Öz
Bu çalışma oksadiazol tetrasübstitüe magnezyum ftalosiyanin bileşiğinin antioksidan aktivitesini inceleyen bir çalışmadır. Oksadiazol sübstitüe ftalonitril türevinin tetramerizasyon reaksiyonu sonucu elde edilen ftalosiyanin bileşiğinin DPPH radikal yakalama aktiviteleri, toplam fenolik ve flavonoid içerikleri gibi in vitro antioksidan aktiviteleri araştırıldı. Bileşiğin, yüksek toplam fenol içeriğinin yanı sıra DPPH ile önemli ölçüde reaksiyona girdiği belirlendi. Elde edilen verilere göre özellikleri incelenen ftalosiyanin bileşiğinin antioksidan aktiviteye sahip olduğu söylenebilir.
Anahtar Kelimeler
Ftalosiyanin Antioksidan DPPH Toplam fenolik içeriği Toplam flavonoid içeriği
Kaynakça
- Ağırtaş, M.S., Cabir, B., Gonca, S., Özdemir, S., (2022). Antioxidant, Antimicrobial, DNA Cleavage, Fluorescence Properties and Synthesis of 4- (3,4,5-Trimethoxybenzyloxy) Phenoxy) Substituted Zinc Phthalocyanine. Polycyc. Aromat. Comp. 42: 5029-5043.
- Amaral, G. P., Puntel, G. O., Corte, C. L. D., Dobrachinski, F., Barcelos, R. P., Bastos, L. L., Ávila, D. S., Rocha, J. B. T., da Silva, E. O., Puntel, R. L., (2012). Félix Alexandre Antunes Soares, The antioxidant properties of different phthalocyanines. Toxicol. in Vitro 26: 125-132.
- Apel, K., Hirt, H., (2004). Reactive Oxygen Species: Metabolism, Oxidative Stress, and Signaling Transduction. Annu. Rev. Plant Biol. 55: 373-399.
- Blois, M.S., (1958). Antioxidant determinations by the use of a stable free radical [10]. Nature. 181(4617): 1199-1200.
- Clarke, G., Ting, K.N., Wiart, C., Fry, J., (2013). Radical Scavenging, Ferric Reducing Activity Potential and Total Phenolics Content Indicates Redundancy in Use of All Three Assays to Screen for Antioxidant Activity of Extracts of Plants from the Malaysian Rainforest. Antioxidan. 4: 1-10.
- Eken-Korkut, S., Ahmetali, E., Bilgi, M., Karataş, Ö., Yerli, Y., Peksel, A., Şener, M. K., (2021). Synthesis and antioxidant activity of zinc(II) phthalocyanine Tetranitroxide. Polyhedron 197: 115045-115051.
- Fatima, K., Masood, N., Luqman, S., (2016). Quenching of singlet oxygen by natural and synthetic antioxidants and assessment of electronic UV/Visible absorption spectra for alleviating or enhancing the efficacy of photodynamic therapy. Biomed. Researc. Ther. 3 (2): 514-527.
- Gobec, M., Tomasic, T., Markovic, T., Mlinaric-Rascan, I., Dolenc, M. S., Jakopin, Z., (2015). Antioxidant and anti-inflammatory properties of 1,2,4-oxadiazole analogs of resveratrol. Chem. Biol. Inter. 240: 200-207.
- Günsel, A., Alıcı, E. H., Bilgiçli, A. T., Arabacı, G. Yaraşır, M. N., (2019). Antioxidant properties of water-soluble phthalocyanines containing quinoline 5-sulfonic acid groups. Turk J. Chem. 43: 1030-1039.
- Kotaiah, Y., Harikrishna, N., Nagaraju, K., Venkata Rao, C., (2012). Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d] pyrimidine derivatives. European J. Med. Chem. 58: 340-345.
- Lushchak, V.I., (2014). Free radicals, reactive oxygen species, oxidative stress and its classification. Chem. Biol. Interact. 224: 164-175.
- Molan, A.L., Mahdy, A.S., (2014). Iraqi medicinal plants: Total flavonoid contents, free-radical scavenging and bacterial beta-glucuronidase inhibition activities. IOSR J. Dent. Med. Sci. 13(5): 72-77.
- Nimse, S.B., Pal, D., (2015). Free radicals, natural antioxidants, and their reaction mechanisms. RSC Adv. 5: 27986-28006.
- Özdemir, M., Köksoy, B., Yalçın, B., Taşkın, T., Acar-Selçuki, N., Salan, Ü., Durmuş, M., Bulut, M., (2020). Novel lutetium(III) phthalocyanine-coumarin dyads; synthesis, characterization, photochemical, theoretical and antioxidant properties. Inorg. Chim. Acta. 517: 120145-120151.
- Sharma, P., Jha, A.B., Dubey, R.S., Pessarakli, M., (2012). Reactive oxygen species, oxidative damage, and antioxidative defense mechanism in plants under stressful conditions. J. Botany. 2012: 1-26.
- Söylemez, N., Yabaş, E., Şahin-Bölükbaşı, S., Sülü, M., (2018). Antioxidant activities of the new tetrasubstituted metal-free, Zn(II) and Co(II) monophthalocyanines. J. Porphyrin Phthalocya. 22: 233-242.
- Yabaş, E., Şahin-Bölükbaşı, S., Şahin-İnan, Z. D., (2022). New water soluble magnesium phthalocyanine as a potential anticancer drug: Cytotoxic and apoptotic effect on different cancer cell lines. J. Porphyrins Phthalocyanine. 65-77.
- Yıldırım, N., Bilgiçli, A.T., Alıcı, E. H., Arabacı, G., Yaraşır, M. N., (2017). Formation, characterization, aggregation, fluorescence and antioxidant properties of novel tetrasubstituted metal-free and metallophthalocyanines bearing (4-(methylthio)phenoxy) moieties. J. Mol. Struc. 1144: 66-79.
Öz
This study is a study examining the antioxidant activity of oxadiazole tetrasubstituted magnesium phthalocyanine compound. In vitro antioxidant activities such as DPPH radical scavenging activities, total phenolic and flavonoid contents of the phthalocyanine compound obtained as a result of the tetramerization reaction of oxadiazole substituted phthalonitrile derivative were investigated. It was found that the compound reacted significantly with DPPH as well as a high total phenol content. According to the obtained data, it can be said that the phthalocyanine compound, whose properties were examined, has antioxidant activity.
Anahtar Kelimeler
Phthalocyanine Antioxidant DPPH Total Phenolic Content Total Flavonoid Content
Kaynakça
- Ağırtaş, M.S., Cabir, B., Gonca, S., Özdemir, S., (2022). Antioxidant, Antimicrobial, DNA Cleavage, Fluorescence Properties and Synthesis of 4- (3,4,5-Trimethoxybenzyloxy) Phenoxy) Substituted Zinc Phthalocyanine. Polycyc. Aromat. Comp. 42: 5029-5043.
- Amaral, G. P., Puntel, G. O., Corte, C. L. D., Dobrachinski, F., Barcelos, R. P., Bastos, L. L., Ávila, D. S., Rocha, J. B. T., da Silva, E. O., Puntel, R. L., (2012). Félix Alexandre Antunes Soares, The antioxidant properties of different phthalocyanines. Toxicol. in Vitro 26: 125-132.
- Apel, K., Hirt, H., (2004). Reactive Oxygen Species: Metabolism, Oxidative Stress, and Signaling Transduction. Annu. Rev. Plant Biol. 55: 373-399.
- Blois, M.S., (1958). Antioxidant determinations by the use of a stable free radical [10]. Nature. 181(4617): 1199-1200.
- Clarke, G., Ting, K.N., Wiart, C., Fry, J., (2013). Radical Scavenging, Ferric Reducing Activity Potential and Total Phenolics Content Indicates Redundancy in Use of All Three Assays to Screen for Antioxidant Activity of Extracts of Plants from the Malaysian Rainforest. Antioxidan. 4: 1-10.
- Eken-Korkut, S., Ahmetali, E., Bilgi, M., Karataş, Ö., Yerli, Y., Peksel, A., Şener, M. K., (2021). Synthesis and antioxidant activity of zinc(II) phthalocyanine Tetranitroxide. Polyhedron 197: 115045-115051.
- Fatima, K., Masood, N., Luqman, S., (2016). Quenching of singlet oxygen by natural and synthetic antioxidants and assessment of electronic UV/Visible absorption spectra for alleviating or enhancing the efficacy of photodynamic therapy. Biomed. Researc. Ther. 3 (2): 514-527.
- Gobec, M., Tomasic, T., Markovic, T., Mlinaric-Rascan, I., Dolenc, M. S., Jakopin, Z., (2015). Antioxidant and anti-inflammatory properties of 1,2,4-oxadiazole analogs of resveratrol. Chem. Biol. Inter. 240: 200-207.
- Günsel, A., Alıcı, E. H., Bilgiçli, A. T., Arabacı, G. Yaraşır, M. N., (2019). Antioxidant properties of water-soluble phthalocyanines containing quinoline 5-sulfonic acid groups. Turk J. Chem. 43: 1030-1039.
- Kotaiah, Y., Harikrishna, N., Nagaraju, K., Venkata Rao, C., (2012). Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d] pyrimidine derivatives. European J. Med. Chem. 58: 340-345.
- Lushchak, V.I., (2014). Free radicals, reactive oxygen species, oxidative stress and its classification. Chem. Biol. Interact. 224: 164-175.
- Molan, A.L., Mahdy, A.S., (2014). Iraqi medicinal plants: Total flavonoid contents, free-radical scavenging and bacterial beta-glucuronidase inhibition activities. IOSR J. Dent. Med. Sci. 13(5): 72-77.
- Nimse, S.B., Pal, D., (2015). Free radicals, natural antioxidants, and their reaction mechanisms. RSC Adv. 5: 27986-28006.
- Özdemir, M., Köksoy, B., Yalçın, B., Taşkın, T., Acar-Selçuki, N., Salan, Ü., Durmuş, M., Bulut, M., (2020). Novel lutetium(III) phthalocyanine-coumarin dyads; synthesis, characterization, photochemical, theoretical and antioxidant properties. Inorg. Chim. Acta. 517: 120145-120151.
- Sharma, P., Jha, A.B., Dubey, R.S., Pessarakli, M., (2012). Reactive oxygen species, oxidative damage, and antioxidative defense mechanism in plants under stressful conditions. J. Botany. 2012: 1-26.
- Söylemez, N., Yabaş, E., Şahin-Bölükbaşı, S., Sülü, M., (2018). Antioxidant activities of the new tetrasubstituted metal-free, Zn(II) and Co(II) monophthalocyanines. J. Porphyrin Phthalocya. 22: 233-242.
- Yabaş, E., Şahin-Bölükbaşı, S., Şahin-İnan, Z. D., (2022). New water soluble magnesium phthalocyanine as a potential anticancer drug: Cytotoxic and apoptotic effect on different cancer cell lines. J. Porphyrins Phthalocyanine. 65-77.
- Yıldırım, N., Bilgiçli, A.T., Alıcı, E. H., Arabacı, G., Yaraşır, M. N., (2017). Formation, characterization, aggregation, fluorescence and antioxidant properties of novel tetrasubstituted metal-free and metallophthalocyanines bearing (4-(methylthio)phenoxy) moieties. J. Mol. Struc. 1144: 66-79.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Mühendislik |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Erken Görünüm Tarihi | 6 Aralık 2023 |
| Yayımlanma Tarihi | 6 Aralık 2023 |
| Yayımlandığı Sayı | Yıl 2023Cilt: 2 Sayı: 1 |
