Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2023, Cilt: 7 Sayı: 2, 224 - 228, 31.12.2023
https://doi.org/10.32571/ijct.1321871

Öz

Kaynakça

  • 1World Cancer Research Fund International Home Page. https://www.wcrf.org/cancer-trends/lung-cancer-statistics. (accessed 23 March 2022)
  • Xia, L.; Tan, S.; Zhou, Y.; Lin, J.; Wang, H.; Oyang, L.; Tian, Y.; Liu, L.; Su, M.; Wang, H.; Cao, D.; Liao, Q. Onco Targets Ther. 2018, 11, 2063-73.
  • Lengauer, C.; Kinzler, K.W.; Vogelstein, B. Nature. 1998, 396, 643–649.
  • Bray, F.; Ferlay, J.; Soerjomataram, I.; Siegel, RL.; Torre, L.A.; Jemal, A. CA Cancer J. Clin. 2018, 68, 394–424.
  • Elbe, E.; Yigitturk, G.; Cavusoglu, T.; Uyanikgil, Y. Bratislava Medical Journal. 2020, 121, 122–128.
  • Chen, C.C.; Kao, C.P.; Chiu, M.M.; Wang, S.H. Oncotarget. 2017, 8(65), 109340–109357.
  • Zhang, C., : Xu, C.,; Gao, X.,; Yao Q. Theranostics. 2022, 12(5), 2115–2132.
  • Makovec, T. Radiol Oncol. 2019, 28;53(2),148-158
  • Tăbăcaru, A.; Botezatu Dediu, A.V.; Mihaela, D.R.; Cârâc, G.; Basliu, V.; Paula, Cabral C. M.; Silva, Francisco.; Pinto, C.I.G.; Guerreiro, F.; Martins, M.; Mendes, F.; Marques, F. Inorganica Chim Acta. 2020, 506, 119517.
  • Chundawat, N.S.; Jadoun, S.; Zarrintaj, P.; Chauhan, N.P.S. Polyhedron. 2021, 207, 115387.
  • Sarıoğlu, A.O.; Kahraman, D.T.; Köse, A.; Sönmez, M. J. Mol Struct. 2022, 1260, 132786.
  • Zappa, C.; Mousa, S.A. Trans. Lung Cancer Res. 2016, 5, 288–300.
  • Le ,X.; Hanna, E.Y. Ann Trans. Med. 2018, 6, 229–229.
  • Chundawat, N.; Jadoun, S.; Zarrintaj P.; Chauhan, N. Polyhedron. 2021, 207, 115387.
  • Cory, S.; Adams, J.M. Nat. Reviews Cancer. 2002, 9, 647–656.
  • Jeong, S.H.; Lee, H.W.; Han, J.H.; Kang, S.Y.; Choi, J.H.; Jung, Y.M. Jpn J Clin Oncol. 2008, 10, 661–669.

Determination of apoptotic effects of newly synthesized avobenzone Sm(III) complex in non-small cell lung cancer

Yıl 2023, Cilt: 7 Sayı: 2, 224 - 228, 31.12.2023
https://doi.org/10.32571/ijct.1321871

Öz

In this study, we aimed to investigate the apoptotic effects of the lanthanide complex TBK-23, which was used in biological imaging due to its magnetic and spectroscopic properties. The study utilized HTB-54 and BEAS-2B cell lines. The cells were subjected to TBK-23 and cisplatin at active doses for a duration of 24 hours. Subsequently, flow cytometry was employed to assess the quantity of apoptotic cells, while quantitative RT-PCR was used to measure the expression levels of BAX, BCL-2, and BCL-xL. While cisplatin at 31 µM increased the proapoptotic BAX expression level in HTB-54 and BEAS-2B cells, TBK-23 increased BAX in cancer cells at the same concentration, but there was no observable effect in healthy cells. TBK-23 was found to have higher inhibitory effect on the expression of the antiapoptotic BCL-2 gene in cancer cells compared to that of cisplatin-treated cells. Consequently, it was determined that TBK-23, a novel metal-based compound, exhibited apoptotic effects similar to that of cisplatin and could be a potential chemotherapeutic agent.

Destekleyen Kurum

Gaziantep Üniversity

Teşekkür

Respiratory Diseases and Respiratory Surgery Research and Practice Center, Gaziantep University

Kaynakça

  • 1World Cancer Research Fund International Home Page. https://www.wcrf.org/cancer-trends/lung-cancer-statistics. (accessed 23 March 2022)
  • Xia, L.; Tan, S.; Zhou, Y.; Lin, J.; Wang, H.; Oyang, L.; Tian, Y.; Liu, L.; Su, M.; Wang, H.; Cao, D.; Liao, Q. Onco Targets Ther. 2018, 11, 2063-73.
  • Lengauer, C.; Kinzler, K.W.; Vogelstein, B. Nature. 1998, 396, 643–649.
  • Bray, F.; Ferlay, J.; Soerjomataram, I.; Siegel, RL.; Torre, L.A.; Jemal, A. CA Cancer J. Clin. 2018, 68, 394–424.
  • Elbe, E.; Yigitturk, G.; Cavusoglu, T.; Uyanikgil, Y. Bratislava Medical Journal. 2020, 121, 122–128.
  • Chen, C.C.; Kao, C.P.; Chiu, M.M.; Wang, S.H. Oncotarget. 2017, 8(65), 109340–109357.
  • Zhang, C., : Xu, C.,; Gao, X.,; Yao Q. Theranostics. 2022, 12(5), 2115–2132.
  • Makovec, T. Radiol Oncol. 2019, 28;53(2),148-158
  • Tăbăcaru, A.; Botezatu Dediu, A.V.; Mihaela, D.R.; Cârâc, G.; Basliu, V.; Paula, Cabral C. M.; Silva, Francisco.; Pinto, C.I.G.; Guerreiro, F.; Martins, M.; Mendes, F.; Marques, F. Inorganica Chim Acta. 2020, 506, 119517.
  • Chundawat, N.S.; Jadoun, S.; Zarrintaj, P.; Chauhan, N.P.S. Polyhedron. 2021, 207, 115387.
  • Sarıoğlu, A.O.; Kahraman, D.T.; Köse, A.; Sönmez, M. J. Mol Struct. 2022, 1260, 132786.
  • Zappa, C.; Mousa, S.A. Trans. Lung Cancer Res. 2016, 5, 288–300.
  • Le ,X.; Hanna, E.Y. Ann Trans. Med. 2018, 6, 229–229.
  • Chundawat, N.; Jadoun, S.; Zarrintaj P.; Chauhan, N. Polyhedron. 2021, 207, 115387.
  • Cory, S.; Adams, J.M. Nat. Reviews Cancer. 2002, 9, 647–656.
  • Jeong, S.H.; Lee, H.W.; Han, J.H.; Kang, S.Y.; Choi, J.H.; Jung, Y.M. Jpn J Clin Oncol. 2008, 10, 661–669.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapısal Biyoloji
Bölüm Makale
Yazarlar

Demet Kahraman 0000-0002-7038-3831

Ahmet Oral Sarıoğlu 0000-0001-7787-7968

Semih Güler 0000-0002-1821-3691

Mehmet Sönmez 0000-0003-3127-666X

Erken Görünüm Tarihi 10 Ocak 2024
Yayımlanma Tarihi 31 Aralık 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 7 Sayı: 2

Kaynak Göster

APA Kahraman, D., Sarıoğlu, A. O., Güler, S., Sönmez, M. (2023). Determination of apoptotic effects of newly synthesized avobenzone Sm(III) complex in non-small cell lung cancer. International Journal of Chemistry and Technology, 7(2), 224-228. https://doi.org/10.32571/ijct.1321871
AMA Kahraman D, Sarıoğlu AO, Güler S, Sönmez M. Determination of apoptotic effects of newly synthesized avobenzone Sm(III) complex in non-small cell lung cancer. Int. J. Chem. Technol. Aralık 2023;7(2):224-228. doi:10.32571/ijct.1321871
Chicago Kahraman, Demet, Ahmet Oral Sarıoğlu, Semih Güler, ve Mehmet Sönmez. “Determination of Apoptotic Effects of Newly Synthesized Avobenzone Sm(III) Complex in Non-Small Cell Lung Cancer”. International Journal of Chemistry and Technology 7, sy. 2 (Aralık 2023): 224-28. https://doi.org/10.32571/ijct.1321871.
EndNote Kahraman D, Sarıoğlu AO, Güler S, Sönmez M (01 Aralık 2023) Determination of apoptotic effects of newly synthesized avobenzone Sm(III) complex in non-small cell lung cancer. International Journal of Chemistry and Technology 7 2 224–228.
IEEE D. Kahraman, A. O. Sarıoğlu, S. Güler, ve M. Sönmez, “Determination of apoptotic effects of newly synthesized avobenzone Sm(III) complex in non-small cell lung cancer”, Int. J. Chem. Technol., c. 7, sy. 2, ss. 224–228, 2023, doi: 10.32571/ijct.1321871.
ISNAD Kahraman, Demet vd. “Determination of Apoptotic Effects of Newly Synthesized Avobenzone Sm(III) Complex in Non-Small Cell Lung Cancer”. International Journal of Chemistry and Technology 7/2 (Aralık 2023), 224-228. https://doi.org/10.32571/ijct.1321871.
JAMA Kahraman D, Sarıoğlu AO, Güler S, Sönmez M. Determination of apoptotic effects of newly synthesized avobenzone Sm(III) complex in non-small cell lung cancer. Int. J. Chem. Technol. 2023;7:224–228.
MLA Kahraman, Demet vd. “Determination of Apoptotic Effects of Newly Synthesized Avobenzone Sm(III) Complex in Non-Small Cell Lung Cancer”. International Journal of Chemistry and Technology, c. 7, sy. 2, 2023, ss. 224-8, doi:10.32571/ijct.1321871.
Vancouver Kahraman D, Sarıoğlu AO, Güler S, Sönmez M. Determination of apoptotic effects of newly synthesized avobenzone Sm(III) complex in non-small cell lung cancer. Int. J. Chem. Technol. 2023;7(2):224-8.