BibTex RIS Kaynak Göster

The effect of antibiotherapy used against the PSA increase in serum PSA levels

Yıl 2015, Cilt: 20 Sayı: 1, 30 - 33, 02.06.2015

Ayhan Karaköse Mehmet Yüksel Necip Pirinççi Sacit Görgel Yusuf Ateşçi Bilal Gümüş

Öz

Aim.To evaluatethe effect of antibiotics in patients with PSA value high than 4 ng / ml ontPSA, fPSA and fPSA / tPSA ratio.Methods.A total of96 patients  included the study withdetected high level than 4 ng / ml serum PSA. Patients were divided into 2groups according to the high level of PSA value. Group 1 included 49 patients with PSA level between 4-10ng/ml. Group 2 included 47 patients with PSA level high than 10 ng/ml. Patientswere treated with  Ciprofloxacin (500mgb.i.d.) orally for 2 weeks. All patients' PSA levels  were evaluated and analyzed before and afterantibiotic treatment. Statistical analyses were performed with SPSS version 18.A p value <0.05 was considered significant.Results.The meanage was 61.6 ±5.7 (51-75) years in group 1 and 63.1 ±8.7 (55-74) years in group2. Suspicious DRE findings were significantly high  in group 2. The mean tPSA values were6.82±0.42 and 5.93±0.36 before and after antibiotic treatment in group 1respectively. There was no significant differences tPSA value before and afterantibiotic treatment in group 1.  Themean tPSA values were 32.53±8.23 and 11.72±5.61 before and after antibiotictreatment in group 2 respectively. The mean tPSA value decreased significantlyafter antibiotic treatment in group 2. Prostate cancer was detected in 32 patients after TRUS guided prostatebiopsy.  Prostate cancer was identifiedin 13 patients in gruop 1 and 19 patients in group 2. Conclusıons.Antibiotic treatment in patients with PSA levels high than 10 ng/ml iseffective on prostate biopsy decision and antibiotic treatment can preventunnecessary prostate biopsies.

Anahtar Kelimeler

Prostate cancer PSA biopsy

Kaynakça

  • Bulbul MA, Wassan W, Hijaz A, et al. The effect of
  • antibiotics on elevated serum prostate-specific antigen
  • in patients with urinary symptoms and negative digital
  • rectal examination: a pilot study. J Med Liban 2002; 50: 23-25. 9.
  • Tan YH, Tan KY, Foo KT. The role of a trial of
  • antibiotics in asymptomatic patients with elevated
  • prostate-specifi c antigen – an Asian perspective. BJU Int 2000; 86: 104.
  • Erol H, Beder N, Calişkan T, et al. Can the effect of antibiotherapy and anti-inflammatory therapy on serum PSA levels discriminate between benign and malign prostatic pathologies? Urol Int 2006; 76: 20- 26.
  • Dai B, Ye DW, Kong YY, et al. Individualized prostate biopsy strategy for Chinese patients with different prostate-specific antigen levels. Asian J Androl 2008; 10: 325-331.
  • Raaijmakers R, Wildhagen MF, Ito K, et al. Prostate- specific antigen change in the European Randomized Study of Screening for Prostate Cancer, section Rotterdam. Urology 2004; 63: 316-320.
  • Kaygisiz O, Ugurlu O, Kosan M, et al. Effects of antibacterial therapy on PSA change in the presence and absence of prostatic inflammation in patients with PSA levels between 4 and 10 ng/mL. Prostate Cancer Prostatic Dis 2006; 9: 235-238.

Yıl 2015, Cilt: 20 Sayı: 1, 30 - 33, 02.06.2015

Ayhan Karaköse Mehmet Yüksel Necip Pirinççi Sacit Görgel Yusuf Ateşçi Bilal Gümüş

Öz

Kaynakça

  • Bulbul MA, Wassan W, Hijaz A, et al. The effect of
  • antibiotics on elevated serum prostate-specific antigen
  • in patients with urinary symptoms and negative digital
  • rectal examination: a pilot study. J Med Liban 2002; 50: 23-25. 9.
  • Tan YH, Tan KY, Foo KT. The role of a trial of
  • antibiotics in asymptomatic patients with elevated
  • prostate-specifi c antigen – an Asian perspective. BJU Int 2000; 86: 104.
  • Erol H, Beder N, Calişkan T, et al. Can the effect of antibiotherapy and anti-inflammatory therapy on serum PSA levels discriminate between benign and malign prostatic pathologies? Urol Int 2006; 76: 20- 26.
  • Dai B, Ye DW, Kong YY, et al. Individualized prostate biopsy strategy for Chinese patients with different prostate-specific antigen levels. Asian J Androl 2008; 10: 325-331.
  • Raaijmakers R, Wildhagen MF, Ito K, et al. Prostate- specific antigen change in the European Randomized Study of Screening for Prostate Cancer, section Rotterdam. Urology 2004; 63: 316-320.
  • Kaygisiz O, Ugurlu O, Kosan M, et al. Effects of antibacterial therapy on PSA change in the presence and absence of prostatic inflammation in patients with PSA levels between 4 and 10 ng/mL. Prostate Cancer Prostatic Dis 2006; 9: 235-238.
Toplam 11 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Articles
Yazarlar

Ayhan Karaköse

Mehmet Yüksel

Necip Pirinççi

Sacit Görgel Bu kişi benim

Yusuf Ateşçi Bu kişi benim

Bilal Gümüş

Yayımlanma Tarihi 2 Haziran 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 20 Sayı: 1

Kaynak Göster

APA Karaköse, A., Yüksel, M., Pirinççi, N., Görgel, S., vd. (2015). The effect of antibiotherapy used against the PSA increase in serum PSA levels. EASTERN JOURNAL OF MEDICINE, 20(1), 30-33.
AMA Karaköse A, Yüksel M, Pirinççi N, Görgel S, Ateşçi Y, Gümüş B. The effect of antibiotherapy used against the PSA increase in serum PSA levels. EASTERN JOURNAL OF MEDICINE. Haziran 2015;20(1):30-33.
Chicago Karaköse, Ayhan, Mehmet Yüksel, Necip Pirinççi, Sacit Görgel, Yusuf Ateşçi, ve Bilal Gümüş. “The Effect of Antibiotherapy Used Against the PSA Increase in Serum PSA Levels”. EASTERN JOURNAL OF MEDICINE 20, sy. 1 (Haziran 2015): 30-33.
EndNote Karaköse A, Yüksel M, Pirinççi N, Görgel S, Ateşçi Y, Gümüş B (01 Haziran 2015) The effect of antibiotherapy used against the PSA increase in serum PSA levels. EASTERN JOURNAL OF MEDICINE 20 1 30–33.
IEEE A. Karaköse, M. Yüksel, N. Pirinççi, S. Görgel, Y. Ateşçi, ve B. Gümüş, “The effect of antibiotherapy used against the PSA increase in serum PSA levels”, EASTERN JOURNAL OF MEDICINE, c. 20, sy. 1, ss. 30–33, 2015.
ISNAD Karaköse, Ayhan vd. “The Effect of Antibiotherapy Used Against the PSA Increase in Serum PSA Levels”. EASTERN JOURNAL OF MEDICINE 20/1 (Haziran 2015), 30-33.
JAMA Karaköse A, Yüksel M, Pirinççi N, Görgel S, Ateşçi Y, Gümüş B. The effect of antibiotherapy used against the PSA increase in serum PSA levels. EASTERN JOURNAL OF MEDICINE. 2015;20:30–33.
MLA Karaköse, Ayhan vd. “The Effect of Antibiotherapy Used Against the PSA Increase in Serum PSA Levels”. EASTERN JOURNAL OF MEDICINE, c. 20, sy. 1, 2015, ss. 30-33.
Vancouver Karaköse A, Yüksel M, Pirinççi N, Görgel S, Ateşçi Y, Gümüş B. The effect of antibiotherapy used against the PSA increase in serum PSA levels. EASTERN JOURNAL OF MEDICINE. 2015;20(1):30-3.