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İnsan immun yetmezlik virüsü ile yaşayan kişilerde adrenal bezin morfometrik analizi

Yıl 2024, Cilt: 49 Sayı: 1, 159 - 169, 29.03.2024
https://doi.org/10.17826/cumj.1391874

Öz

Amaç: İnsan immün yetmezlik virüsü (HIV) enfeksiyonunun adrenal bez morfometrisi üzerine etkisini yaş, cinsiyet, vücut ağırlığı, hayatta kalma durumu ve CD4/CD8 parametrelerine göre değerlendirmeyi amaçladık.
Gereç ve Yöntem: Bu çalışmada, 2008 ve 2020 yılları arasında herhangi bir nedenle görüntülemesi olan 160 HIV enfeksiyonu ile yaşayan kişinin BT (130 erkek ve 30 kadın) arşivi tarandı. BT görüntüleri üzerinde planlanan anatomik ölçümler yapıldı. İnsan immün yetmezlik virüsü taşıyan kişilerin yaşları, takip süreleri, vücut ağırlıkları, boyları, CD4 ve CD8 değerleri, kişilerin BT incelemeleri ile eş zamanlı olarak elde edildi. Anatomik ölçüm olarak adrenal bez şekilleri, uzunluğu, corpus kalınlığı, medial kalınlığı, lateral kalınlığı, komşu anatomik yapılara (özefagus, columna vertebralis, vena cava inferior, aorta abdominalis ve diyafragma) uzaklığı değerlendirildi.
Bulgular: Çalışmamıza, yaş ortalaması 40,29±13,19 (erkek: 39,78±12,50, kadın: 42,53±15,88) olan, vücut ağırlığı ve boy uzunluğu sırasıyla kadınlarda, 67,04±18,10 kg ve 157,92±6,21 cm, erkeklerde ise 77.06±12.93 kg ve 171.67±8.97 cm olan HIV enfeksiyonu ile yaşayan kişiler dahil edildi. Anatomik ölçüm olarak adrenal bezin uzunluğu, corpus kalınlığı, medial crus kalınlığı, lateral crus kalınlığı, ösefagus’a, columna vertebralis’e, vena cava inferior’a, aorta abdominalis’e ve diyafragma’ya uzaklığı sırasıyla sağda; 4.77±1.70 cm, 3.59±1.23 mm, 2.76±0.83 mm, 2.79±0.87 mm, 3.21±1.21 cm, 1.45±0.85 cm, 0.92±0.57 cm, 2.41±0.65 cm, 1.57±0.84 cm ve solda; 5.78±2.8 cm, 3.77±1.43 mm, 3.38±1.17 mm, 2.92±1.06 mm, 3.10±1.26 cm, 2.11±0.7 cm, 4.10±0.83 cm, 0.90±0.45 cm, 1.21±0.73 cm olarak bulundu. En yaygın görülen adrenal bez tipi ise Y olarak kaydedildi. Ayrıca CD4 ve CD8 ortalama değerlerini sırasıyla 322,66±309,35 ve 1024,48 ±930,15 olarak bulundu.
Sonuç: HIV’le yaşayan kişilerin adrenal bezine ait bazı anatomik ölçümlerin yaş, cinsiyet, vücut ağırlığı, hayatta kalım durumu ve CD4/CD8 parametrelerinden etkilenebildiğini bulduk.

Etik Beyan

Ethical approval were obtained from Cukurova University Medical Faculty, Non-invasive clinical research Ethic Board with conclusion number 115/17.

Destekleyen Kurum

none

Teşekkür

none

Kaynakça

  • Sun N, Wu Y, Nanba K, Sbiera S, Kircher S, Kunzke T et al. High-resolution tissue mass spectrometry imaging reveals a refined functional anatomy of the human adult adrenal gland. Endocrinology. 2018;159:1511-24.
  • e Matos VS, do Nascimento ALR, Pereira PG, Rabelo K, Andrade CBV, Moraes ACN et al. Aliskiren reduces the adrenal zona glomerulosa apoptosis and autophagy in wistar rats with 2k1c hypertension. Int J Hypertens. 2020;2020:7684849.
  • Nassoro DD, Mkhoi ML, Sabi I Meremo AJ, Lawala PS, Mwakyula IH. Adrenal insufficiency: a forgotten diagnosis in hiv/aids patients in developing countries. Int J Endocrinol. 2019;2019:2342857.
  • Sharma N, Sharma LK, Anand A, Gadpayle AK, Gaurav K, Mukherjee S et al. Presence, patterns & predictors of hypocortisolism in patients with hiv infection in India. Indian J Med Res. 2018;147:142-150.
  • Naggirinya AB, Mujugira A, Meya DB, Biraro IA, Mupere E, Worodria W et al. Functional adrenal insufficiency among tuberculosis-human immunodeficiency virus co-infected patients: a cross-sectional study in Uganda. BMC Res Notes. 2020;13:224.
  • Marik PE, Kiminyo K, Zaloga GP. Adrenal insufficiency in critically ill patients with human immunodeficiency virus. Crit Care Med. 2002;30:1267–73.
  • Gurun E, Kaya M, Gurun KH. Evaluation of normal adrenal gland volume and morphometry and relationship with waist circumference in an adult population using multidetector computed tomography. Sisli Etfal Hastan Tip Bul. 2021;55:333-8.
  • Serrano-Villar S, Deeks SG. Cd4/cd8 ratio: an emerging biomarker for hiv. Lancet HIV. 2015;2:e76-7.
  • Zaid D, Greenman Y. Human immunodeficiency virus infection and the endocrine system. Endocrinol Metab (Seoul). 2019;34:95-105.
  • Rubin LH, Langenecker SA, Phan KL, Keating SM, Neigh GN, Weber KM et al. Remitted depression and cognition in hiv: the role of cortisol and inflammation. Psychoneuroendocrinology. 2020;114:104609.
  • Mifsud S, Gauci Z, Gruppetta M, Mallia Azzopardi C, Fava S. Adrenal insufficiency in hiv/aids: a review. Expert Rev Endocrinol Metab. 2021;16:351-62.
  • Akin D, Yilmaz MT, Ozbek O, Özbiner H, Çiçekcibaşı AE, Büyükmumcu M et al. Morphometric analysis of suprarenal glands (adrenal glands) with multislice computerized tomography. Int J Morphol. 2017;35:120–7.
  • Ma G, Liu SW, Zhao ZM, Lin XT, Lou L, Li ZP et al. Sectional anatomy of the adrenal gland in the coronal plane. Surg Radiol Anat. 2008;30:271-80.
  • John R, Putta T, Simon B, Eapen A, Jebasingh F, Thomas N et al. Normal adrenal gland thickness on computerized tomography in an Asian Indian adult population. Indian J Radiol Imaging. 2018;28:465-9.
  • Devakar S, Neelopant SA. Assessment of normal adrenal gland thickness on computerized tomography in a tertiary care hospital of Karnataka, India. European Journal of Molecular & Clinical Medicine. 2021;8:2666-71.
  • Gezer Y, Altunisik Toplu S, Yuksel M, Köse A, Memisoğlu F, Özden M et al. Evaluation of cd4/cd8 ratio in treatment follow-up of patients with hiv diagnois in an infection clinic. Annals of Medical Research. 2022;29:743-7.
  • Lu W, Mehraj V, Vyboh K, Cao W, Li T, Routy JP. Cd4:cd8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed hiv-positive patients. J Int AIDS Soc. 2015;18:20052

Morphometric analysis of adrenal gland in people living with human immunodeficiency virus

Yıl 2024, Cilt: 49 Sayı: 1, 159 - 169, 29.03.2024
https://doi.org/10.17826/cumj.1391874

Öz

Purpose: We aimed to evaluate the effect of Human Immunodeficiency Virus (HIV) infection on adrenal gland morphometry according to age, gender, body weight, survival status and CD4/CD8 parameters.
Materials and Methods: In this study, the CT archives (130 men and 30 women) of 160 people living with HIV infection who had imaging for any reason between 2008 and 2020 were scanned. Ages, years of follow-up, body weights, heights, CD4 and CD8 values of people with human immunodeficiency virus were obtained simultaneously with the CT examinations of the people. Anatomical measurements, adrenal gland shapes, length, corpus thickness, medial thickness, lateral thickness, distance to next anatomical structures (esophagus, vertebral column, vena cava inferior, aorta abdominalis and diaphragm) were evaluated.
Results: In our study, the average age was 40.29±13.19 (male: 39.78±12.50, female: 42.53±15.88), body weight and height were respectively 67.04±18.10 kg 157.92±6.21 cm in women and 77.06±12.93 kg, 171.67±8.97 cm in men, living with HIV infection were included. As anatomical measurements, the length, corpus thickness, medial crus thickness, lateral crus thickness, distance to the esophagus, columna vertebralis, vena cava inferior, aorta abdominalis and diaphragm of the adrenal gland were found respectively on the right; 4.77±1.70 cm, 3.59±1.23 mm, 2.76±0.83 mm, 2.79±0.87 mm, 3.21±1.21 cm, 1.45±0.85 cm, 0.92±0.57 cm, 2.41±0.65 cm, 1.57±0.84 cm and on the left; 5.78±2.8 cm, 3.77±1.43 mm, 3.38±1.17 mm, 2.92±1.06 mm, 3.10±1.26 cm, 2.11±0.7 cm, 4.10±0.83 cm, 0.90±0.45 cm, 1.21±0.73 cm. The most common adrenal gland type was recorded as Y. Additionally, the mean values of CD4 and CD8 were found to be 322.66±309.35 and 1024.48±930.15, respectively.
Conclusion: Some anatomical measurements of the adrenal gland of people living with HIV can be affected by age, gender, body weight, survival status and CD4/CD8 parameters.

Kaynakça

  • Sun N, Wu Y, Nanba K, Sbiera S, Kircher S, Kunzke T et al. High-resolution tissue mass spectrometry imaging reveals a refined functional anatomy of the human adult adrenal gland. Endocrinology. 2018;159:1511-24.
  • e Matos VS, do Nascimento ALR, Pereira PG, Rabelo K, Andrade CBV, Moraes ACN et al. Aliskiren reduces the adrenal zona glomerulosa apoptosis and autophagy in wistar rats with 2k1c hypertension. Int J Hypertens. 2020;2020:7684849.
  • Nassoro DD, Mkhoi ML, Sabi I Meremo AJ, Lawala PS, Mwakyula IH. Adrenal insufficiency: a forgotten diagnosis in hiv/aids patients in developing countries. Int J Endocrinol. 2019;2019:2342857.
  • Sharma N, Sharma LK, Anand A, Gadpayle AK, Gaurav K, Mukherjee S et al. Presence, patterns & predictors of hypocortisolism in patients with hiv infection in India. Indian J Med Res. 2018;147:142-150.
  • Naggirinya AB, Mujugira A, Meya DB, Biraro IA, Mupere E, Worodria W et al. Functional adrenal insufficiency among tuberculosis-human immunodeficiency virus co-infected patients: a cross-sectional study in Uganda. BMC Res Notes. 2020;13:224.
  • Marik PE, Kiminyo K, Zaloga GP. Adrenal insufficiency in critically ill patients with human immunodeficiency virus. Crit Care Med. 2002;30:1267–73.
  • Gurun E, Kaya M, Gurun KH. Evaluation of normal adrenal gland volume and morphometry and relationship with waist circumference in an adult population using multidetector computed tomography. Sisli Etfal Hastan Tip Bul. 2021;55:333-8.
  • Serrano-Villar S, Deeks SG. Cd4/cd8 ratio: an emerging biomarker for hiv. Lancet HIV. 2015;2:e76-7.
  • Zaid D, Greenman Y. Human immunodeficiency virus infection and the endocrine system. Endocrinol Metab (Seoul). 2019;34:95-105.
  • Rubin LH, Langenecker SA, Phan KL, Keating SM, Neigh GN, Weber KM et al. Remitted depression and cognition in hiv: the role of cortisol and inflammation. Psychoneuroendocrinology. 2020;114:104609.
  • Mifsud S, Gauci Z, Gruppetta M, Mallia Azzopardi C, Fava S. Adrenal insufficiency in hiv/aids: a review. Expert Rev Endocrinol Metab. 2021;16:351-62.
  • Akin D, Yilmaz MT, Ozbek O, Özbiner H, Çiçekcibaşı AE, Büyükmumcu M et al. Morphometric analysis of suprarenal glands (adrenal glands) with multislice computerized tomography. Int J Morphol. 2017;35:120–7.
  • Ma G, Liu SW, Zhao ZM, Lin XT, Lou L, Li ZP et al. Sectional anatomy of the adrenal gland in the coronal plane. Surg Radiol Anat. 2008;30:271-80.
  • John R, Putta T, Simon B, Eapen A, Jebasingh F, Thomas N et al. Normal adrenal gland thickness on computerized tomography in an Asian Indian adult population. Indian J Radiol Imaging. 2018;28:465-9.
  • Devakar S, Neelopant SA. Assessment of normal adrenal gland thickness on computerized tomography in a tertiary care hospital of Karnataka, India. European Journal of Molecular & Clinical Medicine. 2021;8:2666-71.
  • Gezer Y, Altunisik Toplu S, Yuksel M, Köse A, Memisoğlu F, Özden M et al. Evaluation of cd4/cd8 ratio in treatment follow-up of patients with hiv diagnois in an infection clinic. Annals of Medical Research. 2022;29:743-7.
  • Lu W, Mehraj V, Vyboh K, Cao W, Li T, Routy JP. Cd4:cd8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed hiv-positive patients. J Int AIDS Soc. 2015;18:20052
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Bulaşıcı Hastalıklar, Radyoloji ve Organ Görüntüleme, Klinik Tıp Bilimleri (Diğer)
Bölüm Araştırma
Yazarlar

Ayşe Gül Kabakcı 0000-0001-7144-8759

Ferit Kuşcu 0000-0001-5662-8305

Ferhat Can Pişkin 0000-0003-4092-1077

Yeşim Taşova 0000-0002-5728-058X

Memduha Gülhal Bozkır 0000-0003-4164-4227

Yayımlanma Tarihi 29 Mart 2024
Gönderilme Tarihi 17 Kasım 2023
Kabul Tarihi 12 Mart 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 49 Sayı: 1

Kaynak Göster

MLA Kabakcı, Ayşe Gül vd. “Morphometric Analysis of Adrenal Gland in People Living With Human Immunodeficiency Virus”. Cukurova Medical Journal, c. 49, sy. 1, 2024, ss. 159-6, doi:10.17826/cumj.1391874.