuchi A, Yasuda S, et al. Isolated gestational proteinuria preceding the diagnosis of preeclampsia–an observational study. 2016;95(9):1048-54.
- 30. Erkenekli K, Iskender C, Oztas E, Özgü-Erdinç AS, Yucel A, Uygur DJHip. Clinical, but not laboratory features are predictive of risk of subsequent development of preeclampsia in patients with isolated proteinuria after midgestation. 2015;34(4):495-505.
- 31. Morikawa M, Yamada T, Yamada T, Cho K, Yamada H, Sakuragi N, et al. Pregnancy outcome of women who developed proteinuria in the absence of hypertension after mid-gestation. 2008;36(5):419-24.
- 32. Akaishi R, Yamada T, Morikawa M, Nishida R, Minakami HJBo. Clinical features of isolated gestational proteinuria progressing to pre-eclampsia: retrospective observational study. 2014;4(4):e004870.
- 33. Macdonald-Wallis C, Lawlor DA, Heron J, Fraser A, Nelson SM, Tilling KJPO. Relationships of risk factors for pre-eclampsia with patterns of occurrence of isolated gestational proteinuria during normal term pregnancy. 2011;6(7).
- 34. Vatten LJ, Skjærven RJEhd. Offspring sex and pregnancy outcome by length of gestation. 2004;76(1):47-54.
- 35. Reynolds SA, Roberts JM, Bodnar LM, Haggerty CL, Youk AO, Catov JMJGm. Newborns of preeclamptic women show evidence of sex-specific disparity in fetal growth. 2012;9(6):424-35.
Toplam 35 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Geleneksel, Tamamlayıcı ve Bütünleştirici Tıp (Diğer) |
| Bölüm | Research Articles |
| Yazarlar | |
| Yayımlanma Tarihi | 29 Mart 2024 |
| Gönderilme Tarihi | 25 Ocak 2024 |
| Kabul Tarihi | 4 Mart 2024 |
| Yayımlandığı Sayı | Yıl 2024 Cilt: 3 Sayı: 1 |
