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The Oral-Dental Findıngs of Patients Treated with Antineoplastic Treatments Targeting Non-Head and Neck Tumors in Childhood

Yıl 2024, Cilt: 2 Sayı: 1, 9 - 13, 30.04.2024
https://doi.org/10.62243/edr.1453190

Öz

Aim This study investigates oral complications in pediatric oncology patients undergoing antineoplastic treatments for non-head and neck tumors, with a focus on their impact on tooth development.
Material and method Twenty pediatric patients (aged 3 to 14) undergoing chemotherapy for non-head and neck tumors were examined clinically. Oral and perioral tissues were assessed, and specific complications were documented. Patient records were retrospectively reviewed to identify pre-existing oral issues.
Results The study revealed significant oral complications associated with antineoplastic treatments, including enamel defects (60%), gingivitis (60%), delayed apexification (55%), and mucositis (30%). Additional complications such as lymphadenopathy, delayed eruption, and herpes simplex infection were also observed.
Conclusion Antineoplastic treatments for non-head and neck tumors in pediatric patients can significantly affect tooth development, leading to various oral complications. Early detection and management of these complications are vital for treatment continuity and enhancing the quality of life for pediatric oncology patients.

Kaynakça

  • American Cancer Society. Cancer Facts & Figures 2024. Atlanta: American Cancer Society, 2024.
  • American Cancer Society. Cancer Facts & Figures 2020. Special Section: Cancer in Adolescents and Young Adults. American Cancer Society. Atlanta, Ga. 2020.
  • Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023; 73(1): 17-48. DOI:10.3322/caac.21763
  • Samim, F., Epstein, J.B., Zumsteg, Z.S. et al. Oral and dental health in head and neck cancer survivors. Cancers Head Neck 1, 14 (2016). DOI:10.1186/s41199-016-0015-8
  • Lopes, Geovana & Mazza, Grazieli & Nogueira, Carolina & Kassis, Elias. (2022). Major considerations of the dentist in the diagnosis and treatment of oral cancer in hospitals: a systematic review. MedNEXT Journal of Medical and Health Sciences. 3. DOI:10.54448/mdnt22S303.
  • PDQ® Supportive and Palliative Care Editorial Board. PDQ Oral Complications of Chemotherapy and Head/Neck Radiation. Bethesda, MD: National Cancer Institute. Available at: https://www.cancer.gov/about-cancer/treatment/side-effects/mouth-throat/oral-complications-hp-pdq. Accessed <03/09/2024>. [PMID: 26389320]
  • Ritwik, P., Chrisentery-Singleton, T.E. Oral and dental considerations in pediatric cancers. Cancer Metastasis Rev 39, 43–53 (2020). DOI:10.1007/s10555-020-09842-5
  • Eugenia Garza-Avilés, Juan Eduardo Arizpe Coronado, Jorge Arturo Gutierrez Longoria, Rosendo Carrasco Gutierrez, Gabriel Muñoz Quintana, Sergio Eduardo Nakagoshi Cepeda, Juan Manuel Solis-Soto. Dental management of the childhood cancer patient. Int J Appl Dent Sci 2021;7(3):44-47. DOI:10.22271/oral.2021.v7.i3a.1280
  • Sasada INV, Gregianin LJ, Munerato MC (2016) Oral health and stomatological complications in pediatric cancer patients. Oral Health Care 1: DOI:10.15761/OHC.1000102.
  • Alves AS, Kizi G, Barata AR, Mascarenhas P, Ventura I. Oral Complications of Chemotherapy on Paediatric Patients with Cancer: A Systematic Review and Meta-Analysis. Medical Sciences Forum. 2021; 5(1):25. https://doi.org/10.3390/msf2021005025
  • Fayle SA, Curzon ME. Oral complications in pediatric oncology patients. Pediatr Dent. 1991;13(5):289-295.
  • Eugenia Garza-Avilés, Juan Eduardo Arizpe Coronado, Jorge Arturo Gutierrez Longoria, Rosendo Carrasco Gutierrez, Gabriel Muñoz Quintana, Sergio Eduardo Nakagoshi Cepeda, Juan Manuel Solis-Soto. Dental management of the childhood cancer patient. Int J Appl Dent Sci 2021;7(3):44-47. doi: https://doi.org/10.22271/oral.2021.v7.i3a.1280
  • Abuhamed, J., Nikkilä, A., Raitanen, J. et al. Incidence trends of childhood central nervous system tumors in Finland 1990–2017. BMC Cancer 22, 784 (2022). https://doi.org/10.1186/s12885-022-09862-0
  • https://www.cdc.gov/injury/features/child-injury/index.html
  • https://www.cancersociety.fi/publications/reports/cancer-in-finland-2016/cancer-in-children-and-adolescents/
  • Yue Y, Li F, Li Y, Wang Y, Guo X, Cheng Z, Li N, Ma X, Nie G, Zhao X. Biomimetic Nanoparticles Carrying a Repolarization Agent of Tumor-Associated Macrophages for Remodeling of the Inflammatory Microenvironment Following Photothermal Therapy. ACS Nano. 2021 Sep 28;15(9):15166-15179. doi: 10.1021/acsnano.1c05618. Epub 2021 Sep 1. PMID: 34469109.
  • Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skâlhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, Jahnsen T, Taskén K. Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95. Exp Cell Res. 1998 Feb 1;238(2):305-16. doi: 10.1006/excr.1997.3855. PMID: 9473338.
  • Chen X, Müller GA, Quaas M, Fischer M, Han N, Stutchbury B, Sharrocks AD, Engeland K. The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism. Mol Cell Biol. 2013 Jan;33(2):227-36. doi: 10.1128/MCB.00881-12. Epub 2012 Oct 29. PMID: 23109430; PMCID: PMC3554121.
  • Alnaim L. Therapeutic drug monitoring of cancer chemotherapy. J Oncol Pharm Pract. 2007 Dec;13(4):207-21. doi: 10.1177/1078155207081133. PMID: 18045780.
  • Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. 2011 Jul 13;475(7355):231-4. doi: 10.1038/nature10167. Retraction in: Nature. 2018 Sep;561(7723):420. Erratum in: Nature. 2012 Jan 26;481(7382):534. Erratum in: Nature. 2015 Oct 22;526(7574):596. PMID: 21753854; PMCID: PMC3316487.
  • Bozzetti F. Forcing the vicious circle: sarcopenia increases toxicity, decreases response to chemotherapy and worsens with chemotherapy. Ann Oncol. 2017 Sep 1;28(9):2107-2118. doi: 10.1093/annonc/mdx271. PMID: 28911059.
  • Jirschitzka J, Schmidt GW, Reichelt M, Schneider B, Gershenzon J, D’Auria JC. Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10304-9. doi: 10.1073/pnas.1200473109. Epub 2012 Jun 4. PMID: 22665766; PMCID: PMC3387132.
  • Nelson RL. The comparative clinical pharmacology and pharmacokinetics of vindesine, vincristine, and vinblastine in human patients with cancer. Med Pediatr Oncol. 1982;10(2):115-27. doi: 10.1002/mpo.2950100202. PMID: 7070351.
  • Ludwig S, Sharma P, Wise P, Sposto R, Hollingshead D, Lamb J, Lang S, Fabbri M, Whiteside TL. mRNA and miRNA Profiles of Exosomes from Cultured Tumor Cells Reveal Biomarkers Specific for HPV16-Positive and HPV16-Negative Head and Neck Cancer. Int J Mol Sci. 2020 Nov 13;21(22):8570. doi: 10.3390/ijms21228570. PMID: 33202950; PMCID: PMC7698015.
  • Jiang N, Chen XC, Zhao Y. Analysis of the risk factors for myelosuppression after concurrent chemoradiotherapy for patients with advanced non-small cell lung cancer. Support Care Cancer. 2013 Mar;21(3):785-91. doi: 10.1007/s00520-012-1580-y. Epub 2012 Aug 31. PMID: 22936496.
  • John K, Becker K, Mattejat F. Brustkrebskranke Mütter und ihre Kinder: Erste Ergebnisse zur Effektivität der familienorientierten onkologischen Rehabilitationsmassnahme, gemeinsam gesund werden” [Mothers with breast cancer and their children: initial results regarding the effectiveness of the family oriented oncological rehabilitation program “gemeinsam gesund werden”]. Prax Kinderpsychol Kinderpsychiatr. 2010;59(5):333-58. German. doi: 10.13109/prkk.2010.59.5.333. PMID: 20545294.
  • Elshaer N. Adverse health effects among nurses and clinical pharmacists handling antineoplastic drugs: Adherence to exposure control methods. J Egypt Public Health Assoc. 2017 Sep 1;92(3):144-155. PMID: 30341993.
  • Ueno, T., Yatsuoka, W., Ishiki, H. et al. Effects of an oral mucosa protective formulation on chemotherapy- and/or radiotherapy-induced oral mucositis: a prospective study. BMC Cancer 22, 90 (2022). https://doi.org/10.1186/s12885-021-09107-6
  • Pulito, C., Cristaudo, A., Porta, C.L. et al. Oral mucositis: the hidden side of cancer therapy. J Exp Clin Cancer Res 39, 210 (2020). https://doi.org/10.1186/s13046-020-01715-7
  • Thomas Vanhoutte, Ben Sprangers, Pseudo-AKI associated with targeted anti-cancer agents—the truth is in the eye of the filtration marker, Clinical Kidney Journal, Volume 16, Issue 4, April 2023, Pages 603–610, https://doi.org/10.1093/ckj/sfad011
  • Larsen, A.K., Thomsen, C., Sanden, M. et al. Taste alterations and oral discomfort in patients receiving chemotherapy. Support Care Cancer 29, 7431–7439 (2021). https://doi.org/10.1007/s00520-021-06316-4
  • Obayashi, N., Sugita, M., Shintani, T. et al. Taste–taste associations in chemotherapy-induced subjective taste alterations: findings from a questionnaire survey in an outpatient clinic. Support Care Cancer 31, 552 (2023). https://doi.org/10.1007/s00520-023-08013-w
  • Sabancı, A., Karasu, B., Sabancı, H.I. et al. Impact of periodontal status on the oral mucositis in patients receiving high-dose chemotherapy. Clin Oral Invest 26, 6341–6346 (2022). https://doi.org/10.1007/s00784-022-04588-6
  • Timothy J. Brown et al., Management of Cancer Therapy–Associated Oral Mucositis. JCO Oncol Pract 16, 103-109(2020).
  • Hersh, N., Steiner, I., Siegal, T. et al. Herpes simplex encephalitis in patients receiving chemotherapy and whole-brain radiation therapy. J. Neurovirol. 27, 774–781 (2021). https://doi.org/10.1007/s13365-021-01018-3
  • Güneri, P., Epstein, J.B., Bolukbasi, G. et al. Neutropenic ulcers in oncology: terminology, diagnosis, and management. Support Care Cancer 31, 716 (2023). https://doi.org/10.1007/s00520-023-08187-3
  • Stoufi, E. Radiation and Chemotherapy-Induced Gingival Lesions. In: Periodontal Manifestations of Local and Systemic Diseases. Springer, Cham. 2023. https://doi.org/10.1007/978-3-031-10828-0_17
  • M Carrozzo, J Grau Eriksen, R -J Bensadoun, C B Boers-Doets, R V Lalla, D E Peterson, Oral Mucosal Injury Caused by Targeted Cancer Therapies, JNCI Monographs, Volume 2019, Issue 53, August 2019, lgz012, https://doi.org/10.1093/jncimonographs/lgz012
  • Weycker, D., Hatfield, M., Grossman, A. et al. Risk and consequences of chemotherapy-induced thrombocytopenia in US clinical practice. BMC Cancer 19, 151 (2019). https://doi.org/10.1186/s12885-019-5354-5
  • Soff, G.A., Ray-Coquard, I., Rivera, L.J.M., Fryzek, J., Mullins, M., Bylsma, L.C., et al. Systematic literature review and meta-analysis on use of Thrombopoietic agents for chemotherapy-induced thrombocytopenia. PLoS ONE 17(6): e0257673. (2022) https://doi.org/10.1371/journal.pone.0257673
  • Teixeira, A.B.V., Aguiar, H.C., Tardelli, J.D.C., Dos Reis, A.C. Prevention of Caries in Cancer Patients: A Systematic Review on the Effectiveness of Dental Materials. The European Journal of Prosthodontics and Restorative Dentistry. 2023 Aug;31(3):224-233. DOI: 10.1922/ejprd_2445teixeira10. PMID: 37067356.
  • Hong, C.H.L., Hu, S., Haverman, T. et al. A systematic review of dental disease management in cancer patients. Support Care Cancer 26, 155–174 (2018). https://doi.org/10.1007/s00520-017-3829-y
  • Pombo Lopes J, Rodrigues I, Machado V, Botelho J, Bandeira Lopes L. Chemotherapy and Radiotherapy Long-Term Adverse Effects on Oral Health of Childhood Cancer Survivors: A Systematic Review and Meta-Analysis. Cancers. 2024; 16(1):110. https://doi.org/10.3390/cancers16010110
  • Patni, T., Lee, CT., Li, Y. et al. Factors for poor oral health in long-term childhood cancer survivors. BMC Oral Health 23, 73 (2023). https://doi.org/10.1186/s12903-023-02762-0
  • Sabharwal, A., Stellrecht, E. & Scannapieco, F.A. Associations between dental caries and systemic diseases: a scoping review. BMC Oral Health 21, 472 (2021). https://doi.org/10.1186/s12903-021-01803-w
  • Nokhbatolfoghahaei, H., Paknejad, Z., Bohlouli, M., Rezai Rad, M., Khojasteh, A. (2020). Animal Models in Dental Research. In: Tayebi, L. (eds) Applications of Biomedical Engineering in Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-030-21583-5_18
  • Carlos Flores-Mir, Franco Raul Mauricio, Maria Fernanda Orellana, Paul William Major; Association between Growth Stunting with Dental Development and Skeletal Maturation Stage. Angle Orthod 1 November 2005; 75 (6): 935–940. doi: https://doi.org/10.1043/0003-3219(2005)75[935:ABGSWD]2.0.CO;2
Yıl 2024, Cilt: 2 Sayı: 1, 9 - 13, 30.04.2024
https://doi.org/10.62243/edr.1453190

Öz

Kaynakça

  • American Cancer Society. Cancer Facts & Figures 2024. Atlanta: American Cancer Society, 2024.
  • American Cancer Society. Cancer Facts & Figures 2020. Special Section: Cancer in Adolescents and Young Adults. American Cancer Society. Atlanta, Ga. 2020.
  • Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023; 73(1): 17-48. DOI:10.3322/caac.21763
  • Samim, F., Epstein, J.B., Zumsteg, Z.S. et al. Oral and dental health in head and neck cancer survivors. Cancers Head Neck 1, 14 (2016). DOI:10.1186/s41199-016-0015-8
  • Lopes, Geovana & Mazza, Grazieli & Nogueira, Carolina & Kassis, Elias. (2022). Major considerations of the dentist in the diagnosis and treatment of oral cancer in hospitals: a systematic review. MedNEXT Journal of Medical and Health Sciences. 3. DOI:10.54448/mdnt22S303.
  • PDQ® Supportive and Palliative Care Editorial Board. PDQ Oral Complications of Chemotherapy and Head/Neck Radiation. Bethesda, MD: National Cancer Institute. Available at: https://www.cancer.gov/about-cancer/treatment/side-effects/mouth-throat/oral-complications-hp-pdq. Accessed <03/09/2024>. [PMID: 26389320]
  • Ritwik, P., Chrisentery-Singleton, T.E. Oral and dental considerations in pediatric cancers. Cancer Metastasis Rev 39, 43–53 (2020). DOI:10.1007/s10555-020-09842-5
  • Eugenia Garza-Avilés, Juan Eduardo Arizpe Coronado, Jorge Arturo Gutierrez Longoria, Rosendo Carrasco Gutierrez, Gabriel Muñoz Quintana, Sergio Eduardo Nakagoshi Cepeda, Juan Manuel Solis-Soto. Dental management of the childhood cancer patient. Int J Appl Dent Sci 2021;7(3):44-47. DOI:10.22271/oral.2021.v7.i3a.1280
  • Sasada INV, Gregianin LJ, Munerato MC (2016) Oral health and stomatological complications in pediatric cancer patients. Oral Health Care 1: DOI:10.15761/OHC.1000102.
  • Alves AS, Kizi G, Barata AR, Mascarenhas P, Ventura I. Oral Complications of Chemotherapy on Paediatric Patients with Cancer: A Systematic Review and Meta-Analysis. Medical Sciences Forum. 2021; 5(1):25. https://doi.org/10.3390/msf2021005025
  • Fayle SA, Curzon ME. Oral complications in pediatric oncology patients. Pediatr Dent. 1991;13(5):289-295.
  • Eugenia Garza-Avilés, Juan Eduardo Arizpe Coronado, Jorge Arturo Gutierrez Longoria, Rosendo Carrasco Gutierrez, Gabriel Muñoz Quintana, Sergio Eduardo Nakagoshi Cepeda, Juan Manuel Solis-Soto. Dental management of the childhood cancer patient. Int J Appl Dent Sci 2021;7(3):44-47. doi: https://doi.org/10.22271/oral.2021.v7.i3a.1280
  • Abuhamed, J., Nikkilä, A., Raitanen, J. et al. Incidence trends of childhood central nervous system tumors in Finland 1990–2017. BMC Cancer 22, 784 (2022). https://doi.org/10.1186/s12885-022-09862-0
  • https://www.cdc.gov/injury/features/child-injury/index.html
  • https://www.cancersociety.fi/publications/reports/cancer-in-finland-2016/cancer-in-children-and-adolescents/
  • Yue Y, Li F, Li Y, Wang Y, Guo X, Cheng Z, Li N, Ma X, Nie G, Zhao X. Biomimetic Nanoparticles Carrying a Repolarization Agent of Tumor-Associated Macrophages for Remodeling of the Inflammatory Microenvironment Following Photothermal Therapy. ACS Nano. 2021 Sep 28;15(9):15166-15179. doi: 10.1021/acsnano.1c05618. Epub 2021 Sep 1. PMID: 34469109.
  • Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skâlhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, Jahnsen T, Taskén K. Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95. Exp Cell Res. 1998 Feb 1;238(2):305-16. doi: 10.1006/excr.1997.3855. PMID: 9473338.
  • Chen X, Müller GA, Quaas M, Fischer M, Han N, Stutchbury B, Sharrocks AD, Engeland K. The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism. Mol Cell Biol. 2013 Jan;33(2):227-36. doi: 10.1128/MCB.00881-12. Epub 2012 Oct 29. PMID: 23109430; PMCID: PMC3554121.
  • Alnaim L. Therapeutic drug monitoring of cancer chemotherapy. J Oncol Pharm Pract. 2007 Dec;13(4):207-21. doi: 10.1177/1078155207081133. PMID: 18045780.
  • Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. 2011 Jul 13;475(7355):231-4. doi: 10.1038/nature10167. Retraction in: Nature. 2018 Sep;561(7723):420. Erratum in: Nature. 2012 Jan 26;481(7382):534. Erratum in: Nature. 2015 Oct 22;526(7574):596. PMID: 21753854; PMCID: PMC3316487.
  • Bozzetti F. Forcing the vicious circle: sarcopenia increases toxicity, decreases response to chemotherapy and worsens with chemotherapy. Ann Oncol. 2017 Sep 1;28(9):2107-2118. doi: 10.1093/annonc/mdx271. PMID: 28911059.
  • Jirschitzka J, Schmidt GW, Reichelt M, Schneider B, Gershenzon J, D’Auria JC. Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10304-9. doi: 10.1073/pnas.1200473109. Epub 2012 Jun 4. PMID: 22665766; PMCID: PMC3387132.
  • Nelson RL. The comparative clinical pharmacology and pharmacokinetics of vindesine, vincristine, and vinblastine in human patients with cancer. Med Pediatr Oncol. 1982;10(2):115-27. doi: 10.1002/mpo.2950100202. PMID: 7070351.
  • Ludwig S, Sharma P, Wise P, Sposto R, Hollingshead D, Lamb J, Lang S, Fabbri M, Whiteside TL. mRNA and miRNA Profiles of Exosomes from Cultured Tumor Cells Reveal Biomarkers Specific for HPV16-Positive and HPV16-Negative Head and Neck Cancer. Int J Mol Sci. 2020 Nov 13;21(22):8570. doi: 10.3390/ijms21228570. PMID: 33202950; PMCID: PMC7698015.
  • Jiang N, Chen XC, Zhao Y. Analysis of the risk factors for myelosuppression after concurrent chemoradiotherapy for patients with advanced non-small cell lung cancer. Support Care Cancer. 2013 Mar;21(3):785-91. doi: 10.1007/s00520-012-1580-y. Epub 2012 Aug 31. PMID: 22936496.
  • John K, Becker K, Mattejat F. Brustkrebskranke Mütter und ihre Kinder: Erste Ergebnisse zur Effektivität der familienorientierten onkologischen Rehabilitationsmassnahme, gemeinsam gesund werden” [Mothers with breast cancer and their children: initial results regarding the effectiveness of the family oriented oncological rehabilitation program “gemeinsam gesund werden”]. Prax Kinderpsychol Kinderpsychiatr. 2010;59(5):333-58. German. doi: 10.13109/prkk.2010.59.5.333. PMID: 20545294.
  • Elshaer N. Adverse health effects among nurses and clinical pharmacists handling antineoplastic drugs: Adherence to exposure control methods. J Egypt Public Health Assoc. 2017 Sep 1;92(3):144-155. PMID: 30341993.
  • Ueno, T., Yatsuoka, W., Ishiki, H. et al. Effects of an oral mucosa protective formulation on chemotherapy- and/or radiotherapy-induced oral mucositis: a prospective study. BMC Cancer 22, 90 (2022). https://doi.org/10.1186/s12885-021-09107-6
  • Pulito, C., Cristaudo, A., Porta, C.L. et al. Oral mucositis: the hidden side of cancer therapy. J Exp Clin Cancer Res 39, 210 (2020). https://doi.org/10.1186/s13046-020-01715-7
  • Thomas Vanhoutte, Ben Sprangers, Pseudo-AKI associated with targeted anti-cancer agents—the truth is in the eye of the filtration marker, Clinical Kidney Journal, Volume 16, Issue 4, April 2023, Pages 603–610, https://doi.org/10.1093/ckj/sfad011
  • Larsen, A.K., Thomsen, C., Sanden, M. et al. Taste alterations and oral discomfort in patients receiving chemotherapy. Support Care Cancer 29, 7431–7439 (2021). https://doi.org/10.1007/s00520-021-06316-4
  • Obayashi, N., Sugita, M., Shintani, T. et al. Taste–taste associations in chemotherapy-induced subjective taste alterations: findings from a questionnaire survey in an outpatient clinic. Support Care Cancer 31, 552 (2023). https://doi.org/10.1007/s00520-023-08013-w
  • Sabancı, A., Karasu, B., Sabancı, H.I. et al. Impact of periodontal status on the oral mucositis in patients receiving high-dose chemotherapy. Clin Oral Invest 26, 6341–6346 (2022). https://doi.org/10.1007/s00784-022-04588-6
  • Timothy J. Brown et al., Management of Cancer Therapy–Associated Oral Mucositis. JCO Oncol Pract 16, 103-109(2020).
  • Hersh, N., Steiner, I., Siegal, T. et al. Herpes simplex encephalitis in patients receiving chemotherapy and whole-brain radiation therapy. J. Neurovirol. 27, 774–781 (2021). https://doi.org/10.1007/s13365-021-01018-3
  • Güneri, P., Epstein, J.B., Bolukbasi, G. et al. Neutropenic ulcers in oncology: terminology, diagnosis, and management. Support Care Cancer 31, 716 (2023). https://doi.org/10.1007/s00520-023-08187-3
  • Stoufi, E. Radiation and Chemotherapy-Induced Gingival Lesions. In: Periodontal Manifestations of Local and Systemic Diseases. Springer, Cham. 2023. https://doi.org/10.1007/978-3-031-10828-0_17
  • M Carrozzo, J Grau Eriksen, R -J Bensadoun, C B Boers-Doets, R V Lalla, D E Peterson, Oral Mucosal Injury Caused by Targeted Cancer Therapies, JNCI Monographs, Volume 2019, Issue 53, August 2019, lgz012, https://doi.org/10.1093/jncimonographs/lgz012
  • Weycker, D., Hatfield, M., Grossman, A. et al. Risk and consequences of chemotherapy-induced thrombocytopenia in US clinical practice. BMC Cancer 19, 151 (2019). https://doi.org/10.1186/s12885-019-5354-5
  • Soff, G.A., Ray-Coquard, I., Rivera, L.J.M., Fryzek, J., Mullins, M., Bylsma, L.C., et al. Systematic literature review and meta-analysis on use of Thrombopoietic agents for chemotherapy-induced thrombocytopenia. PLoS ONE 17(6): e0257673. (2022) https://doi.org/10.1371/journal.pone.0257673
  • Teixeira, A.B.V., Aguiar, H.C., Tardelli, J.D.C., Dos Reis, A.C. Prevention of Caries in Cancer Patients: A Systematic Review on the Effectiveness of Dental Materials. The European Journal of Prosthodontics and Restorative Dentistry. 2023 Aug;31(3):224-233. DOI: 10.1922/ejprd_2445teixeira10. PMID: 37067356.
  • Hong, C.H.L., Hu, S., Haverman, T. et al. A systematic review of dental disease management in cancer patients. Support Care Cancer 26, 155–174 (2018). https://doi.org/10.1007/s00520-017-3829-y
  • Pombo Lopes J, Rodrigues I, Machado V, Botelho J, Bandeira Lopes L. Chemotherapy and Radiotherapy Long-Term Adverse Effects on Oral Health of Childhood Cancer Survivors: A Systematic Review and Meta-Analysis. Cancers. 2024; 16(1):110. https://doi.org/10.3390/cancers16010110
  • Patni, T., Lee, CT., Li, Y. et al. Factors for poor oral health in long-term childhood cancer survivors. BMC Oral Health 23, 73 (2023). https://doi.org/10.1186/s12903-023-02762-0
  • Sabharwal, A., Stellrecht, E. & Scannapieco, F.A. Associations between dental caries and systemic diseases: a scoping review. BMC Oral Health 21, 472 (2021). https://doi.org/10.1186/s12903-021-01803-w
  • Nokhbatolfoghahaei, H., Paknejad, Z., Bohlouli, M., Rezai Rad, M., Khojasteh, A. (2020). Animal Models in Dental Research. In: Tayebi, L. (eds) Applications of Biomedical Engineering in Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-030-21583-5_18
  • Carlos Flores-Mir, Franco Raul Mauricio, Maria Fernanda Orellana, Paul William Major; Association between Growth Stunting with Dental Development and Skeletal Maturation Stage. Angle Orthod 1 November 2005; 75 (6): 935–940. doi: https://doi.org/10.1043/0003-3219(2005)75[935:ABGSWD]2.0.CO;2
Toplam 47 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Çocuk Diş Hekimliği, Diş Hekimliği (Diğer)
Bölüm Research Articles
Yazarlar

Gürkan Ünsal 0000-0001-7832-4249

Merve Yelken Kendirci 0000-0001-7894-3752

İsmet Ersalıcı 0000-0002-8991-7063

Yayımlanma Tarihi 30 Nisan 2024
Gönderilme Tarihi 15 Mart 2024
Kabul Tarihi 30 Mart 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 2 Sayı: 1

Kaynak Göster

Vancouver Ünsal G, Yelken Kendirci M, Ersalıcı İ. The Oral-Dental Findıngs of Patients Treated with Antineoplastic Treatments Targeting Non-Head and Neck Tumors in Childhood. EDR. 2024;2(1):9-13.