Öz
Proje Numarası
2021/81
Kaynakça
- Jakhotia S, Sivaprasad M, Shalini T, et al. Circulating levels of Hsp27 in microvascular complications of diabetes: prospects as a biomarker of diabetic nephropathy. J Diabetes Complications. 2018;32(2):221-225.
- Zheng Y, He M, Congdon N. The worldwide epidemic of diabetic retinopathy. Indian J Ophthalmol. 2012;60(5):428-431.
- Do DV, Han G, Abariga SA, Sleilati G, Vedula SS, Hawkins BS. Blood pressure control for diabetic retinopathy. Cochrane Database Syst Rev. 2023;3(3):CD006127.
- Frank RN. Diabetic retinopathy and systemic factors. Middle East Afr J Ophthalmol. 2015;22(2):151-156.
- Boss JD, Singh PK, Pandya HK, et al. Assessment of neurotrophins and inflammatory mediators in vitreous of patients with diabetic retinopathy. Invest Ophthalmol Vis Sci. 2017;58(12):5594-5603.
- Sciacchitano S, Lavra L, Morgante A, et al. Galectin-3: one molecule for an alphabet of diseases, from A to Z. Int J Mol Sci. 2018;19(2):379.
- Papaspyridonos M, McNeill E, de Bono JP, et al. Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction. Arterioscler Thromb Vasc Biol. 2008;28(3):433-440.
- Hara A, Niwa M, Noguchi K, et al. Galectin-3 as a next-generation biomarker for detecting early stage of various diseases. Biomolecules. 2020;10(3):389.
- Reichlin T, Hochholzer W, Stelzig C, et al. Incremental value of copeptin for rapid rule out of acute myocardial infarction. J Am Coll Cardiol. 2009;54(1):60-68.
- Katan M, Christ-Crain M. The stress hormone copeptin: a new prognostic biomarker in acute illness. Swiss Med Wkly. 2010;140:w13101.
- Quadro L, Blaner WS, Salchow DJ, et al. Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein. EMBO J. 1999;18(17):4633-4644.
- Maritim AC, Sanders RA, Watkins JB 3rd. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol. 2003;17(1):24-38.
- Meeusen JW, Johnson JN, Gray A, et al. Soluble ST2 and galectin-3 in pediatric patients without heart failure. Clin Biochem. 2015;48(18):1337-1340.
- Schindler EI, Szymanski JJ, Hock KG, Geltman EM, Scott MG. Short-and long-term biologic variability of galectin-3 and other cardiac biomarkers in patients with stable heart failure and healthy adults. Clin Chem. 2016;62(2):360-366.
- Baek JH, Kim SJ, Kang HG, et al. Galectin-3 activates PPARγ and supports white adipose tissue formation and high-fat diet-induced obesity. Endocrinology. 2015;156(1):147-156.
- Pang J, Rhodes DH, Pini M, et al. Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice. PLoS One. 2013;8(2):e57915.
- Darrow AL, Shohet RV. Galectin-3 deficiency exacerbates hyperglycemia and the endothelial response to diabetes. Cardiovasc Diabetol. 2015;14:73.
- Mendonça HR, Carvalho JNA, Abreu CA, et al. Lack of Galectin-3 attenuates neuroinflammation and protects the retina and optic nerve of diabetic mice. Brain Res. 2018;1700:126-137.
- Jin QH, Lou YF, Li TL, Chen HH, Liu Q, He XJ. Serum galectin-3: a risk factor for vascular complications in type 2 diabetes mellitus. Chin Med J (Engl). 2013;126(11):2109-2115
- Morgenthaler NG, Struck J, Alonso C, Bergmann A. Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem. 2006;52(1):112-119.
- Zhu FX, Wu HL, Tu KS, Chen JX, Zhang M, Shi C. Serum levels of copeptin are associated with type 2 diabetes and diabetic complications in Chinese population. J Diabetes Complications. 2016;30(8):1566-1570.
- Li B, Li N, Guo S, et al. The changing features of serum adropin, copeptin, neprilysin and chitotriosidase which are associated with vascular endothelial function in type 2 diabetic retinopathy patients. J Diabetes Complications. 2020;34(11):107686.
- Yang Q, Graham TE, Mody N, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436(7049):356-362.
- Akbay E, Muslu N, Nayir E, Ozhan O, Kiykim A. Serum retinol binding protein 4 level is related with renal functions in type 2 diabetes. J Endocrinol Invest. 2010;33(10):725-729.
- Malechka VV, Moiseyev G, Takahashi Y, Shin Y, Ma JX. Impaired rhodopsin generation in the rat model of diabetic retinopathy. Am J Pathol. 2017;187(10):2222-2231.
- Farjo KM, Farjo RA, Halsey S, Moiseyev G, Ma JX. Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism. Mol Cell Biol. 2012;32(24):5103-5115.
- Du M, Otalora L, Martin AA, et al. Transgenic mice overexpressing serum retinol-binding protein develop progressive retinal degeneration through a retinoid-independent mechanism. Mol Cell Biol. 2015;35(16):2771-2789.
- Racz B, Petrukhin K. Efect of the advanced non-retinoid RBP4 antagonist on vascular permeability in the mouse diabetic retinopathy model. Investig Ophthalmol Vis Sci. 2017;58(8):5799.
- Zhang C, Li K, Zhang J, et al. Relationship between retinol and risk of diabetic retinopathy: a case-control study. Asia Pac J Clin Nutr. 2019;28(3):607-613.
- Sun W, Shi Y, Yang J, et al. Transthyretin and retinol-binding protein as discriminators of diabetic retinopathy in type 1 diabetes mellitus. Int Ophthalmol. 2022;42(4):1041-1049.
Does vitreous galactin-3, copeptin and retina binding protein-4 concentrations change in diabetic retinopathy?
Öz
Aims: This study aimed to investigate whether the concentrations of Galactin-3 (G-3), Copeptin (CP) and Retina Binding Protein-4 (RBP-4) are affected in the vitreous humor of patients with diabetic retinopathy (DR).
Methods: Thirty-six patients with diabetes mellitus (DM) were included in the study, consisting of 10 patients without DR and 26 patients with proliferative diabetic retinopathy (PDR). The control group comprised 15 patients who underwent vitrectomy for epiretinal membrane and macular hole surgeries. Vitreous CP, G-3, and RBP-4 concentrations were examined using the enzyme-linked immunosorbent assay (ELISA) method. The groups were compared internally
Results: We did not observe any significant differences in the concentrations of G-3, CP and RBP-4 in the vitreous humor between diabetic patients and the control group (p=0.56, p=0.65 and p=0.11, respectively). When comparing vitreous samples of diabetic subgroups with and without DR findings to the control group, no significant differences were detected (p=0.51, p=0.66, and p=0.19, respectively).
Conclusion: Our results indicate that the concentrations of G-3, CP, and RBP-4 in the vitreous humor remain unchanged in both diabetic patients and those with proliferative diabetic retinopathy (DRP).
Anahtar Kelimeler
Copeptin Galactin-3 Retina Binding Protein-4 Diabetes mellitus Diabetic retinopathy
Destekleyen Kurum
Funds were provided by the Scientific Research Support Commission of Tokat Gaziosmanpaşa University.
Proje Numarası
2021/81
Kaynakça
- Jakhotia S, Sivaprasad M, Shalini T, et al. Circulating levels of Hsp27 in microvascular complications of diabetes: prospects as a biomarker of diabetic nephropathy. J Diabetes Complications. 2018;32(2):221-225.
- Zheng Y, He M, Congdon N. The worldwide epidemic of diabetic retinopathy. Indian J Ophthalmol. 2012;60(5):428-431.
- Do DV, Han G, Abariga SA, Sleilati G, Vedula SS, Hawkins BS. Blood pressure control for diabetic retinopathy. Cochrane Database Syst Rev. 2023;3(3):CD006127.
- Frank RN. Diabetic retinopathy and systemic factors. Middle East Afr J Ophthalmol. 2015;22(2):151-156.
- Boss JD, Singh PK, Pandya HK, et al. Assessment of neurotrophins and inflammatory mediators in vitreous of patients with diabetic retinopathy. Invest Ophthalmol Vis Sci. 2017;58(12):5594-5603.
- Sciacchitano S, Lavra L, Morgante A, et al. Galectin-3: one molecule for an alphabet of diseases, from A to Z. Int J Mol Sci. 2018;19(2):379.
- Papaspyridonos M, McNeill E, de Bono JP, et al. Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction. Arterioscler Thromb Vasc Biol. 2008;28(3):433-440.
- Hara A, Niwa M, Noguchi K, et al. Galectin-3 as a next-generation biomarker for detecting early stage of various diseases. Biomolecules. 2020;10(3):389.
- Reichlin T, Hochholzer W, Stelzig C, et al. Incremental value of copeptin for rapid rule out of acute myocardial infarction. J Am Coll Cardiol. 2009;54(1):60-68.
- Katan M, Christ-Crain M. The stress hormone copeptin: a new prognostic biomarker in acute illness. Swiss Med Wkly. 2010;140:w13101.
- Quadro L, Blaner WS, Salchow DJ, et al. Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein. EMBO J. 1999;18(17):4633-4644.
- Maritim AC, Sanders RA, Watkins JB 3rd. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol. 2003;17(1):24-38.
- Meeusen JW, Johnson JN, Gray A, et al. Soluble ST2 and galectin-3 in pediatric patients without heart failure. Clin Biochem. 2015;48(18):1337-1340.
- Schindler EI, Szymanski JJ, Hock KG, Geltman EM, Scott MG. Short-and long-term biologic variability of galectin-3 and other cardiac biomarkers in patients with stable heart failure and healthy adults. Clin Chem. 2016;62(2):360-366.
- Baek JH, Kim SJ, Kang HG, et al. Galectin-3 activates PPARγ and supports white adipose tissue formation and high-fat diet-induced obesity. Endocrinology. 2015;156(1):147-156.
- Pang J, Rhodes DH, Pini M, et al. Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice. PLoS One. 2013;8(2):e57915.
- Darrow AL, Shohet RV. Galectin-3 deficiency exacerbates hyperglycemia and the endothelial response to diabetes. Cardiovasc Diabetol. 2015;14:73.
- Mendonça HR, Carvalho JNA, Abreu CA, et al. Lack of Galectin-3 attenuates neuroinflammation and protects the retina and optic nerve of diabetic mice. Brain Res. 2018;1700:126-137.
- Jin QH, Lou YF, Li TL, Chen HH, Liu Q, He XJ. Serum galectin-3: a risk factor for vascular complications in type 2 diabetes mellitus. Chin Med J (Engl). 2013;126(11):2109-2115
- Morgenthaler NG, Struck J, Alonso C, Bergmann A. Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem. 2006;52(1):112-119.
- Zhu FX, Wu HL, Tu KS, Chen JX, Zhang M, Shi C. Serum levels of copeptin are associated with type 2 diabetes and diabetic complications in Chinese population. J Diabetes Complications. 2016;30(8):1566-1570.
- Li B, Li N, Guo S, et al. The changing features of serum adropin, copeptin, neprilysin and chitotriosidase which are associated with vascular endothelial function in type 2 diabetic retinopathy patients. J Diabetes Complications. 2020;34(11):107686.
- Yang Q, Graham TE, Mody N, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436(7049):356-362.
- Akbay E, Muslu N, Nayir E, Ozhan O, Kiykim A. Serum retinol binding protein 4 level is related with renal functions in type 2 diabetes. J Endocrinol Invest. 2010;33(10):725-729.
- Malechka VV, Moiseyev G, Takahashi Y, Shin Y, Ma JX. Impaired rhodopsin generation in the rat model of diabetic retinopathy. Am J Pathol. 2017;187(10):2222-2231.
- Farjo KM, Farjo RA, Halsey S, Moiseyev G, Ma JX. Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism. Mol Cell Biol. 2012;32(24):5103-5115.
- Du M, Otalora L, Martin AA, et al. Transgenic mice overexpressing serum retinol-binding protein develop progressive retinal degeneration through a retinoid-independent mechanism. Mol Cell Biol. 2015;35(16):2771-2789.
- Racz B, Petrukhin K. Efect of the advanced non-retinoid RBP4 antagonist on vascular permeability in the mouse diabetic retinopathy model. Investig Ophthalmol Vis Sci. 2017;58(8):5799.
- Zhang C, Li K, Zhang J, et al. Relationship between retinol and risk of diabetic retinopathy: a case-control study. Asia Pac J Clin Nutr. 2019;28(3):607-613.
- Sun W, Shi Y, Yang J, et al. Transthyretin and retinol-binding protein as discriminators of diabetic retinopathy in type 1 diabetes mellitus. Int Ophthalmol. 2022;42(4):1041-1049.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Göz Hastalıkları, Göz Hastalıkları ve Göz Ölçümleri (Diğer) |
| Bölüm | Research Articles |
| Yazarlar | |
| Proje Numarası | 2021/81 |
| Erken Görünüm Tarihi | 26 Ekim 2023 |
| Yayımlanma Tarihi | 27 Ekim 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 5 Sayı: 4 |
Üniversitelerarası Kurul (ÜAK) Eşdeğerliği: Ulakbim TR Dizin'de olan dergilerde yayımlanan makale [10 PUAN] ve 1a, b, c hariç uluslararası indekslerde (1d) olan dergilerde yayımlanan makale [5 PUAN]
- Dahil olduğumuz İndeksler (Dizinler) ve Platformlar sayfanın en altındadır.
Not: Dergimiz WOS indeksli değildir ve bu nedenle Q olarak sınıflandırılmamaktadır.
Yüksek Öğretim Kurumu (YÖK) kriterlerine göre yağmacı/şüpheli dergiler hakkındaki kararları ile yazar aydınlatma metni ve dergi ücretlendirme politikasını tarayıcınızdan indirebilirsiniz. https://dergipark.org.tr/tr/journal/3449/page/10809/update
Dergi Dizin ve Platformları
TR Dizin ULAKBİM, Google Scholar, Crossref, Worldcat (OCLC), DRJI, EuroPub, OpenAIRE, Turkiye Citation Index, Turk Medline, ROAD, ICI World of Journal's, Index Copernicus, ASOS Index, General Impact Factor, Scilit.