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The Protective Effects of Borax on Doxorubicin Induced Cardiotoxicity in Rats

Yıl 2021, Cilt: 10 Sayı: 3, 692 - 702, 17.09.2021
https://doi.org/10.17798/bitlisfen.891709

Öz

Boron and boron compounds have benefical effects on health of human and animals.This study was designed to determine the protective effect of borax (BX) in doxorubicin (DXR) induced cardiotoxicity in rats. In this study, 20 Wistar-Albino male rats were used. The rats were divided into four groups including 5 rats in each one; control group (standard pellet food + water + normal saline), doxorubicin (3.75 mg/kg/ip, single dose in a week), doxorubicin + borax (3,75 mg/kg/ip + 25 mg/kg/oral/ respectively), and borax (25 mg/kg/oral, single dose in a week). At the end of the experiment, to evaluate antioxidant activity MDA, GSH, CAT, SOD levels determined in blood samples of rats. Besides, CK levels were investigated to determine the effect of doxorubucine on heart tissue. According to the results, MDA levels increased significantly in doxorubucin induced group (p<0.05). After borax treatment MDA status decreased under the control values (p<0.05). GSH status decreased in all groups. While CAT level decreased in DXR induced group in a statistically important rate (p<0.05), it was observed near control values in BX and BX+DXR induced groups. SOD status indicated increase in BX and DXR groups. In addition, CK levels increased in all groups compared to the control. In the increases only in DXR induced group, significance was determined as p<0.05. As a result, these data indicated that borax may use to prevent cardiotoxic effect of doxorubicin.

Destekleyen Kurum

Yok

Proje Numarası

Yok

Teşekkür

Yok

Kaynakça

  • Baker S.D., Pharm D. 1997. Drug interaction with the taxanes. Pharmacotherapy, 17: 126-132.
  • Muggia F.M., Green M.D. 1991. New anthracycline antitumor antibiotics. Critical Reviews oncology/ Hematology, 11: 43-64.
  • Hideg K., Kálai T. 2007. Novel antioxidants in anthracycline cardiotoxicity. Cardiovascular Toxicology, 7: 160-164.
  • Ferrans V.J. 1983. Anthracycline cardiotoxicity. Advances in Experimental Medicine and Biology, 161: 519-532.
  • Childs A.C., Phaneuf S.L., Dirks A.J., Phillips T., Leeuweburgh C. 2002. Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity and Bcl2. Cancer Research, 62: 4592-4598.
  • Menna P., Salvatorelli E., Minotti G. 2008. Cardiotoxicity of antitumor drugs. Chemical Research in Toxicology, 21: 978-989.
  • Pizzino G., Irrera N., Cucinotta M., Pallio G., Mannino F., Arcoraci V., Squadrito F., Altavilla D., Bitto A. 2017. Oxidative stress: harms and benefits for human health. Oxidative Medicine and Cellular Longevity, 8416763. doi: 10.1155/2017/8416763
  • Zhang H., Davies K.J.A., Forman H.J. 2015. Oxidative stress response and Nrf2 signaling in aging. Free Radical Biology and Medicine, 88: 314-336.
  • El-Kenawi A., Ruffel B. 2017. Inflamattion, ROS, and mutagenesis. Cancer Cell, 32: 727-729.
  • Ren J. 2007. Influence of gender on oxidative stress, lipid peroxidation, protein damage and apoptosis in hearts and brains from spontaneously hypertensive rats. Clinical and Experimental Pharmacology and Physiology, 34: 432-438.
  • Hosseini A., Bakhtiari E., Mousavi S.H. 2017. Protective effect of hibiscus sabdariffa on doxorubicin-induced cytotoxicity in H9c2 cardiomyoblast cells. Iranian Journal of Pharmaceutical Research, 16: 708-713.
  • Capasso I., Esposito E., Maurea N., Montella M., Crispo A., De Laurentiis M., D'Aiuto M., Frasci G., Botti G., Grimaldi M., Cavalcanti E., Esposito G., Fucito A., Brillante G., D'Aiuto G., Ciliberto G. 2013. Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. Trials, 14 (1): 273
  • Møller P., Loft S., Lundby C., Olsen N.V. 2001. Acute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in humans. The FASEB Journal, 15 (7): 1181-1186.
  • Nakamura K., Fushimi K., Kouchi H., Mihara K., Masahiro M, Ohe T., Namba M.1998. Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II. Circulation, 98 (8): 794-799.
  • Abdel-Daim M.M., Kilany O.E., Khalifa H.A., Ahmed A.A.M. 2017. Allicin ameliorates doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis. Cancer Chemotherapy and Pharmacology, 80: 745-753
  • Bishop S., Liu S.J. 2017. Cardioprotective action of the aqueous extract of Terminalia arjuna bark against toxicity induced by doxorubicin. Phytomedicine, 36:210-216.
  • He H., Luo Y., Qiao Y., Zhang Z., Yin D., Yao J., You J., He M. 2018. Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14- 3-3c. Food Function, 9: 4404-4418.
  • Argust P. 1998. Distribution of boron in the environment. Biological Trace Element Research, 66:131-143
  • Turkez H., Geyikoglu F., Mokhtar Y.I., Togar B. 2012. Eicosapentaenoic acid protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced hepatic toxicity in cultured rat hepatocytes. Cytotechnology, 64:15-25.
  • Turkez H., Geyikoglu F., Tatar A., Keles S., Ozkan A. 2007. Effects of some boron compounds on peripheral human blood. Z Naturforsch C, 62: 889-896.
  • Turkez H., Geyikoğlu F., Dirican E., Tatar A. 2012. In vitro studies on chemoprotective effect of borax against aflatoxin B1-induced genetic damage in human lymphocytes. Cytotechnology, 64 (6): 607-612.
  • Routray I., Ali S. 2016. Boron induces lymphocyte proliferation and modulates the priming effects of lipopolysaccharide on macrophages. PLoS One 11: e0150607.
  • Demirkaya E.1., Avci A., Kesik V., Karslioglu Y., Oztas E., Kismet E., Gokcay E., Durak I., Koseoglu V. 2009. Cardioprotective roles of aged garlic extract, grape seed proanthocyanidin, and hazelnut on doxorubicin-induced cardiotoxicity. Canadian Journal of Physiology and Pharmacology, 87: 633-640.
  • Ince S., Kucukkurt I., Cigerci I.H., Fidan A.F., Eryavuz A. 2010. The effects of dietary boric acid and borax supplementation on lipid peroxidation, antioxidant activity, and DNA damage in rats. Journal of Trace Elements in Medicine and Biology, 24: 161-164.
  • Beutler E., Dubon O., Kelly B.M. 1963. Improved method for the determination of blood glutathione. Journal of Laboratory and Clinical Medicine, 61: 882-888.
  • Rizzi R., Caroli A., Bolla P., Acciailoi A., Pagnacco G. 1998. Variability of reduced glutathione levels in Massese ewes and its effect on daily milk production. Journal of of Dairy Research, 55: 345-353.
  • Gutteridge J.M. 1995. Lipit peroxidation and antioxidants as biomarkers of tissue damage. Clinical Chemistry, 41: 1819-1828.
  • Sushil J.K., Mcuie R., Duett J., Herbest J.J.1989. Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes. Diabetes, 38: 1539-1543.
  • Weiss R.B. 1992. The anthracyclines: will we ever find a better doxorubicin? Seminars in Oncology, 19: 670-686.
  • Antunes L.M.G., Takahashi C.S. 1998. Effects of high doses of vitamins C and E against doxorubicine-induced chromosal damage in wistar rat bone marrow cells. Mutation Research, 419: 137-143.
  • Antunes L.M.G., Arajuo M.C., Darin J.D.C., Bianchi M.L.P. 2000. Effects of antioxidants curcium and vitamin C on cisplatin-induced clastogenesis in wistar rat bone marrow cells. Mutation Research, 464: 131-137.
  • Nefic H. 2001. Anticlastogenic effect of Vitamin C on cisplatin induced chromosome aberrations in human lymphocyte cultures. Mutation Research, 498: 89-98.
  • Çelikezen F.Ç., Türkez H., Aydın E. 2015. The antioxidant and genotoxic activities of Na2B4O7.10H2O in vitro. Fresenius Environmental Bulletin, 24: 947-953.
  • Çelikezen F.Ç., Toğar B., Özgeriş F.B., İzgi M.S., Türkez H. 2016. Cytogenetic and oxidative alterations after exposure of cultured human whole blood cells to lithium metaborate dehydrate. Cytotechnology. 68 (4): 821-827.
  • Çelikezen F.Ç., Türkez H., Toğar B, İzgi M.S. 2014. DNA damaging and biochemical effects of potassium tetraborate. Experimental and Clinical Science, 13: 446-450.
  • Kelly G.S. 1997. Boron: a review of its nutritional interactions and therapeutic uses. Alternative Medicine Review, 2: 48-56.
  • Çelikezen F.Ç., Türkez H., Togar B. 2014. In vitro assessment of genotoxic and oxidative effects of zinc borate. Toxicological and Environmental Chemistry, 96: 777-782.
  • Pawa S., Ali S. 2006. Boron Ameliorates Fulminant Hepatic Failure by Counteracting the Changes Associated with the Oxidative Stress. Chemico-Biological Interactions, 160: 89-98.
  • Kim H.1., Oh E., Im H., Mun J., Yang M., Khim J.Y., Lee E., Lim S.H., Kong M.H., Lee M., Sul D. 2006. Oxidative damages in the DNA, lipids, and proteins of rats exposed to isofluranes and alcohols. Toxicology, 220: 169-178.
  • Siu F.K., Lo S.C., Leung M.C. 2004. Effectiveness of multiple pre-ischemia electro-acupuncture on attenuating lipid peroxidation induced by cerebral ischemia in adult rats. Life Science, 75: 1323-1332.
  • Hu Q.1., Li S., Qiao E. Tang Z., Jin E., Jin G., Gu Y. 2014. Effects of boron on structure and antioksidative activities of spleen in rats. Biological Trace Element Research, 158: 73-80.
  • Taşdemir M., Çelikezen F.Ç., Oto G., Özbey F. 2020. The effects of pretreatment with lithium metaborate dihydrate on lipid peroxidation and Ca, Fe, Mg, and K levels in serum of Wistar albino male rats exposed to Cd. Environmental Science and Pollution Research, 27: 7702-7711.
  • Türkez H., Geyikoglu F., Tatar A., Keleş S., Özkan A. 2007. Effects of some boron compounds on peripheral human blood. Z Naturforsch, 62: 889-896.
  • Bukowska B., Kowalska S. 2004. Phenol and cathechol induce prehemolytic and hemolytic changes in human erythrocytes. Toxicol Letter, 152: 73-84.
  • Tapiero H., Townsend D.M., Tew K.D. 2004. The role of carotenoids in the prevention of human pathologies. Biomedicine Pharmacotherapy, 58: 100-110.
  • Kakarla P., Vadluri G., Reddy K.S. 2005. Response of hepatic antioxidant system to exercise training in aging female rat. Journal of Experimental Zoology Part A Comperative Experimental Biology, 303: 203-208.
  • Afaq F., Abidi P., Matin R., Rahman Q. 1998. Activation of alveolar macrophages and peripheral red blood cells in rats exposed to fibers/particles. Toxicol Letter, 99: 175-182.
  • Prasad N.R., Srinivasan M., Pugalendi K.V., Menon V.P. 2006. Protective effect of ferulic acid on gamma-radiation-induced micronuclei, dicentric aberration and lipid peroxidation in human lymphocytes. Mutation Research, 603: 129-134.
  • Hunt C.D., Idso J.P. 1999. Dietary boron as a physiological regulator of the normal inflammatory response: a review and current research progress. The Journal of Trace Elements in Experimental Medicine, 12: 221-233.
  • Kucukkurt I., Ince S., Demirel H.H., Turkmen R., Akbel E., Celik Y. 2015. The Effects of Boron on Arsenic-Induced Lipid Peroxidation and Antioxidant Status in Male and Female Rats. Journal of Biochemical and Molecular Toxicology, DOI: 10.1002/jbt.21729.
  • Barr R.D., Barton S.A., Schull W.J. 1996. Boron levels in man: preliminary evidence of genetic regulation and some implications for human biology. Medical Hypotheses, 46: 286-289.
  • Hall I..H, Starnes C.O., McPhail A.T., Wisian-Neilson P., Das M. K., Harchelroad F. Jr, Spielvogel B.F. 1980. Anti-inflammatory activity of amine cyanoboranes, amine carboxyboranes, and related compounds. Journal of Pharmaceutical Science, 69: 1025-1029.
  • Sugino N., Karube-Harada A., Sakata A., Takiguchi S., Kato H. 2002. Different mechanisms for the induction of copper-zinc superoxide dismutase and manganase superoxide dismutase by progesterone in human endometrial stromal cells. Human Reproduction, 17: 1709-1714.
  • Tung B.T., Rodriguez-Bies E., Thanh H.N., Le-Thi-Thu H., Navas P., Sanchez V.M., López-Lluch G. 2015. Organ and tissue-dependent effect of resveratrol and exercise on antioxidant defenses of old mice. Aging Clinical and Experimental Research, DOI: 10.1007/s40520-40015-40366-40528.
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  • Türkez H. 2007. Bazı Bor Bileşiklerinin İn vitro Şartlarda Periferal İnsan Kanı Üzerine Genetik ve Biyokimyasal Etkileri. Doktora Tezi, Atatürk Üniversitesi, Fen Bilimleri Enstitüsü, Erzurum.
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  • Ince S., Kucukkurt I., Demirel H.H., Acaroz D.A., Akbel E., Cigerci I.H. 2014. Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats. Chemosphere, 108: 197–204.
  • Liu C.X., Jiang L.Y., Wang H., Guo Z.H., Cai X.X. 2007. A novel disposable amperometric biosensor based on trienzyme electrode for the determination of total creatinine kinase. Sensors and Actuators B Chemical, 122: 295-300.
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The Protective Effects of Borax on Doxorubicin Induced Cardiotoxicity In Rats

Yıl 2021, Cilt: 10 Sayı: 3, 692 - 702, 17.09.2021
https://doi.org/10.17798/bitlisfen.891709

Öz

Boron and boron compounds have benefical effects on health of human and animals.This study was designed to determine the protective effect of borax (BX) in doxorubicin (DXR) induced cardiotoxicity in rats. In this study, 20 Wistar-Albino male rats were used. The rats were divided into four groups including 5 rats in each one; control group (standard pellet food + water + normal saline), doxorubicin (3.75 mg/kg/ip, single dose in a week), doxorubicin + borax (3,75 mg/kg/ip + 25 mg/kg/oral/ respectively), and borax (25 mg/kg/oral, single dose in a week). At the end of the experiment, to evaluate antioxidant activity MDA, GSH, CAT, SOD levels determined in blood samples of rats. Besides, CK levels were investigated to determine the effect of doxorubucine on heart tissue. According to the results, MDA levels increased significantly in doxorubucin induced group (p<0.05). After borax treatment MDA status decreased under the control values (p<0.05). GSH status decreased in all groups. While CAT level decreased in DXR induced group in a statistically important rate (p<0.05), it was observed near control values in BX and BX+DXR induced groups. SOD status indicated increase in BX and DXR groups. In addition, CK levels increased in all groups compared to the control. In the increases only in DXR induced group, significance was determined as p<0.05. As a result, these data indicated that borax may use to prevent cardiotoxic effect of doxorubicin.

Proje Numarası

Yok

Kaynakça

  • Baker S.D., Pharm D. 1997. Drug interaction with the taxanes. Pharmacotherapy, 17: 126-132.
  • Muggia F.M., Green M.D. 1991. New anthracycline antitumor antibiotics. Critical Reviews oncology/ Hematology, 11: 43-64.
  • Hideg K., Kálai T. 2007. Novel antioxidants in anthracycline cardiotoxicity. Cardiovascular Toxicology, 7: 160-164.
  • Ferrans V.J. 1983. Anthracycline cardiotoxicity. Advances in Experimental Medicine and Biology, 161: 519-532.
  • Childs A.C., Phaneuf S.L., Dirks A.J., Phillips T., Leeuweburgh C. 2002. Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity and Bcl2. Cancer Research, 62: 4592-4598.
  • Menna P., Salvatorelli E., Minotti G. 2008. Cardiotoxicity of antitumor drugs. Chemical Research in Toxicology, 21: 978-989.
  • Pizzino G., Irrera N., Cucinotta M., Pallio G., Mannino F., Arcoraci V., Squadrito F., Altavilla D., Bitto A. 2017. Oxidative stress: harms and benefits for human health. Oxidative Medicine and Cellular Longevity, 8416763. doi: 10.1155/2017/8416763
  • Zhang H., Davies K.J.A., Forman H.J. 2015. Oxidative stress response and Nrf2 signaling in aging. Free Radical Biology and Medicine, 88: 314-336.
  • El-Kenawi A., Ruffel B. 2017. Inflamattion, ROS, and mutagenesis. Cancer Cell, 32: 727-729.
  • Ren J. 2007. Influence of gender on oxidative stress, lipid peroxidation, protein damage and apoptosis in hearts and brains from spontaneously hypertensive rats. Clinical and Experimental Pharmacology and Physiology, 34: 432-438.
  • Hosseini A., Bakhtiari E., Mousavi S.H. 2017. Protective effect of hibiscus sabdariffa on doxorubicin-induced cytotoxicity in H9c2 cardiomyoblast cells. Iranian Journal of Pharmaceutical Research, 16: 708-713.
  • Capasso I., Esposito E., Maurea N., Montella M., Crispo A., De Laurentiis M., D'Aiuto M., Frasci G., Botti G., Grimaldi M., Cavalcanti E., Esposito G., Fucito A., Brillante G., D'Aiuto G., Ciliberto G. 2013. Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. Trials, 14 (1): 273
  • Møller P., Loft S., Lundby C., Olsen N.V. 2001. Acute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in humans. The FASEB Journal, 15 (7): 1181-1186.
  • Nakamura K., Fushimi K., Kouchi H., Mihara K., Masahiro M, Ohe T., Namba M.1998. Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II. Circulation, 98 (8): 794-799.
  • Abdel-Daim M.M., Kilany O.E., Khalifa H.A., Ahmed A.A.M. 2017. Allicin ameliorates doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis. Cancer Chemotherapy and Pharmacology, 80: 745-753
  • Bishop S., Liu S.J. 2017. Cardioprotective action of the aqueous extract of Terminalia arjuna bark against toxicity induced by doxorubicin. Phytomedicine, 36:210-216.
  • He H., Luo Y., Qiao Y., Zhang Z., Yin D., Yao J., You J., He M. 2018. Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14- 3-3c. Food Function, 9: 4404-4418.
  • Argust P. 1998. Distribution of boron in the environment. Biological Trace Element Research, 66:131-143
  • Turkez H., Geyikoglu F., Mokhtar Y.I., Togar B. 2012. Eicosapentaenoic acid protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced hepatic toxicity in cultured rat hepatocytes. Cytotechnology, 64:15-25.
  • Turkez H., Geyikoglu F., Tatar A., Keles S., Ozkan A. 2007. Effects of some boron compounds on peripheral human blood. Z Naturforsch C, 62: 889-896.
  • Turkez H., Geyikoğlu F., Dirican E., Tatar A. 2012. In vitro studies on chemoprotective effect of borax against aflatoxin B1-induced genetic damage in human lymphocytes. Cytotechnology, 64 (6): 607-612.
  • Routray I., Ali S. 2016. Boron induces lymphocyte proliferation and modulates the priming effects of lipopolysaccharide on macrophages. PLoS One 11: e0150607.
  • Demirkaya E.1., Avci A., Kesik V., Karslioglu Y., Oztas E., Kismet E., Gokcay E., Durak I., Koseoglu V. 2009. Cardioprotective roles of aged garlic extract, grape seed proanthocyanidin, and hazelnut on doxorubicin-induced cardiotoxicity. Canadian Journal of Physiology and Pharmacology, 87: 633-640.
  • Ince S., Kucukkurt I., Cigerci I.H., Fidan A.F., Eryavuz A. 2010. The effects of dietary boric acid and borax supplementation on lipid peroxidation, antioxidant activity, and DNA damage in rats. Journal of Trace Elements in Medicine and Biology, 24: 161-164.
  • Beutler E., Dubon O., Kelly B.M. 1963. Improved method for the determination of blood glutathione. Journal of Laboratory and Clinical Medicine, 61: 882-888.
  • Rizzi R., Caroli A., Bolla P., Acciailoi A., Pagnacco G. 1998. Variability of reduced glutathione levels in Massese ewes and its effect on daily milk production. Journal of of Dairy Research, 55: 345-353.
  • Gutteridge J.M. 1995. Lipit peroxidation and antioxidants as biomarkers of tissue damage. Clinical Chemistry, 41: 1819-1828.
  • Sushil J.K., Mcuie R., Duett J., Herbest J.J.1989. Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes. Diabetes, 38: 1539-1543.
  • Weiss R.B. 1992. The anthracyclines: will we ever find a better doxorubicin? Seminars in Oncology, 19: 670-686.
  • Antunes L.M.G., Takahashi C.S. 1998. Effects of high doses of vitamins C and E against doxorubicine-induced chromosal damage in wistar rat bone marrow cells. Mutation Research, 419: 137-143.
  • Antunes L.M.G., Arajuo M.C., Darin J.D.C., Bianchi M.L.P. 2000. Effects of antioxidants curcium and vitamin C on cisplatin-induced clastogenesis in wistar rat bone marrow cells. Mutation Research, 464: 131-137.
  • Nefic H. 2001. Anticlastogenic effect of Vitamin C on cisplatin induced chromosome aberrations in human lymphocyte cultures. Mutation Research, 498: 89-98.
  • Çelikezen F.Ç., Türkez H., Aydın E. 2015. The antioxidant and genotoxic activities of Na2B4O7.10H2O in vitro. Fresenius Environmental Bulletin, 24: 947-953.
  • Çelikezen F.Ç., Toğar B., Özgeriş F.B., İzgi M.S., Türkez H. 2016. Cytogenetic and oxidative alterations after exposure of cultured human whole blood cells to lithium metaborate dehydrate. Cytotechnology. 68 (4): 821-827.
  • Çelikezen F.Ç., Türkez H., Toğar B, İzgi M.S. 2014. DNA damaging and biochemical effects of potassium tetraborate. Experimental and Clinical Science, 13: 446-450.
  • Kelly G.S. 1997. Boron: a review of its nutritional interactions and therapeutic uses. Alternative Medicine Review, 2: 48-56.
  • Çelikezen F.Ç., Türkez H., Togar B. 2014. In vitro assessment of genotoxic and oxidative effects of zinc borate. Toxicological and Environmental Chemistry, 96: 777-782.
  • Pawa S., Ali S. 2006. Boron Ameliorates Fulminant Hepatic Failure by Counteracting the Changes Associated with the Oxidative Stress. Chemico-Biological Interactions, 160: 89-98.
  • Kim H.1., Oh E., Im H., Mun J., Yang M., Khim J.Y., Lee E., Lim S.H., Kong M.H., Lee M., Sul D. 2006. Oxidative damages in the DNA, lipids, and proteins of rats exposed to isofluranes and alcohols. Toxicology, 220: 169-178.
  • Siu F.K., Lo S.C., Leung M.C. 2004. Effectiveness of multiple pre-ischemia electro-acupuncture on attenuating lipid peroxidation induced by cerebral ischemia in adult rats. Life Science, 75: 1323-1332.
  • Hu Q.1., Li S., Qiao E. Tang Z., Jin E., Jin G., Gu Y. 2014. Effects of boron on structure and antioksidative activities of spleen in rats. Biological Trace Element Research, 158: 73-80.
  • Taşdemir M., Çelikezen F.Ç., Oto G., Özbey F. 2020. The effects of pretreatment with lithium metaborate dihydrate on lipid peroxidation and Ca, Fe, Mg, and K levels in serum of Wistar albino male rats exposed to Cd. Environmental Science and Pollution Research, 27: 7702-7711.
  • Türkez H., Geyikoglu F., Tatar A., Keleş S., Özkan A. 2007. Effects of some boron compounds on peripheral human blood. Z Naturforsch, 62: 889-896.
  • Bukowska B., Kowalska S. 2004. Phenol and cathechol induce prehemolytic and hemolytic changes in human erythrocytes. Toxicol Letter, 152: 73-84.
  • Tapiero H., Townsend D.M., Tew K.D. 2004. The role of carotenoids in the prevention of human pathologies. Biomedicine Pharmacotherapy, 58: 100-110.
  • Kakarla P., Vadluri G., Reddy K.S. 2005. Response of hepatic antioxidant system to exercise training in aging female rat. Journal of Experimental Zoology Part A Comperative Experimental Biology, 303: 203-208.
  • Afaq F., Abidi P., Matin R., Rahman Q. 1998. Activation of alveolar macrophages and peripheral red blood cells in rats exposed to fibers/particles. Toxicol Letter, 99: 175-182.
  • Prasad N.R., Srinivasan M., Pugalendi K.V., Menon V.P. 2006. Protective effect of ferulic acid on gamma-radiation-induced micronuclei, dicentric aberration and lipid peroxidation in human lymphocytes. Mutation Research, 603: 129-134.
  • Hunt C.D., Idso J.P. 1999. Dietary boron as a physiological regulator of the normal inflammatory response: a review and current research progress. The Journal of Trace Elements in Experimental Medicine, 12: 221-233.
  • Kucukkurt I., Ince S., Demirel H.H., Turkmen R., Akbel E., Celik Y. 2015. The Effects of Boron on Arsenic-Induced Lipid Peroxidation and Antioxidant Status in Male and Female Rats. Journal of Biochemical and Molecular Toxicology, DOI: 10.1002/jbt.21729.
  • Barr R.D., Barton S.A., Schull W.J. 1996. Boron levels in man: preliminary evidence of genetic regulation and some implications for human biology. Medical Hypotheses, 46: 286-289.
  • Hall I..H, Starnes C.O., McPhail A.T., Wisian-Neilson P., Das M. K., Harchelroad F. Jr, Spielvogel B.F. 1980. Anti-inflammatory activity of amine cyanoboranes, amine carboxyboranes, and related compounds. Journal of Pharmaceutical Science, 69: 1025-1029.
  • Sugino N., Karube-Harada A., Sakata A., Takiguchi S., Kato H. 2002. Different mechanisms for the induction of copper-zinc superoxide dismutase and manganase superoxide dismutase by progesterone in human endometrial stromal cells. Human Reproduction, 17: 1709-1714.
  • Tung B.T., Rodriguez-Bies E., Thanh H.N., Le-Thi-Thu H., Navas P., Sanchez V.M., López-Lluch G. 2015. Organ and tissue-dependent effect of resveratrol and exercise on antioxidant defenses of old mice. Aging Clinical and Experimental Research, DOI: 10.1007/s40520-40015-40366-40528.
  • Kashiwagi A., Kashiwagi K., Takase M., Hanada H., Nakamura M. 1997. Comparison of catalase in diploid and haploid Rana rugosa using heat and chemical inactivation techniques. Comperative Biochemistry Physiology B Biochemistry and Molecular Biology, 118: 499-503.
  • Goyal M.M., Basak A. 2010. Human catalase: looking for complete identity. Protein Cell, 1: 888-897.
  • Nicholls P. 2012. Classical catalase: ancient and modern. Archives of Biochemistry and Biophysics, 525: 95-101.
  • Verbitskaya G.V. 1975. Experimental and field investigations concerning the hygienicevaluation of boron-containing drinking water. Gig i Sanit, 7: 49-53.
  • Hunt C.D., Herbel J.L., Idso J.P. 1993. Dietary boron modifies the effects of execise training on bone and energy substrate metabolism in the rat. FASEB J, 7: A204
  • Türkez H. 2007. Bazı Bor Bileşiklerinin İn vitro Şartlarda Periferal İnsan Kanı Üzerine Genetik ve Biyokimyasal Etkileri. Doktora Tezi, Atatürk Üniversitesi, Fen Bilimleri Enstitüsü, Erzurum.
  • Tate D.J., Newsome D.A. 2006. A novel zinc compound (zinc monocysteine) enhances the antioxidant capacity of human retinal pigment epithelial cells. Current Eye Research, 31: 675-683.
  • Kurtoğlu F., Kurtoglu V., Celik I., Kececi T., Nizamlioglu M. 2005. Effects of dietary boron supplementation on some biochemical parameters, peripheral blood lymphocytes, splenic plasma cells and bone characteristics of broiler chicks given diets with adequate or inadequate cholecalciferol (vitamin D3) content. British Poultry Science, 46: 87-96.
  • Ince S., Kucukkurt I., Demirel H.H., Acaroz D.A., Akbel E., Cigerci I.H. 2014. Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats. Chemosphere, 108: 197–204.
  • Liu C.X., Jiang L.Y., Wang H., Guo Z.H., Cai X.X. 2007. A novel disposable amperometric biosensor based on trienzyme electrode for the determination of total creatinine kinase. Sensors and Actuators B Chemical, 122: 295-300.
  • Moreira F.T.C., Dutra R.A.F., Noronha J.P., Sales M.G.F. 2014. Novel sensory surface for Creatine Kinase electrochemical detection. Biosensors and Bioelectronics, 56: 217-222.
  • Eren M., Uyanık F., Güçlü B.K., Atasever A. 2012. The influence of dietary boron supplementation on performance some biochemical parameters and organs in broilers. Asian Journal of Veterinary Advances, 7: 1079-1089.
  • Tagawa T., Kono K., Dote T., Usuda K., Nishiura H., Koizumi C., Saito M., Nakaya H., Nagaie H. 2000. Pharmacokinetics and effects after intravenous administration of high-dose boron to rat. International Archives of Occupational Environmental Health, 73: 98-100.
Toplam 67 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Makalesi
Yazarlar

Burçin Çelikezen 0000-0003-3097-9814

Sadettin Tanyıldızı 0000-0001-7012-5392

Gökhan Oto 0000-0002-8492-4846

Proje Numarası Yok
Yayımlanma Tarihi 17 Eylül 2021
Gönderilme Tarihi 9 Mart 2021
Kabul Tarihi 3 Haziran 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 10 Sayı: 3

Kaynak Göster

IEEE B. Çelikezen, S. Tanyıldızı, ve G. Oto, “The Protective Effects of Borax on Doxorubicin Induced Cardiotoxicity In Rats”, Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, c. 10, sy. 3, ss. 692–702, 2021, doi: 10.17798/bitlisfen.891709.



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