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Mineral contents, antimicrobial profile, acute and chronic toxicity of the aqueous extract of Moroccan Thymus vulgaris in rodents

Yıl 2022, Cilt: 9 Sayı: 4, 397 - 414, 21.12.2022

Nidal Naceiri Mrabti Hanae Naceiri Mrabti Latifa Doudach Zineb Khalil Mohamed Reda Kachmar Mouna Mekkaoui Ryan Sheikh Emad M. Abdallah Gokhan Zengin Samiah Hamad Al-mijalli Abdelhakim Bouyahya Moulay El Abbes Faouzi Menana Elhallaoui

https://doi.org/10.21448/ijsm.1106820
Cited By: 1

Öz

Moroccan flora is rich in plants used in traditional medicine, but the further scientific investigation is necessary. The aim of the research was to evaluate the nutritional content and antimicrobial activity of Moroccan Thymus vulgaris, as well as its possible acute and chronic toxicological effects on rodents. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) was used to determine the mineral content. The antimicrobial activity was determined using a well-diffusion test, a minimum inhibitory concentration (MIC), and a minimum bactericidal/fungicidal concentration (MBC/MFC) assay. Acute and chronic toxicity studies were conducted in vivo on mice and rats, respectively. Following that, haematological, serum-biochemistry, and histological investigations were performed. Moroccan Thyme was shown to be a source of numerous minerals which are necessary for health promotion. All antimicrobial testing, disc diffusion, MIC, and MBC tests revealed that thyme had potent antibacterial activity against all microorganisms tested. Staphylococcus aureus was the most susceptible bacterium, followed by Salmonella enterica and Escherichia coli. Additionally, thyme exhibited great antifungal efficacy against Candida albicans. The acute toxicity results indicated that the aqueous extract of T. vulgaris is almost non-toxic when taken orally. According to the chronic toxicity study, the extract is generally safe when taken orally over an extended period of time. The biochemical and haematological characteristics of the serum and blood were within acceptable limits, and histological examination revealed no abnormalities. In conclusion, the findings of this investigation, confirm the antimicrobial efficacy of the aqueous extract of Moroccan T. vulgaris and its safety for experimental animals.

Anahtar Kelimeler

Thymus vulgaris; mineral analysis; toxicity antibacterial antifungal rodents

Destekleyen Kurum

Princess Nourah bint Abdulrahman University

Proje Numarası

PNURSP2022R158

Kaynakça

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Mineral contents, antimicrobial profile, acute and chronic toxicity of the aqueous extract of Moroccan Thymus vulgaris in rodents

Yıl 2022, Cilt: 9 Sayı: 4, 397 - 414, 21.12.2022

Nidal Naceiri Mrabti Hanae Naceiri Mrabti Latifa Doudach Zineb Khalil Mohamed Reda Kachmar Mouna Mekkaoui Ryan Sheikh Emad M. Abdallah Gokhan Zengin Samiah Hamad Al-mijalli Abdelhakim Bouyahya Moulay El Abbes Faouzi Menana Elhallaoui

https://doi.org/10.21448/ijsm.1106820
Cited By: 1

Öz

Moroccan flora is rich in plants used in traditional medicine, but the further scientific investigation is necessary. The aim of the research was to evaluate the nutritional content and antimicrobial activity of Moroccan Thymus vulgaris, as well as its possible acute and chronic toxicological effects on rodents. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) was used to determine the mineral content. The antimicrobial activity was determined using a well-diffusion test, a minimum inhibitory concentration (MIC), and a minimum bactericidal/fungicidal concentration (MBC/MFC) assay. Acute and chronic toxicity studies were conducted in vivo on mice and rats, respectively. Following that, haematological, serum-biochemistry, and histological investigations were performed. Moroccan Thyme was shown to be a source of numerous minerals which are necessary for health promotion. All antimicrobial testing, disc diffusion, MIC, and MBC tests revealed that thyme had potent antibacterial activity against all microorganisms tested. Staphylococcus aureus was the most susceptible bacterium, followed by Salmonella enterica and Escherichia coli. Additionally, thyme exhibited great antifungal efficacy against Candida albicans. The acute toxicity results indicated that the aqueous extract of T. vulgaris is almost non-toxic when taken orally. According to the chronic toxicity study, the extract is generally safe when taken orally over an extended period of time. The biochemical and haematological characteristics of the serum and blood were within acceptable limits, and histological examination revealed no abnormalities. In conclusion, the findings of this investigation, confirm the antimicrobial efficacy of the aqueous extract of Moroccan T. vulgaris and its safety for experimental animals.

Anahtar Kelimeler

Thymus vulgaris Mineral analysis Toxicity Antimicrobial Rodents

Proje Numarası

PNURSP2022R158

Kaynakça

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Toplam 73 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Makaleler
Yazarlar

Nidal Naceiri Mrabti Bu kişi benim 0000-0001-6389-7300

Hanae Naceiri Mrabti Bu kişi benim 0000-0002-8145-2572

Latifa Doudach Bu kişi benim 0000-0002-4687-0066

Zineb Khalil Bu kişi benim 0000-0002-3357-9755

Mohamed Reda Kachmar Bu kişi benim 0000-0001-8191-1129

Mouna Mekkaoui Bu kişi benim 0000-0003-4821-6145

Ryan Sheikh Bu kişi benim 0000-0003-3275-0861

Emad M. Abdallah Bu kişi benim 0000-0003-0549-249X

Gokhan Zengin 0000-0001-6548-7823

Samiah Hamad Al-mijalli Bu kişi benim 0000-0003-3160-6008

Abdelhakim Bouyahya 0000-0001-9317-1631

Moulay El Abbes Faouzi Bu kişi benim 0000-0003-3863-4677

Menana Elhallaoui Bu kişi benim 0000-0002-9863-6298

Proje Numarası PNURSP2022R158
Yayımlanma Tarihi 21 Aralık 2022
Gönderilme Tarihi 21 Nisan 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 9 Sayı: 4

Kaynak Göster

APA Mrabti, N. N., Mrabti, H. N., Doudach, L., Khalil, Z., vd. (2022). Mineral contents, antimicrobial profile, acute and chronic toxicity of the aqueous extract of Moroccan Thymus vulgaris in rodents. International Journal of Secondary Metabolite, 9(4), 397-414. https://doi.org/10.21448/ijsm.1106820

Cited By

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International Journal of Secondary Metabolite
e-ISSN: 2148-6905