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The Role of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratios in Predicting H Pylori Positivity and Severity in Patients with Chronic Gastritis

Yıl 2022, Cilt 44, Sayı 1, 87 - 91, 30.03.2022
https://doi.org/10.7197/cmj.1084756

Öz

Objective: Chronic gastritis is one of the most common diseases in the World. It is estimated that more than half of the World's population will have chronic gastritis at any time in life. H pylori are the most common cause of chronic gastritis. In the previous studies, WBC, neutrophil, lymphocyte, PLT, and mean platelet volume (MPV) values and their ratios are used as inflammatory indicators. Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) is among the most critical indicators. This study aimed to show whether there is a relationship between H pylori positivity and severity and these parameters in patients who underwent Upper Gastrointestinal system endoscopy.
Method: The files of 1689 patients who underwent upper gastrointestinal endoscopy were scanned for this study. According to laboratory results and pathology reports, the patients were divided into H pylori positivity and non-H pylori positivity. The hemogram results of the patients in both groups were examined, and neutrophil, lymphocyte, thrombocyte values were recorded. NLR and PLR were calculated.
Results: 722 (42.7%) of the patients were male, and 967 (57.3%) were female. While H pylori were positive in 838 (49.6%) patients, 851 (50.4%) patients did not have H pylori positivity. Among H pylori-positive patients, 407 patients (48%) had mild, 280 (33%) moderate H pylori positivity, and 151 patients (19%) had severe H pylori positivity. When the patients were divided into mild, moderate, and severe groups according to H pylori positivity, NLR and PLR were statistically significantly lower as H pylori severity increased. On the other hand, when both groups were compared according to H pylori positivity, no statistically significant difference was found between the two groups in terms of age, albumin, AST, ALT, WBC, Neutrophil, PLT, NLR, PLR values.
Conclusions: Our study found that NLR and PLR values were statistically significantly lower as H pylori severity increased. Therefore, when we evaluate our results in light of the literature, we assume that it is more appropriate to use PLR and NLR values together rather than separately as inflammatory markers regarding H pylori severity. 

Kaynakça

  • 1) Sipponen P, Maaroos HI. Chronic gastritis. Scand J Gastroenterol. 2015 Jun;50(6):657-67. doi: 10.3109/00365521.2015.1019918.
  • 2) Bartpho TS, Wattanawongdon W, Tongtawee T, Paoin C, Kangwantas K, Dechsukhum C. Precancerous Gastric Lesions with Helicobacter pylori vacA+/babA2+/oipA+ Genotype Increase the Risk of Gastric Cancer. Biomed Res Int. 2020 Feb 18;2020:7243029. doi: 10.1155/2020/7243029.
  • 3) Liu W, Tian J, Hui W, Kong W, Feng Y, Si J, Gao F. A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis. Sci Rep. 2021 Feb 18;11(1):4143. doi: 10.1038/s41598-021-83647-6.
  • 4) Altun E, Yildiz A, Cevik C, Turan G. The role of high sensitive C-reactive protein and histopathological evaluation in chronic gastritis patients with or without Helicobacter pylori infection. Acta Cir Bras. 2019 Mar 21;34(3):e201900310. doi: 10.1590/s0102-865020190030000010.
  • 5) Lim HH, Jeong IH, An GD, Woo KS, Kim KH, Kim JM, Cha JK, Han JY. Early prediction of severity in acute ischemic stroke and transient ischemic attack using platelet parameters and neutrophil-to-lymphocyte ratio. J Clin Lab Anal. 2019 Mar;33(3):e22714. doi: 10.1002/jcla.22714.
  • 6) Lim HH, Jeong IH, An GD, Woo KS, Kim KH, Kim JM, Cha JK, Han JY. Early prediction of severity in acute ischemic stroke and transient ischemic attack using platelet parameters and neutrophil-to-lymphocyte ratio. J Clin Lab Anal. 2019 Mar;33(3):e22714. doi: 10.1002/jcla.22714.
  • 7) Akıl E, Akıl MA, Varol S, Özdemir HH, Yücel Y, Arslan D, Akyüz A, Alan S. Echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio are novel inflammatory predictors of cerebral ischemic stroke. J Stroke Cerebrovasc Dis. 2014 Oct;23(9):2328-34. doi: 10.1016/j.jstrokecerebrovasdis.2014.04.028
  • 8) Celikbilek A, Ismailogullari S, Zararsiz G. Neutrophil to lymphocyte ratio predicts poor prognosis in ischemic cerebrovascular disease. J Clin Lab Anal. 2014 Jan;28(1):27-31. doi: 10.1002/jcla.21639.
  • 9) Lim HH, Jeong IH, An GD, Woo KS, Kim KH, Kim JM, Cha JK, Han JY. Early prediction of severity in acute ischemic stroke and transient ischemic attack using platelet parameters and neutrophil-to-lymphocyte ratio. J Clin Lab Anal. 2019 Mar;33(3):e22714. doi: 10.1002/jcla.22714.
  • 10) Adlekha S, Chadha T, Krishnan P, Sumangala B. Prevalence of helicobacter pylori infection among patients undergoing upper gastrointestinal endoscopy in a medical college hospital in kerala, India. Ann Med Health Sci Res. 2013 Oct;3(4):559-63. doi: 10.4103/2141-9248.122109.
  • 11) Mana F, Vandebosch S, Miendje Deyi V, Haentjens P, Urbain D. Prevalence of and risk factors for H. pylori infection in healthy children and young adults in Belgium anno 2010/2011. Acta Gastroenterol Belg. 2013 Dec;76(4):381-5. PMID: 24592540.
  • 12) Dorji D, Dendup T, Malaty HM, Wangchuk K, Yangzom D, Richter JM. Epidemiology of Helicobacter pylori in Bhutan: the role of environment and Geographic location. Helicobacter. 2014 Feb;19(1):69-73. doi: 10.1111/hel.12088.
  • 13) Benberin V, Bektayeva R, Karabayeva R, Lebedev A, Akemeyeva K, Paloheimo L, Syrjänen K. Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. Anticancer Res. 2013 Oct;33(10):4595-602. PMID: 24123036.
  • 14) Hanafi MI, Mohamed AM. Helicobacter pylori infection: seroprevalence and predictors among healthy individuals in Al Madinah, Saudi Arabia. J Egypt Public Health Assoc. 2013 Apr;88(1):40-5. doi: 10.1097/01.EPX.0000427043.99834.a4.
  • 15) FERHATOĞLU, M. F., ŞENOL, K., KARTAL, A., KIVILCIM, T., & FİLİZ, A. İ. HELİCOBACTER PYLORİ ERADİKASYONU TAKİBİNDE NÖTROFİL/LENFOSİT ORANININ ÖNEMİ. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi, 2019 52(1), 38-42.
  • 16) Farah R, Khamisy-Farah R. Association of neutrophil to lymphocyte ratio with presence and severity of gastritis due to Helicobacter pylori infection. J Clin Lab Anal. 2014 May;28(3):219-23. doi: 10.1002/jcla.21669.
  • 17) NALBANT, A., & AYDIN, A. Helicobacter pylori enfeksiyonunun D vitamini, hemogram parametreleri ve kan grubu ile ilişkisi. akademik gastroenteroloji dergisi, 2017 16(1), 1-5.
  • 18) Kurtul A, Murat SN, Yarlioglues M, Duran M, Ergun G, Acikgoz SK, Demircelik MB, Cetin M, Akyel A, Kasapkara HA, Ornek E. Association of platelet-to-lymphocyte ratio with severity and complexity of coronary artery disease in patients with acute coronary syndromes. Am J Cardiol. 2014 Oct 1;114(7):972-8. doi: 10.1016/j.amjcard.2014.07.005.
  • 19) Xia W, Ke Q, Wang Y, Wang W, Zhang M, Shen Y, Wu J, Xu X, Zheng S. Predictive value of pre-transplant platelet to lymphocyte ratio for hepatocellular carcinoma recurrence after liver transplantation. World J Surg Oncol. 2015 Feb 18;13:60. doi: 10.1186/s12957-015-0472-2.
  • 20) Şahin, E., & Elboğa, U. The Relationship Between 14 C Urea Breath Test Results and Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios. Medical Bulletin of Haseki/Haseki Tip Bulteni, 2018 56(1).
  • 21) Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol. 2013 Oct;88(1):218-30. doi: 10.1016/j.critrevonc.2013.03.010.
  • 22) Jiang R, Zou X, Hu W, Fan YY, Yan Y, Zhang MX, You R, Sun R, Luo DH, Chen QY, Huang PY, Hua YJ, Guo L, Chen MY. The elevated pretreatment platelet-to-lymphocyte ratio predicts poor outcome in nasopharyngeal carcinoma patients. Tumour Biol. 2015 Sep;36(10):7775-87. doi: 10.1007/s13277-015-3505-0.

Yıl 2022, Cilt 44, Sayı 1, 87 - 91, 30.03.2022
https://doi.org/10.7197/cmj.1084756

Öz

Kaynakça

  • 1) Sipponen P, Maaroos HI. Chronic gastritis. Scand J Gastroenterol. 2015 Jun;50(6):657-67. doi: 10.3109/00365521.2015.1019918.
  • 2) Bartpho TS, Wattanawongdon W, Tongtawee T, Paoin C, Kangwantas K, Dechsukhum C. Precancerous Gastric Lesions with Helicobacter pylori vacA+/babA2+/oipA+ Genotype Increase the Risk of Gastric Cancer. Biomed Res Int. 2020 Feb 18;2020:7243029. doi: 10.1155/2020/7243029.
  • 3) Liu W, Tian J, Hui W, Kong W, Feng Y, Si J, Gao F. A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis. Sci Rep. 2021 Feb 18;11(1):4143. doi: 10.1038/s41598-021-83647-6.
  • 4) Altun E, Yildiz A, Cevik C, Turan G. The role of high sensitive C-reactive protein and histopathological evaluation in chronic gastritis patients with or without Helicobacter pylori infection. Acta Cir Bras. 2019 Mar 21;34(3):e201900310. doi: 10.1590/s0102-865020190030000010.
  • 5) Lim HH, Jeong IH, An GD, Woo KS, Kim KH, Kim JM, Cha JK, Han JY. Early prediction of severity in acute ischemic stroke and transient ischemic attack using platelet parameters and neutrophil-to-lymphocyte ratio. J Clin Lab Anal. 2019 Mar;33(3):e22714. doi: 10.1002/jcla.22714.
  • 6) Lim HH, Jeong IH, An GD, Woo KS, Kim KH, Kim JM, Cha JK, Han JY. Early prediction of severity in acute ischemic stroke and transient ischemic attack using platelet parameters and neutrophil-to-lymphocyte ratio. J Clin Lab Anal. 2019 Mar;33(3):e22714. doi: 10.1002/jcla.22714.
  • 7) Akıl E, Akıl MA, Varol S, Özdemir HH, Yücel Y, Arslan D, Akyüz A, Alan S. Echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio are novel inflammatory predictors of cerebral ischemic stroke. J Stroke Cerebrovasc Dis. 2014 Oct;23(9):2328-34. doi: 10.1016/j.jstrokecerebrovasdis.2014.04.028
  • 8) Celikbilek A, Ismailogullari S, Zararsiz G. Neutrophil to lymphocyte ratio predicts poor prognosis in ischemic cerebrovascular disease. J Clin Lab Anal. 2014 Jan;28(1):27-31. doi: 10.1002/jcla.21639.
  • 9) Lim HH, Jeong IH, An GD, Woo KS, Kim KH, Kim JM, Cha JK, Han JY. Early prediction of severity in acute ischemic stroke and transient ischemic attack using platelet parameters and neutrophil-to-lymphocyte ratio. J Clin Lab Anal. 2019 Mar;33(3):e22714. doi: 10.1002/jcla.22714.
  • 10) Adlekha S, Chadha T, Krishnan P, Sumangala B. Prevalence of helicobacter pylori infection among patients undergoing upper gastrointestinal endoscopy in a medical college hospital in kerala, India. Ann Med Health Sci Res. 2013 Oct;3(4):559-63. doi: 10.4103/2141-9248.122109.
  • 11) Mana F, Vandebosch S, Miendje Deyi V, Haentjens P, Urbain D. Prevalence of and risk factors for H. pylori infection in healthy children and young adults in Belgium anno 2010/2011. Acta Gastroenterol Belg. 2013 Dec;76(4):381-5. PMID: 24592540.
  • 12) Dorji D, Dendup T, Malaty HM, Wangchuk K, Yangzom D, Richter JM. Epidemiology of Helicobacter pylori in Bhutan: the role of environment and Geographic location. Helicobacter. 2014 Feb;19(1):69-73. doi: 10.1111/hel.12088.
  • 13) Benberin V, Bektayeva R, Karabayeva R, Lebedev A, Akemeyeva K, Paloheimo L, Syrjänen K. Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. Anticancer Res. 2013 Oct;33(10):4595-602. PMID: 24123036.
  • 14) Hanafi MI, Mohamed AM. Helicobacter pylori infection: seroprevalence and predictors among healthy individuals in Al Madinah, Saudi Arabia. J Egypt Public Health Assoc. 2013 Apr;88(1):40-5. doi: 10.1097/01.EPX.0000427043.99834.a4.
  • 15) FERHATOĞLU, M. F., ŞENOL, K., KARTAL, A., KIVILCIM, T., & FİLİZ, A. İ. HELİCOBACTER PYLORİ ERADİKASYONU TAKİBİNDE NÖTROFİL/LENFOSİT ORANININ ÖNEMİ. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi, 2019 52(1), 38-42.
  • 16) Farah R, Khamisy-Farah R. Association of neutrophil to lymphocyte ratio with presence and severity of gastritis due to Helicobacter pylori infection. J Clin Lab Anal. 2014 May;28(3):219-23. doi: 10.1002/jcla.21669.
  • 17) NALBANT, A., & AYDIN, A. Helicobacter pylori enfeksiyonunun D vitamini, hemogram parametreleri ve kan grubu ile ilişkisi. akademik gastroenteroloji dergisi, 2017 16(1), 1-5.
  • 18) Kurtul A, Murat SN, Yarlioglues M, Duran M, Ergun G, Acikgoz SK, Demircelik MB, Cetin M, Akyel A, Kasapkara HA, Ornek E. Association of platelet-to-lymphocyte ratio with severity and complexity of coronary artery disease in patients with acute coronary syndromes. Am J Cardiol. 2014 Oct 1;114(7):972-8. doi: 10.1016/j.amjcard.2014.07.005.
  • 19) Xia W, Ke Q, Wang Y, Wang W, Zhang M, Shen Y, Wu J, Xu X, Zheng S. Predictive value of pre-transplant platelet to lymphocyte ratio for hepatocellular carcinoma recurrence after liver transplantation. World J Surg Oncol. 2015 Feb 18;13:60. doi: 10.1186/s12957-015-0472-2.
  • 20) Şahin, E., & Elboğa, U. The Relationship Between 14 C Urea Breath Test Results and Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios. Medical Bulletin of Haseki/Haseki Tip Bulteni, 2018 56(1).
  • 21) Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol. 2013 Oct;88(1):218-30. doi: 10.1016/j.critrevonc.2013.03.010.
  • 22) Jiang R, Zou X, Hu W, Fan YY, Yan Y, Zhang MX, You R, Sun R, Luo DH, Chen QY, Huang PY, Hua YJ, Guo L, Chen MY. The elevated pretreatment platelet-to-lymphocyte ratio predicts poor outcome in nasopharyngeal carcinoma patients. Tumour Biol. 2015 Sep;36(10):7775-87. doi: 10.1007/s13277-015-3505-0.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Cerrahi Tıp Bilimleri Araştırma Yazıları
Yazarlar

Suleyman KOC (Sorumlu Yazar)
SİVAS CUMHURİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ
0000-0001-7794-4518
Türkiye


Mustafa Asım GEDİKLİ
SİVAS CUMHURİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ
0000-0002-3494-7935
Türkiye

Yayımlanma Tarihi 30 Mart 2022
Yayınlandığı Sayı Yıl 2022, Cilt 44, Sayı 1

Kaynak Göster

APA Koc, S. & Gedikli, M. A. (2022). The Role of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratios in Predicting H Pylori Positivity and Severity in Patients with Chronic Gastritis . Cumhuriyet Medical Journal , 44 (1) , 87-91 . DOI: 10.7197/cmj.1084756