Effect of prostatectomy In patients with elevated serum prostate specific antigen levels and Lower Urinary Tract Symptoms: A Prospective Study
Öz
Abstract
Objective: Our aim is to determine the impact of prostatectomy on serum prostate specific antıgen levels in patıents with Lower Urinary Tract symptoms(LUTS), but negative multicore prostate biopsy results and higher serum prostate specific antigen levels
Method: A total of 100 patients referred to our clinics with lower urinary system symptoms without any evidence of suspect prostate carcinoma in digital rectal examination, and transurethral ultrasound (TRUS) but had undergone prostatic biopsy because of higher serum prostate specific antigen (PSA) levels (PSA>4ng/ml) with resultant histopathologically benign diagnoses were retrospectively evaluated. The association between preoperative and postoperative 3 and 6 month serum PSA levels was statistically evaluated in patients who had undergone transurethral resection of the prostate (TUR-P) or open prostatectomy resection with the diagnosis of benign prostatic hyperplasia (BPH), and also correlation between changes in serum PSA levels and histopathologic diagnosis was analysed.
Results: The preoperative mean total PSA (tPSA) and free PSA (fPSA) values were 16.89 ng/mL and 3.65ng/mL, respectively. Postoperative 3 month- mean tPSA and fPSA values were 1.34 and 0.4ng/mL, while postoperative 6 month mean tPSA and fPSA values were determined as 1.59 and 0.56ng/mL, respectively. Postoperative histopathologic evaluation of the surgical specimens of the patients revealed BPH in 84%, BPH + prostatitis in 12%, and prostate cancer 4% of the cases, respectively.
Conclusion: BPH surgery can be performed safely on patients with symptomatic BPH and increased PSA levels without any evidence of prostate carcinoma. Favourable and comforting results can be achieved with BPH surgery, which improves symptoms and normalises PSA values.
Key words: Prostate specific antigen, Benign Prostatic Hyperplasia, Prostatectomy
Anahtar Kelimeler
Prostate specific antigen benign prostatic hyperplasia prostatectomy
Kaynakça
- Marks LS, Dorey FJ, Rhodes T et al. Serum prostate specific antigen levels after transurethral resection of prostate: a longitudinal characterization in men with benign prostatic hyperplasia. J Urol 1996; 156: 1035- 1039.
- Fonseca RC, Gomes CM, Meireles EB et al. Prostate specific antigen levels following transurethral resection of the prostate. Int Braz J Urol 2008; 34: 41- 48.
- Van Renterghem K, Van Koeveringe G, Van Kerrebroeck P. Rising PSA in patients with minor LUTS without evidence of prostatic carcinoma: a missing link? Int Urol Nephrol 2007; 39: 1107-1113.
- Van Renterghem K, Van Koeveringe G, Achten R et al. Clinical relevance of transurethral resection of the prostate in "asymptomatic" patients with an elevated prostate-specific antigen level. Eur Urol 2007; 52: 819-826.
- Ferrero Doria R, Pérez Flores D, Terrer Artes C et al. Impact of prostatic benign hyperplasia and prostatic inflammation on the increase of prostate specific antigen levels. Actas Urol Esp 1997; 21: 100-104.
- Nadler RB, Humphrey PA, Smith DS et al. Effect of inflammation and benign prostatic hyperplasia on elevated serum prostate specific antigen levels. J Urol 1995; 154: 407-413.
- Irani J, Levillain P, Goujon JM et al. Inflammation in benign prostatic hyperplasia: correlation with prostate specific antigen value. J Urol 1997; 157: 1301-1303.
- Helfand BT, Anderson CB, Fought A et al. Postoperative PSA and PSA velocity identify presence of prostate cancer after various surgical interventions for benign prostatic hyperplasia. Urology 2009; 74: 177-183.
Effect of prostatectomy In patients with elevated serum prostate specific antigen levels and Lower Urinary Tract Symptoms: A Prospective Study
Öz
Abstract
Objective: Our aim is to determine the impact of prostatectomy on serum prostate specific antıgen levels in patıents with Lower Urinary Tract symptoms(LUTS), but negative multicore prostate biopsy results and higher serum prostate specific antigen levels
Method: A total of 100 patients referred to our clinics with lower urinary system symptoms without any evidence of suspect prostate carcinoma in digital rectal examination, and transurethral ultrasound (TRUS) but had undergone prostatic biopsy because of higher serum prostate specific antigen (PSA) levels (PSA>4ng/ml) with resultant histopathologically benign diagnoses were retrospectively evaluated. The association between preoperative and postoperative 3 and 6 month serum PSA levels was statistically evaluated in patients who had undergone transurethral resection of the prostate (TUR-P) or open prostatectomy resection with the diagnosis of benign prostatic hyperplasia (BPH), and also correlation between changes in serum PSA levels and histopathologic diagnosis was analysed.
Results: The preoperative mean total PSA (tPSA) and free PSA (fPSA) values were 16.89 ng/mL and 3.65ng/mL, respectively. Postoperative 3 month- mean tPSA and fPSA values were 1.34 and 0.4ng/mL, while postoperative 6 month mean tPSA and fPSA values were determined as 1.59 and 0.56ng/mL, respectively. Postoperative histopathologic evaluation of the surgical specimens of the patients revealed BPH in 84%, BPH + prostatitis in 12%, and prostate cancer 4% of the cases, respectively.
Conclusion: BPH surgery can be performed safely on patients with symptomatic BPH and increased PSA levels without any evidence of prostate carcinoma. Favourable and comforting results can be achieved with BPH surgery, which improves symptoms and normalises PSA values.
Key words: Prostate specific antigen, Benign Prostatic Hyperplasia, Prostatectomy
Anahtar Kelimeler
Kaynakça
- Marks LS, Dorey FJ, Rhodes T et al. Serum prostate specific antigen levels after transurethral resection of prostate: a longitudinal characterization in men with benign prostatic hyperplasia. J Urol 1996; 156: 1035- 1039.
- Fonseca RC, Gomes CM, Meireles EB et al. Prostate specific antigen levels following transurethral resection of the prostate. Int Braz J Urol 2008; 34: 41- 48.
- Van Renterghem K, Van Koeveringe G, Van Kerrebroeck P. Rising PSA in patients with minor LUTS without evidence of prostatic carcinoma: a missing link? Int Urol Nephrol 2007; 39: 1107-1113.
- Van Renterghem K, Van Koeveringe G, Achten R et al. Clinical relevance of transurethral resection of the prostate in "asymptomatic" patients with an elevated prostate-specific antigen level. Eur Urol 2007; 52: 819-826.
- Ferrero Doria R, Pérez Flores D, Terrer Artes C et al. Impact of prostatic benign hyperplasia and prostatic inflammation on the increase of prostate specific antigen levels. Actas Urol Esp 1997; 21: 100-104.
- Nadler RB, Humphrey PA, Smith DS et al. Effect of inflammation and benign prostatic hyperplasia on elevated serum prostate specific antigen levels. J Urol 1995; 154: 407-413.
- Irani J, Levillain P, Goujon JM et al. Inflammation in benign prostatic hyperplasia: correlation with prostate specific antigen value. J Urol 1997; 157: 1301-1303.
- Helfand BT, Anderson CB, Fought A et al. Postoperative PSA and PSA velocity identify presence of prostate cancer after various surgical interventions for benign prostatic hyperplasia. Urology 2009; 74: 177-183.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Articles |
| Yazarlar | |
| Yayımlanma Tarihi | 6 Ocak 2015 |
| Yayımlandığı Sayı | Yıl 2014 Cilt: 19 Sayı: 3 |