Öz
Akut toksisite görülebileceği gibi karbamazepin kullananlarda kronik toksisite görülebilmektedir ve bu nedenlerle acil servise başvuru olabilmektedir. Karbamazepin toksisitesinde nörolojik bulgular ön plandadır. Denge bozukluğu, baş dönmesi ve şuur değişikliği ile acil servise getirilen ve takip ve tedavi sırasında karbamazepin zehirlenmesi düşündüğümüz 18 yaşındaki bir olgu aktif kömür ve hemodiyaliz ile tedavi edilmiştir. Karbamazepin kullanan ve nörolojik semptomlarla acil servise başvuran hastalarda karbamazepin intoksikasyonu akla gelmelidir. Tedavisinde aktif kömür ve erken dönemde uygulanacak olan hemodiyaliz çok faydalı olabilmektedir.
Anahtar Kelimeler
Kaynakça
- 1. Rho JM, Sankar R: The pharmacologic basis of antiepileptic drug action. Epilepsia 40: 1471, 1999.2. Mégarbane B, Leprince P, Deye N, et al. Extracorporeal life support in a case of acute carbamazepine poisoning with life-threatening refractory myocardial failure. Intensive Care Med 2006;32:1409-13.
- 3. Li TG, Yan Y, Wang NN, Zhao M. Acute carbamazepine poisoning treated with resin hemoperfusion successfully. Am J Emerg Med. 2011;29(5):518-22.
- 4. Yang X, Xin S, Zhang Y, Li T. Early hemoperfusion for emergency treatment of carbamazepine poisoning. Am J Emerg Med. 2018;36(6):926-930.
- 5. Spiller HA. Management of carbamazepine overdose. Pediatr Emerg Care. 2001;17(6):452-6.
- 6. Soderstrom J, Murray L, Little M, Daly FM. Toxicology case of the month: carbamazepine overdose. Emerg Med J 2006; 23; 869-71.
- 7. Ghannoum M, Yates C, Galvao TF, Sowinski KM, Vo TH, Coogan A, Gosselin S, Lavergne V, Nolin TD, Hoffman RS; EXTRIP workgroup. Extracorporeal treatment for carbamazepine poisoning: systematic review and recommendations from the EXTRIP workgroup. Clin Toxicol (Phila). 2014;52(10):993-1004.8. Brahmi N, Kouraichi N, Abderrazek H, Thabet H, Amamou M. Clinical experience with carbamazepine overdose: relationship between serum concentration and neurological severity. J Clin Psychopharmacol. 2008;28(2):241-3.
- 9. Tapolyai M, Campbell M, Dailey K, Udvary-Nagy S. Hemodialysis is as effective as hemoperfusion for drug removal in carbamazepine poisoning. Nephron 2002; 90: 213-5.
Öz
Acute toxicity may be seen, and chronic toxicity may be seen in carbamazepine users and emergency services can be applied for these reasons. Neurological findings in the carbamazepine toxicity are the anterior plan. A case of 18-year-old man who was admitted to emergency service with dysbalance, dizziness and consciousness change and carbamazepine intoxication during follow-up and was treated with active charcoal and hemodialysis. Carbamazepine intoxication should be considered in patients who are taking carbamazepine and who are referred to emergency services with neurological symptoms. Active Charcoal and hemodialysis to be applied in the early period in the treatment can be very useful.
Anahtar Kelimeler
Carbamazepine emergency service hemodialysis activated charcoal
Kaynakça
- 1. Rho JM, Sankar R: The pharmacologic basis of antiepileptic drug action. Epilepsia 40: 1471, 1999.2. Mégarbane B, Leprince P, Deye N, et al. Extracorporeal life support in a case of acute carbamazepine poisoning with life-threatening refractory myocardial failure. Intensive Care Med 2006;32:1409-13.
- 3. Li TG, Yan Y, Wang NN, Zhao M. Acute carbamazepine poisoning treated with resin hemoperfusion successfully. Am J Emerg Med. 2011;29(5):518-22.
- 4. Yang X, Xin S, Zhang Y, Li T. Early hemoperfusion for emergency treatment of carbamazepine poisoning. Am J Emerg Med. 2018;36(6):926-930.
- 5. Spiller HA. Management of carbamazepine overdose. Pediatr Emerg Care. 2001;17(6):452-6.
- 6. Soderstrom J, Murray L, Little M, Daly FM. Toxicology case of the month: carbamazepine overdose. Emerg Med J 2006; 23; 869-71.
- 7. Ghannoum M, Yates C, Galvao TF, Sowinski KM, Vo TH, Coogan A, Gosselin S, Lavergne V, Nolin TD, Hoffman RS; EXTRIP workgroup. Extracorporeal treatment for carbamazepine poisoning: systematic review and recommendations from the EXTRIP workgroup. Clin Toxicol (Phila). 2014;52(10):993-1004.8. Brahmi N, Kouraichi N, Abderrazek H, Thabet H, Amamou M. Clinical experience with carbamazepine overdose: relationship between serum concentration and neurological severity. J Clin Psychopharmacol. 2008;28(2):241-3.
- 9. Tapolyai M, Campbell M, Dailey K, Udvary-Nagy S. Hemodialysis is as effective as hemoperfusion for drug removal in carbamazepine poisoning. Nephron 2002; 90: 213-5.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Vaka Takdimi |
| Yazarlar | |
| Yayımlanma Tarihi | 21 Eylül 2018 |
| Yayımlandığı Sayı | Yıl 2018 Cilt: 1 Sayı: 1 |
