The apoptotic paradox in schizophrenia

Hüseyin Aydın; Yusuf Kenan Tekin; Serpil Erşan; Hayrettin Yavuz; Ethem Erdal Erşan

doi:10.7197/223.vi.577914

EN

The apoptotic paradox in schizophrenia

Abstract

Objective: Understanding the role of apoptosis in abnormal neurodevelopment and neurodegenerative processes is crucial. In this study, it is aimed to determine how apoptosis biomarkers are affected in patients with schizophrenia and severity of the disease and also whether apoptosis biomarkers can be used as blood-based biomarkers in diagnosis of the disease.

Method: This is a cross-sectional prospective study performed at a tertiary university hospital and city hospital in Turkey. Volunteers (n=60) diagnosed with schizophrenia were divided into three groups (Mild, Moderate and Severe) according to the Clinical Global Impressions Scale developed by Guy. The control group was constituted from volunteers who were similar to the patient group (n=40) in terms of age and gender. Serum levels of Caspase-8(C-8), Granzyme B (GrB) and Cytcochrome C (CYCS) were measured by ELISA method from blood samples collected from patient and control groups.

Results: It was observed that Caspase 8 and GrB levels were lower in all three groups compared with the control group, and the highest decrease was in the 3rd group (P<0,.5). CYCS level on the other hand increased, and the highest increase was observed in 3rd Group (P<0.05).

Conclusions: It is hypothesised that increase in serum CYCS level of patients with schizophrenia may be a blood based biomarker in which apoptosis occurs.

Keywords

Schizophrenia,Apoptosis,Caspase-8,Granzyme-B

Kaynakça

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