Araştırma Makalesi
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Ischemia-modified albumin levels in patients with peptic ulcer

Yıl 2018, Cilt: 17 Sayı: 2, 74 - 77, 24.09.2018
https://doi.org/10.17941/agd.462657

Öz

Background and Aims: Ischemia-modified albumin is a recently introduced marker in the evaluation of ischemia and oxidative stress. The aims of this study are to measure serum levels of ischemia-modified albumin before and after treatment in patients with peptic ulcer disease, to calculate the ischemia-modified albumin to albumin ratio, and to compare these values to those from the control group. Materials and Methods: Between November 2016 and April 2017, 32 patients who underwent upper gastrointestinal system endoscopy for any reason, and were found to have peptic ulcers were included in the study, along with 28 healthy controls. Some patients who had Helicobacter pylori as a result of biopsy recieved eradication therapy, while others were treated with antisecretory therapy. Ischemia-modified albumin levels in both the patient and control groups before and after treatment were measured spectrophotometrically, and ischemia-modified albumin to albumin ratios were calculated. Results: There was no statistically significant difference observed in the age and sex distributions between the patient and control groups. The mean ischemia-modified albumin value in the peptic ulcer patient group was 0.19±0.49 absorbance units, and the mean ischemia-modified albumin to albumin ratio was 0.42±0.11. The mean ischemia-modified albumin value in the control group was 0.45±0.16 absorbance units, and the mean ischemia-modified albumin to albumin ratio was 0.11±0.40. The difference was statistically significant (p <0.0001). After treatment in the peptic ulcer patient group, ischemia-modified albumin level was 0.20±0.72 absorbance units and ischemia-modified albumin to albumin ratio as 0.45±0.17. When the post-treatment values were compared with values from the control group, the difference was statistically significant (p <0.0001). When pre-treatment values were compared to post-treatment values, statistically significant difference was not observed. Conclusion: Ischemia-modified albumin level and ischemia-modified albumin to albumin ratio, both indicators of oxidative stress, are elevated in patients with peptic ulcer post-treatment.

Kaynakça

  • 1. Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes - review and clinical implications. Clin Chem Lab Med 2011;49:177-84.
  • 2. Szabo S. Gastroduodenal mucosal injury-acute and chonic: Pathways, mediators, and mechanism. J Clin Gastroenterol 1991;13(Suppl)1:S1-8.
  • 3. Aykaç G, Uysal M, Yalçın AS, et al. The effects of chronic ethanol ingestion on hepatic lipid peroxide, glutathione, glutathione peroxidase and glutathione transferase in rats. Toxicology 1985;36:71-6.
  • 4. Calatayud S, Barrachina D, Esplugues J. Nitric oxide: Relation to integrity, injury, and healing of the gastric mucosa. Mic Res Technique 2001;53:325-35.
  • 5. Abe S, Sasano H, Katoh K, et al. Immunohistochemical studies on EGF family growth factors in normal and ulcerated human gastric mucosa. Dig Dis Sci 1997;42:1199-209.
  • 6. Kwiencien S, Brzozowski T, Konturek PC, Konturek SJ. The role of reactive oxygen species in action of nitric oxide-donors on stress-induced gastric mucosal lesions. J Physiol Pharmacol 2002;53:761-73.
  • 7. Özdem S, Çete Y, Dönmez L, et al. Serum levels of ischemia-modified albumin (IMA) in healthy adults and patients with acute coronary syndrome. Turkr J Emerg Med 2005;5:169-74.
  • 8. Zurawska-Plaksej E, Grzebyk E, Marciniak D, et al. Oxidatively modified forms of albumin in patients with risk factors of metabolic syndrome. J Endocrinol Invest 2014;37:819-27.
  • 9. Fidan E, Menteşe A, Kavgacı H, et al. Increased ischemia-modified albumin levels in patients with gastric cancer. Neoplasma 2012;59:393-7.
  • 10. Ellidag HY, Eren E, Aydin O, et al. Ischemia modified albumin levels and oxidative stress in patients with bladder cancer. Asian Pac J Cancer Prev 2013;14:2759-63.
  • 11. Konturek PC. Physiological, immunohistochemical and molecular aspects gastric adaptation to stress, aspirin and to H. pylori-derived gastrotoxins. J Physiol Pharmacol 1997;48:3-42.

Peptik ülserli hastalarda iskemi modifiye albumin düzeyleri

Yıl 2018, Cilt: 17 Sayı: 2, 74 - 77, 24.09.2018
https://doi.org/10.17941/agd.462657

Öz

Giriş ve Amaç: İskemi modifiye albümin; iskemi ve oksidatif stresin değerlendirilmesinde yeni kullanılmaya başlanan bir belirteçtir. Bu çalışmanın amacı peptik ülser hastalarında tedavi öncesi ve sonrası serum iskemi modifiye albümin değerlerini ölçmek, iskemi modifiye albümin/ albümin oranını hesaplamak ve kontrol grubuyla karşılaştırmaktır. Gereç ve Yöntem: Çalışmaya Kasım 2016-Nisan 2017 tarihleri arasında Keçiören Eğitim ve Araştırma Hastanesi Gastroenteroloji Kliniğinde herhangi bir nedenle üst gastrointestinal sistem endoskopisi yapılmış ve peptik ülser saptanmış 32 hasta ve 28 sağlıklı kontrol dahil edildi. Biyopsi sonucu Helicobacter pylori saptanan hastalara eradikasyon tedavisi başlanırken, saptanmayanlara antisekretuvar tedavi verildi. Hastaların ve kontrol grubunun tedavi öncesi ve tedavi sonrası iskemi modifiye albümin değerleri spektrofotometrik olarak ölçüldü, iskemi modifiye albümin/albümin oranları hesaplandı. Bulgular: Hastalar ve kontrol grubu arasında yaş ve cinsiyet dağılımı açısından istatistiksel olarak anlamlı fark yoktu. Peptik ülser hastalarının tedavi öncesi ortalama iskemi modifiye albümin değeri 0.19±0.49 absorbans unit, ortalama iskemi modifiye albümin/albümin oranı 0.42±0.11, kontrol grubunun ortalama iskemi modifiye albümin değeri 0.45±0.16 absorbans unit, iskemi modifiye albümin/albümin 0.11±0.40 olarak hesaplandı. Aradaki fark istatistiksel olarak anlamlı idi (p<0.0001). Tedavi sonrası iskemi modifiye albümin 0.20±0.72 absorbans unit, iskemi modifiye albümin/albümin oranı 0.45±0.17 olarak hesaplandı. Tedavi sonrası değerler kontrol grubu ile karşılaştırıldığında aradaki fark istatistiksel olarak anlamlı idi (p<0.0001). Tedavi öncesi ve sonrası değerleri kendi içinde karşılaştırıldığında aradaki farkın istatistiksel olarak anlamlı olmadığı saptandı. Sonuç: Peptik ülserli hastalarda tedavi sonrasında da oksidatif stres belirteci olan iskemi modifiye albümin değeri ve iskemi modifiye albümin/albümin yüksek seyretmektedir.


Kaynakça

  • 1. Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes - review and clinical implications. Clin Chem Lab Med 2011;49:177-84.
  • 2. Szabo S. Gastroduodenal mucosal injury-acute and chonic: Pathways, mediators, and mechanism. J Clin Gastroenterol 1991;13(Suppl)1:S1-8.
  • 3. Aykaç G, Uysal M, Yalçın AS, et al. The effects of chronic ethanol ingestion on hepatic lipid peroxide, glutathione, glutathione peroxidase and glutathione transferase in rats. Toxicology 1985;36:71-6.
  • 4. Calatayud S, Barrachina D, Esplugues J. Nitric oxide: Relation to integrity, injury, and healing of the gastric mucosa. Mic Res Technique 2001;53:325-35.
  • 5. Abe S, Sasano H, Katoh K, et al. Immunohistochemical studies on EGF family growth factors in normal and ulcerated human gastric mucosa. Dig Dis Sci 1997;42:1199-209.
  • 6. Kwiencien S, Brzozowski T, Konturek PC, Konturek SJ. The role of reactive oxygen species in action of nitric oxide-donors on stress-induced gastric mucosal lesions. J Physiol Pharmacol 2002;53:761-73.
  • 7. Özdem S, Çete Y, Dönmez L, et al. Serum levels of ischemia-modified albumin (IMA) in healthy adults and patients with acute coronary syndrome. Turkr J Emerg Med 2005;5:169-74.
  • 8. Zurawska-Plaksej E, Grzebyk E, Marciniak D, et al. Oxidatively modified forms of albumin in patients with risk factors of metabolic syndrome. J Endocrinol Invest 2014;37:819-27.
  • 9. Fidan E, Menteşe A, Kavgacı H, et al. Increased ischemia-modified albumin levels in patients with gastric cancer. Neoplasma 2012;59:393-7.
  • 10. Ellidag HY, Eren E, Aydin O, et al. Ischemia modified albumin levels and oxidative stress in patients with bladder cancer. Asian Pac J Cancer Prev 2013;14:2759-63.
  • 11. Konturek PC. Physiological, immunohistochemical and molecular aspects gastric adaptation to stress, aspirin and to H. pylori-derived gastrotoxins. J Physiol Pharmacol 1997;48:3-42.
Toplam 11 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Evrim Kahramanoğlu Aksoy 0000-0001-8887-3428

Ferdane Sapmaz 0000-0003-1278-110X

Özlem Doğan Bu kişi benim 0000-0003-3078-999X

Özgür Albuz 0000-0002-8534-1781

Metin Uzman 0000-0002-5412-8523

Yayımlanma Tarihi 24 Eylül 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 17 Sayı: 2

Kaynak Göster

APA Kahramanoğlu Aksoy, E., Sapmaz, F., Doğan, Ö., Albuz, Ö., vd. (2018). Peptik ülserli hastalarda iskemi modifiye albumin düzeyleri. Akademik Gastroenteroloji Dergisi, 17(2), 74-77. https://doi.org/10.17941/agd.462657

test-5