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The Possible Relationship Between Plasma Homocysteine, Folate and Vitamin B12 Levels and Limbus Vertebra

Yıl 2018, Cilt: 5 Sayı: 3, 107 - 111, 28.09.2018

Öz

Aim:
In spite of the fact that a few mechanisms have been proposed to take part in
the development of the limbus vertebra, the mechanism of LV is still vague. The
aim of this study was to determine the plasma levels of Hcy, folate and vitamin
B12 in a group of women with LV and to compare with those of age-and body mass
index-matched women in order to explore their possible contribution to the
pathophysiology of LV.

Material
and Methods:
The current study was based on a
consecutive series of 171 premenopausal women who were diagnosed with LV and
190 age- and body mass index-matched premenopausal women without LV. Demographics,
dual-energy X-ray absorptiometry results, and plasma homocysteine, folate, and
vitamin B12 levels were assessed.

Results:
The anthropometric, clinical, densitometric and biochemical
features were not statistically different between two groups, except for Hcy
levels (p < 0.001). While Hcy levels were significantly negatively
correlated with age (r = -0.162, p = 0.034) in the LV group; there was no such
relation in the control group (r = 0.026, p = 0.721).


























Discussion:
Premenopausal young women with LV have higher Hcy levels compared
to age- and body mass index-matched premenopausal women. High Hcy levels may
play role in the pathogenesis of LV formation.

Kaynakça

  • 1. Ghelman B, Freiberger RH. The limbus vertebra: an anterior disc herniation demonstrated by discography. AJR Am J Roentgenol. 1976; 127(5): 854-5.
  • 2. Hellstrom M, Jacobsson B, Sward L, Peterson L. Radiologic abnormalities of the thoraco-lumbar spine in athletes. Acta Radiol. 1990; 31(2): 127-32.
  • 3. Kim DJ, Koh JM, Lee O, Kim NJ, Lee YS, Kim YS, et al. Homocysteine enhances apoptosis in human bone marrow stromal cells. Bone. 2006; 39(3): 582-90.
  • 4. Herrmann M, Widmann T, Colaianni G, Colucci S, Zallone A, Herrmann W. Increased osteoclast activity in the presence of increased homocysteine concentrations. Clin Chem. 2005; 51(12): 2348-53.
  • 5. Vaes BL, Lute C, Blom HJ, Bravenboer N, de Vries TJ, Everts V, et al. Vitamin B(12) deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid. Calcif Tissue Int. 2009; 84(5): 413-22.
  • 6. Tyagi N, Kandel M, Munjal C, Qipshidze N, Vacek JC, Pushpakumar SB, et al. Homocysteine mediated decrease in bone blood flow and remodeling: role of folic acid. J Orthop Res. 2011; 29(10): 1511-6.
  • 7. Blouin S, Thaler HW, Korninger C, Schmid R, Hofstaetter JG, Zoehrer R, et al. Bone matrix quality and plasma homocysteine levels. Bone. 2009; 44(5): 959-64.
  • 8. Herrmann M, Tami A, Wildemann B, Wolny M, Wagner A, Schorr H, et al. Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone. Bone. 2009; 44(3): 467-75.
  • 9. Thaler R, Agsten M, Spitzer S, Paschalis EP, Karlic H, Klaushofer K, et al. Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation. J Biol Chem. 2011; 286(7): 5578-88.
  • 10. Kim GS, Kim CH, Park JY, Lee KU, Park CS. Effects of vitamin B12 on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells and UMR106 osteoblastic cells. Metabolism. 1996; 45(12): 1443-6.
  • 11. Roman-Garcia P, Quiros-Gonzalez I, Mottram L, Lieben L, Sharan K, Wangwiwatsin A, et al. Vitamin B(1)(2)-dependent taurine synthesis regulates growth and bone mass. J Clin Invest. 2014; 124(7): 2988-3002.
  • 12. Holstein JH, Herrmann M, Splett C, Herrmann W, Garcia P, Histing T, et al. Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans. Am J Clin Nutr. 2009; 90(5): 1440-5.
  • 13. Koyama K, Nakazato K, Min S, Gushiken K, Hatakeda Y, Seo K, et al. COL11A1 gene is associated with limbus vertebra in gymnasts. Int J Sports Med. 2012; 33(7): 586-90.
  • 14. Bennett DL, Nassar L, DeLano MC. Lumbar spine MRI in the elite-level female gymnast with low back pain. Skeletal Radiol. 2006; 35(7): 503-9.
  • 15. Yamauchi M. Collagen: The Major Matrix Molecule in Mineralized Tissues. In: Anderson JJB, Garner SC editors. Calcium and Phosphorus Nutrition in Health and Disease. Florida: CRC Press; 1995.p.127-47.
  • 16. Bailey AJ, Paul RG, Knott L. Mechanisms of maturation and ageing of collagen. Mech Ageing Dev. 1998; 106(1-2): 1-56.
  • 17. Knott L, Bailey AJ. Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance. Bone. 1998; 22(3): 181-7.
  • 18. Gjesdal CG, Vollset SE, Ueland PM, Refsum H, Drevon CA, Gjessing HK, et al. Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study. Arch Intern Med. 2006; 166(1): 88-94.
  • 19. Jacques PF, Rosenberg IH, Rogers G, Selhub J, Bowman BA, Gunter EW, et al. Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr. 1999; 69(3): 482-9.
  • 20. Baines M, Kredan MB, Usher J, Davison A, Higgins G, Taylor W, et al. The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B12 and vitamin B6 with bone mineral density in postmenopausal British women. Bone. 2007; 40(3): 730-6.
  • 21. Swart KM, van Schoor NM, Lips P. Vitamin B12, folic acid, and bone. Curr Osteoporos Rep. 2013; 11(3): 213-8.
  • 22. Bahtiri E, Islami H, Rexhepi S, Qorraj-Bytyqi H, Thaci K, Thaci S, et al. Relationship of homocysteine levels with lumbar spine and femur neck BMD in postmenopausal women. Acta Reumatol Port. 2015; 40(4): 355-62.
  • 23. Zhang H, Tao X, Wu J. Association of homocysteine, vitamin B12, and folate with bone mineral density in postmenopausal women: a meta-analysis. Arch Gynecol Obstet. 2014; 289(5): 1003-9.
  • 24. Bozkurt N, Erdem M, Yilmaz E, Erdem A, Biri A, Kubatova A, et al. The relationship of homocyteine, B12 and folic acid with the bone mineral density of the femur and lumbar spine in Turkish postmenopausal women. Arch Gynecol Obstet. 2009; 280(3): 381-7.
  • 25. Ouzzif Z, Oumghar K, Sbai K, Mounach A, Derouiche el M, El Maghraoui A. Relation of plasma total homocysteine, folate and vitamin B12 levels to bone mineral density in Moroccan healthy postmenopausal women. Rheumatol Int. 2012; 32(1): 123-8.
  • 26. Cagnacci A, Bagni B, Zini A, Cannoletta M, Generali M, Volpe A. Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation. Bone. 2008; 42(2): 314-20.
  • 27. Haliloglu B, Aksungar FB, Ilter E, Peker H, Akin FT, Mutlu N, et al. Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women. Arch Gynecol Obstet. 2010; 281(4): 663-8.
  • 28. Rumbak I, Zizic V, Sokolic L, Cvijetic S, Kajfez R, Colic Baric I. Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status. Arch Gynecol Obstet. 2012; 285(4): 991-1000.
  • 29. van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, van der Klift M, de Jonge R, Lindemans J, et al. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med. 2004; 350(20): 2033-41.
  • 30. Cagnacci A, Baldassari F, Rivolta G, Arangino S, Volpe A. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women. Bone. 2003; 33(6): 956-9.
  • 31. Kakehasi AM, Carvalho AV, Maksud FA, Barbosa AJ. Serum levels of vitamin B12 are not related to low bone mineral density in postmenopausal Brazilian women. Rev Bras Reumatol. 2012; 52(6): 863-9.

Plazma Homosistein, Folat ve Vitamin B12 Düzeyleri ile Limbus Vertebra Arasındaki Olası İlişki

Yıl 2018, Cilt: 5 Sayı: 3, 107 - 111, 28.09.2018

Öz

Amaç: Limbus vertebra (LV) gelişiminde rol alan birkaç mekanizma önerilmiş olmasına rağmen, LV'nin mekanizması hala belirsizdir. Bu çalışmanın amacı, LV'lı bir grupta Hcy, folat ve vitamin B12'nin plazma düzeylerini belirlemek ve yaş ve beden kitle indeksi eşleştirilmiş kadınlarla karşılaştırmak ve LV patofizyolojisine olası katkılarını araştırmaktır.

Gereç ve Yöntemler: Bu çalışma, LV tanısı konan 171 premenopozal kadın ile LV'siz 190 yaş ve vücut kitle indeksi eşleştirilmiş premenopozal kadını içermektedir. Demografik, dual enerji X-ışını absorpsiyometri sonuçları ve plazma homosistein, folat ve vitamin B12 düzeyleri değerlendirilmiştir.

Bulgular: Antropometrik, klinik, dansitometrik ve biyokimyasal özellikler, Hcy düzeyleri dışında iki grup arasında istatistiksel olarak farklı değildi (p <0.001). Hcy düzeyleri LV grubunda yaşla birlikte anlamlı derecede negatif iken (r = -0.162, p = 0.034); kontrol grubunda böyle bir ilişki yoktu (r = 0.026, p = 0.721).

Tartışma: LV'li premenopozal genç kadınlar, yaş ve beden kitle indeksi eşleştirilmiş premenopozal kadınlara göre daha yüksek Hcy seviyelerine sahiptir. Yüksek Hcy seviyeleri, LV oluşumunun patogenezinde rol oynayabilir.

Kaynakça

  • 1. Ghelman B, Freiberger RH. The limbus vertebra: an anterior disc herniation demonstrated by discography. AJR Am J Roentgenol. 1976; 127(5): 854-5.
  • 2. Hellstrom M, Jacobsson B, Sward L, Peterson L. Radiologic abnormalities of the thoraco-lumbar spine in athletes. Acta Radiol. 1990; 31(2): 127-32.
  • 3. Kim DJ, Koh JM, Lee O, Kim NJ, Lee YS, Kim YS, et al. Homocysteine enhances apoptosis in human bone marrow stromal cells. Bone. 2006; 39(3): 582-90.
  • 4. Herrmann M, Widmann T, Colaianni G, Colucci S, Zallone A, Herrmann W. Increased osteoclast activity in the presence of increased homocysteine concentrations. Clin Chem. 2005; 51(12): 2348-53.
  • 5. Vaes BL, Lute C, Blom HJ, Bravenboer N, de Vries TJ, Everts V, et al. Vitamin B(12) deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid. Calcif Tissue Int. 2009; 84(5): 413-22.
  • 6. Tyagi N, Kandel M, Munjal C, Qipshidze N, Vacek JC, Pushpakumar SB, et al. Homocysteine mediated decrease in bone blood flow and remodeling: role of folic acid. J Orthop Res. 2011; 29(10): 1511-6.
  • 7. Blouin S, Thaler HW, Korninger C, Schmid R, Hofstaetter JG, Zoehrer R, et al. Bone matrix quality and plasma homocysteine levels. Bone. 2009; 44(5): 959-64.
  • 8. Herrmann M, Tami A, Wildemann B, Wolny M, Wagner A, Schorr H, et al. Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone. Bone. 2009; 44(3): 467-75.
  • 9. Thaler R, Agsten M, Spitzer S, Paschalis EP, Karlic H, Klaushofer K, et al. Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation. J Biol Chem. 2011; 286(7): 5578-88.
  • 10. Kim GS, Kim CH, Park JY, Lee KU, Park CS. Effects of vitamin B12 on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells and UMR106 osteoblastic cells. Metabolism. 1996; 45(12): 1443-6.
  • 11. Roman-Garcia P, Quiros-Gonzalez I, Mottram L, Lieben L, Sharan K, Wangwiwatsin A, et al. Vitamin B(1)(2)-dependent taurine synthesis regulates growth and bone mass. J Clin Invest. 2014; 124(7): 2988-3002.
  • 12. Holstein JH, Herrmann M, Splett C, Herrmann W, Garcia P, Histing T, et al. Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans. Am J Clin Nutr. 2009; 90(5): 1440-5.
  • 13. Koyama K, Nakazato K, Min S, Gushiken K, Hatakeda Y, Seo K, et al. COL11A1 gene is associated with limbus vertebra in gymnasts. Int J Sports Med. 2012; 33(7): 586-90.
  • 14. Bennett DL, Nassar L, DeLano MC. Lumbar spine MRI in the elite-level female gymnast with low back pain. Skeletal Radiol. 2006; 35(7): 503-9.
  • 15. Yamauchi M. Collagen: The Major Matrix Molecule in Mineralized Tissues. In: Anderson JJB, Garner SC editors. Calcium and Phosphorus Nutrition in Health and Disease. Florida: CRC Press; 1995.p.127-47.
  • 16. Bailey AJ, Paul RG, Knott L. Mechanisms of maturation and ageing of collagen. Mech Ageing Dev. 1998; 106(1-2): 1-56.
  • 17. Knott L, Bailey AJ. Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance. Bone. 1998; 22(3): 181-7.
  • 18. Gjesdal CG, Vollset SE, Ueland PM, Refsum H, Drevon CA, Gjessing HK, et al. Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study. Arch Intern Med. 2006; 166(1): 88-94.
  • 19. Jacques PF, Rosenberg IH, Rogers G, Selhub J, Bowman BA, Gunter EW, et al. Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr. 1999; 69(3): 482-9.
  • 20. Baines M, Kredan MB, Usher J, Davison A, Higgins G, Taylor W, et al. The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B12 and vitamin B6 with bone mineral density in postmenopausal British women. Bone. 2007; 40(3): 730-6.
  • 21. Swart KM, van Schoor NM, Lips P. Vitamin B12, folic acid, and bone. Curr Osteoporos Rep. 2013; 11(3): 213-8.
  • 22. Bahtiri E, Islami H, Rexhepi S, Qorraj-Bytyqi H, Thaci K, Thaci S, et al. Relationship of homocysteine levels with lumbar spine and femur neck BMD in postmenopausal women. Acta Reumatol Port. 2015; 40(4): 355-62.
  • 23. Zhang H, Tao X, Wu J. Association of homocysteine, vitamin B12, and folate with bone mineral density in postmenopausal women: a meta-analysis. Arch Gynecol Obstet. 2014; 289(5): 1003-9.
  • 24. Bozkurt N, Erdem M, Yilmaz E, Erdem A, Biri A, Kubatova A, et al. The relationship of homocyteine, B12 and folic acid with the bone mineral density of the femur and lumbar spine in Turkish postmenopausal women. Arch Gynecol Obstet. 2009; 280(3): 381-7.
  • 25. Ouzzif Z, Oumghar K, Sbai K, Mounach A, Derouiche el M, El Maghraoui A. Relation of plasma total homocysteine, folate and vitamin B12 levels to bone mineral density in Moroccan healthy postmenopausal women. Rheumatol Int. 2012; 32(1): 123-8.
  • 26. Cagnacci A, Bagni B, Zini A, Cannoletta M, Generali M, Volpe A. Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation. Bone. 2008; 42(2): 314-20.
  • 27. Haliloglu B, Aksungar FB, Ilter E, Peker H, Akin FT, Mutlu N, et al. Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women. Arch Gynecol Obstet. 2010; 281(4): 663-8.
  • 28. Rumbak I, Zizic V, Sokolic L, Cvijetic S, Kajfez R, Colic Baric I. Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status. Arch Gynecol Obstet. 2012; 285(4): 991-1000.
  • 29. van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, van der Klift M, de Jonge R, Lindemans J, et al. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med. 2004; 350(20): 2033-41.
  • 30. Cagnacci A, Baldassari F, Rivolta G, Arangino S, Volpe A. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women. Bone. 2003; 33(6): 956-9.
  • 31. Kakehasi AM, Carvalho AV, Maksud FA, Barbosa AJ. Serum levels of vitamin B12 are not related to low bone mineral density in postmenopausal Brazilian women. Rev Bras Reumatol. 2012; 52(6): 863-9.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Yavuz Samanci

Suat Erol Çelik Bu kişi benim

Yayımlanma Tarihi 28 Eylül 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 5 Sayı: 3

Kaynak Göster

APA Samanci, Y., & Çelik, S. E. (2018). The Possible Relationship Between Plasma Homocysteine, Folate and Vitamin B12 Levels and Limbus Vertebra. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 5(3), 107-111.
AMA Samanci Y, Çelik SE. The Possible Relationship Between Plasma Homocysteine, Folate and Vitamin B12 Levels and Limbus Vertebra. CBU-SBED. Eylül 2018;5(3):107-111.
Chicago Samanci, Yavuz, ve Suat Erol Çelik. “The Possible Relationship Between Plasma Homocysteine, Folate and Vitamin B12 Levels and Limbus Vertebra”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 5, sy. 3 (Eylül 2018): 107-11.
EndNote Samanci Y, Çelik SE (01 Eylül 2018) The Possible Relationship Between Plasma Homocysteine, Folate and Vitamin B12 Levels and Limbus Vertebra. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 5 3 107–111.
IEEE Y. Samanci ve S. E. Çelik, “The Possible Relationship Between Plasma Homocysteine, Folate and Vitamin B12 Levels and Limbus Vertebra”, CBU-SBED, c. 5, sy. 3, ss. 107–111, 2018.
ISNAD Samanci, Yavuz - Çelik, Suat Erol. “The Possible Relationship Between Plasma Homocysteine, Folate and Vitamin B12 Levels and Limbus Vertebra”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 5/3 (Eylül 2018), 107-111.
JAMA Samanci Y, Çelik SE. The Possible Relationship Between Plasma Homocysteine, Folate and Vitamin B12 Levels and Limbus Vertebra. CBU-SBED. 2018;5:107–111.
MLA Samanci, Yavuz ve Suat Erol Çelik. “The Possible Relationship Between Plasma Homocysteine, Folate and Vitamin B12 Levels and Limbus Vertebra”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, c. 5, sy. 3, 2018, ss. 107-11.
Vancouver Samanci Y, Çelik SE. The Possible Relationship Between Plasma Homocysteine, Folate and Vitamin B12 Levels and Limbus Vertebra. CBU-SBED. 2018;5(3):107-11.