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Endoplazmik Retikulum Stresinin Psikiyatrideki Yeri

Yıl 2022, Cilt: 2 Sayı: 1, 63 - 74, 16.06.2022

Öz

Psikiyatrik hastalıkların etyolojisinde bugüne kadar hücre içi çeşitli patofizyolojik mekanizmalar araştırma konusu olmuştur. Endoplazmik retikulum, hücre içinde bulunan ve bazı önemli homeostatik süreçlerde yer alan bir organeldir. Endoplazmik retikulum stresi, çeşitli uyaranlar sonucunda bu homeostatik mekanizmalarda meydana gelen değişimleri ifade etmektedir. Endoplazmik retikulum stresi bugüne kadar birçok hastalık için araştırma konusu olmuştur. Bu derlemede, psikiyatrik hastalıkların oluşumunda endoplazmik retikulum stresinin etkisinin güncel literatür verileri doğrultusunda tartışılması, olası patofizyolojik mekanizmaların aydınlatılması ve yeni tedavi seçeneklerinin geliştirilmesi hususlarında yapılacak çalışmalara ışık tutması amaçlanmıştır.

Kaynakça

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The Role of Endoplasmic Reticulum Stress in Psychiatry

Yıl 2022, Cilt: 2 Sayı: 1, 63 - 74, 16.06.2022

Öz

Various intracellular pathophysiological mechanisms have been the subject of research in the ethology of psychiatric diseases so far. The endoplasmic reticulum is an organelle located inside the cell and involved in some essential homeostatic processes. Endoplasmic reticulum stress refers to the changes that occur in these homeostatic mechanisms due to various stimuli. Endoplasmic reticulum stress has been the subject of research for many diseases until today. This review aims to discuss the effect of endoplasmic reticulum stress in the formation of psychiatric diseases in line with current literature data, illuminate possible pathophysiological mechanisms, and shed light on the studies to be done on the development of new treatment options.

Kaynakça

  • Acosta-Alvear, D., Zhou, Y., Blais, A., Tsikitis, M., Lents, N. H., Arias, C., … Dynlacht, B. D. (2007). XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Molecular Cell. https://doi.org/10.1016/j.molcel.2007.06.011
  • Adachi, Y., Yamamoto, K., Okada, T., Yoshida, H., Harada, A. ve Mori, K. (2008). ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. Cell Structure and Function. https://doi.org/10.1247/csf.07044
  • Behnke, J., Mann, M. J., Scruggs, F. L., Feige, M. J. ve Hendershot, L. M. (2016). Members of the Hsp70 Family Recognize Distinct Types of Sequences to Execute ER Quality Control. Molecular Cell, 63(5), 739-752. https://doi.org/10.1016/j.molcel.2016.07.012
  • Bernales, S., McDonald, K. L. ve Walter, P. (2006). Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biology. https://doi.org/10.1371/journal.pbio.0040423
  • Bettigole, S. E. ve Glimcher, L. H. (2015). Endoplasmic reticulum stress in immunity. 33 Annual Review of Immunology, 107-138. https://doi.org/10.1146/annurev-immunol-032414-112116
  • Bi, M., Naczki, C., Koritzinsky, M., Fels, D., Blais, J., Hu, N., … Koumenis, C. (2005). ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO Journal. https://doi.org/10.1038/sj.emboj.7600777
  • Bommiasamy, H., Back, S. H., Fagone, P., Lee, K., Meshinchi, S., Vink, E., … Brewer, J. W. (2009). ATF6α induces XBP1-independent expansion of the endoplasmic reticulum. Journal of Cell Science. https://doi.org/10.1242/jcs.045625
  • Borgese, N., Francolini, M. ve Snapp, E. (2006). Endoplasmic reticulum architecture: structures in flux. Current Opinion in Cell Biology. https://doi.org/10.1016/j.ceb.2006.06.008
  • Bown, C., Wang, J. F., MacQueen, G. ve Young, L. T. (2000). Increased temporal cortex ER stress proteins in depressed subjects who died by suicide. Neuropsychopharmacology, 22(3), 327-332. https://doi.org/10.1016/S0893-133X(99)00091-3
  • Breen, M. S., White, C. H., Shekhtman, T., Lin, K., Looney, D., Woelk, C. H. ve Kelsoe, J. R. (2016). Lithium-responsive genes and gene networks in bipolar disorder patient-derived lymphoblastoid cell lines. The Pharmacogenomics Journal, 16(5), 446-453. https://doi.org/10.1038/TPJ.2016.50
  • Carrara, M., Prischi, F., Nowak, P. R., Kopp, M. C. ve Ali, M. M. U. (2015). Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling. eLife, 2015(4). https://doi.org/10.7554/eLife.03522
  • Casas, C. (2017). GRP78 at the centre of the stage in cancer and neuroprotection. Frontiers in Neuroscience. Frontiers Research Foundation. https://doi.org/10.3389/fnins.2017.00177
  • Cox, J. S. ve Walter, P. (1996). A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell. doi:10.1016/S0092-8674(00)81360-4
  • English, A. R., Zurek, N. ve Voeltz, G. K. (2009). Peripheral ER structure and function. Current Opinion in Cell Biology. https://doi.org/10.1016/j.ceb.2009.04.004
  • Han, J., Back, S. H., Hur, J., Lin, Y. H., Gildersleeve, R., Shan, J., … Kaufman, R. J. (2013). ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature Cell Biology, 15(5), 481-490. https://doi.org/10.1038/ncb2738
  • Harding, H. P., Zhang, Y., Bertolotti, A., Zeng, H. ve Ron, D. (2000). Perk is essential for translational regulation and cell survival during the unfolded protein response. Molecular Cell, 5(5), 897-904. https://doi.org/10.1016/S1097-2765(00)80330-5
  • Harrison, R. (2002). Structure and function of xanthine oxidoreductase: Where are we now? Free Radical Biology and Medicine, 33(6), 774-797. https://doi.org/10.1016/S0891-5849(02)00956-5
  • Hayashi, A., Kasahara, T., Kametani, M., Toyota, T., Yoshikawa, T. ve Kato, T. (2009). Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder. International Journal of Neuropsychopharmacology, 12(1), 33-43. https://doi.org/10.1017/S1461145708009358
  • Haze, K., Yoshida, H., Yanagi, H., Yura, T. ve Mori, K. (1999). Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.10.11.3787
  • Hetz, C. (2012). The unfolded protein response: Controlling cell fate decisions under ER stress and beyond. Nature Reviews Molecular Cell Biology. Nature Publishing Group. https://doi.org/10.1038/nrm3270
  • Hill, M. N., Hellemans, K. G. C., Verma, P., Gorzalka, B. B. ve Weinberg, J. (2012, Ekim). Neurobiology of chronic mild stress: Parallels to major depression. Neuroscience and Biobehavioral Reviews. doi:10.1016/j.neubiorev.2012.07.001
  • Hiramatsu, N., Chiang, W. C., Kurt, T. D., Sigurdson, C. J. ve Lin, J. H. (2015). Multiple mechanisms of unfolded protein response-ınduced cell death. American Journal of Pathology. https://doi.org/10.1016/j.ajpath.2015.03.009
  • Huang, G. B., Zhao, T., Muna, S. S., Bagalkot, T. R., Jin, H. M., Chae, H. J. ve Chung, Y. C. (2013). Effects of chronic social defeat stress on behaviour, endoplasmic reticulum proteins and choline acetyltransferase in adolescent mice. International Journal of Neuropsychopharmacology, 16(7), 1635-1647. https://doi.org/10.1017/S1461145713000060
  • Imai, T., Kosuge, Y., Saito, H., Uchiyama, T., Wada, T., Shimba, S., … Ito, Y. (2016). Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition. Journal of Pharmacological Sciences. https://doi.org/10.1016/j.jphs.2016.03.004
  • Jangra, A., Dwivedi, S., Sriram, C. S., Gurjar, S. S., Kwatra, M., Sulakhiya, K., … Lahkar, M. (2016). Honokiol abrogates chronic restraint stress-induced cognitive impairment and depressive-like behaviour by blocking endoplasmic reticulum stress in the hippocampus of mice. European Journal of Pharmacology, 770, 25-32. https://doi.org/10.1016/j.ejphar.2015.11.047
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  • Lee, A.-H., Iwakoshi, N. N. ve Glimcher, L. H. (2003). XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Molecular and Cellular Biology, 23(21), 7448-7459. https://doi.org/10.1128/mcb.23.21.7448-7459.2003
  • Leonidas, M. (2012). The distribution of the stress protein HSP70 in the cerebellum of patients with schizophrenia. Neuroscience and Medicine, 2012(4), 368-373. https://doi.org/10.4236/NM.2012.34045
  • Li, M. X., Li, Q., Sun, X. J., Luo, C., Li, Y. Y. J., Wang, Y. N., … Chen, H. (2019). Increased Homer1-mGluR5 mediates chronic stress-induced depressive-like behaviors and glutamatergic dysregulation via activation of PERK-eIF2α. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 95. https://doi.org/10.1016/j.pnpbp.2019.109682
  • Lin, J. H., Li, H., Yasumura, D., Cohen, H. R., Zhang, C., Panning, B., … Walter, P. (2007). IRE1 signaling affects cell fate during the unfolded protein response. Science. https://doi.org/10.1126/science.1146361
  • Liu, L., Zhao, Z., Lu, L., Liu, J., Sun, J., Wu, X. ve Dong, J. (2019). Icariin and icaritin ameliorated hippocampus neuroinflammation via inhibiting HMGB1-related pro-inflammatory signals in lipopolysaccharide-induced inflammation model in C57BL/6 J mice. International Immunopharmacology, 68, 95-105. https://doi.org/10.1016/j.intimp.2018.12.055
  • Liu, Y., Yang, N., Hao, W., Zhao, Q., Ying, T., Liu, S., … Zuo, P. (2011). Dynamic proteomic analysis of protein expression profiles in whole brain of Balb/c mice subjected to unpredictable chronic mild stress: Implications for depressive disorders and future therapies. Neurochemistry International, 58(8), 904-913. https://doi.org/10.1016/j.neuint.2011.02.019
  • Mao, J., Hu, Y., Ruan, L., Ji, Y. ve Lou, Z. (2019a). Role of endoplasmic reticulum stress in depression (Review). Molecular Medicine Reports, 20(6), 4774-4780. https://doi.org/10.3892/mmr.2019.10789
  • Mao, J., Hu, Y., Ruan, L., Ji, Y. ve Lou, Z. (2019b). Role of endoplasmic reticulum stress in depression (Review). Molecular Medicine Reports, 20(6), 4774-4780. https://doi.org/10.3892/mmr.2019.10789
  • Michel, T. M., Camara, S., Tatschner, T., Frangou, S., Sheldrick, A. J., Riederer, P. ve Grünblatt, E. (2010). Increased xanthine oxidase in the thalamus and putamen in depression. World Journal of Biological Psychiatry, 11(2 PART 2), 314-320. https://doi.org/10.3109/15622970802123695
  • Nevell, L., Zhang, K., Aiello, A. E., Koenen, K., Galea, S., Soliven, R., … Uddin, M. (2014). Elevated systemic expression of ER stress related genes is associated with stress-related mental disorders in the Detroit Neighborhood Health Study. Psychoneuroendocrinology, 43, 62-70. https://doi.org/10.1016/j.psyneuen.2014.01.013
  • Oakes, S. A. ve Papa, F. R. (2015). The Role of Endoplasmic Reticulum Stress in Human Pathology. Annual Review of Pathology: Mechanisms of Disease, 10(1), 173-194. https://doi.org/10.1146/annurev-pathol-012513-104649
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  • Pavlovsky, A. A., Boehning, D., Li, D., Zhang, Y., Fan, X. ve Green, T. A. (2013). Psychological stress, cocaine and natural reward each induce endoplasmic reticulum stress genes in rat brain. Neuroscience, 246, 160-169. https://doi.org/10.1016/j.neuroscience.2013.04.057
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  • Ye, J., Rawson, R. B., Komuro, R., Chen, X., Davé, U. P., Prywes, R., … Goldstein, J. L. (2000). ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Molecular Cell. https://doi.org/10.1016/S1097-2765(00)00133-7
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Toplam 61 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Psikiyatri
Bölüm Derlemeler
Yazarlar

Mustafa Karaağaç 0000-0001-5737-5880

Yayımlanma Tarihi 16 Haziran 2022
Gönderilme Tarihi 13 Ocak 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 2 Sayı: 1

Kaynak Göster

APA Karaağaç, M. (2022). Endoplazmik Retikulum Stresinin Psikiyatrideki Yeri. Current Research and Reviews in Psychology and Psychiatry, 2(1), 63-74.