Helicobacter pylori frequency and upper gastrointestinal system endoscopic findings in autoimmune hepatic diseases

Elmas Kasap; Ufuk Demirci; Tahir Buran; Hakan Yüceyar

doi:10.17940/endoskopi.466540

Araştırma Makalesi

Helicobacter pylori frequency and upper gastrointestinal system endoscopic findings in autoimmune hepatic diseases

Yıl 2016, Cilt: 24 Sayı: 3, 65 - 68, 02.01.2017

Elmas Kasap Ufuk Demirci Tahir Buran Hakan Yüceyar

https://doi.org/10.17940/endoskopi.466540

Öz

Background and Aims: Helicobacter pylori is the main cause of gastric lesions in chronic gastritis, autoimmune gastritis, peptic ulcer disease, and gastric cancer. Autoimmune liver disease is associated with various upper gastrointestinal mucosal lesions, which are not linked to the severity of the disease. The aim of this study was to retrospectively investigate upper gastrointestinal mucosal lesions in relation to the prevalence of Helicobacter pylori infection in autoimmune liver disease. Materials and Methods: This study included 99 patients with autoimmune liver disease and 110 dyspeptic patients as the control group. Endoscopy was performed in all patients, with biopsy specimens taken from the antrum and gastric body for histological examination and Helicobacter pylori detection. Patients were excluded if they had a history of acid suppression therapy, antibiotic or non-steroidal anti-inflammatory drug treatment, or if antrum and gastric body biopsy specimens could not be taken. Results: Helicobacter pylori was detected in 60% of autoimmune hepatitis cases, 57% of primary biliary cirrhosis cases, and 63% of controls. There was no statistically significant difference between the three groups. Abnormal findings during upper gastrointestinal endoscopy were found in 45% of autoimmune hepatitis cases, 52% primary biliary cirrhosis cases, and 43% of dyspeptic controls. Conclusion: Helicobacter pylori was detected in autoimmune liver disease cases at a similar frequency as in the control group. Endoscopic antral gastritis was more prevalent in autoimmune hepatitis than in primary biliary cirrhosis, but autoimmune liver disease was not significantly characterized by more upper gastrointestinal mucosal lesions than in dyspeptic controls.

Anahtar Kelimeler

Autoimmune liver disease, autoimmune hepatitis, primary biliary cirrhosis, Helicobacter pylori

Kaynakça

1. Hasni S, Ippolito A, Illei GG. Helicobacter pylori and autoimmune diseases. Oral Dis 2011;17:621-7.
2. Trivedi PJ, Adams HD. Mucosal immunity in liver autoimmunity. A comprehensive review. J Autoimmun 2013;46:97-111.
3. Hasni S. Role of Helicobacter pylori infection in autoimmune diseases. Curr Opin Rheumatol 2012;24:429-34.
4. Helicobacter pylori In: Feldman M, Friedman LS and Brandt LJ, Editors. Sleisenger and Fordtran’s Gastrointestinal and Liver Diseases, 9 rd ed. 2010; 833-41.
5. Bassi V, Marino G, Iengo A, et al. Autoimmune thyroid diseases and Helicobacter pylori. The correlation is present only in Graves’s disease. World J Gastroenterol 2012;18:1093-7.
6. Daniel SS, Koutsoumpa AL, Mytilinaiou MG, et al. Helicobacter pylori and autoimmune disease: Cause or bystander. World J Gastroenterol 2014; 20:613-29.
7. Brun R, Kuo K. Functional dyspepsia. Therap Adv Gastroenterol 2010;3:145-64.
8. Radic M. Role of Helicobacter pylori infection in autoimmune systemic rheumatic disease. World J Gastroenterol 2014;20:12839-46.
9. Linz B, Balloux F, Moodley Y, et al. An African origin for the intimate association between humans and Helicobacter pylori. Nature 2007;445:915-8.
10. Ozaydın N, Turkyilmaz SA, Cali S. Prevalence and risk factors of helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the 13C-Urea breath test. BMC Public Health 2013;13:1215.
11. Shapira Y, Agmon N, Renaudineau Y, et al. Serum markers of infections in patients with primary biliary cirrhosis: evidence of infection burden. Exp Mol Pathol 2012;93:386-90.
12. Ram M, Barzilai O, Shapira Y, et al. Helicobacter pylori serology in autoimmune diseases - fact or fiction? Clin Chem Lab Med 2013;51:1075- 82.
13. Durazzo M, Rosina F, Premoli A, et al. Lack of association between seroprevalence of Helicobacter pylori infection and primary biliary cirrhosis. World J Gastroenterol 2004;10:3179-81.
14. Feng H1, Zhou X, Zhang G. Association between cirrhosis and Helicobacter pylori infection: a meta-analysis. Eur J Gastroenterol Hepatol 2014;26:1309-19.
15. Kitano S, Dolgor B. Does portal hypertension contribute to the pathogenesis of gastric ulcer associated with liver cirrhosis? Journal of Gastroenterology 2000;35:79-86.
16. Kim DJ, Kim HY, Kim SJ, et al. Helicobacter pylori infection and peptic ulcer disease in patients with liver cirrhosis. Korean J Intern Med 2008;23:16-21..
17. Calvet X, Navarro M, Gil M, et al. Epidemiology of peptic ulcer disease in cirrhotic patients: role of Helicobacter pylori infection. Am J Gastroenterol 1998;93:2501-7.
18. Nam YJ, Kim SJ, Shin WC, et al. Gastric pH and Helicobacter pylori infection in patients with liver cirrhosis. Korean J Hepatol 2004;10:216- 22.
19. Bulajic M, Panic N, Löhr JM. Helicobacter pylori and pancreatic diseases. World J Gastrointest Pathophysiol 2014;5:380-3.
20. Aghili R, Jafarzadeh F, Ghorbani R, et al. The association of Helicobacter pylori infection with Hashimoto’s thyroiditis. Acta Medica Iranica 2013;51:293-6.

Otoimmün karaciğer hastalıklarında Helicobacter pylori ve üst gastrointestinal endoskopi bulgularının sıklığı

Yıl 2016, Cilt: 24 Sayı: 3, 65 - 68, 02.01.2017

Elmas Kasap Ufuk Demirci Tahir Buran Hakan Yüceyar

https://doi.org/10.17940/endoskopi.466540

Öz

Giriş ve Amaç: Helicobacter pylori birçok gastrik hastalığın nedenidir. Otoimmün karaciğer hastalıklarına diğer hastalıklar ile ilişkisiz olan çeşitli üst gastrointestinal sistem mukozal bulguları eşlik edebilir. Çalışmamızdaki amacımız retrospektif olarak otoimmun karaciğer hastalıklarında üst gastrointestinal endoskopi bulgularını taramak ve Helicobacter pylori ile ilişkisini araştırmaktır. Gereç ve Yöntem: Bu çalışmaya 99 otoimmün karaciğer hastası ve 110 kontrol grubu hastası dahil edilmiştir. Her hastanın antrumdan ve gastrik yüzeyden alınan endoskopik biyopsileri incelenmiş ve Helicobacter pylori varlığı değerlendirilmiştir. Hastalar daha öncesinde asit süpresyon, antibiyotik ya da steroid dışı inflamatuvar baskılayıcı ajan tedavisi almış ise ve veya çeşitli nedenler ile gastrik biyopsi alınmamış ise çalışmaya dahil edilmedi.Bulgular: Helicobacter pylori otoimmün hepatit hastalarında %60, primer biliyer siroz hastalarında %57 ve kontrol grubunda %63 saptandı. Üç grup arasında belirgin bir farklılık yoktu. Patolojik endoskopik bulgular otoimmün hepatit hastalarında %45, primer biliyer siroz hastalarında %52 ve kontrol grubunda %43 saptandı. Sonuç: Helicobacter pylori otoimmün hastalar ile kontrol grubu arasında benzer bulundu. Endoskopik antral gastrit otoimmün hepatit hastalarında yüksek saptansa da otoimmün karaciğer hastalarında dispeptik gruba göre belirgin bir endoskopik bulgu farklılığı saptanmadı.

Anahtar Kelimeler

Otoimmün karaciğer hastalığı, otoimmün hepatit, primer biliyer siroz, Helicobacter pylori, gastrik lezyon

Kaynakça

1. Hasni S, Ippolito A, Illei GG. Helicobacter pylori and autoimmune diseases. Oral Dis 2011;17:621-7.
2. Trivedi PJ, Adams HD. Mucosal immunity in liver autoimmunity. A comprehensive review. J Autoimmun 2013;46:97-111.
3. Hasni S. Role of Helicobacter pylori infection in autoimmune diseases. Curr Opin Rheumatol 2012;24:429-34.
4. Helicobacter pylori In: Feldman M, Friedman LS and Brandt LJ, Editors. Sleisenger and Fordtran’s Gastrointestinal and Liver Diseases, 9 rd ed. 2010; 833-41.
5. Bassi V, Marino G, Iengo A, et al. Autoimmune thyroid diseases and Helicobacter pylori. The correlation is present only in Graves’s disease. World J Gastroenterol 2012;18:1093-7.
6. Daniel SS, Koutsoumpa AL, Mytilinaiou MG, et al. Helicobacter pylori and autoimmune disease: Cause or bystander. World J Gastroenterol 2014; 20:613-29.
7. Brun R, Kuo K. Functional dyspepsia. Therap Adv Gastroenterol 2010;3:145-64.
8. Radic M. Role of Helicobacter pylori infection in autoimmune systemic rheumatic disease. World J Gastroenterol 2014;20:12839-46.
9. Linz B, Balloux F, Moodley Y, et al. An African origin for the intimate association between humans and Helicobacter pylori. Nature 2007;445:915-8.
10. Ozaydın N, Turkyilmaz SA, Cali S. Prevalence and risk factors of helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the 13C-Urea breath test. BMC Public Health 2013;13:1215.
11. Shapira Y, Agmon N, Renaudineau Y, et al. Serum markers of infections in patients with primary biliary cirrhosis: evidence of infection burden. Exp Mol Pathol 2012;93:386-90.
12. Ram M, Barzilai O, Shapira Y, et al. Helicobacter pylori serology in autoimmune diseases - fact or fiction? Clin Chem Lab Med 2013;51:1075- 82.
13. Durazzo M, Rosina F, Premoli A, et al. Lack of association between seroprevalence of Helicobacter pylori infection and primary biliary cirrhosis. World J Gastroenterol 2004;10:3179-81.
14. Feng H1, Zhou X, Zhang G. Association between cirrhosis and Helicobacter pylori infection: a meta-analysis. Eur J Gastroenterol Hepatol 2014;26:1309-19.
15. Kitano S, Dolgor B. Does portal hypertension contribute to the pathogenesis of gastric ulcer associated with liver cirrhosis? Journal of Gastroenterology 2000;35:79-86.
16. Kim DJ, Kim HY, Kim SJ, et al. Helicobacter pylori infection and peptic ulcer disease in patients with liver cirrhosis. Korean J Intern Med 2008;23:16-21..
17. Calvet X, Navarro M, Gil M, et al. Epidemiology of peptic ulcer disease in cirrhotic patients: role of Helicobacter pylori infection. Am J Gastroenterol 1998;93:2501-7.
18. Nam YJ, Kim SJ, Shin WC, et al. Gastric pH and Helicobacter pylori infection in patients with liver cirrhosis. Korean J Hepatol 2004;10:216- 22.
19. Bulajic M, Panic N, Löhr JM. Helicobacter pylori and pancreatic diseases. World J Gastrointest Pathophysiol 2014;5:380-3.
20. Aghili R, Jafarzadeh F, Ghorbani R, et al. The association of Helicobacter pylori infection with Hashimoto’s thyroiditis. Acta Medica Iranica 2013;51:293-6.

Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Bölüm	Makaleler
Yazarlar	Elmas Kasap Ufuk Demirci Tahir Buran Bu kişi benim Hakan Yüceyar
Yayımlanma Tarihi	2 Ocak 2017
Yayımlandığı Sayı	Yıl 2016 Cilt: 24 Sayı: 3

Kaynak Göster

APA	Kasap, E., Demirci, U., Buran, T., Yüceyar, H. (2017). Helicobacter pylori frequency and upper gastrointestinal system endoscopic findings in autoimmune hepatic diseases. Endoskopi Gastrointestinal, 24(3), 65-68. https://doi.org/10.17940/endoskopi.466540
AMA	Kasap E, Demirci U, Buran T, Yüceyar H. Helicobacter pylori frequency and upper gastrointestinal system endoscopic findings in autoimmune hepatic diseases. Endoskopi Gastrointestinal. Ocak 2017;24(3):65-68. doi:10.17940/endoskopi.466540
Chicago	Kasap, Elmas, Ufuk Demirci, Tahir Buran, ve Hakan Yüceyar. “Helicobacter Pylori Frequency and Upper Gastrointestinal System Endoscopic Findings in Autoimmune Hepatic Diseases”. Endoskopi Gastrointestinal 24, sy. 3 (Ocak 2017): 65-68. https://doi.org/10.17940/endoskopi.466540.
EndNote	Kasap E, Demirci U, Buran T, Yüceyar H (01 Ocak 2017) Helicobacter pylori frequency and upper gastrointestinal system endoscopic findings in autoimmune hepatic diseases. Endoskopi Gastrointestinal 24 3 65–68.
IEEE	E. Kasap, U. Demirci, T. Buran, ve H. Yüceyar, “Helicobacter pylori frequency and upper gastrointestinal system endoscopic findings in autoimmune hepatic diseases”, Endoskopi Gastrointestinal, c. 24, sy. 3, ss. 65–68, 2017, doi: 10.17940/endoskopi.466540.
ISNAD	Kasap, Elmas vd. “Helicobacter Pylori Frequency and Upper Gastrointestinal System Endoscopic Findings in Autoimmune Hepatic Diseases”. Endoskopi Gastrointestinal 24/3 (Ocak 2017), 65-68. https://doi.org/10.17940/endoskopi.466540.
JAMA	Kasap E, Demirci U, Buran T, Yüceyar H. Helicobacter pylori frequency and upper gastrointestinal system endoscopic findings in autoimmune hepatic diseases. Endoskopi Gastrointestinal. 2017;24:65–68.
MLA	Kasap, Elmas vd. “Helicobacter Pylori Frequency and Upper Gastrointestinal System Endoscopic Findings in Autoimmune Hepatic Diseases”. Endoskopi Gastrointestinal, c. 24, sy. 3, 2017, ss. 65-68, doi:10.17940/endoskopi.466540.
Vancouver	Kasap E, Demirci U, Buran T, Yüceyar H. Helicobacter pylori frequency and upper gastrointestinal system endoscopic findings in autoimmune hepatic diseases. Endoskopi Gastrointestinal. 2017;24(3):65-8.