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Association between systemic inflamatuary index and epicardial adipose tissue in patients with Type 2 Diabetes Mellitus

Yıl 2022, Cilt 44, Sayı 1, 62 - 66, 30.03.2022
https://doi.org/10.7197/cmj.1088573

Öz

Objective: Epicardial adipose tissue is the visceral fat located between the myocardium and the pericardium. Increases in epicardial adipose tissue are closely associated with the occurrence of cardiovascular diseases. The systemic immune inflammation index is a new parameter developed to determine the inflammatory status of patients. In our study, we aimed to evaluate the relationship between systemic immun inflammation index and epicardial adipose tissue in patients with diabetes mellitus.
Method: 119 patients with T2DM and 50 volunteers were included to study. SII was obtained with formulatıon of neutrophil/lymphocyte x platelet. Epicardial fat tissue was obtained by transthoracic echocardiography. The relationship between systemic immune inflammation index and epicardial adipose tissue was evaluated in patients with Diabetes Mellitus
Results: In our study, ıt was shown that epicardial adipose tissue was higher in diabetic patients. There was a significant correlation between Body surface area , duration of diabetes mellitus, HbA1c, systemic immune inflammation index, mean platelet volume , neutrophil lymphocyte ratio and epicardial adipose tissue. In linear regression analysis, it was observed that duration of diabetes mellitus (β =0.049 (0.011-0.087); P=0.011) and SII (β=0.013 (0.001-0.018) P=0.008) were independent predictors of EAT.
Conclusions: In our study, it was shown that there is a significant relationship between epicardial adipose tissue and systemic immune inflammation index in diabetic patients. In patients with diabetes mellitus, systemic immune inflammation index may provide a useful estimate of epicardial adipose tissue, which has been shown to be associated with cardiovascular events.

Kaynakça

  • 1.Clarke P, Gray A, Legood R, J Leal, R R Holman. The impact of diabetes-related complications on health-care costs: results from the UK prospective diabetes study (UKPDS Study no. 65). Diabet Med. 2003; 20:442–50.
  • 2.A joint editorial statement by the American diabetes association, the national heart, lung and blood institute, the juvenile diabetes foundation international, the national institute of diabetes and digestive and kidney diseases, the American heart association. Diabetes mellitus: a major risk factor for cardiovascular disease. Circulation. 1999; 100:1132–43.
  • 3.Xiaoyou Su, Jing Xu, Chao Zheng. The relationship between non-alcoholic fatty liver and skeletal muscle mass to visceral fat area ratio in women with type 2 diabetes. BMC Endocrine Disorders. 2019; 19:76.
  • 4. Montecucco F, Liberale L, Bonaventura A, Vecchiè A, Dallegri F, F Carbone F et al. The Role of Inflammation in Cardiovascular Outcome. Curr Atheroscler Rep. 2017; 19:11. 5.Yang YL, Wu CH, Hsu PF, Chen SC, Huang SS, Chan WL,et al. Systemic immune inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. Eur J Clin Invest. 2020;50: e13230.
  • 6.Gottdiener JS, Arnold AM, Aurigemma GP, J F Polak, R P Tracy, D W Kitzman, et al. Predictors of congestive heart failure in the elderly: the cardiovascular health study. J Am Coll Cardiol.2000; 35:1628–37.
  • 7 Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA. 1979; 241:2035–58.
  • 8. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014; 37: 81-90.
  • 9.Dereli S, Bayramoğlu A, Yontar OC, Cerşit S, Gürsoy MO . Epicardial fat thickness: A new predictor of successful electrical cardioversion and atrial fibrillation recurrence. Echocardiography. 2018; 35:1926-31.
  • 10. Levesque C. Medical management of type 2 diabetes. J Nurse Pract. 2011; 7:492–01.
  • 11. Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type2 diabetes mellitus-present and future perspectives. Nat Rev Endocrinol. 2011; 8:228–36.
  • 12. Mahabadi Amir A, Massaro Joseph M, Rosito Guido A, Levy D, Murabito JM, Wolf PA, O'Donnell CJ et al. Association of pericardial fat, intrathoracic fat, and visceral abdominal at with cardiovascular disease burden: The Framingham Heart Study. Eur Heart J. 2009; 30:850–6.
  • 13. Yun CH, Lin TY, Wu YJ, Liu CC, Kuo JY, Yeh H et al. Pericardial and thoracicperi-aortic adipose tissues contribute to systemic inflammation and calcified coronary atherosclerosis independent of body fat composition, anthropometric measures and traditional cardiovascular risks. Eur J Radiol. 2012; 81:749–56.
  • 14. Nolan CJ, Damm P, Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet. 2011; 378:169–81.
  • 15. Iacobellis G, Diaz S, Mendez A, Goldberg R. Increased epicardial fat and plasma leptin in type 1 diabetes independently of obesity. Nutr Metab Cardiovasc Dis NMCD. 2014; 24:725–29.
  • 16. Cetin M, Cakici M, Polat M, Suner A, Zencir C, Ardic I et al. Relation of epicardial fat thickness with carotid intima-media thickness in patients with type 2 diabetes mellitus. Int J Endocrinol. 2013; 2013:1-6.
  • 17. Iacobellis G, Barbaro G, Gerstein HC. Relationship of epicardial fat thickness and fasting glucose. Int J Cardiol. 2008; 128:424–26.
  • 18.Al Chekakie MO, Welles CC, Metoyer R, Ibrahim A, Shapira AR, Cytron J et al. Pericardial fat is independently associated with human atrial fibrillation. J Am Coll Cardiol. 2010; 56:784–22.
  • 19.Nakanishi K, Fukuda S, Tanaka A, Otsuka K, Sakamoto M, Taguchi H ,et al. Peri-atrial epicardial adipose tissue is associated with new-onset non valvular atrial fibrillation. Circ J. 2012; 76:2748–54.
  • 20. Wong CX, Abed HS, Molaee P, Nelson AJ, Brooks AG, Sharma G et al. Pericardial fat is associated with atrial fibrillation severity and ablation outcome. J Am Coll Cardiol. 2011; 57:1745- 51.
  • 21 Yudkin JS, Stehouwer CD, Emeis JJ, S W Coppack. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol. 1999; 19:972–78.
  • 22. Nakanishi K, Fukuda S, Tanaka A, Otsuka K, Sakamoto M, Taguchi H et al. Peri-atrial epicardial adipose tissue is associated with new-onset non valvular atrial fibrillation. Circ J. 2012; 76:2748–54.
  • 23. Baloglu I, Turkmen K, Selcuk NY, Tonbul HZ, Ozcicek A, Hamur H et al. The Relationship Between Visceral Adiposity Index and Epicardial Adipose Tissue in Patients with Type 2 Diabetes Mellitus. Exp Clin Endocrinol Diabetes. 2021; 129:390-5
  • 24. Derya MA, Demir V, Ede H. Relationship between neutrophil/lymphocyte ratio and epicardial fat tissue thickness in patients with newly diagnosed hypertension J Int Med Res. 2018; 46: 940–50.
  • 25. Emin MA, Hamur H, Demirtas l, Bakirci EM, Ozcicek A, Ozcicek A et al. Predictors of epicardial adipose tissue in patients with type 2 diabetes mellitus Diabetol Metab Syndr 2014; 6: 55-59
  • 26.Nie D, Gong H, Mao X, Li Z. Systemic immune-inflammation index predicts prognosis in patients with epithelial ovarian cancer: a retrospective study. Gynecol Oncol. 2019; 152:259–64.
  • 27.Seo M, Yamada T, Morita T, Y Furukawa, S Tamaki, Y Iwasaki et al. Prognostic value of systemic immune-inflammation index in patients with chronic heart failure. Eur Heart J. 2018;39:564-69.
  • 28.Huang Y, Gao Y, Wu Y, Lin H. Prognostic value of systemic immune-inflammation index in patients with urologic cancers: a meta-analysis. Cancer Cell Int. 2020; 20:1-8.
  • 29. Bağcı A, Aksoy F, Baş HA. Systemic Immune-Inflammation Index May Predict the Development of Contrast-Induced Nephropathy in Patients with ST-Segment Elevation Myocardial Infarction. Angiology. 2021 Jul 12;33197211030053.
  • 30. Bjerg L, Gudbjörnsdottir S, Franzén S, Carstensen B, Witte DR, Jørgensen ME, et al. Duration of diabetes-related complications and mortality in type 1 diabetes: a national cohort study International Journal of Epidemiology, 2021 30;50:1250-59.

Yıl 2022, Cilt 44, Sayı 1, 62 - 66, 30.03.2022
https://doi.org/10.7197/cmj.1088573

Öz

Kaynakça

  • 1.Clarke P, Gray A, Legood R, J Leal, R R Holman. The impact of diabetes-related complications on health-care costs: results from the UK prospective diabetes study (UKPDS Study no. 65). Diabet Med. 2003; 20:442–50.
  • 2.A joint editorial statement by the American diabetes association, the national heart, lung and blood institute, the juvenile diabetes foundation international, the national institute of diabetes and digestive and kidney diseases, the American heart association. Diabetes mellitus: a major risk factor for cardiovascular disease. Circulation. 1999; 100:1132–43.
  • 3.Xiaoyou Su, Jing Xu, Chao Zheng. The relationship between non-alcoholic fatty liver and skeletal muscle mass to visceral fat area ratio in women with type 2 diabetes. BMC Endocrine Disorders. 2019; 19:76.
  • 4. Montecucco F, Liberale L, Bonaventura A, Vecchiè A, Dallegri F, F Carbone F et al. The Role of Inflammation in Cardiovascular Outcome. Curr Atheroscler Rep. 2017; 19:11. 5.Yang YL, Wu CH, Hsu PF, Chen SC, Huang SS, Chan WL,et al. Systemic immune inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. Eur J Clin Invest. 2020;50: e13230.
  • 6.Gottdiener JS, Arnold AM, Aurigemma GP, J F Polak, R P Tracy, D W Kitzman, et al. Predictors of congestive heart failure in the elderly: the cardiovascular health study. J Am Coll Cardiol.2000; 35:1628–37.
  • 7 Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA. 1979; 241:2035–58.
  • 8. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014; 37: 81-90.
  • 9.Dereli S, Bayramoğlu A, Yontar OC, Cerşit S, Gürsoy MO . Epicardial fat thickness: A new predictor of successful electrical cardioversion and atrial fibrillation recurrence. Echocardiography. 2018; 35:1926-31.
  • 10. Levesque C. Medical management of type 2 diabetes. J Nurse Pract. 2011; 7:492–01.
  • 11. Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type2 diabetes mellitus-present and future perspectives. Nat Rev Endocrinol. 2011; 8:228–36.
  • 12. Mahabadi Amir A, Massaro Joseph M, Rosito Guido A, Levy D, Murabito JM, Wolf PA, O'Donnell CJ et al. Association of pericardial fat, intrathoracic fat, and visceral abdominal at with cardiovascular disease burden: The Framingham Heart Study. Eur Heart J. 2009; 30:850–6.
  • 13. Yun CH, Lin TY, Wu YJ, Liu CC, Kuo JY, Yeh H et al. Pericardial and thoracicperi-aortic adipose tissues contribute to systemic inflammation and calcified coronary atherosclerosis independent of body fat composition, anthropometric measures and traditional cardiovascular risks. Eur J Radiol. 2012; 81:749–56.
  • 14. Nolan CJ, Damm P, Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet. 2011; 378:169–81.
  • 15. Iacobellis G, Diaz S, Mendez A, Goldberg R. Increased epicardial fat and plasma leptin in type 1 diabetes independently of obesity. Nutr Metab Cardiovasc Dis NMCD. 2014; 24:725–29.
  • 16. Cetin M, Cakici M, Polat M, Suner A, Zencir C, Ardic I et al. Relation of epicardial fat thickness with carotid intima-media thickness in patients with type 2 diabetes mellitus. Int J Endocrinol. 2013; 2013:1-6.
  • 17. Iacobellis G, Barbaro G, Gerstein HC. Relationship of epicardial fat thickness and fasting glucose. Int J Cardiol. 2008; 128:424–26.
  • 18.Al Chekakie MO, Welles CC, Metoyer R, Ibrahim A, Shapira AR, Cytron J et al. Pericardial fat is independently associated with human atrial fibrillation. J Am Coll Cardiol. 2010; 56:784–22.
  • 19.Nakanishi K, Fukuda S, Tanaka A, Otsuka K, Sakamoto M, Taguchi H ,et al. Peri-atrial epicardial adipose tissue is associated with new-onset non valvular atrial fibrillation. Circ J. 2012; 76:2748–54.
  • 20. Wong CX, Abed HS, Molaee P, Nelson AJ, Brooks AG, Sharma G et al. Pericardial fat is associated with atrial fibrillation severity and ablation outcome. J Am Coll Cardiol. 2011; 57:1745- 51.
  • 21 Yudkin JS, Stehouwer CD, Emeis JJ, S W Coppack. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol. 1999; 19:972–78.
  • 22. Nakanishi K, Fukuda S, Tanaka A, Otsuka K, Sakamoto M, Taguchi H et al. Peri-atrial epicardial adipose tissue is associated with new-onset non valvular atrial fibrillation. Circ J. 2012; 76:2748–54.
  • 23. Baloglu I, Turkmen K, Selcuk NY, Tonbul HZ, Ozcicek A, Hamur H et al. The Relationship Between Visceral Adiposity Index and Epicardial Adipose Tissue in Patients with Type 2 Diabetes Mellitus. Exp Clin Endocrinol Diabetes. 2021; 129:390-5
  • 24. Derya MA, Demir V, Ede H. Relationship between neutrophil/lymphocyte ratio and epicardial fat tissue thickness in patients with newly diagnosed hypertension J Int Med Res. 2018; 46: 940–50.
  • 25. Emin MA, Hamur H, Demirtas l, Bakirci EM, Ozcicek A, Ozcicek A et al. Predictors of epicardial adipose tissue in patients with type 2 diabetes mellitus Diabetol Metab Syndr 2014; 6: 55-59
  • 26.Nie D, Gong H, Mao X, Li Z. Systemic immune-inflammation index predicts prognosis in patients with epithelial ovarian cancer: a retrospective study. Gynecol Oncol. 2019; 152:259–64.
  • 27.Seo M, Yamada T, Morita T, Y Furukawa, S Tamaki, Y Iwasaki et al. Prognostic value of systemic immune-inflammation index in patients with chronic heart failure. Eur Heart J. 2018;39:564-69.
  • 28.Huang Y, Gao Y, Wu Y, Lin H. Prognostic value of systemic immune-inflammation index in patients with urologic cancers: a meta-analysis. Cancer Cell Int. 2020; 20:1-8.
  • 29. Bağcı A, Aksoy F, Baş HA. Systemic Immune-Inflammation Index May Predict the Development of Contrast-Induced Nephropathy in Patients with ST-Segment Elevation Myocardial Infarction. Angiology. 2021 Jul 12;33197211030053.
  • 30. Bjerg L, Gudbjörnsdottir S, Franzén S, Carstensen B, Witte DR, Jørgensen ME, et al. Duration of diabetes-related complications and mortality in type 1 diabetes: a national cohort study International Journal of Epidemiology, 2021 30;50:1250-59.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Dahili Tıp Bilimleri Araştırma Yazıları
Yazarlar

Levent ÖZDEMİR (Sorumlu Yazar)
King Fahad Specialist Hospital
0000-0002-1253-5673
Türkiye


Vural POLAT
SİVAS CUMHURİYET ÜNİVERSİTESİ
0000-0001-9553-3990
Türkiye

Yayımlanma Tarihi 30 Mart 2022
Yayınlandığı Sayı Yıl 2022, Cilt 44, Sayı 1

Kaynak Göster

APA Özdemir, L. & Polat, V. (2022). Association between systemic inflamatuary index and epicardial adipose tissue in patients with Type 2 Diabetes Mellitus . Cumhuriyet Medical Journal , 44 (1) , 62-66 . DOI: 10.7197/cmj.1088573