Olgu Sunumu
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Aksiller lokalizasyonu olan nadir yüksek dereceli miksofibrosarkom olgusu

Yıl 2020, Cilt: 3 Sayı: 1, 35 - 38, 21.04.2020
https://doi.org/10.33713/egetbd.655419

Öz

Miksofibrosarkom nadir görülen yumuşak bir doku sarkomudur. Çoğunlukla ekstremitelerde lokalizedir. Kesin tanı histopatolojik inceleme ile yapılsa da, görüntüleme yöntemleri derecelendirme ve tedavi planlamasında önemli rol oynamaktadır. Aksiller bölge nadiren dahil olabilse de literatürde bildirilmiş bir durum yoktur. Tümörün bol miktarda nörovasküler bir yapıya sahip olması göz önüne alındığında, tümörün geniş cerrahi marjlarla eksize edilmesi zordur. Olgumuz literatürde aksiller lokalizasyonu olan ilk olgu olduğu için dikkat çekicidir. Geniş marjlı cerrahi eksizyon tedavinin en önemli basamağıdır. R0 rezeksiyonu sağkalım üzerinde önemli bir etkiye sahiptir. Sonuç olarak, aksiller MFS'de kemoterapinin ardından geniş cerrahi eksizyonun lokal nüksü azaltmada olumlu bir katkısı olacağını düşünüyoruz

Kaynakça

  • 1. Angervall L, Kindblom LG, Merck C. Myxofibrosarcoma: A study of 30 cases. Acta Pathol Microbiol Scand 1977;85A:127–140. (PMID:15396)
  • 2. Look Hong NJ, Hornicek FJ, Raskin KA, Yoon SS, Szymonifka J, Yeap B, et al. Prognostic factors and outcomes of patients with myxofibrosarcoma. Ann Surg Oncol 2013;20:80-86. (PMID:22890594)
  • 3. Mentzel E, van den Berg E, Molenaar AA. Myxofibrosarcoma. In: Fletcher CDM, Unni KK, Mertens F, ed. Yumuşak Doku ve Kemik Tümörlerinin Patolojisi ve Genetiği Lyon, Fransa: IARC Press; 2002: 102-103.
  • 4. Weiss SW, Goldblum JR. Fibrosarkom. In: Weiss S, Goldblum JR, ed. Enzinger ve Weiss'in Yumuşak Doku Tümörleri. 4. baskı St Louis, Mo: MosbyInc; 2001: 422–425.
  • 5. Huang HY, Lal P, Qin J, Brennan MF, Antonescu CR. Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems. Human pathology 2004;35:612-621.( PMID: 15138937)
  • 6. Haglund KE, Raut CP, Nascimento AF, Wang Q, George S, Baldini EH. Recurrence patterns and survival for patients with intermediate- and high-grade myxofibrosarcoma. Int J Radiat Oncol Biol Phys 2012;82:361-367. (PMID: 20951504)
  • 7. Mutter RW, Singer S, Zhang Z, Brennan MF, Alektiar KM. The enigma of myxofibrosarcoma of the extremity. Cancer 2012;118:518-527. (PMID: 21717447)
  • 8. Gronchi A, Lo Vullo S, Colombo C, Collini P, Stacchiotti S, Mariani L, et al. Extremity soft tissue sarcoma in a series of patients treated at a single institution: local control directly impacts survival. Ann Surg 2010;251:506–511. (PMID: 20130465)
  • 9. Lin CN, Chou SC, Li CF, Tsai KB, Chen WC, Hsiung CY, et al. Prognostic factors of myxofibrosarcomas: implications of margin status, tumor necrosis, and mitotic rate on survival. J Surg Oncol 2006;93:294-303. (PMID: 16496357)
  • 10. Fletcher CD, Bridge JA, Hogendoorn PC, et al. WHO classification of tumours of softtissueand bone. 4th edition. Lyon (France): IARC Press; 2013:39-40.
  • 11. Evans HL. Low-grade fibromyxoidsarcoma: a report of 12 cases. Am J Surg Pathol 1993;17:595–600. (PMID: 8333558)
  • 12. Sanfilippo R, Miceli R, Grosso F, Fiore M, Puma E, Pennacchioli E, et al. Myxofibrosarcoma: prognostic factors and survival in a series of patients treated at a single institution. Ann Surg Oncol 2011;18: 720-725. (PMID: 20878245)

A case of high-grade myxofibrosarcoma with rare axillary localization

Yıl 2020, Cilt: 3 Sayı: 1, 35 - 38, 21.04.2020
https://doi.org/10.33713/egetbd.655419

Öz

Myxofibrosarcoma is a rare soft tissue sarcoma. It is mostly localized at extremities. Although definitive diagnosis is made by histopathological examination, imaging modalities play an important role in grading and treatment planning. Although axillary region can be involved rarely, there is no reported case in the literature. Given that tumor has an abundant neurovascular structure, it is challenging to excise tumor with wide surgical margins. Our case is striking as it is the first case with axillary localization in the literature. The surgical excision with wide margin is the most important step of the treatment. The R0 resection has an important impact on survival. In conclusion, we think that, in axillary MFS, wide surgical excision followed by chemotherapy will have positive contribution in reducing local recurrence.

Kaynakça

  • 1. Angervall L, Kindblom LG, Merck C. Myxofibrosarcoma: A study of 30 cases. Acta Pathol Microbiol Scand 1977;85A:127–140. (PMID:15396)
  • 2. Look Hong NJ, Hornicek FJ, Raskin KA, Yoon SS, Szymonifka J, Yeap B, et al. Prognostic factors and outcomes of patients with myxofibrosarcoma. Ann Surg Oncol 2013;20:80-86. (PMID:22890594)
  • 3. Mentzel E, van den Berg E, Molenaar AA. Myxofibrosarcoma. In: Fletcher CDM, Unni KK, Mertens F, ed. Yumuşak Doku ve Kemik Tümörlerinin Patolojisi ve Genetiği Lyon, Fransa: IARC Press; 2002: 102-103.
  • 4. Weiss SW, Goldblum JR. Fibrosarkom. In: Weiss S, Goldblum JR, ed. Enzinger ve Weiss'in Yumuşak Doku Tümörleri. 4. baskı St Louis, Mo: MosbyInc; 2001: 422–425.
  • 5. Huang HY, Lal P, Qin J, Brennan MF, Antonescu CR. Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems. Human pathology 2004;35:612-621.( PMID: 15138937)
  • 6. Haglund KE, Raut CP, Nascimento AF, Wang Q, George S, Baldini EH. Recurrence patterns and survival for patients with intermediate- and high-grade myxofibrosarcoma. Int J Radiat Oncol Biol Phys 2012;82:361-367. (PMID: 20951504)
  • 7. Mutter RW, Singer S, Zhang Z, Brennan MF, Alektiar KM. The enigma of myxofibrosarcoma of the extremity. Cancer 2012;118:518-527. (PMID: 21717447)
  • 8. Gronchi A, Lo Vullo S, Colombo C, Collini P, Stacchiotti S, Mariani L, et al. Extremity soft tissue sarcoma in a series of patients treated at a single institution: local control directly impacts survival. Ann Surg 2010;251:506–511. (PMID: 20130465)
  • 9. Lin CN, Chou SC, Li CF, Tsai KB, Chen WC, Hsiung CY, et al. Prognostic factors of myxofibrosarcomas: implications of margin status, tumor necrosis, and mitotic rate on survival. J Surg Oncol 2006;93:294-303. (PMID: 16496357)
  • 10. Fletcher CD, Bridge JA, Hogendoorn PC, et al. WHO classification of tumours of softtissueand bone. 4th edition. Lyon (France): IARC Press; 2013:39-40.
  • 11. Evans HL. Low-grade fibromyxoidsarcoma: a report of 12 cases. Am J Surg Pathol 1993;17:595–600. (PMID: 8333558)
  • 12. Sanfilippo R, Miceli R, Grosso F, Fiore M, Puma E, Pennacchioli E, et al. Myxofibrosarcoma: prognostic factors and survival in a series of patients treated at a single institution. Ann Surg Oncol 2011;18: 720-725. (PMID: 20878245)
Toplam 12 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Cerrahi
Bölüm Olgu Sunumu
Yazarlar

Yeliz Yılmaz Bozok 0000-0003-1811-122X

Murat Kemal Atahan 0000-0002-0096-8789

Furkan Tosun 0000-0003-0384-8181

Sultan Deniz Altındağ 0000-0002-7167-2432

Asli Kahraman Akkalp 0000-0001-5781-8506

Yayımlanma Tarihi 21 Nisan 2020
Kabul Tarihi 5 Ocak 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 3 Sayı: 1

Kaynak Göster

EndNote Yılmaz Bozok Y, Atahan MK, Tosun F, Altındağ SD, Kahraman Akkalp A (01 Nisan 2020) A case of high-grade myxofibrosarcoma with rare axillary localization. Ege Tıp Bilimleri Dergisi 3 1 35–38.

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