Öz
Amaç: Son yıllarda yapılan çalışmalar kanser ve inflamatuvar yanıt arasında bir ilişki olduğunu
göstermiştir. Bu çalışmada inflamatuvar parametrelerden nötrofil/lenfosit oranı, trombosit/
lenfosit oranı ve sistemik immün inflamasyon indeksinin parotise ait kitlelerin ayırıcı tanısında
kullanılıp kullanılamayacağını incelemeyi amaçladık.
Gereç ve Yöntem: Bu retrospektif çalışmamızda Dicle Üniversitesi Tıp Fakültesi Kulak Burun
Boğaz Polikliniği’ne parotiste kitle ile başvurmuş ve opere edilmiş toplam 100 hasta ile 70
sağlıklı birey kontrol grubu olarak çalışmaya alınmıştır. Hastaların 18’inin malign patolojisi
varken 82’sinin patolojisi benign idi. Malign hasta grubu, benign hasta grubu ve kontrol grubu
hemogram tetkikinden oranlanarak elde edilen nötrofil/lenfosit oranı, trombosit/lenfosit oranı
ve sistemik immün inflamatuvar indeks parametreleri açısından karşılaştırıldı.
Bulgular: Sistemik immün inflamatuvar indeks ve nötrofil/lenfosit oranı yönünden üç grup
arasında anlamlı fark varken (p=0.006, p=0.000) trombosit/lenfosit oranı açısından gruplar arasında
anlamlı farklılık gözlenmedi (p=0.285). Gruplar sistemik immün inflamatuvar indeks ve
nötrofil/lenfosit oranı açısından ikili olarak karşılaştırıldığında, kontrol grubu ile benign hasta
grubu arasında (p<0.017) ve kontrol grubu ile malign hasta grubu arasında (p<0.017) anlamlı
farklılık görüldü. Ancak benign hasta grubu ile malign hasta grubu arasında istatistiksel olarak
anlamlı bir farklılık izlenmedi (p=0.858, p=0.177)
Sonuç: Sistemik inflamatuvar parametreler düşük maliyetli ve tam kan sayımı ile elde edildiklerinden
ulaşılmaları kolaydır. Nötrofil/lenfosit oranı ve sistemik immün inflamatuvar indeks
parametreleri parotis kitlesi olan ve olmayan bireylerde anlamlı farklılık gösterirken, parotisin
benign ve malign patolojilerini ayırt etmede bu parametreler açısından istatistiksel olarak anlamlı
farklılık izlenmedi.
Anahtar Kelimeler
Nötrofil/lenfosit oranı Parotis bezi Trombosit/lenfosit oranı
Kaynakça
- 1. Karabağ S, Ersözlü T. Parotidektomi yapılan olguların histopatolojik ve cerrahi sonuçları: Tek merkez deneyimi. Namık Kemal Tıp Dergisi. 2020; 8(1):11-15.
- 2. Nagler R, Laufer D. Tumors of the major and minor salivary glands: review of 25 years of experience. Anticancer Research. 1997; 17(1B):701-707.
- 3. Pinkston JA, Cole P. Incidence rates of salivary gland tumors: Results from a populationbased study. Otolaryngology–Head and Neck Surgery. 1999; 120(6):834-840.
- 4. Şimşek G, Akın İ, Köybaşıoğlu F. Tükürük bezi kitlelerinde ince iğne aspirasyon sitolojisinin tanısal değeri. Kulak Burun Boğaz Ihtis Derg. 2009; 19(2):71-76.
- 5. Özbay İ, Topuz MF, Kucur C et al. Parotis bezi tümörü nedeniyle ameliyat edilen olgularımızın retrospektif analizi. Genel Tıp Dergisi. 2019; 29(4):163-168.
- 6. Guntinas-Lichius O, Klussmann JP, Wittekindt C. Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations. The Laryngoscope. 2006; 116(4):534-540.
- 7. Bailey BJ, Johnson JT, Newlands SD. Head & Neck Surgery Otolaryngology 4th Ed. Volume 2 Hardcover; 2006. p. 1020-1130.
- 8. Garrett SL, Trott K, Sebastiano C, et al. Sensitivity of fine-needle aspiration and imaging modalities in the diagnosis of lowgrade mucoepidermoid carcinoma of the parotid gland. Annals of Otology, Rhinology & Laryngology. 2019; 128(8):755-759.
- 9. Balkwill F, Mantovani A. Inflammation and cancer: Back to Virchow? The lancet. 2001; 357(9255):539-545.
- 10. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002; 420(6917):860-867.
- 11. An I, Ucmak D, Öztürk M. Neutrophil/ Iymphocyte ratio, platelet/Iymphocyte ratio, mean platelet volume and C-reactive protein values in psoriatic arthritis patients. Ann Med Res. 2019; 26(5):894-898.
- 12. 12. An İ, Uçmak D. Psöriazis vulgaris hastalarında nötrofil/lenfosit oranı, trombosit/ lenfosit oranı, ortalama trombosit hacmi ve C-reaktif protein değerleri, Dicle Tıp Dergisi. 2018; 45(3):327-334.
- 13. Kawata A, Une Y, Hosokawa M. Tumorinfiltrating lymphocytes and prognosis of hepatocellular carcinoma. Jpn J Clin Oncol. 1992; 22(4):256-263.
- 14. Yamashita Ji, Ogawa M, Shirakusa T. Free-form neutrophil elastase is an independent marker predicting recurrence in primary breast cancer. Journal of leukocyte biology. 1995;57(3):375- 378.
- 15. 15. Palumbo JS, Talmage KE, Massari JV, et al. Platelets and fibrin (ogen) increase metastatic potential by impeding natural killer cell– mediated elimination of tumor cells. Blood. 2005; 105(1):178-185.
- 16. Borsig L, Wong R, Hynes RO, et al. Synergistic effects of L-and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proc Natl Acad Sci USA. 2002; 99(4):2193-2198.
- 17. Phulari RG, Rathore RS, Shah AK, et al. Neutrophil: Lymphocyte ratio and oral squamous cell carcinoma: A preliminary study. JOMFP. 2019; 23(1):78.
- 18. Kemal Y, Yucel I, Ekiz K. Elevated serum neutrophil to lymphocyte and platelet to lymphocyte ratios could be useful in lung cancer diagnosis. APJCP. 2014; 15(6):2651- 2654.
- 19. Deveci İ, Sürmeli M. Correlation of Systemic Immune-Inflammation Index and Neutrophilto- Lymphocyte Ratio with Histopathological Findings in Patients with Tongue Cancer. Haydarpasa Numune Med J. 2018; 58(3):122- 127.
- 20. Hsueh C, Tao L, Zhang M. The prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer. Oncotarget. 2017; 8(36):60514.
- 21. Wong BW, Stafford ND, Green VL. Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma. Head &Neck. 2016; 38(S1):E1903-E8.
- 22. Damar M, Dinç AE, Erdem D, et al. Pretreatment neutrophil-lymphocyte ratio in salivary gland tumors is associated with malignancy. Otolaryngol Head Neck Surg. 2016; 155(6):988-996.
- 23. Ekici NY, Kuran G. Parotis bezi tümörü olan hastalarda benign ve malign kitlelerin ayırıcı tanısında sistemik inflamatuvar belirteçlerin önemi.
- 24. http://www.kbb-forum.net/journal/uploads/ pdf/pdf_KBB_436.pdf
- 25. Li J, Chen Q, Luo X. Neutrophil-to-lymphocyte ratio positively correlates to age in healthy population. J Clin Lab Anal. 2015; 29(6):437- 443.
- 26. Bakshi SS. Pretreatment Neutrophil- Lymphocyte Ratio in Salivary Gland Tumors Is Associated with Malignancy. Otolaryngology Head and Neck Surgery. 2016; 155(6):1069- 1075
Öz
Objective: Studies in recent years have shown a relationship between cancer and inflammatory
response. In this study, we aimed to investigate whether neutrophil/lymphocyte ratio, platelet/
lymphocyte ratio and systemic immune inflammation index can be used in the differential diagnosis
of parotid masses.
Materials and Methods: In this retrospective study, 100 patients who came to Dicle University
Faculty of Medicine Otorhinolaryngology outpatient clinic with a parotid mass and were operated
were determined as the study group. 70 healthy individuals were determined as the control group. While 18 of the patients had malignant pathology, 82 of them were benign. Malignant patient group,
benign patient group and control group were compared in terms of neutrophil/lymphocyte ratio, platelet/
lymphocyte ratio and systemic immune inflammation index parameters obtained from the hemogram examination.
Results: While there was a significant difference between the three groups in terms of systemic immune
inflammation index and neutrophil/lymphocyte ratio (p=0.006, p=0.000), no significant difference was observed
between the groups in terms of platelet/lymphocyte ratio (p=0.285). When the groups were compared
in terms of systemic immune inflammation index and neutrophil/lymphocyte ratio in pairs, there was
a significant difference between control group and benign patient group (p<0.017) and between control
group and malignant patient group (p<0.017), but there was no statistically significant difference between
benign patient group and malignant patient group (p= 0.855, p=0.187)
Conclusion: Systemic inflammatory parameters are easy to access as they are obtained with low cost
and complete blood count. While neutrophil/lymphocyte ratio and systemic immune inflammation index
parameters differed significantly in individuals with and without parotid mass, there was no statistically
significant difference in distinguishing between benign and malignant pathologies.
Anahtar Kelimeler
Neutrophil / lymphocyte ratio Parotid gland Platelet / lymphocyte ratio
Kaynakça
- 1. Karabağ S, Ersözlü T. Parotidektomi yapılan olguların histopatolojik ve cerrahi sonuçları: Tek merkez deneyimi. Namık Kemal Tıp Dergisi. 2020; 8(1):11-15.
- 2. Nagler R, Laufer D. Tumors of the major and minor salivary glands: review of 25 years of experience. Anticancer Research. 1997; 17(1B):701-707.
- 3. Pinkston JA, Cole P. Incidence rates of salivary gland tumors: Results from a populationbased study. Otolaryngology–Head and Neck Surgery. 1999; 120(6):834-840.
- 4. Şimşek G, Akın İ, Köybaşıoğlu F. Tükürük bezi kitlelerinde ince iğne aspirasyon sitolojisinin tanısal değeri. Kulak Burun Boğaz Ihtis Derg. 2009; 19(2):71-76.
- 5. Özbay İ, Topuz MF, Kucur C et al. Parotis bezi tümörü nedeniyle ameliyat edilen olgularımızın retrospektif analizi. Genel Tıp Dergisi. 2019; 29(4):163-168.
- 6. Guntinas-Lichius O, Klussmann JP, Wittekindt C. Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations. The Laryngoscope. 2006; 116(4):534-540.
- 7. Bailey BJ, Johnson JT, Newlands SD. Head & Neck Surgery Otolaryngology 4th Ed. Volume 2 Hardcover; 2006. p. 1020-1130.
- 8. Garrett SL, Trott K, Sebastiano C, et al. Sensitivity of fine-needle aspiration and imaging modalities in the diagnosis of lowgrade mucoepidermoid carcinoma of the parotid gland. Annals of Otology, Rhinology & Laryngology. 2019; 128(8):755-759.
- 9. Balkwill F, Mantovani A. Inflammation and cancer: Back to Virchow? The lancet. 2001; 357(9255):539-545.
- 10. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002; 420(6917):860-867.
- 11. An I, Ucmak D, Öztürk M. Neutrophil/ Iymphocyte ratio, platelet/Iymphocyte ratio, mean platelet volume and C-reactive protein values in psoriatic arthritis patients. Ann Med Res. 2019; 26(5):894-898.
- 12. 12. An İ, Uçmak D. Psöriazis vulgaris hastalarında nötrofil/lenfosit oranı, trombosit/ lenfosit oranı, ortalama trombosit hacmi ve C-reaktif protein değerleri, Dicle Tıp Dergisi. 2018; 45(3):327-334.
- 13. Kawata A, Une Y, Hosokawa M. Tumorinfiltrating lymphocytes and prognosis of hepatocellular carcinoma. Jpn J Clin Oncol. 1992; 22(4):256-263.
- 14. Yamashita Ji, Ogawa M, Shirakusa T. Free-form neutrophil elastase is an independent marker predicting recurrence in primary breast cancer. Journal of leukocyte biology. 1995;57(3):375- 378.
- 15. 15. Palumbo JS, Talmage KE, Massari JV, et al. Platelets and fibrin (ogen) increase metastatic potential by impeding natural killer cell– mediated elimination of tumor cells. Blood. 2005; 105(1):178-185.
- 16. Borsig L, Wong R, Hynes RO, et al. Synergistic effects of L-and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proc Natl Acad Sci USA. 2002; 99(4):2193-2198.
- 17. Phulari RG, Rathore RS, Shah AK, et al. Neutrophil: Lymphocyte ratio and oral squamous cell carcinoma: A preliminary study. JOMFP. 2019; 23(1):78.
- 18. Kemal Y, Yucel I, Ekiz K. Elevated serum neutrophil to lymphocyte and platelet to lymphocyte ratios could be useful in lung cancer diagnosis. APJCP. 2014; 15(6):2651- 2654.
- 19. Deveci İ, Sürmeli M. Correlation of Systemic Immune-Inflammation Index and Neutrophilto- Lymphocyte Ratio with Histopathological Findings in Patients with Tongue Cancer. Haydarpasa Numune Med J. 2018; 58(3):122- 127.
- 20. Hsueh C, Tao L, Zhang M. The prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer. Oncotarget. 2017; 8(36):60514.
- 21. Wong BW, Stafford ND, Green VL. Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma. Head &Neck. 2016; 38(S1):E1903-E8.
- 22. Damar M, Dinç AE, Erdem D, et al. Pretreatment neutrophil-lymphocyte ratio in salivary gland tumors is associated with malignancy. Otolaryngol Head Neck Surg. 2016; 155(6):988-996.
- 23. Ekici NY, Kuran G. Parotis bezi tümörü olan hastalarda benign ve malign kitlelerin ayırıcı tanısında sistemik inflamatuvar belirteçlerin önemi.
- 24. http://www.kbb-forum.net/journal/uploads/ pdf/pdf_KBB_436.pdf
- 25. Li J, Chen Q, Luo X. Neutrophil-to-lymphocyte ratio positively correlates to age in healthy population. J Clin Lab Anal. 2015; 29(6):437- 443.
- 26. Bakshi SS. Pretreatment Neutrophil- Lymphocyte Ratio in Salivary Gland Tumors Is Associated with Malignancy. Otolaryngology Head and Neck Surgery. 2016; 155(6):1069- 1075
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Araştırma makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Temmuz 2020 |
| Kabul Tarihi | 18 Haziran 2020 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 3 Sayı: 2 |
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