Sekiz Haftalık Core Egzersizin İnflamatuar Biyobelirteçlere Akut Etkisinin İncelenmesi: Ampute Futbolcular Üzerine Bir Çalışma
Öz
Amaç: Egzersizin inflamatuar biyo-belirteçler üzerine olumlu etkileri olduğu bilinmektedir. Fakat core egzersiz gibi spesifik egzersizlerin inflamatuar belirteçler üzerindeki etkisine yönelik sonuçlar sınırlıdır. Bu nedenle bu çalışmanın amacı, core egzersizin inflamatuar biyo-belirteçler olan interlökin 6 (IL-6), C-reaktif protein (CRP) ve albümine akut etkisinin incelenmesidir.
Materyal ve Metot: Bu çalışmada nicel veri toplama metotlarından deneysel yöntem kullanılmıştır. Araştırma örneklemini, yaşları 19-36 arasında değişen 11 elit ampute futbolcu oluşturmaktadır. Katılımcılar core egzersiz grubu (EG) ve kontrol grubu (KG) olarak iki gruba rastgele yöntemle ayrıldı. Araştırmanın 0.haftasında, katılımcıların kan örnekleri aerobik yüklenme (AY) öncesinde ve sonrasında alındı. 8 haftalık (haftada 3 gün) egzersiz programı sonrasında aynı işlem tekrarlandı. Kan ölçümleri kapsamında IL-6, CRP ve albümin değerlerine bakılmıştır. Araştırmanın istatistiksel işlemleri için SPSS paket program 25 kullanılmıştır. Verilerin normallik analizi sonucunda verilerin normal dağılmadı tespit edilmiş ve non-parametrik testlerden Wilcoxon Testi uygulanmıştır. Araştırmada anlamlılık düzeyi p=0,05 olarak belirlenmiştir.
Bulgular: Araştırma sonuçlarına göre EG’nun 0. ve 8. hafta AY öncesi ve sonrası akut IL-6 seviyeleri arasında sırasıyla p=0.043 ve p=0.028 düzeyinde anlamlı fark tespit edilmiştir. 0. ve 8. hafta AY öncesi ve sonrası akut albümin seviyeleri arasında AY öncesi p=0.041 düzeyinde anlamlı fark tespit edilmiştir. 0. ve 8. hafta AY öncesi ve sonrası akut CRP seviyeleri değişmemiştir (p>0.05). KG’nun 0. ve 8. hafta AY öncesi ve sonrası akut IL-6 seviyeleri arasında sırasıyla p=0.043 ve p=0.043 düzeyinde anlamlı fark tespit edilmiştir. KG’nun albümin ve CRP seviyeleri arasında istatistiksel olarak anlamlı fark tespit edilmemiştir.
Sonuçlar: Core egzersiz ampute futbolcularda IL-6 ve albumin değerlerine olumlu etki etmiştir. Bu nedenle core egzersizlerin, ampute futbolcuların rütin futbol antrenman programına dahil edilmesi önerilmektedir.
Anahtar Kelimeler
Destekleyen Kurum
İnönü Üniversitesi Bilimsel Araştırma Projeleri Birimi
Proje Numarası
TDK 2020/2317
Kaynakça
- Calabrese, M., Garofano, M., Palumbo, R., Di Pietro, P., Izzo, C., Damato, A., ... & Vecchione, C. (2021). Exercise training and cardiac rehabilitation in COVID-19 patients with cardiovascular complications: state of art. Life, 11(3), 259.
- Yu, B., Tong, S., Wu, Y., Abdelrahim, M. E., & Cao, M. (2021). Effects of resistance training on exercise ability in chronic obstructive pulmonary disease subjects: A systematic review and meta‐analysis. International Journal of Clinical Practice, 75(9), e14373.
- Ashcraft, K. A., Warner, A. B., Jones, L. W., & Dewhirst, M. W. (2019, January). Exercise as adjunct therapy in cancer. In Seminars in radiation oncology (Vol. 29, No. 1, pp. 16-24). WB Saunders.
- Picard, M., Tauveron, I., Magdasy, S., Benichou, T., Bagheri, R., Ugbolue, U. C., ... & Dutheil, F. (2021). Effect of exercise training on heart rate variability in type 2 diabetes mellitus patients: A systematic review and meta-analysis. PloS one, 16(5), e0251863.
- Pawelec, G., Goldeck, D., & Derhovanessian, E. (2014). Inflammation, ageing and chronic disease. Current opinion in immunology, 29, 23-28.
- Burini, R. C., Anderson, E., Durstine, J. L., & Carson, J. A. (2020). Inflammation, physical activity, and chronic disease: an evolutionary perspective. Sports Medicine and Health Science, 2(1), 1-6.
- Begum, S., & Latunde-Dada, G. O. (2019). Anemia of inflammation with an emphasis on chronic kidney disease. Nutrients, 11(10), 2424. Beavers, K. M., Brinkley, T. E., & Nicklas, B. J. (2010). Effect of exercise training on chronic inflammation. Clinica chimica acta, 411(11-12), 785-793.
- Trochimiak, T., & Hübner-Woźniak, E. (2014). Review EFFECT OF EXERCISE ON THE LEVEL OF IMMUNOGLOBULIN A IN SALIVA. Biology of Sport, 29(4), 255-261.
- Gaitanos, G. C., Williams, C., Boobis, L. H., & Brooks, S. (1993). Human muscle metabolism during intermittent maximal exercise. Journal of applied physiology, 75(2), 712-719.
- Wedell-Neergaard, A. S., Lehrskov, L. L., Christensen, R. H., Legaard, G. E., Dorph, E., Larsen, M. K., ... & Krogh-Madsen, R. (2019). Exercise-induced changes in visceral adipose tissue mass are regulated by IL-6 signaling: a randomized controlled trial. Cell metabolism, 29(4), 844-855.
- Sadjapong, U., Yodkeeree, S., Sungkarat, S., & Siviroj, P. (2020). Multicomponent exercise program reduces frailty and inflammatory biomarkers and improves physical performance in community-dwelling older adults: A randomized controlled trial. International Journal of Environmental Research and Public Health, 17(11), 3760.
- Ostrowski, K., Rohde, T., Zacho, M., Asp, S., & Pedersen, B. K. (1998). Evidence that interleukin‐6 is produced in human skeletal muscle during prolonged running. The Journal of physiology, 508(3), 949-953.
- Lobo, S. M., Lobo, F. R., Bota, D. P., Lopes-Ferreira, F., Soliman, H. M., Meélot, C., & Vincent, J. L. (2003). C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest, 123(6), 2043-2049.
- Keppel, G. (1991). Design and analysis: A researcher's handbook. Prentice-Hall, Inc.: e0213256.
- Karvonen, J., & Vuorimaa, T. (1988). Heart rate and exercise intensity during sports activities. Sports medicine, 5(5), 303-311.
- Hooper J, McCreanor G, Marshall WJ, Myers P. Primary Care & Laboratory Medicine. ACB Venture. 1996: 16-44.
- Mardia, K. V. (1974). Applications of some measures of multivariate skewness and kurtosis in testing normality and robustness studies. Sankhyā: The Indian Journal of Statistics, Series B, 115-128.
- Sarıakçalı, B., Duman, G., Ceylan, L., Polat, M., Hazar, S., & Eliöz, M. (2021). Spor bilimleri fakültesinde uygulama eğitimin biyokimyasal ve hematolojik parametrelere etkisi. Spor ve Performans Araştırmaları Dergisi, 12(3), 222-232.
- Koca, H. B., Yıldırım, İ., Işık, Ö., Koca, T., & Bal, T. (2018). Genç Yetişkin Kadınlarda Düzenli Aerobik Egzersizlerin İnflamatuar Belirteçler Üzerine Etkisi. Spor ve Performans Araştırmaları Dergisi, 9(1), 25-34.
- Sadjapong, U., Yodkeeree, S., Sungkarat, S., & Siviroj, P. (2020). Multicomponent exercise program reduces frailty and inflammatory biomarkers and improves physical performance in community-dwelling older adults: A randomized controlled trial. International Journal of Environmental Research and Public Health, 17(11), 3760.
- Rose, G. L., Skinner, T. L., Mielke, G. I., & Schaumberg, M. A. (2021). The effect of exercise intensity on chronic inflammation: A systematic review and meta-analysis. Journal of Science and Medicine in Sport, 24(4), 345-351.
- Neefkes-Zonneveld, C. R., Bakkum, A. J., Bishop, N. C., van Tulder, M. W., & Janssen, T. W. (2015). Effect of long-term physical activity and acute exercise on markers of systemic inflammation in persons with chronic spinal cord injury: a systematic review. Archives of Physical Medicine and Rehabilitation, 96(1), 30-42.
- Donia, S. A., Allison, D. J., Gammage, K. L., & Ditor, D. S. (2019). The effects of acute aerobic exercise on mood and inflammation in individuals with multiple sclerosis and incomplete spinal cord injury. NeuroRehabilitation, 45(1), 117-124.
- Metsios, G. S., Moe, R. H., & Kitas, G. D. (2020). Exercise and inflammation. Best Practice & Research Clinical Rheumatology, 34(2), 101504.
- WEIL, M. H., HENNING, R. J., & PURI, V. K. (1979). Colloid oncotic pressure: clinical significance. Critical Care Medicine, 7(3), 113-116.
- Ostrowski, K., Rohde, T., Zacho, M., Asp, S., & Pedersen, B. K. (1998). Evidence that interleukin‐6 is produced in human skeletal muscle during prolonged running. The Journal of physiology, 508(3), 949-953.
- Peters Jr, T. (1995). All about albumin: biochemistry, genetics, and medical applications. Academic press.
- Nagashima, K., Cline, G. W., Mack, G. W., Shulman, G. I., & Nadel, E. R. (2000). Intense exercise stimulates albumin synthesis in the upright posture. Journal of Applied Physiology, 88(1), 41-46.
- Gillen, C. M., Lee, R., Mack, G. W., Tomaselli, C. M., Nishiyasu, T., & Nadel, E. R. (1991). Plasma volume expansion in humans after a single intense exercise protocol. Journal of Applied Physiology, 71(5), 1914-1920.
- Çolak, T., Bamaç, B., Çolak, S., Duman, C., Bayazit, B., Öztürk, S., ... & Yildiz, F. (2010). The influence of a single bout of wrestling exercise on serum levels of ischemia-modified albumin. Journal of Exercise Science & Fitness, 8(2), 67-72.
Investigation of Acute Effects of Eight-Week Core Exercise on Inflammatory Biomarkers: A Study on Amputee Football Players
Öz
Abstract
Objective: It is known that exercise has positive effects on inflammatory biomarkers. However, the results on the effect of specific exercises such as core exercises on inflammatory markers are limited. Therefore, the aim of this study is to examine the acute effects of core exercise on inflammatory biomarkers interleukin 6 (IL-6), C-reactive protein (CRP) and albumin.
Materials and Methods: In this study, the experimental method, one of the quantitative data collection methods, was used. The research sample consists of 11 elite amputee football players aged between 19-36. Participants were randomly divided into two groups as core exercise group (EG) and control group (KG). At week 0 of the study, blood samples of the participants were taken before and after the aerobic exercise (AY). The same procedure was repeated after an 8-week (3 days a week) exercise program. Within the scope of blood measurements, IL-6, CRP and albumin values were checked. SPSS package program 25 was used for the statistical processes of the research. As a result of the normality analysis of the data, it was determined that the data were not normally distributed and the Wilcoxon Test, one of the non-parametric tests, was applied. The level of significance in the study was determined as p=0.05.
Results: According to the results of the study, a significant difference was found between the levels of p=0.043 and p=0.028 between acute IL-6 levels before and after the 0th and 8th weeks of EG, respectively. A significant difference was found between the levels of acute albumin before and after the 0th and 8th weeks of AR at the level of p=0.041 before the AR. Acute CRP levels did not change before and after 0th and 8th weeks (p>0.05). A significant difference was found between the levels of p=0.043 and p=0.043 between acute IL-6 levels before and after the 0th and 8th weeks of CG, respectively. No statistically significant difference was found between the albumin and CRP levels of KG.
Conclusion: Core exercise had a positive effect on IL-6 and albumin levels in amputee football players. For this reason, it is recommended to include core exercises in the routine football training program of amputee football players.
Anahtar Kelimeler
Keywords: Inflammatory Effect Exercise Amputee Football IL-6 Albumin
Proje Numarası
TDK 2020/2317
Kaynakça
- Calabrese, M., Garofano, M., Palumbo, R., Di Pietro, P., Izzo, C., Damato, A., ... & Vecchione, C. (2021). Exercise training and cardiac rehabilitation in COVID-19 patients with cardiovascular complications: state of art. Life, 11(3), 259.
- Yu, B., Tong, S., Wu, Y., Abdelrahim, M. E., & Cao, M. (2021). Effects of resistance training on exercise ability in chronic obstructive pulmonary disease subjects: A systematic review and meta‐analysis. International Journal of Clinical Practice, 75(9), e14373.
- Ashcraft, K. A., Warner, A. B., Jones, L. W., & Dewhirst, M. W. (2019, January). Exercise as adjunct therapy in cancer. In Seminars in radiation oncology (Vol. 29, No. 1, pp. 16-24). WB Saunders.
- Picard, M., Tauveron, I., Magdasy, S., Benichou, T., Bagheri, R., Ugbolue, U. C., ... & Dutheil, F. (2021). Effect of exercise training on heart rate variability in type 2 diabetes mellitus patients: A systematic review and meta-analysis. PloS one, 16(5), e0251863.
- Pawelec, G., Goldeck, D., & Derhovanessian, E. (2014). Inflammation, ageing and chronic disease. Current opinion in immunology, 29, 23-28.
- Burini, R. C., Anderson, E., Durstine, J. L., & Carson, J. A. (2020). Inflammation, physical activity, and chronic disease: an evolutionary perspective. Sports Medicine and Health Science, 2(1), 1-6.
- Begum, S., & Latunde-Dada, G. O. (2019). Anemia of inflammation with an emphasis on chronic kidney disease. Nutrients, 11(10), 2424. Beavers, K. M., Brinkley, T. E., & Nicklas, B. J. (2010). Effect of exercise training on chronic inflammation. Clinica chimica acta, 411(11-12), 785-793.
- Trochimiak, T., & Hübner-Woźniak, E. (2014). Review EFFECT OF EXERCISE ON THE LEVEL OF IMMUNOGLOBULIN A IN SALIVA. Biology of Sport, 29(4), 255-261.
- Gaitanos, G. C., Williams, C., Boobis, L. H., & Brooks, S. (1993). Human muscle metabolism during intermittent maximal exercise. Journal of applied physiology, 75(2), 712-719.
- Wedell-Neergaard, A. S., Lehrskov, L. L., Christensen, R. H., Legaard, G. E., Dorph, E., Larsen, M. K., ... & Krogh-Madsen, R. (2019). Exercise-induced changes in visceral adipose tissue mass are regulated by IL-6 signaling: a randomized controlled trial. Cell metabolism, 29(4), 844-855.
- Sadjapong, U., Yodkeeree, S., Sungkarat, S., & Siviroj, P. (2020). Multicomponent exercise program reduces frailty and inflammatory biomarkers and improves physical performance in community-dwelling older adults: A randomized controlled trial. International Journal of Environmental Research and Public Health, 17(11), 3760.
- Ostrowski, K., Rohde, T., Zacho, M., Asp, S., & Pedersen, B. K. (1998). Evidence that interleukin‐6 is produced in human skeletal muscle during prolonged running. The Journal of physiology, 508(3), 949-953.
- Lobo, S. M., Lobo, F. R., Bota, D. P., Lopes-Ferreira, F., Soliman, H. M., Meélot, C., & Vincent, J. L. (2003). C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest, 123(6), 2043-2049.
- Keppel, G. (1991). Design and analysis: A researcher's handbook. Prentice-Hall, Inc.: e0213256.
- Karvonen, J., & Vuorimaa, T. (1988). Heart rate and exercise intensity during sports activities. Sports medicine, 5(5), 303-311.
- Hooper J, McCreanor G, Marshall WJ, Myers P. Primary Care & Laboratory Medicine. ACB Venture. 1996: 16-44.
- Mardia, K. V. (1974). Applications of some measures of multivariate skewness and kurtosis in testing normality and robustness studies. Sankhyā: The Indian Journal of Statistics, Series B, 115-128.
- Sarıakçalı, B., Duman, G., Ceylan, L., Polat, M., Hazar, S., & Eliöz, M. (2021). Spor bilimleri fakültesinde uygulama eğitimin biyokimyasal ve hematolojik parametrelere etkisi. Spor ve Performans Araştırmaları Dergisi, 12(3), 222-232.
- Koca, H. B., Yıldırım, İ., Işık, Ö., Koca, T., & Bal, T. (2018). Genç Yetişkin Kadınlarda Düzenli Aerobik Egzersizlerin İnflamatuar Belirteçler Üzerine Etkisi. Spor ve Performans Araştırmaları Dergisi, 9(1), 25-34.
- Sadjapong, U., Yodkeeree, S., Sungkarat, S., & Siviroj, P. (2020). Multicomponent exercise program reduces frailty and inflammatory biomarkers and improves physical performance in community-dwelling older adults: A randomized controlled trial. International Journal of Environmental Research and Public Health, 17(11), 3760.
- Rose, G. L., Skinner, T. L., Mielke, G. I., & Schaumberg, M. A. (2021). The effect of exercise intensity on chronic inflammation: A systematic review and meta-analysis. Journal of Science and Medicine in Sport, 24(4), 345-351.
- Neefkes-Zonneveld, C. R., Bakkum, A. J., Bishop, N. C., van Tulder, M. W., & Janssen, T. W. (2015). Effect of long-term physical activity and acute exercise on markers of systemic inflammation in persons with chronic spinal cord injury: a systematic review. Archives of Physical Medicine and Rehabilitation, 96(1), 30-42.
- Donia, S. A., Allison, D. J., Gammage, K. L., & Ditor, D. S. (2019). The effects of acute aerobic exercise on mood and inflammation in individuals with multiple sclerosis and incomplete spinal cord injury. NeuroRehabilitation, 45(1), 117-124.
- Metsios, G. S., Moe, R. H., & Kitas, G. D. (2020). Exercise and inflammation. Best Practice & Research Clinical Rheumatology, 34(2), 101504.
- WEIL, M. H., HENNING, R. J., & PURI, V. K. (1979). Colloid oncotic pressure: clinical significance. Critical Care Medicine, 7(3), 113-116.
- Ostrowski, K., Rohde, T., Zacho, M., Asp, S., & Pedersen, B. K. (1998). Evidence that interleukin‐6 is produced in human skeletal muscle during prolonged running. The Journal of physiology, 508(3), 949-953.
- Peters Jr, T. (1995). All about albumin: biochemistry, genetics, and medical applications. Academic press.
- Nagashima, K., Cline, G. W., Mack, G. W., Shulman, G. I., & Nadel, E. R. (2000). Intense exercise stimulates albumin synthesis in the upright posture. Journal of Applied Physiology, 88(1), 41-46.
- Gillen, C. M., Lee, R., Mack, G. W., Tomaselli, C. M., Nishiyasu, T., & Nadel, E. R. (1991). Plasma volume expansion in humans after a single intense exercise protocol. Journal of Applied Physiology, 71(5), 1914-1920.
- Çolak, T., Bamaç, B., Çolak, S., Duman, C., Bayazit, B., Öztürk, S., ... & Yildiz, F. (2010). The influence of a single bout of wrestling exercise on serum levels of ischemia-modified albumin. Journal of Exercise Science & Fitness, 8(2), 67-72.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Analitik Biyokimya, Spor Hekimliği |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Proje Numarası | TDK 2020/2317 |
| Erken Görünüm Tarihi | 27 Ağustos 2022 |
| Yayımlanma Tarihi | 28 Ağustos 2022 |
| Gönderilme Tarihi | 25 Ağustos 2022 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 2 Sayı: 2 |
e-ISSN: 2791-9935