Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2022, Cilt: 4 Sayı: 1, 3 - 7, 30.04.2022
https://doi.org/10.55994/ejcc.1050495

Öz

Kaynakça

  • 1- Wilbur J, Shian B. Deep venous thrombosis and pulmonary embolism: Current therapy. Am Fam Physician. 2017; 95: 295–302.
  • 2- Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola V-P, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J 2020; 41: 543-603.
  • 3- Javaudin F, Lascarrou JB, Esquina H, Baert V, Hubert H, Leclere B, et al. Improving identification of pulmonary embolism-related out-of-hospital cardiac arrest to optimize thrombolytic therapy during resuscitation. Crit Care. 2019; 23: 409.
  • 4- Link MS, Berkow LC, Kudenchuk PJ, Halperin HR, Hess EP, Moitra VK, et al. Part 7: Adult Advanced Cardiovascular Life Support: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015; 132: 444-64.
  • 5- Cohen AT, Dobromirski M, Gurwith MM. Managing pulmonary embolism from presentation to extended treatment. Thromb Res 2014; 133: 139-48.
  • 6- Konstantinides SV, Barcos S, Lankeit M, Meyer G. Management of Pulmonary Embolism: An Update. J Am Coll Cardiol 2016; 67: 976-90.
  • 7- Greco F, Misuraca G, Serafini O, Guzzo D, Plastina F. Thrombolytic therapy during cardiopulmonary resuscitation for acute massive pulmonary embolism. A case report. Minerva Cardioangiol. 2001; 49: 433-6.
  • 8- Javaudin F, Lascarrou JB, Le Bastard Q, Bourry Q, Latour C, Carvalho HD, et al. Thrombolysis during resuscitation for out-of-hospital cardiac arrest caused by pulmonary embolism increases 30-day survival: Findings from the French National Cardiac Arrest Registry. Chest 2019; 156: 1167-75.
  • 9- Summers K, Schultheis J, Raiff D, Dahhan T. Evaluation of Rescue Thrombolysis in Cardiac Arrest Secondary to Suspected or Confirmed Pulmonary Embolism. Ann Pharmacother. 2019; 53: 711-5.
  • 10- Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola V-P, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Respir J. 2019; 54. pii: 1901647.
  • 11- Prom R, Dull R, Delk B. Successful Alteplase Bolus Administration for a Presumed Massive Pulmonary Embolism During Cardiopulmonary Resuscitation. Ann Pharmacother. 2013; 47: 1730-5.
  • 12- Sharifi M, Berger J, Beeston P, Bay C, Vajo Z, Javadpoor S; “PEAPETT” Investigators. Pulseless electrical activity in pulmonary embolism treated with thrombolysis (from the “PEAPETT” study). Am J Emerg Med. 2016; 34: 1963-7.
  • 13- Bauer MP, Vliegen HW, Huisman MV. Massive pulmonary embolism with cardiac arrest after an intracardiac electrophysiological study: a strong case for venous thromboprophylaxis. Blood Coagul Fibrinolysis. 2006; 17: 57-8.
  • 14- Pala S, Kahveci G, Bozok S. Acute massive pulmonary embolism with hemodynamic compromise treated successfully with thrombolytic therapy. Clin Appl Thromb Hemost. 2009; 15: 708-10.
  • 15- Er F, Nia AM, Gassanov N, Caglayan E, Erdmann E, Hoppe UC. Impact of rescue-thrombolysis during cardiopulmonary resuscitation in patients with pulmonary embolism. PLoS One. 2009; 4: e8323.
  • 16- Close MD, Cherkas D. Successful treatment of presumed massive pulmonary embolism during cardiac arrest. Am J Emerg Med. 2011; 29: 132 e3-e4.
  • 17- Landy C, Plancade D, Gagnon N, Schaeffer E, Nadaud J, Favier JC. Complication of intraosseous administration of systemic fibrinolysis for a massive pulmonary embolism with cardiac arrest. Resuscitation. 2012; 83: e149-50.
  • 18- Bailen MR, Cuadra JA, Aguayo De, Hoyos E. Thrombolysis during cardiopulmonary resuscitation in fulminant pulmonary embolism: a review. Crit Care Med. 2001; 29: 2211-9.
  • 19- Kearon C, Akl EA, Comerota AJ, Prandoni P, Bounameaux H, Goldhaber SZ, Nelson ME, et al. Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012; 141(2 Suppl): e419S-e496S.
  • 20- Piazza G, Goldhaber SZ. Fibrinolysis for acute pulmonary embolism. Vasc Med. 2010; 15: 419-28.
  • 21- Goldhaber SZ, Agnelli G, Levine MN. Reduced dose bolus alteplase vs conventional alteplase infusion for pulmonary embolism thrombolysis: an international multicenter randomized trial. The Bolus Alteplase Pulmonary Embolism Group. Chest. 1994; 106: 718-24.
  • 22- Zhang Z, Zhai ZG, Liang LR, Liu FF, Yang YH, Wang C. Lower dosage of recombinant tissue-type plasminogen activator (rt-PA) in the treatment of acute pulmonary embolism: a systematic review and meta-analysis. Thromb Res. 2014; 133: 357-63.
  • 23- Fischer M, Böttiger BW, Popov-Cenic S, Hossmann KA. Thrombolysis using plasminogen activator and heparin reduces cerebral no-reflow after resuscitation from cardiac arrest: an experimental study in the cat. Intensive Care Med. 1996; 22: 1214-23.
  • 24- Böttiger BW, Martin E. Thrombolytic therapy during cardiopulmonary resuscitation and the role of coagulation activation after cardiac arrest. Curr Opin Crit Care. 2001; 7: 176-83.
  • 25- Spöhr F, Böttiger BW. Thrombolytics in CPR. Current advantages in cardiopulmonary resuscitation. Minerva Anestesiol. 2005; 71: 291-6.

Evaluation of Systemic Thrombolytic Treatment in the Emergency Service in Unstable and Resuscitated Patients Due to Massive Pulmonary Embolism

Yıl 2022, Cilt: 4 Sayı: 1, 3 - 7, 30.04.2022
https://doi.org/10.55994/ejcc.1050495

Öz

Background: PE accounts for 3% of out-of-hospital cardiac arrest. In this case, treating patients with thrombolysis during resuscitation has been associated with better survival.
Objective: The aim of this study is to evaluate the use of systemic thrombolytic in unstable and/or resuscitated patients who are evaluated in the red area in emergency service practice and who are diagnosed with massive pulmonary embolism with bedside examinations.
Methods: This prospective study was designed on 17 patients who were transferred as unstable to the emergency service of a tertiary hospital by Emergency Health Services and/or who needed resuscitation due to non-shockable fatal rhythm disorder on admission and who underwent systemic thrombolysis due to the diagnosis of pulmonary embolism during resuscitation.
Results: Of the 17 patients included in the study, 52.9% were discharged and improvement was detected in unstable vital findings in 47.1% patients after thrombolysis. Of the bedside examinations performed on admission, ECG showed T wave negativity at V1-4 deviations and P-pulmonale in 41.2% patients and ECHO showed right ventricle dilatation indicating right ventricle dysfunction in 82.4% patients. CTPA taken after stabilization showed thrombus at bilateral pulmonary artery in 88.2% patients.
Conclusion: Cardiopulmonary arrest caused by PE is a life-threatening condition that requires urgent systemic thrombolysis. Patients who are evaluated as unstable or in need of resuscitation in the emergency service should be diagnosed quickly as a result of examinations performed at bed-side and thrombolytic treatment should be started.

Kaynakça

  • 1- Wilbur J, Shian B. Deep venous thrombosis and pulmonary embolism: Current therapy. Am Fam Physician. 2017; 95: 295–302.
  • 2- Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola V-P, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J 2020; 41: 543-603.
  • 3- Javaudin F, Lascarrou JB, Esquina H, Baert V, Hubert H, Leclere B, et al. Improving identification of pulmonary embolism-related out-of-hospital cardiac arrest to optimize thrombolytic therapy during resuscitation. Crit Care. 2019; 23: 409.
  • 4- Link MS, Berkow LC, Kudenchuk PJ, Halperin HR, Hess EP, Moitra VK, et al. Part 7: Adult Advanced Cardiovascular Life Support: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015; 132: 444-64.
  • 5- Cohen AT, Dobromirski M, Gurwith MM. Managing pulmonary embolism from presentation to extended treatment. Thromb Res 2014; 133: 139-48.
  • 6- Konstantinides SV, Barcos S, Lankeit M, Meyer G. Management of Pulmonary Embolism: An Update. J Am Coll Cardiol 2016; 67: 976-90.
  • 7- Greco F, Misuraca G, Serafini O, Guzzo D, Plastina F. Thrombolytic therapy during cardiopulmonary resuscitation for acute massive pulmonary embolism. A case report. Minerva Cardioangiol. 2001; 49: 433-6.
  • 8- Javaudin F, Lascarrou JB, Le Bastard Q, Bourry Q, Latour C, Carvalho HD, et al. Thrombolysis during resuscitation for out-of-hospital cardiac arrest caused by pulmonary embolism increases 30-day survival: Findings from the French National Cardiac Arrest Registry. Chest 2019; 156: 1167-75.
  • 9- Summers K, Schultheis J, Raiff D, Dahhan T. Evaluation of Rescue Thrombolysis in Cardiac Arrest Secondary to Suspected or Confirmed Pulmonary Embolism. Ann Pharmacother. 2019; 53: 711-5.
  • 10- Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola V-P, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Respir J. 2019; 54. pii: 1901647.
  • 11- Prom R, Dull R, Delk B. Successful Alteplase Bolus Administration for a Presumed Massive Pulmonary Embolism During Cardiopulmonary Resuscitation. Ann Pharmacother. 2013; 47: 1730-5.
  • 12- Sharifi M, Berger J, Beeston P, Bay C, Vajo Z, Javadpoor S; “PEAPETT” Investigators. Pulseless electrical activity in pulmonary embolism treated with thrombolysis (from the “PEAPETT” study). Am J Emerg Med. 2016; 34: 1963-7.
  • 13- Bauer MP, Vliegen HW, Huisman MV. Massive pulmonary embolism with cardiac arrest after an intracardiac electrophysiological study: a strong case for venous thromboprophylaxis. Blood Coagul Fibrinolysis. 2006; 17: 57-8.
  • 14- Pala S, Kahveci G, Bozok S. Acute massive pulmonary embolism with hemodynamic compromise treated successfully with thrombolytic therapy. Clin Appl Thromb Hemost. 2009; 15: 708-10.
  • 15- Er F, Nia AM, Gassanov N, Caglayan E, Erdmann E, Hoppe UC. Impact of rescue-thrombolysis during cardiopulmonary resuscitation in patients with pulmonary embolism. PLoS One. 2009; 4: e8323.
  • 16- Close MD, Cherkas D. Successful treatment of presumed massive pulmonary embolism during cardiac arrest. Am J Emerg Med. 2011; 29: 132 e3-e4.
  • 17- Landy C, Plancade D, Gagnon N, Schaeffer E, Nadaud J, Favier JC. Complication of intraosseous administration of systemic fibrinolysis for a massive pulmonary embolism with cardiac arrest. Resuscitation. 2012; 83: e149-50.
  • 18- Bailen MR, Cuadra JA, Aguayo De, Hoyos E. Thrombolysis during cardiopulmonary resuscitation in fulminant pulmonary embolism: a review. Crit Care Med. 2001; 29: 2211-9.
  • 19- Kearon C, Akl EA, Comerota AJ, Prandoni P, Bounameaux H, Goldhaber SZ, Nelson ME, et al. Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012; 141(2 Suppl): e419S-e496S.
  • 20- Piazza G, Goldhaber SZ. Fibrinolysis for acute pulmonary embolism. Vasc Med. 2010; 15: 419-28.
  • 21- Goldhaber SZ, Agnelli G, Levine MN. Reduced dose bolus alteplase vs conventional alteplase infusion for pulmonary embolism thrombolysis: an international multicenter randomized trial. The Bolus Alteplase Pulmonary Embolism Group. Chest. 1994; 106: 718-24.
  • 22- Zhang Z, Zhai ZG, Liang LR, Liu FF, Yang YH, Wang C. Lower dosage of recombinant tissue-type plasminogen activator (rt-PA) in the treatment of acute pulmonary embolism: a systematic review and meta-analysis. Thromb Res. 2014; 133: 357-63.
  • 23- Fischer M, Böttiger BW, Popov-Cenic S, Hossmann KA. Thrombolysis using plasminogen activator and heparin reduces cerebral no-reflow after resuscitation from cardiac arrest: an experimental study in the cat. Intensive Care Med. 1996; 22: 1214-23.
  • 24- Böttiger BW, Martin E. Thrombolytic therapy during cardiopulmonary resuscitation and the role of coagulation activation after cardiac arrest. Curr Opin Crit Care. 2001; 7: 176-83.
  • 25- Spöhr F, Böttiger BW. Thrombolytics in CPR. Current advantages in cardiopulmonary resuscitation. Minerva Anestesiol. 2005; 71: 291-6.
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yoğun Bakım
Bölüm Original Articles
Yazarlar

Özlem Bilir 0000-0001-9016-1665

Alpaslan Ünlü 0000-0001-6427-4594

Filiz Taşçı 0000-0002-8981-171X

Gökhan Ersunan 0000-0002-4523-0294

İsmail Ataş

Yayımlanma Tarihi 30 Nisan 2022
Gönderilme Tarihi 30 Aralık 2021
Kabul Tarihi 8 Nisan 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 4 Sayı: 1

Kaynak Göster

APA Bilir, Ö., Ünlü, A., Taşçı, F., Ersunan, G., vd. (2022). Evaluation of Systemic Thrombolytic Treatment in the Emergency Service in Unstable and Resuscitated Patients Due to Massive Pulmonary Embolism. Eurasian Journal of Critical Care, 4(1), 3-7. https://doi.org/10.55994/ejcc.1050495
AMA Bilir Ö, Ünlü A, Taşçı F, Ersunan G, Ataş İ. Evaluation of Systemic Thrombolytic Treatment in the Emergency Service in Unstable and Resuscitated Patients Due to Massive Pulmonary Embolism. Eurasian j Crit Care. Nisan 2022;4(1):3-7. doi:10.55994/ejcc.1050495
Chicago Bilir, Özlem, Alpaslan Ünlü, Filiz Taşçı, Gökhan Ersunan, ve İsmail Ataş. “Evaluation of Systemic Thrombolytic Treatment in the Emergency Service in Unstable and Resuscitated Patients Due to Massive Pulmonary Embolism”. Eurasian Journal of Critical Care 4, sy. 1 (Nisan 2022): 3-7. https://doi.org/10.55994/ejcc.1050495.
EndNote Bilir Ö, Ünlü A, Taşçı F, Ersunan G, Ataş İ (01 Nisan 2022) Evaluation of Systemic Thrombolytic Treatment in the Emergency Service in Unstable and Resuscitated Patients Due to Massive Pulmonary Embolism. Eurasian Journal of Critical Care 4 1 3–7.
IEEE Ö. Bilir, A. Ünlü, F. Taşçı, G. Ersunan, ve İ. Ataş, “Evaluation of Systemic Thrombolytic Treatment in the Emergency Service in Unstable and Resuscitated Patients Due to Massive Pulmonary Embolism”, Eurasian j Crit Care, c. 4, sy. 1, ss. 3–7, 2022, doi: 10.55994/ejcc.1050495.
ISNAD Bilir, Özlem vd. “Evaluation of Systemic Thrombolytic Treatment in the Emergency Service in Unstable and Resuscitated Patients Due to Massive Pulmonary Embolism”. Eurasian Journal of Critical Care 4/1 (Nisan 2022), 3-7. https://doi.org/10.55994/ejcc.1050495.
JAMA Bilir Ö, Ünlü A, Taşçı F, Ersunan G, Ataş İ. Evaluation of Systemic Thrombolytic Treatment in the Emergency Service in Unstable and Resuscitated Patients Due to Massive Pulmonary Embolism. Eurasian j Crit Care. 2022;4:3–7.
MLA Bilir, Özlem vd. “Evaluation of Systemic Thrombolytic Treatment in the Emergency Service in Unstable and Resuscitated Patients Due to Massive Pulmonary Embolism”. Eurasian Journal of Critical Care, c. 4, sy. 1, 2022, ss. 3-7, doi:10.55994/ejcc.1050495.
Vancouver Bilir Ö, Ünlü A, Taşçı F, Ersunan G, Ataş İ. Evaluation of Systemic Thrombolytic Treatment in the Emergency Service in Unstable and Resuscitated Patients Due to Massive Pulmonary Embolism. Eurasian j Crit Care. 2022;4(1):3-7.

Indexing and Abstracting

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