Predictive value of NLRC3 levels for pulmonary hypertension in patients with chronic obstructive pulmonary disease
Öz
Objectives: Chronic obstructive pulmonary disease (COPD) is a medical condition defined by persistent airflow limitation and respiratory symptoms caused by airway and/or alveolar abnormalities. Pulmonary hypertension (PH) is one of the cardiovascular comorbidities associated with COPD. We investigated the correlation of NLRC3 levels in patients with COPD with prognostic and surrogate parameters of PH on echocardiography and examined whether it could be used to predict PH in this patient population.
Methods: A total of 80 patients diagnosed with COPD and 40 healthy volunteers as the control group were included in the study. The COPD group was further divided into two subgroups according to the systolic pulmonary artery pressure (sPAP) as follows: sPAP<35 mmHg and sPAP≥35 mmHg. The enzyme-linked immunosorbent assay (ELISA) method was used to determine the levels of NLRC3 in peripheral blood.
Results: Patients with sPAP≥35 mmHg had a lower mean NLRC3 level than those with sPAP<35 mmHg (P=0.006). The NLRC3 levels showed a significant negative correlation with sPAP, tricuspid regurgitation velocity, right atrium, and pulmonary artery diameter. For NLRC3, the cut-off value was found to be 271,486 ng/L, with a sensitivity of 74%, and specificity of 63% in distinguishing patients with sPAP≥35 mmHg from all patients with sPAP<35 mmHg.
Conclusions: Our study results suggest that NLRC3 levels measured from peripheral blood are predictive of PH in patients with COPD. Although the exact function of NLRC3 in the lungs, COPD, and PH have not been completely understood, we believe these findings will serve as a model for future studies.
Anahtar Kelimeler
NLRC3 chronic obstructive pulmonary disease pulmonary hypertension echocardiography
Etik Beyan
The study protocol was approved by the the Tekirdağ Namık Kemal University, Non-Interventional Clinical Research Ethics Committee (No: 2019.164.09.24, date: 24/09/2019).
Destekleyen Kurum
Tekirdağ Namık Kemal University (project number: NKUBAP.02.TU.20.249).
Proje Numarası
NKUBAP.02.TU.20.249
Kaynakça
- 1. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023. Available from: https://goldcopd.org/2023-gold-report-2/ Accessed on September 1, 2023.
- 2. Jyothula S, Safdar Z. Update on pulmonary hypertension complicating chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2009;4:351-63. doi: 10.2147/copd.s5102.
- 3. Seeger W, Adir Y, Barberà JA, et al. Pulmonary hypertension in chronic lung diseases. J Am Coll Cardiol. 2013;62(25 Suppl):D109-116. doi: 10.1016/j.jacc.2013.10.036.
- 4. Davis BK, Wen H, Ting JP. The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol. 2011;29:707-735. doi: 10.1146/annurev-immunol-031210-101405.
- 5. Chen G, Shaw MH, Kim YG, Nuñez G. NOD-like receptors: role in innate immunity and inflammatory disease. Annu Rev Pathol. 2009;4:365-398. doi: 10.1146/annurev.pathol.4.110807.092239.
- 6. Karki R, Man SM, Malireddi RKS, et al. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016;540(7634):583-587. doi: 10.1038/nature20597.
- 7. Zha LH, Zhou J, Li TZ, et al. NLRC3: a novel noninvasive biomarker for pulmonary hypertension diagnosis. Aging Dis. 2018;9(5):843-851. doi: 10.14336/AD.2017.1102.
- 8. Chaouat A, Naeije R, Weitzenblum E. Pulmonary hypertension in COPD. Eur Respir J. 2008;32(5):1371-1385. doi: 10.1183/09031936.00015608.
- 9. Chaput C, Sander LE, Suttorp N, Opitz B. NOD-like receptors in lung siseases. Front Immunol. 2013;4:393. doi: 10.3389/fimmu.2013.00393.
- 10. Schneider M, Zimmermann AG, Roberts RA, et al. The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat Immunol. 2012;13(9):823-831. doi: 10.1038/ni.2378.
- 11. Ghio S, Klersy C, Magrini G, et al. Prognostic relevance of the echocardiographic assessment of right ventricular function in patients with idiopathic pulmonary arterial hypertension. Int J Cardiol. 2010;140(3):272-278. doi: 10.1016/j.ijcard.2008.11.051.
- 12. Zha LH, Zhou J, Li TZ, et al. NLRC3 inhibits MCT-induced pulmonary hypertension in rats via attenuating PI3K activation. J Cell Physiol. 2019;234(9):15963-15976. doi: 10.1002/jcp.28255.
Öz
Proje Numarası
NKUBAP.02.TU.20.249
Kaynakça
- 1. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023. Available from: https://goldcopd.org/2023-gold-report-2/ Accessed on September 1, 2023.
- 2. Jyothula S, Safdar Z. Update on pulmonary hypertension complicating chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2009;4:351-63. doi: 10.2147/copd.s5102.
- 3. Seeger W, Adir Y, Barberà JA, et al. Pulmonary hypertension in chronic lung diseases. J Am Coll Cardiol. 2013;62(25 Suppl):D109-116. doi: 10.1016/j.jacc.2013.10.036.
- 4. Davis BK, Wen H, Ting JP. The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol. 2011;29:707-735. doi: 10.1146/annurev-immunol-031210-101405.
- 5. Chen G, Shaw MH, Kim YG, Nuñez G. NOD-like receptors: role in innate immunity and inflammatory disease. Annu Rev Pathol. 2009;4:365-398. doi: 10.1146/annurev.pathol.4.110807.092239.
- 6. Karki R, Man SM, Malireddi RKS, et al. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016;540(7634):583-587. doi: 10.1038/nature20597.
- 7. Zha LH, Zhou J, Li TZ, et al. NLRC3: a novel noninvasive biomarker for pulmonary hypertension diagnosis. Aging Dis. 2018;9(5):843-851. doi: 10.14336/AD.2017.1102.
- 8. Chaouat A, Naeije R, Weitzenblum E. Pulmonary hypertension in COPD. Eur Respir J. 2008;32(5):1371-1385. doi: 10.1183/09031936.00015608.
- 9. Chaput C, Sander LE, Suttorp N, Opitz B. NOD-like receptors in lung siseases. Front Immunol. 2013;4:393. doi: 10.3389/fimmu.2013.00393.
- 10. Schneider M, Zimmermann AG, Roberts RA, et al. The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat Immunol. 2012;13(9):823-831. doi: 10.1038/ni.2378.
- 11. Ghio S, Klersy C, Magrini G, et al. Prognostic relevance of the echocardiographic assessment of right ventricular function in patients with idiopathic pulmonary arterial hypertension. Int J Cardiol. 2010;140(3):272-278. doi: 10.1016/j.ijcard.2008.11.051.
- 12. Zha LH, Zhou J, Li TZ, et al. NLRC3 inhibits MCT-induced pulmonary hypertension in rats via attenuating PI3K activation. J Cell Physiol. 2019;234(9):15963-15976. doi: 10.1002/jcp.28255.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Göğüs Hastalıkları |
| Bölüm | Original Article |
| Yazarlar | |
| Proje Numarası | NKUBAP.02.TU.20.249 |
| Erken Görünüm Tarihi | 28 Aralık 2023 |
| Yayımlanma Tarihi | 4 Mayıs 2024 |
| Gönderilme Tarihi | 11 Eylül 2023 |
| Kabul Tarihi | 21 Aralık 2023 |
| Yayımlandığı Sayı | Yıl 2024 Cilt: 10 Sayı: 3 |
