Bacterial Isolation and Antibiotic Susceptibility Test Results from Burn Wound Infection in the Southeastern Anatolia Region of Turkey
Öz
This study was conducted to find the bacterial profile isolated from the wound areas of the patients hospitalized in our burn center, which is the only one in our region and to find the sensitive antibiotics to be used in the treatment.
In this study, the culture reports of 395 patients, whose wound culture results were (+), obtained from 1415 patients hospitalized in Gazi Yaşargil Training and Research Hospital burn center between January 2010 and January 2020, were included.
Of the 394 patients, 217 (55%) were male and 117 (45%) were female. The average age of the patients is 12,86±17,34 years. The average burn degree is 2,67. In the wound culture results, 70,55% of gram (+) and 28,68% of gram (-) bacteria were found. Candida albicans were found in wound culture growth results with a rate of 0,07%. The most common gram (+) pathogen is Staphylococcus aureus with 23,09% (n: 91). In our study, the resistance rate of Staphylococcus aureus to methicillin was 20,31%. The most common gram (-) pathogen was E. coli with 9,13% (n: 36) and Pseudomonas aeruginosa with 9,13% (n: 36). Gram (+) organisms were mostly isolated with a rate of 78,95% in the culture results of patients who needed intensive care clinically due to infection. Staphylococcus aureus is the most common bacteria with 21,05%.
As a result of our study, it was found that the most common cause of burn infection in our region was S. aureus, P. aeruginosa, and E. coli. We hope that the use of broad-spectrum antibiotics that can be effective against these bacteria will contribute to clinical treatment until culture results are available.
Anahtar Kelimeler
Kaynakça
- WHO. Burns. (2018). Available from: http://www.who.int/news-room/factsheets/detail/burns Date: May 27, 2019.
- GBD 2015. Disease and Injury Incidence and Prevalence Collaborators: Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1545-602. 10.1016/S0140-6736(16)31678-6.
- Pruitt BA Jr, McManus AT, Kim SH, Goodwin CW. Burn wound infections: Current status. World J Surg. 1998;22:135-45. 10.1007/s002689900361
- Weber JM, McManus AT. Nursing Committee of the International Society for Burn Injuries: Infection control in burn patients. Burns. 2004;30:A16-24. 10.1016/j.burns.2004.08.003
- Farina JA, Rosique MJ, Rosique RG. Curbing inflammation in burn patients . Int J Inflam. 2013;2013:715645. 10.1155/2013/715645
- Church D, Elsayed S, Reid O, Winston B, Lindsay R. Burn wound infections. Clin Microbiol Rev. 2006;19:403-34. 10.1128/CMR.19.2.403-434.2006
- Raz-Pasteur A, Hussein K, Finkelstein R, Ullmann Y, Egozi D. Blood stream infections (BSI) in severe burn patients--early and late BSI: A 9-year study. Burns. 2013;39:636-42. 10.1016/j.burns.2012.09.015
- Burn Wound Infections. (2011). Available from: http://search.medscape.com/search/?q=Burn%20Wound%20Infections Date: August 31, 2013.
- Fitzwater J, Purdue GF, Hunt JL, O'Keefe GE. The risk factors and time course of sepsis and organ dysfunction after burn trauma. J Trauma. 2003;54:959-66. 10.1097/01.TA.0000029382.26295.AB
- Rafla K, Tredget E. Infection control in the burn unit . Burns. 2011;37:5-15. 10.1016/j.burns.2009.06.198
- Weinstein RA, Mayhall CG. The epidemiology of burn wound infections: then and now. Clin Infect Dis. 2003;37:543-50. 10.1086/376993
- Antibiotic Resistance Threats in the United States, 2013. (2013). Available from: http://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threats-2013-508.pdf. Date: December 25, 2018.
- Read A, Woods R. Antibiotic resistance management. Evol Med Public Health. 2014;2014:147.
- Ventola CL. The antibiotic resistance crisis. Part 1: causes and threats . PT. 2015; 40:277-83.
- Greenhalgh DG, Saffle JR, Holmes JH 4th, et al. American Burn Association consensus conference to define sepsis and infection in burns. J Burn Care Res. 2007;28:776-90.
- Datta S, Ghosh T, Sarkar D, Tudu NK, Chatterjee TK, Jana A. Bacteriological profile of burn wounds and their antibiotic susceptibility pattern in a tertiary care hospital. Int J Sci Stud. 2016;4:141-45.
- Meroj A. Jasem et al. The most frequent bacterial infections in burn injuries at burn units of two hospitals in Baghdad. Iraqi Journal of Public Health (2018) 2:1
- Saaiq M, Ahmad S, Zaib MS. Burn wound infections and antibiotic susceptibility patterns at Pakistan Institute of Medical Sciences, Islamabad, Pakistan. World J Plast Surg. 2015;4:9-15.
- Chaudhary NA, Munawar MD, Khan MT, et al. Epidemiology, bacteriological profile, and antibiotic sensitivity pattern of burn wounds in the burn unit of a tertiary care hospital. Cureus. 2019;11(6):e4794.
- Dhopte A., Bamal R. and Kumar Tiwari V. A prospective analysis of risk factors for pediatric burn mortality at a tertiary burn center in North India.
- “Central Asian and Eastern European Surveillance of Antimicrobial Resistance. Annual report 2018”. Available from: http://www.euro.who.int/en/healthtopics/diseaseprevention/antimicrobialresistance/publications/2018/central-asianandeastern-european-surveillance-of-antimicrobialresistance-annual-report-2018
- Mater M.E, Yamani A.E, Aljuffri A.A Saudi. Med J. 2020;41(7):726-732. doi: 10.15537/smj.2020.7.25141
- Mehta M, Dutta P, Gupta V. Bacterial isolates from burn wound infections and their antibiograms: A eight-year study. Indian J Plast Surg. 2007;40:25-28. 10.4103/0970-0358.32659
- Al Laham NA, Elmanama AA, Tayh GA. Possible risk factors associated with burn wound colonization in burn units of Gaza strip hospitals, Palestine. Ann Burns Fire Disasters. 2013;26:68-75.
- Mostaqimur Rahman, Hafiza Sultana, Md. Abdullahil Mosawuir, Status of Extended Spectrum Beta-Lactamase (ESBL) Producing bacteria isolated from surgical and burn wound at tertiary care hospital in Dhaka City. Bangladesh Journal of Infectious Diseases. June 2018. DOI: http://dx.doi.org/10.3329/bjid.v5i1.37712
Türkiye’nin Güneydoğu Anadolu Bölgesinde Yanık Yarası Enfeksiyonundan Bakteri İzolasyonu ve Antibiyotik Duyarlılık Testi Sonuçları
Öz
Bu çalışma, bölgemizde tek olan yanık merkezimizde yatan hastaların yara bölgelerinden izole edilen bakteri profilini ve tedavide kullanılacak uygun duyarlı antibiyotikleri bulmak amacıyla yapılmıştır.
Bu çalışmada Ocak 2010-Ocak 2020 tarihleri arasında Gazi Yaşargil Eğitim ve Araştırma Hastanesi yanık merkezinde yatan 1415 hastanın (+) yara kültürü sonucu alınan 395 hastanın kültür raporları dahil edildi.
394 hastanın 217’si (%55) erkek, 117’si (%45) kadındı. Hastaların ortalama yaşı 12,86 ± 17,34’tür. Ortalama yanma derecesi 2,67’dir. Yara kültürü sonuçlarında %70,55 gram (+) ve %28,68 gram (-) bakteri bulundu. Yara kültürü üreme sonuçlarında %0,07 oranında Candida albicans saptanmıştır. En sık görülen gram (+) patojen %23,09 (n: 91) ile Staphylococcus aureus’tur. Çalışmamızda Staphylococcus aureus'un metisiline direnç oranı %20,31 olarak bulundu. En sık görülen gram (-) patojen %9,13 (n: 36) ile E. coli ve %9,13 (n: 36) ile Pseudomonas aeruginosa idi. Enfeksiyon nedeniyle klinik olarak yoğun bakıma ihtiyaç duyan hastaların kültür sonuçlarında en çok %78,95 oranında gram (+) organizma izole edildi. Staphylococcus aureus %21,05 ile en yaygın bakteri idi.
Çalışmamız sonucunda bölgemizde en sık yanık enfeksiyonu nedeninin S. aureus, P. aeruginosa ve E. coli olduğu saptanmıştır. Kültür sonuçları çıkana kadar bu bakterilere karşı etkili olabilecek geniş spektrumlu antibiyotik kullanımının klinik tedaviye katkı sağlayacağını umuyoruz.
Anahtar Kelimeler
Kaynakça
- WHO. Burns. (2018). Available from: http://www.who.int/news-room/factsheets/detail/burns Date: May 27, 2019.
- GBD 2015. Disease and Injury Incidence and Prevalence Collaborators: Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1545-602. 10.1016/S0140-6736(16)31678-6.
- Pruitt BA Jr, McManus AT, Kim SH, Goodwin CW. Burn wound infections: Current status. World J Surg. 1998;22:135-45. 10.1007/s002689900361
- Weber JM, McManus AT. Nursing Committee of the International Society for Burn Injuries: Infection control in burn patients. Burns. 2004;30:A16-24. 10.1016/j.burns.2004.08.003
- Farina JA, Rosique MJ, Rosique RG. Curbing inflammation in burn patients . Int J Inflam. 2013;2013:715645. 10.1155/2013/715645
- Church D, Elsayed S, Reid O, Winston B, Lindsay R. Burn wound infections. Clin Microbiol Rev. 2006;19:403-34. 10.1128/CMR.19.2.403-434.2006
- Raz-Pasteur A, Hussein K, Finkelstein R, Ullmann Y, Egozi D. Blood stream infections (BSI) in severe burn patients--early and late BSI: A 9-year study. Burns. 2013;39:636-42. 10.1016/j.burns.2012.09.015
- Burn Wound Infections. (2011). Available from: http://search.medscape.com/search/?q=Burn%20Wound%20Infections Date: August 31, 2013.
- Fitzwater J, Purdue GF, Hunt JL, O'Keefe GE. The risk factors and time course of sepsis and organ dysfunction after burn trauma. J Trauma. 2003;54:959-66. 10.1097/01.TA.0000029382.26295.AB
- Rafla K, Tredget E. Infection control in the burn unit . Burns. 2011;37:5-15. 10.1016/j.burns.2009.06.198
- Weinstein RA, Mayhall CG. The epidemiology of burn wound infections: then and now. Clin Infect Dis. 2003;37:543-50. 10.1086/376993
- Antibiotic Resistance Threats in the United States, 2013. (2013). Available from: http://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threats-2013-508.pdf. Date: December 25, 2018.
- Read A, Woods R. Antibiotic resistance management. Evol Med Public Health. 2014;2014:147.
- Ventola CL. The antibiotic resistance crisis. Part 1: causes and threats . PT. 2015; 40:277-83.
- Greenhalgh DG, Saffle JR, Holmes JH 4th, et al. American Burn Association consensus conference to define sepsis and infection in burns. J Burn Care Res. 2007;28:776-90.
- Datta S, Ghosh T, Sarkar D, Tudu NK, Chatterjee TK, Jana A. Bacteriological profile of burn wounds and their antibiotic susceptibility pattern in a tertiary care hospital. Int J Sci Stud. 2016;4:141-45.
- Meroj A. Jasem et al. The most frequent bacterial infections in burn injuries at burn units of two hospitals in Baghdad. Iraqi Journal of Public Health (2018) 2:1
- Saaiq M, Ahmad S, Zaib MS. Burn wound infections and antibiotic susceptibility patterns at Pakistan Institute of Medical Sciences, Islamabad, Pakistan. World J Plast Surg. 2015;4:9-15.
- Chaudhary NA, Munawar MD, Khan MT, et al. Epidemiology, bacteriological profile, and antibiotic sensitivity pattern of burn wounds in the burn unit of a tertiary care hospital. Cureus. 2019;11(6):e4794.
- Dhopte A., Bamal R. and Kumar Tiwari V. A prospective analysis of risk factors for pediatric burn mortality at a tertiary burn center in North India.
- “Central Asian and Eastern European Surveillance of Antimicrobial Resistance. Annual report 2018”. Available from: http://www.euro.who.int/en/healthtopics/diseaseprevention/antimicrobialresistance/publications/2018/central-asianandeastern-european-surveillance-of-antimicrobialresistance-annual-report-2018
- Mater M.E, Yamani A.E, Aljuffri A.A Saudi. Med J. 2020;41(7):726-732. doi: 10.15537/smj.2020.7.25141
- Mehta M, Dutta P, Gupta V. Bacterial isolates from burn wound infections and their antibiograms: A eight-year study. Indian J Plast Surg. 2007;40:25-28. 10.4103/0970-0358.32659
- Al Laham NA, Elmanama AA, Tayh GA. Possible risk factors associated with burn wound colonization in burn units of Gaza strip hospitals, Palestine. Ann Burns Fire Disasters. 2013;26:68-75.
- Mostaqimur Rahman, Hafiza Sultana, Md. Abdullahil Mosawuir, Status of Extended Spectrum Beta-Lactamase (ESBL) Producing bacteria isolated from surgical and burn wound at tertiary care hospital in Dhaka City. Bangladesh Journal of Infectious Diseases. June 2018. DOI: http://dx.doi.org/10.3329/bjid.v5i1.37712
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Cerrahi |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Yayımlanma Tarihi | 12 Nisan 2023 |
| Gönderilme Tarihi | 16 Aralık 2022 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 3 Sayı: 1 |
Kaynak Göster
AIJHS dergisi ve AIJHS'de yayımlanan tüm makaleler Creative Commons Atıf-Gayri Ticari 4.0 Uluslararası Lisansı ile lisanslanmıştır.