Klinik Araştırma
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The Effect of Internal Use of Black Seed (Nigella sativa) Oil on Serum Total IgE, Hemogram Parameters and Quality of Life in Patients with Allergic Rhinitis

Yıl 2022, Cilt: 3 Sayı: 3, 17 - 41, 29.08.2022
https://doi.org/10.53445/batd.1124981

Öz

Kaynakça

  • Adegbiji, W.A., Aremu, S.K., Aluko, A., Adewoye, R.K. (2020). Knowledge and awareness of nasal allergy among patients in a developing country. Journal of family medicin-e and primary care, 9(3), 1477–1482. https://doi.org/10.4103/jfmpc.jfmpc_914_19.
  • Ahmad, A., Husain, A., Mujeeb, M., Khan, S.A., Najmi, A. K., Siddique, N.A., Damanhouri, Z.A., Anwar, F. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific journal of tropical biomedicine, 3(5), 337–352. https://doi.org/10.1016/S2221-1691(13)60075-1.
  • Bousquet, J., Khaltaev, N., Cruz, A.A., Denburg, J., Fokkens, W.J., Togias, A., Zuberbier, T., Baena-Cagnani, C.E., Canonica, G.W., van Weel, C., Agache, I., Aït-Khaled, N., Bachert, C., Blaiss, M.S., Bonini, S., Boulet, L.P., Bousquet, P.J., Camargos, P., Carlsen, K.H., Chen, Y., AllerGen (2008). Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy, 63(86), 8–160. https://doi.org/10.1111/j.1398-9995.2007.01620.x.
  • Durham, S.R., Creticos, P.S., Nelson, H.S., Li, Z., Kaur, A., Meltzer, E.O., Nolte, H. (2016). Treatment effect of sublingual immunotherapy tablets and pharmacotherapies for seasonal and perennial allergic rhinitis: Pooled analyses. The Journal of allergy and clinical immunology, 138(4), 1081–1088. https://doi.org/10.1016/j.jaci.2016.04.061.
  • García-Almaraz, R., Reyes-Noriega, N., Del-Río-Navarro, B. E., Berber, A., Navarrete-Rodríguez, E. M., Ellwood, P., Ramírez, O. J. S. (2021). Prevalence and risk factors associated with allergic rhinitis in Mexican school children: Global Asthma Network Phase I. World Allergy Organization Journal, 14(1), 1-18. http://doi.org/10.1016/j.waojou.2020.100492.
  • Genç, S., Selçuk, A. (2013). Allerjik Rinitte Diğer Farmakoterapi Seçenekleri ve Alternatif Tedavi Yöntemleri. Asthma Allergy Immunology, 11, 59-70. https://aai.org.tr/uploads/pdf_259.pdf.
  • Nayeem, M., Ahmed, M., Jawed, A., Alshahrani, S., Makeen, H., Taha, M., Hussain, S., Jahan, S., Khan, A. (2022). A meta-analysis of Nigella sativa in respiratory disorders. Black Seeds (Nigella sativa). Pharmacological and Therapeutic Applications, 177-196. https://doi.org/10.1016/B978-0-12-824462-3.00007-X.
  • Rahmani, A.H., Alzohairy, M.A., Khan, M.A., Aly, S.M. (2014). Therapeutic implications of black seed and its constituent thymoquinone in the prevention of cancer through inactivation and activation of molecular pathways. Evidence-Based Complementary and Alternative Medicine, 2014, 13. https://doi.org/10.1155/2014/724658.
  • Seedat, R.Y. (2013). Treatment of allergic rhinitis. Current Allergy & Clinical Immunology, 26(1), 11-16. https://www.researchgate.net/publication/236590194_Treatment_of_allergic_rhinitis.
  • Small, P., Kim, H. (2011). Allergic rhinitis. Allergy, asthma, and clinical immunology: official journal of the Canadian Society of Allergy and Clinical Immunology, 7(1), 1-8. https://doi.org/10.1186/1710-1492-7-S1-S3.
  • Varshney, J., & Varshney, H. (2015). Allergic rhinitis: an overview. Indian Journal of Otolaryngology and Head & Neck Surgery, 67(2), 143-149. https://doi.org/10.1007/s12070-015-0828-5.
  • Sancaklı, Ö., Belverenli, H. (2019). Alerjik Rinitli Hastaların Klinik Özellikleri ve ID Komorbidite Olarak Adenoid Hipertrofisinin Değerlendirilmesi. Journal of Dr. Behcet Uz Children's Hospital, 9(2):125-130. https://doi.org/10.5222/buchd.2019.47704.
  • Belgü Ulçay, A., Uçal, Y., Ekinci, A. Güler Alis, M., Yıldırım, O. Dizdar, D. (2014). Assessment of Quality of Life and Coexistent Allergic Conjunctivitis in Patients with Allergic Rhinitis in Van Province. Turk Otolarengoloji Arsivi/Turkish Archives of Otolaryngology. 52, 87-92. https://doi.org/10.5152/tao.2014.579.
  • Işık, S., Çağlayan-Sözmen, Ş., Asilsoy, S., Kılıçarslan, S.K., Anal, Ö., Karaman, Ö., Uzuner, N. (2018). Knowledge levels related to allergen specific immunotherapy and perspectives of parents whose children were diagnosed with asthma and/or allergic rhinitis in Turkey. Turkish Journal of Pediatrics, 60(1), 50-55. https://doi.org/10.24953/turkjped.2018.01.007.
  • Özşeker, F., Büyüköztürk, S., Gelincik, A., İşsever, H., Erdenen, F., Özşeker, H., Çolakoğlu, B., Dal, M., İnci, E., Güvenç, M.G. 2012. "Bir Türkçe Rinit Yaşam Kalitesi Ölçeği" Geliştirme ve Geçerlilik Çalışması. Nobel Medicine 8(2):32-40. https://www.nobelmedicus.com/Content/1/23/32-40.pdf.
  • Mou, Y.K., Wang, H.R., Zhang, W.B., Zhang, Y., Ren, C., Song, X.C. (2022). Allergic Rhinitis and Depression: Profile and Proposal. Frontiers in psychiatry, 12, 820497. https://doi.org/10.3389/fpsyt.2021.820497.
  • Nur Husna, S.M., Tan, H.T., Md Shukri, N., Mohd Ashari, N.S., Wong, K.K. (2022). Allergic Rhinitis: A Clinical and Pathophysiological Overview. Frontiers in medicine, 9, 874114. https://doi.org/10.3389/fmed.2022.874114.
  • Siddiqui, Z.A., Walker, A., Pirwani, M.M., Tahiri, M., Syed, I. (2022). Allergic rhinitis: diagnosis and management. British journal of hospital medicine, 83(2), 1–9. https://doi.org/10.12968/hmed.2021.0570.
  • Xu, Y., Zhang, J., & Wang, J. (2014). The efficacy and safety of selective H1-antihistamine versus leukotriene receptor antagonist for seasonal allergic rhinitis: a meta-analysis. PloS one, 9(11), 112815. https://doi.org/10.1371/journal.pone.0112815.
  • Gholamnezhad, Z., Havakhah, S., & Boskabady, M.H. (2016). Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review. Journal of ethnopharmacology, 190, 372–386. https://doi.org/10.1016/j.jep.2016.06.061.
  • Gholamnezhad, Z., Shakeri, F., Saadat, S., Ghorani, V., Boskabady, M.H. (2019). Clinical and experimental effects of Nigella sativa and its constituents on respiratory and allergic disorders. Avicenna journal of phytomedicine, 9(3), 195–212. https://pubmed.ncbi.nlm.nih.gov/31143688/.
  • Tuncel, T., Çetemen, A., Karabel, M., Kelekçi, S., Şen, V., Gürkan, M.F. (2014). Astım ve/veya allerjik rinitli çocuklarda tamamlayıcı ve alternatif tıp uygulamaları. Asthma Allergy Immunol, 12, 146-151. https://app.trdizin.gov.tr/publication/paper/detail/TVRZM05qRTVPUT09.
  • Nikakhlagh, S., Rahim, F., Aryani, F. H., Syahpoush, A., Brougerdnya, M. G., & Saki, N. (2011). Herbal treatment of allergic rhinitis: the use of Nigella sativa. American journal of otolaryngology, 32, 402–407. https://doi.org/10.1016/j.amjoto.2010.07.019.
  • Kalus, U., Pruss, A., Bystron, J., Jurecka, M., Smekalova, A., Lichius, J.J., Kiesewetter, H. (2003). Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytotherapy research: PTR, 17, 1209–1214. Erişim 04.08.2020, https://doi.org/10.1002/ptr.1356.
  • Alsamarai, A.M., Abdulsatar, M., Ahmad Alobaidi, A.H. (2012). Evaluation of therapeutic efficacy of Nigella sativa (Black Seed) for treatment of allergic rhinitis. Allergic Rhinitis, 12, 197-215. https://doi.org/10.5772/26946.
  • Ansari, M. Ansari, N., Junejo, S., Munawar, A., Ansari, M., Phil, M. (2010). Montelukast Versus Nigella Sativa for Management of Seasonal Allergic Rhinitis: A Single Blind Comparative Clinical Trial. Pakistan Journal of Medical Sciences Online, 26(2), 249-254. https://www.pjms.com.pk/issues/aprjun2010/pdf/article01.pdf.
  • Alsamarai, A. M., Abdulsatar, M., Ahmed Alobaidi, A.H. (2014). Evaluation of topical black seed oil in the treatment of allergic rhinitis. Anti-inflammatory & anti-allergy agents in medicinal chemistry, 13, 75–82. https://doi.org/10.2174/18715230113129990014.
  • Ansari, M.A., Ahmed, S.P., Haider, S., Ansari, N. (2006). Nigella sativa: a non-conventional herbal option for the management of seasonal allergic rhinitis. Pak J Pharm, 23(2), 31–35. http://www.pakjp.pk/wp-content/uploads/pdfs/23/2/6-23-2-2006.pdf.
  • Rezaeian, A., Amoushahi Khouzani, S. (2018). Effect of Nigella sativa Nasal Spray on the Treatment of Chronic Rhinosinusitis Without a Nasal Polyp. Allergy & rhinology (Providence, R.I.), 9:1-5. https://doi.org/10.1177/2152656718800059.
  • Koshak, A., Wei, L., Koshak, E., Wali, S., Alamoudi, O., Demerdash, A., Qutub, M., Pushparaj, P.N., Heinrich, M. (2017). Nigella sativa Supplementation Improves Asthma Control and Biomarkers: A Randomized, Double-Blind, Placebo-Controlled Trial. Phytotherapy research: PTR, 31(3), 403–409. https://doi.org/10.1002/ptr.5761.

Alerjik Rinitli Hastalarda Çörek Otu (Nigella Sativa) Yağının Dâhilen Kullanımının Serum Total IgE, Hemogram Parametreleri ve Yaşam Kalitesi Üzerine Etkisi

Yıl 2022, Cilt: 3 Sayı: 3, 17 - 41, 29.08.2022
https://doi.org/10.53445/batd.1124981

Öz

Alerjik rinit (AR) solunan alerjenlere karşı immünoglobülin E (IgE) aracılı mukozal inflamasyonu içeren bir hastalıktır. Çörek otu, yüzyıllardır alerjik hastalıklar dâhil birçok hastalığın önlenmesinde ve tedavisinde kullanılan tıbbi bir bitkidir. Araştırmada, AR tanılı hastalarda çörek otu yağı takviyesinin, serum total IgE, hemogram parametreleri ve yaşam kalitesi üzerindeki etkileri incelenerek AR tedavisinde yardımcı bir tedavi metodu olarak kullanılabilme durumunun değerlendirilmesi amaçlanmıştır. Araştırma, Sağlık Bilimleri Üniversitesi İstanbul Bağcılar Eğitim ve Araştırma Hastanesi Kulak Burun Boğaz polikliniğinde Ağustos 2021-Mart 2022 tarihleri arasında yetişkin 56 orta-şiddetli AR hastası ile yürütülmüştür. Çalışma (n=28) ve kontrol (n=28) gruplarına ayrılan hastalar 4 hafta boyunca farmakolojik tedavi almıştır, çalışma grubu ek olarak günde 2 kez çörek otu yağı kapsülü tüketmiştir. Hastalara tedavi öncesi (0. gün) ve sonrası (30. gün) total IgE, hemogram testi ve yaşam kalitesi ölçeği uygulanmıştır. Çalışma ve kontrol gruplarında tedavi öncesi ve sonrası eozinofil sayısı, eozinofil yüzdesi ve total IgE değerlerinde anlamlı farklılık saptanmamıştır (p>0,05). Yaşam kalitesi ölçeği ve burun semptomları puan ortalamaları her iki grupta tedavi sonrası belirgin şekilde düşmüş olup tedavi öncesine göre anlamlı farklılık saptanmıştır (p<0,05). Sonuç olarak, çalışma ve kontrol gruplarında total IgE ve hemogram parametrelerindeki değişimin benzer olduğu, yaşam kalitesi ve burun semptomlarındaki iyileşmenin çalışma grubunda daha fazla olduğu tespit edilmiştir.

Kaynakça

  • Adegbiji, W.A., Aremu, S.K., Aluko, A., Adewoye, R.K. (2020). Knowledge and awareness of nasal allergy among patients in a developing country. Journal of family medicin-e and primary care, 9(3), 1477–1482. https://doi.org/10.4103/jfmpc.jfmpc_914_19.
  • Ahmad, A., Husain, A., Mujeeb, M., Khan, S.A., Najmi, A. K., Siddique, N.A., Damanhouri, Z.A., Anwar, F. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific journal of tropical biomedicine, 3(5), 337–352. https://doi.org/10.1016/S2221-1691(13)60075-1.
  • Bousquet, J., Khaltaev, N., Cruz, A.A., Denburg, J., Fokkens, W.J., Togias, A., Zuberbier, T., Baena-Cagnani, C.E., Canonica, G.W., van Weel, C., Agache, I., Aït-Khaled, N., Bachert, C., Blaiss, M.S., Bonini, S., Boulet, L.P., Bousquet, P.J., Camargos, P., Carlsen, K.H., Chen, Y., AllerGen (2008). Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy, 63(86), 8–160. https://doi.org/10.1111/j.1398-9995.2007.01620.x.
  • Durham, S.R., Creticos, P.S., Nelson, H.S., Li, Z., Kaur, A., Meltzer, E.O., Nolte, H. (2016). Treatment effect of sublingual immunotherapy tablets and pharmacotherapies for seasonal and perennial allergic rhinitis: Pooled analyses. The Journal of allergy and clinical immunology, 138(4), 1081–1088. https://doi.org/10.1016/j.jaci.2016.04.061.
  • García-Almaraz, R., Reyes-Noriega, N., Del-Río-Navarro, B. E., Berber, A., Navarrete-Rodríguez, E. M., Ellwood, P., Ramírez, O. J. S. (2021). Prevalence and risk factors associated with allergic rhinitis in Mexican school children: Global Asthma Network Phase I. World Allergy Organization Journal, 14(1), 1-18. http://doi.org/10.1016/j.waojou.2020.100492.
  • Genç, S., Selçuk, A. (2013). Allerjik Rinitte Diğer Farmakoterapi Seçenekleri ve Alternatif Tedavi Yöntemleri. Asthma Allergy Immunology, 11, 59-70. https://aai.org.tr/uploads/pdf_259.pdf.
  • Nayeem, M., Ahmed, M., Jawed, A., Alshahrani, S., Makeen, H., Taha, M., Hussain, S., Jahan, S., Khan, A. (2022). A meta-analysis of Nigella sativa in respiratory disorders. Black Seeds (Nigella sativa). Pharmacological and Therapeutic Applications, 177-196. https://doi.org/10.1016/B978-0-12-824462-3.00007-X.
  • Rahmani, A.H., Alzohairy, M.A., Khan, M.A., Aly, S.M. (2014). Therapeutic implications of black seed and its constituent thymoquinone in the prevention of cancer through inactivation and activation of molecular pathways. Evidence-Based Complementary and Alternative Medicine, 2014, 13. https://doi.org/10.1155/2014/724658.
  • Seedat, R.Y. (2013). Treatment of allergic rhinitis. Current Allergy & Clinical Immunology, 26(1), 11-16. https://www.researchgate.net/publication/236590194_Treatment_of_allergic_rhinitis.
  • Small, P., Kim, H. (2011). Allergic rhinitis. Allergy, asthma, and clinical immunology: official journal of the Canadian Society of Allergy and Clinical Immunology, 7(1), 1-8. https://doi.org/10.1186/1710-1492-7-S1-S3.
  • Varshney, J., & Varshney, H. (2015). Allergic rhinitis: an overview. Indian Journal of Otolaryngology and Head & Neck Surgery, 67(2), 143-149. https://doi.org/10.1007/s12070-015-0828-5.
  • Sancaklı, Ö., Belverenli, H. (2019). Alerjik Rinitli Hastaların Klinik Özellikleri ve ID Komorbidite Olarak Adenoid Hipertrofisinin Değerlendirilmesi. Journal of Dr. Behcet Uz Children's Hospital, 9(2):125-130. https://doi.org/10.5222/buchd.2019.47704.
  • Belgü Ulçay, A., Uçal, Y., Ekinci, A. Güler Alis, M., Yıldırım, O. Dizdar, D. (2014). Assessment of Quality of Life and Coexistent Allergic Conjunctivitis in Patients with Allergic Rhinitis in Van Province. Turk Otolarengoloji Arsivi/Turkish Archives of Otolaryngology. 52, 87-92. https://doi.org/10.5152/tao.2014.579.
  • Işık, S., Çağlayan-Sözmen, Ş., Asilsoy, S., Kılıçarslan, S.K., Anal, Ö., Karaman, Ö., Uzuner, N. (2018). Knowledge levels related to allergen specific immunotherapy and perspectives of parents whose children were diagnosed with asthma and/or allergic rhinitis in Turkey. Turkish Journal of Pediatrics, 60(1), 50-55. https://doi.org/10.24953/turkjped.2018.01.007.
  • Özşeker, F., Büyüköztürk, S., Gelincik, A., İşsever, H., Erdenen, F., Özşeker, H., Çolakoğlu, B., Dal, M., İnci, E., Güvenç, M.G. 2012. "Bir Türkçe Rinit Yaşam Kalitesi Ölçeği" Geliştirme ve Geçerlilik Çalışması. Nobel Medicine 8(2):32-40. https://www.nobelmedicus.com/Content/1/23/32-40.pdf.
  • Mou, Y.K., Wang, H.R., Zhang, W.B., Zhang, Y., Ren, C., Song, X.C. (2022). Allergic Rhinitis and Depression: Profile and Proposal. Frontiers in psychiatry, 12, 820497. https://doi.org/10.3389/fpsyt.2021.820497.
  • Nur Husna, S.M., Tan, H.T., Md Shukri, N., Mohd Ashari, N.S., Wong, K.K. (2022). Allergic Rhinitis: A Clinical and Pathophysiological Overview. Frontiers in medicine, 9, 874114. https://doi.org/10.3389/fmed.2022.874114.
  • Siddiqui, Z.A., Walker, A., Pirwani, M.M., Tahiri, M., Syed, I. (2022). Allergic rhinitis: diagnosis and management. British journal of hospital medicine, 83(2), 1–9. https://doi.org/10.12968/hmed.2021.0570.
  • Xu, Y., Zhang, J., & Wang, J. (2014). The efficacy and safety of selective H1-antihistamine versus leukotriene receptor antagonist for seasonal allergic rhinitis: a meta-analysis. PloS one, 9(11), 112815. https://doi.org/10.1371/journal.pone.0112815.
  • Gholamnezhad, Z., Havakhah, S., & Boskabady, M.H. (2016). Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review. Journal of ethnopharmacology, 190, 372–386. https://doi.org/10.1016/j.jep.2016.06.061.
  • Gholamnezhad, Z., Shakeri, F., Saadat, S., Ghorani, V., Boskabady, M.H. (2019). Clinical and experimental effects of Nigella sativa and its constituents on respiratory and allergic disorders. Avicenna journal of phytomedicine, 9(3), 195–212. https://pubmed.ncbi.nlm.nih.gov/31143688/.
  • Tuncel, T., Çetemen, A., Karabel, M., Kelekçi, S., Şen, V., Gürkan, M.F. (2014). Astım ve/veya allerjik rinitli çocuklarda tamamlayıcı ve alternatif tıp uygulamaları. Asthma Allergy Immunol, 12, 146-151. https://app.trdizin.gov.tr/publication/paper/detail/TVRZM05qRTVPUT09.
  • Nikakhlagh, S., Rahim, F., Aryani, F. H., Syahpoush, A., Brougerdnya, M. G., & Saki, N. (2011). Herbal treatment of allergic rhinitis: the use of Nigella sativa. American journal of otolaryngology, 32, 402–407. https://doi.org/10.1016/j.amjoto.2010.07.019.
  • Kalus, U., Pruss, A., Bystron, J., Jurecka, M., Smekalova, A., Lichius, J.J., Kiesewetter, H. (2003). Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytotherapy research: PTR, 17, 1209–1214. Erişim 04.08.2020, https://doi.org/10.1002/ptr.1356.
  • Alsamarai, A.M., Abdulsatar, M., Ahmad Alobaidi, A.H. (2012). Evaluation of therapeutic efficacy of Nigella sativa (Black Seed) for treatment of allergic rhinitis. Allergic Rhinitis, 12, 197-215. https://doi.org/10.5772/26946.
  • Ansari, M. Ansari, N., Junejo, S., Munawar, A., Ansari, M., Phil, M. (2010). Montelukast Versus Nigella Sativa for Management of Seasonal Allergic Rhinitis: A Single Blind Comparative Clinical Trial. Pakistan Journal of Medical Sciences Online, 26(2), 249-254. https://www.pjms.com.pk/issues/aprjun2010/pdf/article01.pdf.
  • Alsamarai, A. M., Abdulsatar, M., Ahmed Alobaidi, A.H. (2014). Evaluation of topical black seed oil in the treatment of allergic rhinitis. Anti-inflammatory & anti-allergy agents in medicinal chemistry, 13, 75–82. https://doi.org/10.2174/18715230113129990014.
  • Ansari, M.A., Ahmed, S.P., Haider, S., Ansari, N. (2006). Nigella sativa: a non-conventional herbal option for the management of seasonal allergic rhinitis. Pak J Pharm, 23(2), 31–35. http://www.pakjp.pk/wp-content/uploads/pdfs/23/2/6-23-2-2006.pdf.
  • Rezaeian, A., Amoushahi Khouzani, S. (2018). Effect of Nigella sativa Nasal Spray on the Treatment of Chronic Rhinosinusitis Without a Nasal Polyp. Allergy & rhinology (Providence, R.I.), 9:1-5. https://doi.org/10.1177/2152656718800059.
  • Koshak, A., Wei, L., Koshak, E., Wali, S., Alamoudi, O., Demerdash, A., Qutub, M., Pushparaj, P.N., Heinrich, M. (2017). Nigella sativa Supplementation Improves Asthma Control and Biomarkers: A Randomized, Double-Blind, Placebo-Controlled Trial. Phytotherapy research: PTR, 31(3), 403–409. https://doi.org/10.1002/ptr.5761.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makaleleri
Yazarlar

Seher Usta Heybet 0000-0001-9003-2505

Kanat Tayfun 0000-0002-5162-6797

Ahmet Yaser Müslümanoğlu 0000-0002-8691-0886

Erken Görünüm Tarihi 29 Ağustos 2022
Yayımlanma Tarihi 29 Ağustos 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 3 Sayı: 3

Kaynak Göster

APA Usta Heybet, S., Tayfun, K., & Müslümanoğlu, A. Y. (2022). Alerjik Rinitli Hastalarda Çörek Otu (Nigella Sativa) Yağının Dâhilen Kullanımının Serum Total IgE, Hemogram Parametreleri ve Yaşam Kalitesi Üzerine Etkisi. Bütünleyici Ve Anadolu Tıbbı Dergisi, 3(3), 17-41. https://doi.org/10.53445/batd.1124981

Bütünleyici ve Anadolu Tıbbı Dergisi

Journal of Integrative and Anatolian Medicine