Araştırma Makalesi
Evaluation of Electrolyte Imbalance and Blood Gas Parameters in Patients Who Had Rotavirus Gastroenteritis
Öz
Aim: In the present study, the cases admitted to the hospital because of acute gastroenteritis and diagnosed with common RVGE were evaluated in terms of demographic, epidemiological, clinical, and laboratory data.
Methods: The clinical and laboratory data of the cases who applied to Selçuk University Faculty of Medicine, Pediatric Emergency Clinic because of acute gastroenteritis aged 0-18 were evaluated retrospectively in the study. Clinical findings, time of admission, place of observation, blood gas and electrolyte levels, electrolyte imbalance, and length of hospital stays of the patients were recorded.
Results: Among the AGE patients who were included in the study, 148 (61.2%) were male and 94 (38.8%) were female. The incidence of hypokalemia in patients who had RV(+) GE was statistically significant. Statistically significant differences were detected between the groups in terms of creatinine, potassium, AST, ALT and albumin values of biochemical parameters. When the blood gas analysis of patients who had AGE was evaluated, although acidosis was detected in 24 (9.9%) patients who had pH value, alkalosis was detected in 27 (11.2%) patients.
Conclusion: Cases with metabolic acidosis in rotavirus gastroenteritis are hospitalized more frequently, and for this reason, blood gas studies in cases of RV gastroenteritis will guide clinicians.
Anahtar Kelimeler
Kaynakça
- Walker CLF, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, et al. Global burden of childhood pneumonia and diarrhoea. Lancet 2013;381:1405-16.
- Farthing M, Salam MA, Lindberg G, Dite P, Khalif I, Salazar-Lindo E, et al. Acute diarrhea in adults and children: a global perspective. J Clin Gastroenterol 2013;47:12-20.
- Bozdayı G, Dogan B, Dalgıc B, Bostancı I, Sarı S, Battaloglu NO, et al. Diversity of human rotavirus G9 among children in Turkey. J MedVirol 2008; 80(4): 733-40.
- Parashar UD, Gibson CJ, Bresse JS, Glass RI. Rotavirus and severe childhood diarrhea. Emerg Infect Dis. 2006;12:304-6.
- Kirişci Ö, Muratdağı G. Bir Devlet Hastanesine Akut Gastroenterit ile Başvuran Hastalarda Rotavirüs ve Enterik Adenovirüs Enfeksiyonu Sıklığı. Sakarya Tıp Dergisi 2019;9:585-91.
- Dalgıç N, Haşim Ö, Pullu M, Sancar M, Kafadar İ, Yılmaz A. Is Rotavirus Diarrhea a Systemic Viral Infection? Journal of Pediatric Infection. 2010;4:48-55.
- Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R and Szajewska H; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases. Evidence-Based Guidelines for the Management of Acute Gastroenteritis in Children in Europe: Update 2014. J Pediatr Gastroenterol Nutr 2014; 59 (1):132-52.
- Casagranda I. Point-of-care testing in critical care: the clinician's point of view. Clin Chem Lab Med 2010;48:931-4.
- Flegar‐Mestric Z, Perkov S. Comparability of point-of-care whole-blood electrolyte and substrate testing using a Stat Profile Critical Care Xpress analyzer and standard laboratory methods. Clin Chem Lab Med 2006;44(7):898-903.
- Leino A, Kurvinen K. Interchangeability of blood gas, electrolyte and metabolite results measured with point-of-care, blood gas and core laboratory analyzers. Clin Chem Lab Med 2011;49(7):1187-91.
- RM Kliegman, RE Behrman, HB Jenson, BMD Stanton. Reference intervals. Nelson Textbook of Pediatrics, 20th edition, Philedelphia: 2016.
- Johansen K, Hedlund KO, Zweyberg-Wirgart B, Bennet R. Complications attributable to rotavirus-induced diarrhoea in a Swedish paediatric population: reportfrom an 11-year surveillance. Scand J Infect Dis 2008;40:958-64.
- Wiegering V, Kaiser J, Tappe D, Weissbrich B, Morbach H, Girschick HJ. Gastroenteritis in childhood: a retrospective study of 650 hospitalized pediatric patients. Int J Infect Dis 2011;15(6):401-7.
- Hungerford D, Vivancos R, EuroRotaNet Network Members. In-season and out-of-season variation of rotavirus genotype distribution and age of infection across 12 European countries before the introduction of routine vaccination, 2007/08 to 2012/13. Euro Surveill 2016;21(2).
- Salim H, Karyana IP, Sanjaya-Putra IG, Budiarsa S, Soenarto Y. Risk factors of rotavirus diarrhea in hospitalized children in Sanglah Hospital, Denpasar: a prospective cohort study. BMC Gastroenterol 2014;14:54.
- Tagbo BN, Mwenda JM, Eke CB, Edelu BO, Chukwubuike C, Armah G, et al. Rotavirus diarrhoea hospitalizations among children under 5 years of age in Nigeria, 2011–2016. Vaccine 2018;36(51):7759-64.
- Mathew A, Rao PS, Sowmyanarayanan TV, Kang G. Severity of rotavirus gastroenteritis in an Indian population: report from a 3 year surveillance study. Vaccine 2014;32(1):45-8.
- Adal E, Bezen D, Önal Z, Önal H. Etiologic and Epidemiologic Factors in Acute Gastroenteritis of Infants. JOPP 2011;3:35-40.
- Kızılırmak A, Çalışkan E, Temizkan RC. Rotavirus and Adenovirus Frequency in Children with Acute Gastroenteritis. Konuralp Medical Journal 2017;9.35-9
- Palanduz A. Infectious Gastroenteritis: Etiologic Agents and Clinical Assessment. Journal of Pediatric Infection 2009;3:116-8
- Aydin A, Arslan N, Bim G. The Evaluation Of Admission Signs And Treatment Response Of Patients With Acute Gastroenteritis. J DEU Med 2006;20:1-5.
- Gürbüz F, Tezer H, Şayli T. Etiologic Factors And Clinical Findings Of Patients Hospitalized Children For Acute Gastroenteritis: Epidemiologic Study. Turkish J. Pediatr. Dis 2010;4:211-8.
- Malaki M. Mean platelet volume a key or obstacle in clinical affairs. Int J Crit Illn Inj Sci. 2015;5(3):217-8.
- Mete E, Akelma AZ, Cizmeci MN, Bozkaya D, Kanburoglu MK. Decreased mean platelet volume in children with acute rotavirus gastroenteritis. Platelets 2014;25:51-4.
- Çelik T, Güler E, Berksoy AE, Nur A. Mean Platelet Volume as a Negative Marker of Inflammation in Children with Rotavirus Gastroenteritis. Iran J Pediatr 2014;24(5),:617-22.
- Nokes DJ, Abwao J, Pamba A, Peenze I, Dewar J, Maghenda JK, et al. Incidence and clinical characteristics of group A rotavirus infections among children admitted to hospital in Kilifi, Kenya. PLoS Med 2008;5:e153.
- Çubuk E, Aktar F, Yılmaz K, Sabaz MN, Solmaz M, Asena M, et al. Retrospective Analysis of Patients Admitted To Our Pediatrics Outpatient Clinic Between 2011 and 2015 With A Complaint of Diarrhea With Adenovirus and/or Rotavirus Positivity. Van Medical Journal 2018;25:374-80
- Intusoma U, Sornsrivichai V, Jiraphongsa C, Varavithaya W. Epidemiology, clinical manifestations and burden of rotavirus diarrhea in children under five seen at Ramathibodi Hospital, Thailand. J Med Assoc Thai 2008;91:1350-5.
- Hoxha T, Xhelili L, Azemi M, Avdiu M, Ismaili-Jaha V, Efendija-Beqa U, et al. Performance of clinical signs in the diagnosis of dehydration in children with acute gastroenteritis. Med Arch 2015;69:10-2.
- Wildi-Runge S, Allemann S, Schaad UB, Heininger U. A 4-year study on clinical characteristics of children hospitalized with rotavirus gastroenteritis. Eur J Pediatr 2009;168:1343-8.
Rotavirus Gastroenteriti Olan Hastalarda Elektrolit Dengesizliği ve Kan Gazı Parametrelerinin Değerlendirilmesi
Öz
Amaç: Bu çalışmada akut gastroenterit nedeniyle hastaneye başvuran ve yaygın RVGE tanısı konulan olgular demografik, epidemiyolojik, klinik ve laboratuvar verileri açısından değerlendirildi.
Yöntemler: Çalışmada Selçuk Üniversitesi Tıp Fakültesi Çocuk Acil Kliniğine akut gastroenterit nedeniyle başvuran 0-18 yaş arası olguların klinik ve laboratuvar verileri retrospektif olarak değerlendirildi. Hastaların klinik bulguları, başvuru zamanı, gözlem yeri, kan gazı ve elektrolit düzeyleri, elektrolit dengesizliği ve hastanede kalış süreleri kaydedildi.
Bulgular: Çalışmaya alınan AGE hastalarının 148'i (%61,2) erkek, 94'ü (%38,8) kadındı. RV(+) GE olan hastalarda hipokalemi insidansı istatistiksel olarak anlamlıydı. Biyokimyasal parametrelerin kreatinin, potasyum, AST, ALT ve albümin değerleri açısından gruplar arasında istatistiksel olarak anlamlı farklılıklar tespit edildi. AGE olan hastaların kan gazı analizi değerlendirildiğinde pH değeri olan 24 (%9,9) hastada asidoz saptanmasına rağmen 27 (%11,2) hastada alkaloz saptandı.
Sonuç: Rotavirüs gastroenteritinde metabolik asidozlu olgular daha sık hastaneye yatırılmaktadır ve bu nedenle RV gastroenterit olgularında kan gazı çalışmaları klinisyenlere yol gösterici olacaktır.
Anahtar Kelimeler
Kaynakça
- Walker CLF, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, et al. Global burden of childhood pneumonia and diarrhoea. Lancet 2013;381:1405-16.
- Farthing M, Salam MA, Lindberg G, Dite P, Khalif I, Salazar-Lindo E, et al. Acute diarrhea in adults and children: a global perspective. J Clin Gastroenterol 2013;47:12-20.
- Bozdayı G, Dogan B, Dalgıc B, Bostancı I, Sarı S, Battaloglu NO, et al. Diversity of human rotavirus G9 among children in Turkey. J MedVirol 2008; 80(4): 733-40.
- Parashar UD, Gibson CJ, Bresse JS, Glass RI. Rotavirus and severe childhood diarrhea. Emerg Infect Dis. 2006;12:304-6.
- Kirişci Ö, Muratdağı G. Bir Devlet Hastanesine Akut Gastroenterit ile Başvuran Hastalarda Rotavirüs ve Enterik Adenovirüs Enfeksiyonu Sıklığı. Sakarya Tıp Dergisi 2019;9:585-91.
- Dalgıç N, Haşim Ö, Pullu M, Sancar M, Kafadar İ, Yılmaz A. Is Rotavirus Diarrhea a Systemic Viral Infection? Journal of Pediatric Infection. 2010;4:48-55.
- Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R and Szajewska H; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases. Evidence-Based Guidelines for the Management of Acute Gastroenteritis in Children in Europe: Update 2014. J Pediatr Gastroenterol Nutr 2014; 59 (1):132-52.
- Casagranda I. Point-of-care testing in critical care: the clinician's point of view. Clin Chem Lab Med 2010;48:931-4.
- Flegar‐Mestric Z, Perkov S. Comparability of point-of-care whole-blood electrolyte and substrate testing using a Stat Profile Critical Care Xpress analyzer and standard laboratory methods. Clin Chem Lab Med 2006;44(7):898-903.
- Leino A, Kurvinen K. Interchangeability of blood gas, electrolyte and metabolite results measured with point-of-care, blood gas and core laboratory analyzers. Clin Chem Lab Med 2011;49(7):1187-91.
- RM Kliegman, RE Behrman, HB Jenson, BMD Stanton. Reference intervals. Nelson Textbook of Pediatrics, 20th edition, Philedelphia: 2016.
- Johansen K, Hedlund KO, Zweyberg-Wirgart B, Bennet R. Complications attributable to rotavirus-induced diarrhoea in a Swedish paediatric population: reportfrom an 11-year surveillance. Scand J Infect Dis 2008;40:958-64.
- Wiegering V, Kaiser J, Tappe D, Weissbrich B, Morbach H, Girschick HJ. Gastroenteritis in childhood: a retrospective study of 650 hospitalized pediatric patients. Int J Infect Dis 2011;15(6):401-7.
- Hungerford D, Vivancos R, EuroRotaNet Network Members. In-season and out-of-season variation of rotavirus genotype distribution and age of infection across 12 European countries before the introduction of routine vaccination, 2007/08 to 2012/13. Euro Surveill 2016;21(2).
- Salim H, Karyana IP, Sanjaya-Putra IG, Budiarsa S, Soenarto Y. Risk factors of rotavirus diarrhea in hospitalized children in Sanglah Hospital, Denpasar: a prospective cohort study. BMC Gastroenterol 2014;14:54.
- Tagbo BN, Mwenda JM, Eke CB, Edelu BO, Chukwubuike C, Armah G, et al. Rotavirus diarrhoea hospitalizations among children under 5 years of age in Nigeria, 2011–2016. Vaccine 2018;36(51):7759-64.
- Mathew A, Rao PS, Sowmyanarayanan TV, Kang G. Severity of rotavirus gastroenteritis in an Indian population: report from a 3 year surveillance study. Vaccine 2014;32(1):45-8.
- Adal E, Bezen D, Önal Z, Önal H. Etiologic and Epidemiologic Factors in Acute Gastroenteritis of Infants. JOPP 2011;3:35-40.
- Kızılırmak A, Çalışkan E, Temizkan RC. Rotavirus and Adenovirus Frequency in Children with Acute Gastroenteritis. Konuralp Medical Journal 2017;9.35-9
- Palanduz A. Infectious Gastroenteritis: Etiologic Agents and Clinical Assessment. Journal of Pediatric Infection 2009;3:116-8
- Aydin A, Arslan N, Bim G. The Evaluation Of Admission Signs And Treatment Response Of Patients With Acute Gastroenteritis. J DEU Med 2006;20:1-5.
- Gürbüz F, Tezer H, Şayli T. Etiologic Factors And Clinical Findings Of Patients Hospitalized Children For Acute Gastroenteritis: Epidemiologic Study. Turkish J. Pediatr. Dis 2010;4:211-8.
- Malaki M. Mean platelet volume a key or obstacle in clinical affairs. Int J Crit Illn Inj Sci. 2015;5(3):217-8.
- Mete E, Akelma AZ, Cizmeci MN, Bozkaya D, Kanburoglu MK. Decreased mean platelet volume in children with acute rotavirus gastroenteritis. Platelets 2014;25:51-4.
- Çelik T, Güler E, Berksoy AE, Nur A. Mean Platelet Volume as a Negative Marker of Inflammation in Children with Rotavirus Gastroenteritis. Iran J Pediatr 2014;24(5),:617-22.
- Nokes DJ, Abwao J, Pamba A, Peenze I, Dewar J, Maghenda JK, et al. Incidence and clinical characteristics of group A rotavirus infections among children admitted to hospital in Kilifi, Kenya. PLoS Med 2008;5:e153.
- Çubuk E, Aktar F, Yılmaz K, Sabaz MN, Solmaz M, Asena M, et al. Retrospective Analysis of Patients Admitted To Our Pediatrics Outpatient Clinic Between 2011 and 2015 With A Complaint of Diarrhea With Adenovirus and/or Rotavirus Positivity. Van Medical Journal 2018;25:374-80
- Intusoma U, Sornsrivichai V, Jiraphongsa C, Varavithaya W. Epidemiology, clinical manifestations and burden of rotavirus diarrhea in children under five seen at Ramathibodi Hospital, Thailand. J Med Assoc Thai 2008;91:1350-5.
- Hoxha T, Xhelili L, Azemi M, Avdiu M, Ismaili-Jaha V, Efendija-Beqa U, et al. Performance of clinical signs in the diagnosis of dehydration in children with acute gastroenteritis. Med Arch 2015;69:10-2.
- Wildi-Runge S, Allemann S, Schaad UB, Heininger U. A 4-year study on clinical characteristics of children hospitalized with rotavirus gastroenteritis. Eur J Pediatr 2009;168:1343-8.
Toplam 30 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Original Article |
| Yazarlar | |
| Erken Görünüm Tarihi | 29 Aralık 2023 |
| Yayımlanma Tarihi | 31 Aralık 2023 |
| Gönderilme Tarihi | 12 Kasım 2022 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 33 Sayı: 6 |
Genel Tıp Dergisi Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı (CC BY NC) ile lisanslanmıştır.