Öz
Objective: The effects of prenatal coronavirus 2019 disease (COVID-19) exposure on the infantile neurological development are unknown. It has been considered that the inflammatory, thrombotic, and vascular changes occurred in the placentas taken from pregnant women diagnosed with COVID-19 and the inflammatory nature of COVID-19 infection may lead to negative obstetric and neurological events. We aimed to assess the potential neurological effects of prenatal COVID-19 exposure on the infant.
Methods: The present study included 2–12-month-old infants born to women with positive real-time reverse transcription polymerase chain reaction test results for COVID-19 from the population of pregnant patients under routine follow-up. The neurological examinations and the Denver II Developmental Screening Test (DDST II) were performed for 41 infants aged 2–12 months to assess the neurological effects of prenatal COVID-19 exposure.
Results: The average gestational age of the infants was 38.7 ± 1.9 weeks, and the average birth weight was 3198 ± 543 g. Eight of the infants had a history of hospitalization in the neonatal intensive care unit. The neurological examination and the neuromotor development of 40 (96%) infants were normal for their age group. Only one infant had abnormal neurological examination and DDST II result.
Conclusion: The findings of the study suggest that prenatal COVID-19 exposure has no negative neurological impact on infants. Long-term prospective studies with larger sample sizes are needed for more comprehensive assessment of the neurological effects of prenatal COVID-19 exposure on the infants.
Anahtar Kelimeler
Destekleyen Kurum
None
Kaynakça
- Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records. Lancet. 2020;395:809-15.
- Shanes ED, Mithal LB, Otero S, Azad HA, Miller ES, Goldstein JA. Placental pathology in COVID-19. Am J Clin Pathol. 2020;154:23-32
- Baergen RN, Heller DS. Placental pathology in covid-19 positive mothers: Preliminary findings. Pediatr Dev Pathol. 2020;23(3):177-180.
- Frankenburg WK, Dodds JB. The Denver developmental screening test. J Pediatr. 1967 Aug;71(2):181-91
- Yalaz K, Anlar B, Bayoğlu B. Denver II Gelişimsel Tarama Testi “Türkiye Standardizasyonu”. Denver II Developmental Screening Test Handbook. Ankara: Anıl Grup Matbaacılık, 2010 ‘Turkish’.
- Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med. 2000;342(20):1500-7.
- Mor G, Cardenas I. The immune system in pregnancy: A unique complexity. Am J Reprod Immunol. 2010;63(6):425-33.
- Ashdown H, Dumont Y, Ng M, Poole S, Boksa P, Luheshi GN. The role of cytokines in mediating effects of prenatal infection on the fetus: Implications for schizophrenia. Mol Psychiatry. 2006;11(1):47-55.
- Gilmore JH, Fredrik Jarskog L, Vadlamudi S, Lauder JM. Prenatal infection and risk for schizophrenia: IL-1beta, IL-6, and TNF alpha inhibit cortical neuron dendrite development. Neuropsychopharmacology. 2004;29:1221-9.
- Atladottir HO, Thorsen P, Ostergaard L, Schendel DE, Lemcke S, Abdallah M, et al. Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. J Autism Dev Disord. 2010; 40:1423–30.
- Vivanti AJ, Vauloup-Fellous C, Prevot S, et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11:3572.
- Tiantian Xiao, Shiwen Xi, Linkong Zeng, et al. Multicentre observational study on neonates exposed to SARS-CoV- 2 in China: the Neo-SARS-CoV 2 Study protocol. BMJ Open. 2020;10(7):e038004.
Öz
Kaynakça
- Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records. Lancet. 2020;395:809-15.
- Shanes ED, Mithal LB, Otero S, Azad HA, Miller ES, Goldstein JA. Placental pathology in COVID-19. Am J Clin Pathol. 2020;154:23-32
- Baergen RN, Heller DS. Placental pathology in covid-19 positive mothers: Preliminary findings. Pediatr Dev Pathol. 2020;23(3):177-180.
- Frankenburg WK, Dodds JB. The Denver developmental screening test. J Pediatr. 1967 Aug;71(2):181-91
- Yalaz K, Anlar B, Bayoğlu B. Denver II Gelişimsel Tarama Testi “Türkiye Standardizasyonu”. Denver II Developmental Screening Test Handbook. Ankara: Anıl Grup Matbaacılık, 2010 ‘Turkish’.
- Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med. 2000;342(20):1500-7.
- Mor G, Cardenas I. The immune system in pregnancy: A unique complexity. Am J Reprod Immunol. 2010;63(6):425-33.
- Ashdown H, Dumont Y, Ng M, Poole S, Boksa P, Luheshi GN. The role of cytokines in mediating effects of prenatal infection on the fetus: Implications for schizophrenia. Mol Psychiatry. 2006;11(1):47-55.
- Gilmore JH, Fredrik Jarskog L, Vadlamudi S, Lauder JM. Prenatal infection and risk for schizophrenia: IL-1beta, IL-6, and TNF alpha inhibit cortical neuron dendrite development. Neuropsychopharmacology. 2004;29:1221-9.
- Atladottir HO, Thorsen P, Ostergaard L, Schendel DE, Lemcke S, Abdallah M, et al. Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. J Autism Dev Disord. 2010; 40:1423–30.
- Vivanti AJ, Vauloup-Fellous C, Prevot S, et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11:3572.
- Tiantian Xiao, Shiwen Xi, Linkong Zeng, et al. Multicentre observational study on neonates exposed to SARS-CoV- 2 in China: the Neo-SARS-CoV 2 Study protocol. BMJ Open. 2020;10(7):e038004.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Articles |
| Yazarlar | |
| Yayımlanma Tarihi | 15 Haziran 2023 |
| Gönderilme Tarihi | 14 Nisan 2022 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 13 Sayı: 2 |
Kaynak Göster
