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Drug-Drug Interaction Intensity Differences Depending On The Hematopoietic Stem Cell Transplantation Type And Existing Polypharmacy Prior To Transplantation

Yıl 2023, Cilt: 10 Sayı: 3, 211 - 221, 28.09.2023
https://doi.org/10.34087/cbusbed.1243203

Öz

Introduction: Drug drug interactions can effect the success of stem cell transplantation process. Therefore, analyzing the risk of these interactions would be helpful for practitioners. This study was conducted to identify drug-drug interactions in allogeneic and autologous stem cell transplantation patients before and after transplantation.
Methods: Patients who underwent allogeneic stem cell transplantation and autologous stem cell transplantation were included in the study. Patients’ treatment sheets were collected ten days before transplantation day, on the transplantation day, and ten days after transplantation day. Drug-drug interactions were analyzed by using four drug-drug interaction checking databases.
Results: 50 patients from both transplantation types were included. The mean ages for allogeneic and autologous transplants were 42.4 and 51.8, respectively. 52% of allogeneic transplants and 28% of autologous transplants were on ≥5 drugs at tenth day before transplantation. The means of interactions in allogeneic and autologous stem cell transplantation patients were 75.42 and 43.62, respectively. The detection of at least one contraindicated interaction in allogeneic and autologous transplant patients were 94% and 92%, respectively. In 48% of allogeneic transplants and 36% of autologous transplants, two or more contraindicated interactions were detected.
Conclusion: Allogeneic stem cell transplantation patients experienced almost two times more drug-drug interactions than autologous stem cell transplantation patients. Transplantation type, being in the pre and post-transplantation period and the drug number at the beginning of the transplantation process matter in terms of the number of drug-drug interactions. Identifying interactions in terms of transplantation type and existing medications is very important.

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Kaynakça

  • 1. Saleem, A, Masood, I, Khan T.M, Clinical relevancy and determinants of potential drug-drug interactions in chronic kidney disease patients: results from a retrospective analysis, Integrated Pharmacy Research and Practice, 2017, 6, 71-77.
  • 2. Dechanont S, Maphanta S, Butthum B, Kongkaew C. Hospital admissions/visits associated with drug-drug interactions: a systematic review and meta-analysis. Pharmacoepidemiology and Drug Safety, 2014, 23(5), 489-497.
  • 3. van Leeuwen R.W, Swart E.L, Boom F.A, Schuitenmaker M.S, Hugtenburg J.G, Potential drug interactions and duplicate prescriptions among ambulatory cancer patients: a prevalence study using an advanced screening method, BMC Cancer, 2010, 10, 679.
  • 4. Lees J, Chan A, Polypharmacy in elderly patients with cancer: clinical implications and management, Lancet Oncology, 2011, 12(13), 1249-1257.
  • 5. Trevisan D.D, Silva J.B, Oliveira H.C, Secoli S.R, Lima M.H, Prevalence and clinical significance of potential drug-drug interaction in hematopoietic stem cell transplantation, Cancer Chemotherapy and Pharmacology, 2015, 75(2), 393-400.
  • 6. Riechelmann R.P, Del Giglio A, Drug interactions in oncology: how common are they?, Annals of Oncology, 2009, 20(12), 1907-1912.
  • 7. Copelan E.A. Hematopoietic Stem-Cell Transplantation, New England Journal of Medicine, 2006, 354(17), 1813-26.
  • 8. Gratwohl A, Baldomero H, Aljurf M, Pasquini M.C, Bouzas L.F, Yoshimi A, et al. Hematopoietic Stem Cell Transplantation: A Global Perspective, JAMA, 2010, 303(16), 1617-24.
  • 9. Guastaldi R.B, Reis A.M, Figueras A, Secoli S.R, Prevalence of potential drug-drug interactions in bone marrow transplant patients, International Journal of Clinical Pharmacy, 2011, 33(6), 1002-1009.
  • 10. Valverde I.A, da Silva M.J, Retto M.P, Association between potential drug interactions and clinical outcomes in hematopoietic stem cell transplantations, Journal of Oncology Pharmacy Practice, 2019, 25(5), 1105-1111.
  • 11. Lexicomp Drug Interactions, UpToDate. https://www.uptodate.com/, 2022,Accessed 01 Nov 2022.
  • 12. IBM Micromedex, Drug Interactions. https://www.micromedexsolutions.com/, 2022, Accessed 01 Nov 2022.
  • 13. Drugs.com, Drug Interactions Checker. https://www.drugs.com/, 2022, Accessed 01 Nov 2022.
  • 14. Epocrate, Interaction Check. https://online.epocrates.com/, 2022, Accessed 01 Nov 2022.
  • 15. World Health Organization, Collaborating Centre for Drug Statistics Methodology, ATC/DDD Index 2022. https://www.whocc.no/atc_ddd_index/, 2022, Accessed 01 Jun 2022.
  • 16. Saito H, Ogasawara K, Suzuki T, Kuroda H, Kobayashi M, Yoshida K, et al, Adverse effects of intravenous acetazolamide administration for evaluation of cerebrovascular reactivity using brain perfusion single-photon emission computed tomography in patients with major cerebral artery steno-occlusive diseases, Neurologia medico-chirurgica, 2011, 51(7), 479-483.
  • 17. Kataoka H, Treatment of hypochloremia with acetazolamide in an advanced heart failure patient and importance of monitoring urinary electrolytes, Journal of Cardiology Cases, 2018, 17(3): 80-84.
  • 18. Yang Z, Liu J, Zhou Y, Zhao X, Zhao Q, Liu J, The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis, Journal of Infection, 2020, 81(1): e13-e20.
  • 19. Liu J, Shah S.K, Basu-Ray I, Garcia-Diaz J, Khalid K, Saeed M, QT prolongation in HIV-positive patients: Review article, Indian Heart Journal, 2019, 71(6), 434-9.
  • 20. Balk T, van der Sijs I, van Gelder T, Janssen J, van der Sluis I, van Leeuwen R, et al, Drug–drug interactions in pediatric oncology patients, Pediatric Blood & Cancer, 2017, 64(7), 10.1002/pbc.26410.
  • 21. Ram R, Gafter-Gvili A, Yeshurun M, Paul M, Raanani P, Shpilberg O, Prophylaxis regimens for GVHD: systematic review and meta-analysis, Bone Marrow Transplantation, 2009, 43(8), 643-653.
  • 22. Fox R.I, Morgan S.L, Smith H.T, Robbins B.A, Choc M.G, Baggott J.E, Combined oral cyclosporin and methotrexate therapy in patients with rheumatoid arthritis elevates methotrexate levels and reduces 7-hydroxymethotrexate levels when compared with methotrexate alone, Rheumatology (Oxford), 2003, 42(8), 989-994.
  • 23. Tholakanahalli V.N, Potti A, Hanley J.F, Merliss A.D, Fluconazole-induced torsade de pointes, Annals of Pharmacotherapy, 2001, 35(4), 432-434.
  • 24. Pham C.P, de Feiter P.W, van der Kuy P.H, van Mook W.N, Long QTc interval and torsade de pointes caused by fluconazole, Annals of Pharmacotherapy, 2006, 40(7-8), 1456-1461.
  • 25. Emamhadi M, Sanaei-Zadeh H, Nikniya M, Zamani N, Dart R.C, Electrocardiographic manifestations of tramadol toxicity with special reference to their ability for prediction of seizures, American Journal of Emergency Medicine, 2012, 30(8), 1481-1485.
  • 26. Funk K.A, Bostwick J.R, A comparison of the risk of QT prolongation among SSRIs, Annals of Pharmacotherapy, 2013, 47(10), 1330-1341.
  • 27. Morris A.D, Chen J, Lau E, Poh J, Domperidone-Associated QT Interval Prolongation in Non-oncologic Pediatric Patients: A Review of the Literature, Canadian Journal of Hospital Pharmacy, 2016, 69(3), 224-230.
  • 28. Wong S.F, New dosing schedules of dasatinib for CML and adverse event management, Journal of Hematology & Oncology, 2009, 2: 10.
  • 29. 29. Hasnain M, Vieweg W.V.R, Howland R.H, Kogut C, Breden Crouse E.L, Koneru J.N, et al, Quetiapine, QTc interval prolongation, and torsade de pointes: a review of case reports, Therapeutic Advances in Psychopharmacology, 2014, 4(3), 130-8.
  • 30. 30. Takahashi N, Miura M, Niioka T, Sawada K, Influence of H2-receptor antagonists and proton pump inhibitors on dasatinib pharmacokinetics in Japanese leukemia patients, Cancer Chemotherapy and Pharmacology, 2012, 69(4), 999-1004

Hematopoietik Kök Hücre Nakli Türüne ve Nakil Öncesi Mevcut Polifarmasiye Bağlı Olarak İlaç-İlaç Etkileşimi Farklılıkları

Yıl 2023, Cilt: 10 Sayı: 3, 211 - 221, 28.09.2023
https://doi.org/10.34087/cbusbed.1243203

Öz

Amaç: İlaç ilaç etkileşimleri, kök hücre nakli işleminin başarısını etkileyebilmektedir. Bu nedenle, bu etkileşimlerin riskini analiz etmek sağlık profesyonelleri için gerekliliktir. Bu çalışma, allojenik ve otolog kök hücre nakli hastalarında nakil öncesi ve sonrası ilaç-ilaç etkileşimlerini belirlemek amacıyla yapılmıştır.
Material and Methods: Çalışmaya allojenik kök hücre nakli ve otolog kök hücre nakli yapılan hastalar dahil edildi. Hastaların nakil gününden on gün önce, nakil gününde ve nakil gününden on gün sonrasına ait tedavi şemaları toplandı. İlaç-ilaç etkileşimleri, dört ilaç-ilaç etkileşimi kontrol veri tabanı kullanılarak analiz edildi.
Bulgular: Her iki transplantasyon tipinden 50 hasta dahil edildi. Allojenik ve otolog nakiller için ortalama yaş sırasıyla 42.4 ve 51.8 idi. Allojenik nakillerin %52'si ve otolog nakillerin %28'i nakilden önceki onuncu günde ≥5 ilaç kullanıyordu. Allojenik ve otolog kök hücre nakli hastalarında ortalama etkileşim sayıları sırasıyla 75.42 ve 43.62 idi. Allojenik ve otolog nakil hastalarında sırasıyla %94 ve %92 oranında en az bir kontrendike etkileşimin saptandı. Allojenik nakillerin %48'inde ve otolog nakillerin %36'sında iki veya daha fazla kontrendike etkileşim tespit edildi.
Sonuç: Allojenik kök hücre nakli hastaları, otolog kök hücre nakli hastalarına göre neredeyse iki kat daha fazla ilaç-ilaç etkileşimine maruz kaldı. Transplantasyon tipi, hastanın transplantasyon öncesi ve sonrası dönemde olması ve transplantasyon sürecinin başındaki ilaç sayısı ilaç-ilaç etkileşim sayısı açısından önemlidir. Transplantasyon tipi ve hastaların mevcut ilaçları açısından etkileşimlerin belirlenmesi önem arz etmektedir.
Anahtar Kelimeler İlaç-ilaç etkileşimleri, hematopoietik kök hücre nakli, klinik eczacılık, HKHN, KİT

Proje Numarası

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Kaynakça

  • 1. Saleem, A, Masood, I, Khan T.M, Clinical relevancy and determinants of potential drug-drug interactions in chronic kidney disease patients: results from a retrospective analysis, Integrated Pharmacy Research and Practice, 2017, 6, 71-77.
  • 2. Dechanont S, Maphanta S, Butthum B, Kongkaew C. Hospital admissions/visits associated with drug-drug interactions: a systematic review and meta-analysis. Pharmacoepidemiology and Drug Safety, 2014, 23(5), 489-497.
  • 3. van Leeuwen R.W, Swart E.L, Boom F.A, Schuitenmaker M.S, Hugtenburg J.G, Potential drug interactions and duplicate prescriptions among ambulatory cancer patients: a prevalence study using an advanced screening method, BMC Cancer, 2010, 10, 679.
  • 4. Lees J, Chan A, Polypharmacy in elderly patients with cancer: clinical implications and management, Lancet Oncology, 2011, 12(13), 1249-1257.
  • 5. Trevisan D.D, Silva J.B, Oliveira H.C, Secoli S.R, Lima M.H, Prevalence and clinical significance of potential drug-drug interaction in hematopoietic stem cell transplantation, Cancer Chemotherapy and Pharmacology, 2015, 75(2), 393-400.
  • 6. Riechelmann R.P, Del Giglio A, Drug interactions in oncology: how common are they?, Annals of Oncology, 2009, 20(12), 1907-1912.
  • 7. Copelan E.A. Hematopoietic Stem-Cell Transplantation, New England Journal of Medicine, 2006, 354(17), 1813-26.
  • 8. Gratwohl A, Baldomero H, Aljurf M, Pasquini M.C, Bouzas L.F, Yoshimi A, et al. Hematopoietic Stem Cell Transplantation: A Global Perspective, JAMA, 2010, 303(16), 1617-24.
  • 9. Guastaldi R.B, Reis A.M, Figueras A, Secoli S.R, Prevalence of potential drug-drug interactions in bone marrow transplant patients, International Journal of Clinical Pharmacy, 2011, 33(6), 1002-1009.
  • 10. Valverde I.A, da Silva M.J, Retto M.P, Association between potential drug interactions and clinical outcomes in hematopoietic stem cell transplantations, Journal of Oncology Pharmacy Practice, 2019, 25(5), 1105-1111.
  • 11. Lexicomp Drug Interactions, UpToDate. https://www.uptodate.com/, 2022,Accessed 01 Nov 2022.
  • 12. IBM Micromedex, Drug Interactions. https://www.micromedexsolutions.com/, 2022, Accessed 01 Nov 2022.
  • 13. Drugs.com, Drug Interactions Checker. https://www.drugs.com/, 2022, Accessed 01 Nov 2022.
  • 14. Epocrate, Interaction Check. https://online.epocrates.com/, 2022, Accessed 01 Nov 2022.
  • 15. World Health Organization, Collaborating Centre for Drug Statistics Methodology, ATC/DDD Index 2022. https://www.whocc.no/atc_ddd_index/, 2022, Accessed 01 Jun 2022.
  • 16. Saito H, Ogasawara K, Suzuki T, Kuroda H, Kobayashi M, Yoshida K, et al, Adverse effects of intravenous acetazolamide administration for evaluation of cerebrovascular reactivity using brain perfusion single-photon emission computed tomography in patients with major cerebral artery steno-occlusive diseases, Neurologia medico-chirurgica, 2011, 51(7), 479-483.
  • 17. Kataoka H, Treatment of hypochloremia with acetazolamide in an advanced heart failure patient and importance of monitoring urinary electrolytes, Journal of Cardiology Cases, 2018, 17(3): 80-84.
  • 18. Yang Z, Liu J, Zhou Y, Zhao X, Zhao Q, Liu J, The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis, Journal of Infection, 2020, 81(1): e13-e20.
  • 19. Liu J, Shah S.K, Basu-Ray I, Garcia-Diaz J, Khalid K, Saeed M, QT prolongation in HIV-positive patients: Review article, Indian Heart Journal, 2019, 71(6), 434-9.
  • 20. Balk T, van der Sijs I, van Gelder T, Janssen J, van der Sluis I, van Leeuwen R, et al, Drug–drug interactions in pediatric oncology patients, Pediatric Blood & Cancer, 2017, 64(7), 10.1002/pbc.26410.
  • 21. Ram R, Gafter-Gvili A, Yeshurun M, Paul M, Raanani P, Shpilberg O, Prophylaxis regimens for GVHD: systematic review and meta-analysis, Bone Marrow Transplantation, 2009, 43(8), 643-653.
  • 22. Fox R.I, Morgan S.L, Smith H.T, Robbins B.A, Choc M.G, Baggott J.E, Combined oral cyclosporin and methotrexate therapy in patients with rheumatoid arthritis elevates methotrexate levels and reduces 7-hydroxymethotrexate levels when compared with methotrexate alone, Rheumatology (Oxford), 2003, 42(8), 989-994.
  • 23. Tholakanahalli V.N, Potti A, Hanley J.F, Merliss A.D, Fluconazole-induced torsade de pointes, Annals of Pharmacotherapy, 2001, 35(4), 432-434.
  • 24. Pham C.P, de Feiter P.W, van der Kuy P.H, van Mook W.N, Long QTc interval and torsade de pointes caused by fluconazole, Annals of Pharmacotherapy, 2006, 40(7-8), 1456-1461.
  • 25. Emamhadi M, Sanaei-Zadeh H, Nikniya M, Zamani N, Dart R.C, Electrocardiographic manifestations of tramadol toxicity with special reference to their ability for prediction of seizures, American Journal of Emergency Medicine, 2012, 30(8), 1481-1485.
  • 26. Funk K.A, Bostwick J.R, A comparison of the risk of QT prolongation among SSRIs, Annals of Pharmacotherapy, 2013, 47(10), 1330-1341.
  • 27. Morris A.D, Chen J, Lau E, Poh J, Domperidone-Associated QT Interval Prolongation in Non-oncologic Pediatric Patients: A Review of the Literature, Canadian Journal of Hospital Pharmacy, 2016, 69(3), 224-230.
  • 28. Wong S.F, New dosing schedules of dasatinib for CML and adverse event management, Journal of Hematology & Oncology, 2009, 2: 10.
  • 29. 29. Hasnain M, Vieweg W.V.R, Howland R.H, Kogut C, Breden Crouse E.L, Koneru J.N, et al, Quetiapine, QTc interval prolongation, and torsade de pointes: a review of case reports, Therapeutic Advances in Psychopharmacology, 2014, 4(3), 130-8.
  • 30. 30. Takahashi N, Miura M, Niioka T, Sawada K, Influence of H2-receptor antagonists and proton pump inhibitors on dasatinib pharmacokinetics in Japanese leukemia patients, Cancer Chemotherapy and Pharmacology, 2012, 69(4), 999-1004
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Hematoloji
Bölüm Araştırma Makalesi
Yazarlar

Ayşe Günay 0000-0002-4411-3459

Eren Demirpolat 0000-0003-4405-4660

Betul Aycan 0000-0002-4503-8032

Ali Ünal 0000-0001-7011-3412

Proje Numarası -
Yayımlanma Tarihi 28 Eylül 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 10 Sayı: 3

Kaynak Göster

APA Günay, A., Demirpolat, E., Aycan, B., Ünal, A. (2023). Drug-Drug Interaction Intensity Differences Depending On The Hematopoietic Stem Cell Transplantation Type And Existing Polypharmacy Prior To Transplantation. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 10(3), 211-221. https://doi.org/10.34087/cbusbed.1243203
AMA Günay A, Demirpolat E, Aycan B, Ünal A. Drug-Drug Interaction Intensity Differences Depending On The Hematopoietic Stem Cell Transplantation Type And Existing Polypharmacy Prior To Transplantation. CBU-SBED. Eylül 2023;10(3):211-221. doi:10.34087/cbusbed.1243203
Chicago Günay, Ayşe, Eren Demirpolat, Betul Aycan, ve Ali Ünal. “Drug-Drug Interaction Intensity Differences Depending On The Hematopoietic Stem Cell Transplantation Type And Existing Polypharmacy Prior To Transplantation”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 10, sy. 3 (Eylül 2023): 211-21. https://doi.org/10.34087/cbusbed.1243203.
EndNote Günay A, Demirpolat E, Aycan B, Ünal A (01 Eylül 2023) Drug-Drug Interaction Intensity Differences Depending On The Hematopoietic Stem Cell Transplantation Type And Existing Polypharmacy Prior To Transplantation. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 10 3 211–221.
IEEE A. Günay, E. Demirpolat, B. Aycan, ve A. Ünal, “Drug-Drug Interaction Intensity Differences Depending On The Hematopoietic Stem Cell Transplantation Type And Existing Polypharmacy Prior To Transplantation”, CBU-SBED, c. 10, sy. 3, ss. 211–221, 2023, doi: 10.34087/cbusbed.1243203.
ISNAD Günay, Ayşe vd. “Drug-Drug Interaction Intensity Differences Depending On The Hematopoietic Stem Cell Transplantation Type And Existing Polypharmacy Prior To Transplantation”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 10/3 (Eylül 2023), 211-221. https://doi.org/10.34087/cbusbed.1243203.
JAMA Günay A, Demirpolat E, Aycan B, Ünal A. Drug-Drug Interaction Intensity Differences Depending On The Hematopoietic Stem Cell Transplantation Type And Existing Polypharmacy Prior To Transplantation. CBU-SBED. 2023;10:211–221.
MLA Günay, Ayşe vd. “Drug-Drug Interaction Intensity Differences Depending On The Hematopoietic Stem Cell Transplantation Type And Existing Polypharmacy Prior To Transplantation”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, c. 10, sy. 3, 2023, ss. 211-2, doi:10.34087/cbusbed.1243203.
Vancouver Günay A, Demirpolat E, Aycan B, Ünal A. Drug-Drug Interaction Intensity Differences Depending On The Hematopoietic Stem Cell Transplantation Type And Existing Polypharmacy Prior To Transplantation. CBU-SBED. 2023;10(3):211-2.