Klindamisin tedavisine bağlı olarak papülopüstüler cilt döküntüsü, lökositoklastik vaskülit ve oral kandidiyazis gelişen olgu
Öz
Antibiyotiklere bağlı olarak
pekçok istenmeyen olay ve yan etkiler gelişebilmektedir. Klindamisin linkozamid
grubunda yer alan bir antibiyotik olup, en sık karşılaşılan yan etkisi Clostridium difficile’ye bağlı olarak
antibiyotikle ilişkili ishal ve psödomembranöz enterokolit gelişmesidir. Bu
yazıda, klindamisin tedavisinin ikinci gününde papülopüstüler cilt döküntüsü,
lökositoklastik vaskülit ve oral kandidiyazis gelişen 36 yaşında bir kadın hasta sunularak
literatür gözden geçirildi.
Anahtar Kelimeler
Klindamisin yan etki papülopüstüler döküntü lökositoklastik vaskülit mukozit
Kaynakça
- 1. Özaras R, Tabak F, Öztürk R. Antibiyotikler III. Akılcı Antibiyotik Kullanımı ve Erişkinde Toplumdan Edinilmiş Enfeksiyonlar Sempozyum Dizisi, Kasım 2002; 31, s. 55-82.
- 2. Sivapalasingam S, Steigbigel NH. Macrolides, Clindamycin, and Ketolides. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases,8th edi.,Elsevier, 2015; 29, 358-376.e6.
- 3. Monteagudo B, Cabanillas M, Iriarte P, et al. Clindamycin-induced maculopapular exanthema with preferential ınvolvement of striae distensae: a Koebner phenomenon? Acta Dermatovenerol Croat 2018; 26: 61-3.
- 4. Sulewski RJ Jr, Blyumin M, Kerdel FA. Acute generalized exanthematous pustulosis due to clindamycin. Dermatol Online J 2008; 14: 14.
- 5. Lambert WC, Kolber LR, Proper SA. Leukocytoclastic angiitis induced by clindamycin. Cutis 1982; 30: 615-9.
- 6. Heta S and Robo I. The side effects of the most commonly used group of antibiotics in periodontal treatments. Med Sci 2018; 6: 1-6.
- 7. Vudalı EY, Kınıklı S, Cesur S. Antibiyotiklerin yan etkileri. Turk J Clin Lab 2014; 5: 18-27.
- 8. Boras VV, Andabak-Rogulj A, Brailo V, Šimunković SK, Gabrić D,Vrdoljak DV. Adverse drug reactions in the oral cavity. Acta Clin Croat 2015; 54: 208-15.
- 9. Özdemir Ş, Bilen H. Oral kandidiyazis ve diğer fungal hastalıklar. Turkiye Klinikleri J Dermatol-Special Topics 2015; 8: 35-8.
A case of papulopustular skin rash, leukocytoclastic vasculitis and oral candidiasis due to clindamycin treatment
Öz
Many
adverse events and side effects may occur due to antibiotics. Clindamycin is an
antibiotic in the linkosamide group and the most common side effect is the
development of antibiotic-associated diarrhea and pseudomembranous
enterocolitis due to Clostridium difficile.
In this article, a 36-year-old
woman who developed papulopustular skin rash, leukocytoclastic vasculitis and
oral candidiasis on the second day of clindamycin treatment was presented and
the literature was reviewed.
Anahtar Kelimeler
Clindamycin adverse efffect papulopistular rache leucosytoklastic vasculitis mucositis
Kaynakça
- 1. Özaras R, Tabak F, Öztürk R. Antibiyotikler III. Akılcı Antibiyotik Kullanımı ve Erişkinde Toplumdan Edinilmiş Enfeksiyonlar Sempozyum Dizisi, Kasım 2002; 31, s. 55-82.
- 2. Sivapalasingam S, Steigbigel NH. Macrolides, Clindamycin, and Ketolides. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases,8th edi.,Elsevier, 2015; 29, 358-376.e6.
- 3. Monteagudo B, Cabanillas M, Iriarte P, et al. Clindamycin-induced maculopapular exanthema with preferential ınvolvement of striae distensae: a Koebner phenomenon? Acta Dermatovenerol Croat 2018; 26: 61-3.
- 4. Sulewski RJ Jr, Blyumin M, Kerdel FA. Acute generalized exanthematous pustulosis due to clindamycin. Dermatol Online J 2008; 14: 14.
- 5. Lambert WC, Kolber LR, Proper SA. Leukocytoclastic angiitis induced by clindamycin. Cutis 1982; 30: 615-9.
- 6. Heta S and Robo I. The side effects of the most commonly used group of antibiotics in periodontal treatments. Med Sci 2018; 6: 1-6.
- 7. Vudalı EY, Kınıklı S, Cesur S. Antibiyotiklerin yan etkileri. Turk J Clin Lab 2014; 5: 18-27.
- 8. Boras VV, Andabak-Rogulj A, Brailo V, Šimunković SK, Gabrić D,Vrdoljak DV. Adverse drug reactions in the oral cavity. Acta Clin Croat 2015; 54: 208-15.
- 9. Özdemir Ş, Bilen H. Oral kandidiyazis ve diğer fungal hastalıklar. Turkiye Klinikleri J Dermatol-Special Topics 2015; 8: 35-8.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 22 Eylül 2019 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 1 Sayı: 4 |
Kaynak Göster
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Assoc Prof Dr Muhammed KIZILGÜL was qualified as an Associated Editor in ACMJ on 15/02/2020,
Assoc. Prof. Dr. Ercan YUVANÇ leaved, Assoc. Prof. Dr. Alpaslan TANOĞLU became the Editör in Chief in ACMJ on 13/05/2020.