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Acute Administration of High Dose Trimetazidine Inhibits Pentylenetetrazol-Induced Seizures in Rats

Yıl 2017, Cilt: 39 Sayı: 1, 380 - 388, 28.03.2017
https://doi.org/10.7197/cmj.v39i1.5000189853

Öz

Introduction: Resistant epilepsy is widely seen in clinical settings manipulate the researchers to pursuit novel anti-epileptic treatments. Although trimetazidine (TMZ) is commonly used in the treatment of angina and ischemic diseases, it is considered that the drug may be beneficial in the treatment of epileptic seizures and convulsions. We aimed to evaluate electrophysiologically the protective effects of high dose acute TMZ on epileptic seizures and convulsions in a rat model of epilepsy induced by pentilentetrazol (PTZ).

Materials and methods: Forty-eight male Sprague-Dawley rats were used for the EEG evaluation (Group-A; n=24) and behavioral assessment (Group-B; n=24). Grup-A1 and Grup-B1 were determined as control group and given no medication. 35 mg/kg (Group-A2, -A3 and -A4) and 70 mg/kg (Group-B2, -B3 and -B4) of PTZ were administered intraperitoneally (ip.) so as to generate seizures and convulsions. Group-A2 and Group-B2 were treated with saline. 40 mg/kg (Grup-A3 and Grup-B3) and 80 mg/kg of TMZ (Group-A4 and Group-B4) were administered to the treatment groups by ip. Brain malondialdehyde (MDA) levels, spike-percentage values, Racine’s Convulsion Scale (RCS) scores and "first myoclonic jerk (FMJ)" latencies of each rat were determined.

Results: Brain MDA levels, spike-percentage values, RCS scores, and FMJ latencies of Group-A2 and Group-B2 were significantly increased compared to those of the control’s (Grup-A1 and Grup-B1) (P<0.05 for all comparisons). However, in TMZ treated groups (Group-A3 and -A4; Group-B3 and -B4) the elevated values of these parameters were found to be significantly decreased (P<0.05 for all comparisons).

Conclusion: This study has demonstrated that the high dose acute TMZ administration may prevent PTZ-induced seizures and convulsions in rats. Furthermore, it can be also said that TMZ has a neuroprotective effects on oxidative stress associated with PTZ. Therefore, it may be considered for use with therapeutic purposes of TMZ in resistant epilepsy patients in the future.

Yıl 2017, Cilt: 39 Sayı: 1, 380 - 388, 28.03.2017
https://doi.org/10.7197/cmj.v39i1.5000189853

Öz

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Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Dahili Tıp Bilimleri Araştırma Yazıları
Yazarlar

Serkan Gürgül

Nilgün Erten

Serdar savaş Gül

Nurten Erdal

Coşar Uzun

Volkan Solmaz

Oytun Erbaş

Yayımlanma Tarihi 28 Mart 2017
Yayımlandığı Sayı Yıl 2017Cilt: 39 Sayı: 1

Kaynak Göster

AMA Gürgül S, Erten N, Gül Ss, Erdal N, Uzun C, Solmaz V, Erbaş O. Acute Administration of High Dose Trimetazidine Inhibits Pentylenetetrazol-Induced Seizures in Rats. CMJ. Mart 2017;39(1):380-388. doi:10.7197/cmj.v39i1.5000189853