Öz
Aim: The aim of this study was to investigate whether hematological parameters play a significant role in the relationship between hematological parameters and seizure occurrence in children with febrile seizures (FS) by comparing them to a healthy control group with no fever or seizures.
Materials and Methods: One-hundred forty-one patients diagnosed with FS and with available a complete blood count results and a control group of 143 children were finally enrolled.
Results: The study group consisted of 141 patients, 57 girls (40.4%) and 84 boys (59.6%) (M/F=1.4). Mean age at the time of first FS was 22.89 ± 13.95 months. Ninety-two (65.2%) of the study group were diagnosed with simple FS, 32 (22.7%) with complex FS, and 17 (12.1%) with febrile status epilepticus (FSE).
Conclusion: Since our neutrophil, lymphocyte, eosinophil, and mean platelet volume (MPV) results were statistically significant in patients with FS, it is thought that these markers may represent potential predictive parameters in that condition.
Anahtar Kelimeler
Etik Beyan
Ethical approval for the study was obtained from the institutional review board (no.2022/7-53). This study conformed to the Helsinki Declaration.
Destekleyen Kurum
This study was not funded by any supporter.
Kaynakça
- Capovilla G, Mastrangelo M, Romeo A, Vigevano F. Recommendations for the management of "febrile seizures": Ad Hoc TaskForce of LICE Guidelines Commission. Epilepsia 2009;50 Suppl 1:2–6.
- Kc Leung A, Hon KL, Nh Leung T. Febrile seizures: an overview. Drugs Context 2018; 7: 212536.
- Wallace SJ. Febrile seizures. Epilepsy 1996;2(1): 28- 33.
- Trinka E, Cock H, Hesdorffer D, Rosetti AO, Scheffer IE, Shinnar S, et al. A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia 2015;56(10): 1515-23.
- Gontko-Romanowska K, Żaba Z, Panieński P, Steinborn B, Szemień M, Łukasik-Głębocka M, et al. The assessment of risk factors for febrile seizures in children. Neurol Neurochir Pol. 2017;51(6):454-8.
- Sharawat IK, Singh J, Dawman L, Singh A. Evaluation of Risk Factors Associated with First Episode Febrile Seizure. J Clin Diagn Res. 2016;10(5):SC10-3.
- Gontko-Romanowska K, Żaba Z, Panieński P, Steinborn B, Szemień M, Łukasik-Głębocka M et al. The assessment of laboratory parameters in children with fever and febrile seizures. Brain Behav. 2017;15;7(7):e00720.
- Berg AT, Shinnar S. Complex febrile seizures. Epilepsia. 1996;37: 126–33.
- Huang WX, Yu F, Sanchez RM, Liu YQ, Min JW, Hu JJ, et al. TRPV1 promotes repetitive febrile seizures by pro inflammatory cytokines in immature brain. Brain Behav. Immun. 2015;48: 68–77.
- Choy M, Dube CM, Ehrengruber M, Baram TZ. Inflammatory processes, febrile seizures, and subsequent epileptogenesis. Epilepsy Curr. 2014;14:15–22.
- Broom M. Physiology of fever. Paediatric Nursing. 2007;19,(6):40-5.
- Güneş A, Fidan S, Dulkadir R, Ünlü E. Evaluation of risk factors associated with first episode febrile seizure. Eur Rev Med Pharmacol Sci. 2021;25(22):7089-92.
- Liu Z, Li X, Zhang M, Huang X, Bai H, Tavası Z. The role of Mean Platelet Volume/platelet count Ratio and Neutrophil to Lymphocyte Ratio on the risk of Febrile Seizure. Sci Rep. 2018;11;8(1):15123.
- Bertolani MF, Portolani M, Marotti F, Sabbattini AM, Chiossi C, Bandieri MR, et al. A study of childhood febrile convulsions with particular reference to HHV-6 infection: pathogenic considerations Childs Nerv Syst. 1996; 12(9):534-9.
- Busse WW. Mechanisms and advances in allergic diseases. J allergy Clin Immunol. 2000;105(6-2):593-8.
- WY Lin, CH Muo, YC Ku, FC Sung, CH Kao. Risk of subsequent asthma in children with febrile seizures: a nationwide population-based retrospective cohort study. Pediatr Neurol. 2014;51(6):795-9.
- Yamamoto H, Sedgwick JB, Vrtis RF, Busse WW. The effect of transendothelial migration on eosinophil function. Am J Respir Cell Mol Biol. 2000;23(3):379-88.
- O’Connell EM, Nutman TB. Eosinophilia in infectious diseases. Immunol Allergy Clin North Am. 2015;35(3):493-522.
- Pitman MC, Anstey NM, Davis JS. Eosinophils in severe sepsis in northern australia: do the usual rules apply in the tropics? Crit Care Med. 2013;41:e286-8.
- Farmakiotis D, Varughese J, Sue P, Andrews P, Brimmage M, Dobroszycki J, Coyle CM. Typhoid Fever in an inner city hospital: a 5-year retrospective review. J Travel Med. 2013;20:17–21.
- Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011;17;47–58.
- Abuhandan M, Solmaz A, Geter S, Kaya C, Güzel B, Yetkin I, et al. Evaluation of selenium levels and mean platelet volume in patients with simple febrile convulsion. Iran J Pediatr. 2014;24;401-5.
- Korniluk A, Koper-Lenkiewicz OM, Joanna Kamińska, Kemona H, Dymicka-Piekarska V. Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions. Mediators Inflamm. 2019;17;2019:9213074.
- Tang L, Chen JR. The Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of Febrile Seizures. J Inflamm Res. 2021;18;14:5381-5392.
- Aydın H, Bucak İH, Mehmet Turgut M. Comparison of laboratory parameters between children with and without febrile convulsion. J Surg Med. 2021;5(2):149-152.
Öz
Amaç: Bu çalışmanın amacı, ateşli nöbet (FN) geçiren çocuklarda hematolojik parametreler ile nöbet oluşumu arasındaki ilişkide hematolojik parametrelerin önemli bir rol oynayıp oynamadığını, ateşi ve nöbeti olmayan sağlıklı bir kontrol grubu ile karşılaştırarak araştırmaktır.
Gereç ve Yöntem: FN tanısı almış ve hemogram sonuçları bulunan 141 hasta ve 143 sağlıklı çocuk kontrol grubu olarak çalışmaya dahil edildi.
Bulgular: Çalışma grubu 57 Kız (%40,4), 84 Erkek (59,6) olmak üzere 141 hastadan (E/K=1,4) oluşmaktadır. Hastaların ilk FN geçirme yaş aralığı 22,89 ± 13,95 aydır. Hasta grubunun 92’si (%65,2) basit FK, 32’si (%22,7) komplike FN ve 17’si (%12,1) febril status epileptikus (FSE) tanısı almıştı.
Sonuç: Çalışmamızda FN’li hastalarda nötrofil, lenfosit, eozinofil ve ortalama trombosit hacmi (MPV) sonuçlarının istatistiksel olarak anlamlı tespit edilmesi nedeniyle bu belirteçlerin FN’de öngörücü parametreler olabileceği düşünülmektedir.
Anahtar Kelimeler
Etik Beyan
Ethical approval for the study was obtained from the institutional review board (no.2022/7-53). This study conformed to the Helsinki Declaration.
Destekleyen Kurum
This study was not funded by any supporter.
Kaynakça
- Capovilla G, Mastrangelo M, Romeo A, Vigevano F. Recommendations for the management of "febrile seizures": Ad Hoc TaskForce of LICE Guidelines Commission. Epilepsia 2009;50 Suppl 1:2–6.
- Kc Leung A, Hon KL, Nh Leung T. Febrile seizures: an overview. Drugs Context 2018; 7: 212536.
- Wallace SJ. Febrile seizures. Epilepsy 1996;2(1): 28- 33.
- Trinka E, Cock H, Hesdorffer D, Rosetti AO, Scheffer IE, Shinnar S, et al. A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia 2015;56(10): 1515-23.
- Gontko-Romanowska K, Żaba Z, Panieński P, Steinborn B, Szemień M, Łukasik-Głębocka M, et al. The assessment of risk factors for febrile seizures in children. Neurol Neurochir Pol. 2017;51(6):454-8.
- Sharawat IK, Singh J, Dawman L, Singh A. Evaluation of Risk Factors Associated with First Episode Febrile Seizure. J Clin Diagn Res. 2016;10(5):SC10-3.
- Gontko-Romanowska K, Żaba Z, Panieński P, Steinborn B, Szemień M, Łukasik-Głębocka M et al. The assessment of laboratory parameters in children with fever and febrile seizures. Brain Behav. 2017;15;7(7):e00720.
- Berg AT, Shinnar S. Complex febrile seizures. Epilepsia. 1996;37: 126–33.
- Huang WX, Yu F, Sanchez RM, Liu YQ, Min JW, Hu JJ, et al. TRPV1 promotes repetitive febrile seizures by pro inflammatory cytokines in immature brain. Brain Behav. Immun. 2015;48: 68–77.
- Choy M, Dube CM, Ehrengruber M, Baram TZ. Inflammatory processes, febrile seizures, and subsequent epileptogenesis. Epilepsy Curr. 2014;14:15–22.
- Broom M. Physiology of fever. Paediatric Nursing. 2007;19,(6):40-5.
- Güneş A, Fidan S, Dulkadir R, Ünlü E. Evaluation of risk factors associated with first episode febrile seizure. Eur Rev Med Pharmacol Sci. 2021;25(22):7089-92.
- Liu Z, Li X, Zhang M, Huang X, Bai H, Tavası Z. The role of Mean Platelet Volume/platelet count Ratio and Neutrophil to Lymphocyte Ratio on the risk of Febrile Seizure. Sci Rep. 2018;11;8(1):15123.
- Bertolani MF, Portolani M, Marotti F, Sabbattini AM, Chiossi C, Bandieri MR, et al. A study of childhood febrile convulsions with particular reference to HHV-6 infection: pathogenic considerations Childs Nerv Syst. 1996; 12(9):534-9.
- Busse WW. Mechanisms and advances in allergic diseases. J allergy Clin Immunol. 2000;105(6-2):593-8.
- WY Lin, CH Muo, YC Ku, FC Sung, CH Kao. Risk of subsequent asthma in children with febrile seizures: a nationwide population-based retrospective cohort study. Pediatr Neurol. 2014;51(6):795-9.
- Yamamoto H, Sedgwick JB, Vrtis RF, Busse WW. The effect of transendothelial migration on eosinophil function. Am J Respir Cell Mol Biol. 2000;23(3):379-88.
- O’Connell EM, Nutman TB. Eosinophilia in infectious diseases. Immunol Allergy Clin North Am. 2015;35(3):493-522.
- Pitman MC, Anstey NM, Davis JS. Eosinophils in severe sepsis in northern australia: do the usual rules apply in the tropics? Crit Care Med. 2013;41:e286-8.
- Farmakiotis D, Varughese J, Sue P, Andrews P, Brimmage M, Dobroszycki J, Coyle CM. Typhoid Fever in an inner city hospital: a 5-year retrospective review. J Travel Med. 2013;20:17–21.
- Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011;17;47–58.
- Abuhandan M, Solmaz A, Geter S, Kaya C, Güzel B, Yetkin I, et al. Evaluation of selenium levels and mean platelet volume in patients with simple febrile convulsion. Iran J Pediatr. 2014;24;401-5.
- Korniluk A, Koper-Lenkiewicz OM, Joanna Kamińska, Kemona H, Dymicka-Piekarska V. Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions. Mediators Inflamm. 2019;17;2019:9213074.
- Tang L, Chen JR. The Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of Febrile Seizures. J Inflamm Res. 2021;18;14:5381-5392.
- Aydın H, Bucak İH, Mehmet Turgut M. Comparison of laboratory parameters between children with and without febrile convulsion. J Surg Med. 2021;5(2):149-152.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Çocuk Nörolojisi |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Aralık 2023 |
| Gönderilme Tarihi | 30 Temmuz 2023 |
| Kabul Tarihi | 8 Aralık 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 9 Sayı: 3 |
