BibTex RIS Kaynak Göster

Comparison of the effects of antiglaucomatous fixed combinations and patients compliance: Dorzolamide-timolol maleate and latanoprost-timolol maleate

Yıl 2012, Cilt: 39 Sayı: 1, 61 - 69, 01.03.2012
https://doi.org/10.5798/diclemedj.0921.2012.01.0096

Öz

Objectives: We aimed to compare the effects of fixed combinations of dorzolamide/timolol maleate (DTFC) and la-tanoprost/timolol maleate (LTFC) at primary open angle glaucoma patients and assess the patient compliance to treatment. Materials and Methods: Forty-four eyes of 24 patients taking LTFC, 35 eyes of 24 patients taking DTFC and totally 79 eyes of 48 patients were included in this study. Patients were followed for 6 months. At 3rd month, diurnal in-traocular pressure (IOP) fluctuations were assessed. Perimetry and retinal nerve fiber layer (RNFL) analyze were repeated at 6th month. Results: Both medicines had efficiently controlled the IOP and diurnal fluctuations and statistically no significant dif-ference was observed (p>0.05). Perimetric and RNFL measurements were not different in both groups(p>0.05).When we have compared the results of baseline and 6th months, MD and sLV values decreased, RNFL in some cases in-creased on the other hand we have also observed a decrease in some cases(p0.05). Most of the patients did not forget to take their medicines (DTSK %54.2 and LTSK %66.7) and in following visits, compliance and adherence were improved in both groups. It is detected that duration of medi-cine use may affect the compliance (p=0.007). Conclusion: It is observed that two medicines controlled the IOP and diurnal fluctuations clinically efficient and effec-tively, had reasonable side effects and had high patient compliance to treatment.

Kaynakça

  • Zimmerman R, Sakıyalak D, Krupin T, Rosenberg LF. Pri- mary open-angle glaucoma. Yanoff M, Duker JS. Ophtal- mology, Second edition. St. Louis: Mosby, 2004:1482-7.
  • Leske MC, Heijl A, Hussein M, Bengtsson B, Hyman L, Ko- maroff E. Factors of glaucoma progression and the effect of treatment: the early manifest glaucoma trial. Arch Ophthal- mol 2003; 121(1): 48-56.
  • Kass MA, Heuer DK, Higginbotham EJ, et al. The Ocular Hypertension Treatment Study: A randomized trial deter- mines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol 2002;120(6):701-13.
  • Collobaborative Normal-Tension Glaucoma Study Group: The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Am J Ophthalmol 1998;126(4):498-505.
  • Patel SC, Spaeth GL. Compliance in patients prescribed eye- drops for glaucoma. Ophthalmic Surg 1995;26(3):233-6.
  • Miyake K, Ota I, Icbaraki N, et al. Enhanced disruption of the blood-aqueus barrier and the incidence of angiographic cystoid macular edema by topical timolol and its preserva- tive in early postoperative pseudophakia. Arch Ophthalmol 2001;119(3):387-94.
  • European Glaucoma Society. Terminology and guidelines for glaucoma, 3nd Edition. Savona: 2008:119.
  • Orhan M. Hümör aköz dinamiği. Turaçlı ME, Önol M, Yalvaç SI. Glokom. Ankara: SFN, 2003;4-10.
  • Turaçlı ME. Tıbbi tedavi. Turaçlı ME, Önol M, Yalvaç SI. Glokom. Ankara: SFN, 2003;162-96.
  • Kurtulmuşoğlu MÖ, Önol M. Glokom Tedavisinde Fiks Kombinasyonlar. Glokom-Katarakt 2007;2(3):149-56.
  • Bayer A. Kombine tıbbi tedavi. Glokom. Türk Oftalmoloji Derneği eğitim yayınları no 9: Epsilon, 2009;379-87.
  • Shin DH, Feldman RM, Sheu WP. Fixed Combination Latanoprost/Timolol Study Group: Efficacy and safety of the fixed combinations latanoprost/yimolol versus dorzol- amide/timolol in patients with elevated intraocular pres- sure. Ophthalmology 2004;111(2):276-82.
  • Konstas AGP, Kozobolis VP, Lallos N, Christodoulakis E, Stewart JA, Stewart WC. Daytime diurnal curve compari- son between the fixed combinations of latanoprost 0.005 % / timolol maleate 0.5 % and dorzolamide 2 % / timolol maleate 0.5 %. Eye 2004;18:1264-9.
  • Siesky B, Harris A, Sines D, et al. A comparative analysis of the effects of the fixed combination of timolol and dorzol- amide versus latanoprost plus timolol on ocular hemody- namics and visual function in patients with primary open- angle glaucoma. J Ocul Pharmacol Ther 2006;22(5):353- 61.
  • Cvenkel B, Stewart JA, Nelson LA, Stewart WC. Dorzol- amide/timolol fixed combination versus latanoprost/timo- lol fixed combination in patients with primary open-angle glaucoma or ocular hypertension. Current Eye Research 2008;33(2):163-8.
  • Feldman RM. A comparison of fixed combination of latano- prost and timolol with fixed combination of dorzolamide and timolol in patients with elevated intraocular pressure. Invest Ophthalmol Vis Sci 2002;43:E-Abstract 295.
  • VanVeldhuisen PC, Ederer F, Gaasterland DE, , et al. The advanced glaucoma intervention study (AGIS): 7. The rela- tionship between control of intraocular pressure and visual field deterioration. American J Ophthalmol 2000;130:429- 40.
  • Williams ZY, Schuman JS, Gamell L, et al. Optical coher- ence tomography measurement of nerve fiber layer thick- ness and the likelihood of a visual field defect. Am J Oph- thalmol 2002;134(4):538-46.
  • Üstündağ C. Glokomlu gözlerde optik koherens tomografi ile saptanan retina sinir lifi kalınlıklarının görme alanı in- deksleri ile korelasyonu. T Oft Gaz 2001;31:600-4.
  • Nordstrom BL , Friedman DS, Mozaffari E, Quigley HA, Walker AM. Persistence and adherence with topical glau- coma therapy. Am J Ophthalmol 2005;140:598-606.
  • Eren MH, Altan Ç, Akagündüz U, Bayraktar Ş, Yılmaz ÖF. Glokomun medikal tedavisinde hasta uyumu. Glokom-Ka- tarakt 2008;3(3):158-64.

Comparison of the effects of antiglaucomatous fixed combinations and patients compliance: Dorzolamide-timolol maleate and latanoprost-timolol maleate

Yıl 2012, Cilt: 39 Sayı: 1, 61 - 69, 01.03.2012
https://doi.org/10.5798/diclemedj.0921.2012.01.0096

Öz

Amaç: Primer açık açılı glokomu olan hastalarda, dorzolamid-timolol maleat (DTSK) ve latanoprost-timolol maleat (LTSK) sabit kombinasyonlarının etkilerini karşılaştırmayı ve tedaviye hasta uyumunu değerlendirmeyi amaçladık. Gereç ve yöntem: LTSK kullanan 24 hastanın 44 gözü, DTSK kullanan 24 hastanın 35 gözü olmak üzere toplam 48 hastanın 79 gözü çalışma kapsamına alındı. Hastalar 6 ay takip edildi. Üçüncü ayda gün içi göz içi basıncı (GİB) dal-galanmalarına bakıldı. Görme alanı ve retina sinir lifi tabakası (RSLT) analizi 6.ayda tekrarlandı. Bulgular: Her iki ilacın da GİB\'nı ve gün içi dalgalanmalarını etkin bir şekilde kontrol ettiği ve aralarında istatistiksel olarak anlamlı bir fark bulunmadığı gözlendi(p>0.05). Görme alanı ve RSLT ölçümlerinde iki grup arasında istatistik-sel olarak anlamlı bir fark yoktu(p>0.05). Başlangıç ve altıncı ay karşılaştırıldığında, MD ve sLV değerlerinde azalma, RSLT ölçümlerinde ise azalma ve artma yönünde değişiklikler istatistiksel olarak anlamlı bulundu(p0.05). Her iki grupta da başlangıçta hastaların çoğu ilaç alımını unutmadı(DTSK %54.2 ve LTSK %66.7). Ta-kip eden kontrollerde, iki grupta da kompliyans ve adherens arttı. İlaç kullanım süresinin kompliyansı etkileyebildiği bulundu (p=0.007). Sonuç: Her iki ilacın da, GİB\'nı ve gün içi dalgalanmalarını etkin ve klinik olarak yeterli bir şekilde kontrol edebildiği, tolere edilebilir yan etkilere sahip oldukları ve hastaların tedavi uyumlarının yüksek olduğu görüldü.

Kaynakça

  • Zimmerman R, Sakıyalak D, Krupin T, Rosenberg LF. Pri- mary open-angle glaucoma. Yanoff M, Duker JS. Ophtal- mology, Second edition. St. Louis: Mosby, 2004:1482-7.
  • Leske MC, Heijl A, Hussein M, Bengtsson B, Hyman L, Ko- maroff E. Factors of glaucoma progression and the effect of treatment: the early manifest glaucoma trial. Arch Ophthal- mol 2003; 121(1): 48-56.
  • Kass MA, Heuer DK, Higginbotham EJ, et al. The Ocular Hypertension Treatment Study: A randomized trial deter- mines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol 2002;120(6):701-13.
  • Collobaborative Normal-Tension Glaucoma Study Group: The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Am J Ophthalmol 1998;126(4):498-505.
  • Patel SC, Spaeth GL. Compliance in patients prescribed eye- drops for glaucoma. Ophthalmic Surg 1995;26(3):233-6.
  • Miyake K, Ota I, Icbaraki N, et al. Enhanced disruption of the blood-aqueus barrier and the incidence of angiographic cystoid macular edema by topical timolol and its preserva- tive in early postoperative pseudophakia. Arch Ophthalmol 2001;119(3):387-94.
  • European Glaucoma Society. Terminology and guidelines for glaucoma, 3nd Edition. Savona: 2008:119.
  • Orhan M. Hümör aköz dinamiği. Turaçlı ME, Önol M, Yalvaç SI. Glokom. Ankara: SFN, 2003;4-10.
  • Turaçlı ME. Tıbbi tedavi. Turaçlı ME, Önol M, Yalvaç SI. Glokom. Ankara: SFN, 2003;162-96.
  • Kurtulmuşoğlu MÖ, Önol M. Glokom Tedavisinde Fiks Kombinasyonlar. Glokom-Katarakt 2007;2(3):149-56.
  • Bayer A. Kombine tıbbi tedavi. Glokom. Türk Oftalmoloji Derneği eğitim yayınları no 9: Epsilon, 2009;379-87.
  • Shin DH, Feldman RM, Sheu WP. Fixed Combination Latanoprost/Timolol Study Group: Efficacy and safety of the fixed combinations latanoprost/yimolol versus dorzol- amide/timolol in patients with elevated intraocular pres- sure. Ophthalmology 2004;111(2):276-82.
  • Konstas AGP, Kozobolis VP, Lallos N, Christodoulakis E, Stewart JA, Stewart WC. Daytime diurnal curve compari- son between the fixed combinations of latanoprost 0.005 % / timolol maleate 0.5 % and dorzolamide 2 % / timolol maleate 0.5 %. Eye 2004;18:1264-9.
  • Siesky B, Harris A, Sines D, et al. A comparative analysis of the effects of the fixed combination of timolol and dorzol- amide versus latanoprost plus timolol on ocular hemody- namics and visual function in patients with primary open- angle glaucoma. J Ocul Pharmacol Ther 2006;22(5):353- 61.
  • Cvenkel B, Stewart JA, Nelson LA, Stewart WC. Dorzol- amide/timolol fixed combination versus latanoprost/timo- lol fixed combination in patients with primary open-angle glaucoma or ocular hypertension. Current Eye Research 2008;33(2):163-8.
  • Feldman RM. A comparison of fixed combination of latano- prost and timolol with fixed combination of dorzolamide and timolol in patients with elevated intraocular pressure. Invest Ophthalmol Vis Sci 2002;43:E-Abstract 295.
  • VanVeldhuisen PC, Ederer F, Gaasterland DE, , et al. The advanced glaucoma intervention study (AGIS): 7. The rela- tionship between control of intraocular pressure and visual field deterioration. American J Ophthalmol 2000;130:429- 40.
  • Williams ZY, Schuman JS, Gamell L, et al. Optical coher- ence tomography measurement of nerve fiber layer thick- ness and the likelihood of a visual field defect. Am J Oph- thalmol 2002;134(4):538-46.
  • Üstündağ C. Glokomlu gözlerde optik koherens tomografi ile saptanan retina sinir lifi kalınlıklarının görme alanı in- deksleri ile korelasyonu. T Oft Gaz 2001;31:600-4.
  • Nordstrom BL , Friedman DS, Mozaffari E, Quigley HA, Walker AM. Persistence and adherence with topical glau- coma therapy. Am J Ophthalmol 2005;140:598-606.
  • Eren MH, Altan Ç, Akagündüz U, Bayraktar Ş, Yılmaz ÖF. Glokomun medikal tedavisinde hasta uyumu. Glokom-Ka- tarakt 2008;3(3):158-64.
Toplam 21 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Araştırma Yazıları
Yazarlar

İrfan Uzun

Kubilay Çetinkaya Bu kişi benim

Yayımlanma Tarihi 1 Mart 2012
Gönderilme Tarihi 2 Mart 2015
Yayımlandığı Sayı Yıl 2012 Cilt: 39 Sayı: 1

Kaynak Göster

APA Uzun, İ., & Çetinkaya, K. (2012). Comparison of the effects of antiglaucomatous fixed combinations and patients compliance: Dorzolamide-timolol maleate and latanoprost-timolol maleate. Dicle Tıp Dergisi, 39(1), 61-69. https://doi.org/10.5798/diclemedj.0921.2012.01.0096
AMA Uzun İ, Çetinkaya K. Comparison of the effects of antiglaucomatous fixed combinations and patients compliance: Dorzolamide-timolol maleate and latanoprost-timolol maleate. diclemedj. Mart 2012;39(1):61-69. doi:10.5798/diclemedj.0921.2012.01.0096
Chicago Uzun, İrfan, ve Kubilay Çetinkaya. “Comparison of the Effects of Antiglaucomatous Fixed Combinations and Patients Compliance: Dorzolamide-Timolol Maleate and Latanoprost-Timolol Maleate”. Dicle Tıp Dergisi 39, sy. 1 (Mart 2012): 61-69. https://doi.org/10.5798/diclemedj.0921.2012.01.0096.
EndNote Uzun İ, Çetinkaya K (01 Mart 2012) Comparison of the effects of antiglaucomatous fixed combinations and patients compliance: Dorzolamide-timolol maleate and latanoprost-timolol maleate. Dicle Tıp Dergisi 39 1 61–69.
IEEE İ. Uzun ve K. Çetinkaya, “Comparison of the effects of antiglaucomatous fixed combinations and patients compliance: Dorzolamide-timolol maleate and latanoprost-timolol maleate”, diclemedj, c. 39, sy. 1, ss. 61–69, 2012, doi: 10.5798/diclemedj.0921.2012.01.0096.
ISNAD Uzun, İrfan - Çetinkaya, Kubilay. “Comparison of the Effects of Antiglaucomatous Fixed Combinations and Patients Compliance: Dorzolamide-Timolol Maleate and Latanoprost-Timolol Maleate”. Dicle Tıp Dergisi 39/1 (Mart 2012), 61-69. https://doi.org/10.5798/diclemedj.0921.2012.01.0096.
JAMA Uzun İ, Çetinkaya K. Comparison of the effects of antiglaucomatous fixed combinations and patients compliance: Dorzolamide-timolol maleate and latanoprost-timolol maleate. diclemedj. 2012;39:61–69.
MLA Uzun, İrfan ve Kubilay Çetinkaya. “Comparison of the Effects of Antiglaucomatous Fixed Combinations and Patients Compliance: Dorzolamide-Timolol Maleate and Latanoprost-Timolol Maleate”. Dicle Tıp Dergisi, c. 39, sy. 1, 2012, ss. 61-69, doi:10.5798/diclemedj.0921.2012.01.0096.
Vancouver Uzun İ, Çetinkaya K. Comparison of the effects of antiglaucomatous fixed combinations and patients compliance: Dorzolamide-timolol maleate and latanoprost-timolol maleate. diclemedj. 2012;39(1):61-9.