Tedavinin Sirolimus’tan Everolimus’a değiştirilmesi sonucu Everolimus’a bağlı pnömonit gelişen bir böbrek transplantasyonu hastası olgusu
Öz
DOI: 10.26650/cjm.2019.43.33
Pnömonit
mammalian target of rapamycin inhibitörleri tedavisinde görülen bir yan
etkidir. Biz bu olguda tedavinin sirolimustan everolimusa değiştirilmesi sonucu
everolimusa bağlı pnömonit gelişen bir hastayı sunuyoruz. 33 yaşında kadın
hasta tedavisinin sirolimustan everolimusa değiştirilmesinden sonra gelişen
kliniğimize halsizlik, öksürük, gece terlemesi ve yüksek ateş şikayetleriyle
başvurdu. Toraks BT’de buzlu cam görüntüsü ve asiner nodüller görüldü.
Everolimus tedavisi kesildikten sonra hastanın şikayetleri tamamen geriledi.
Sirolimustan everolimusa geçiş sonucu pnömonit daha önce gözlemlenmemiştir.
Everolimus alan hastalarda pulmoner semptomlar gelişirse everolimusa bağlı
pnömonit düşünülmelidir.
Cite this article as: Kaya E, Karakoç A,
Velidedeoğlu M, Pekmezci S, Trabulus S, Seyahi N. A Case of Everolimus Related
Pneumonitis Occurred After Switching Treatment from Sirolimus in a Kidney
Transplant Patient. Cerrahpasa Med J 2019; 43(1): 37-39.
Anahtar Kelimeler
Everolimus Sirolimus m-TOR inhibitörleri ilaca bağlı pnömonit böbrek transplantasyonu
Kaynakça
- 1. White DA, Camus P, Endo M, Escudier B, Calvo E, Akaza H, et al. Noninfectious pneumonitis after everolimus therapy for advanced renal cell carcinoma. Am J Respir Crit Care Med 2010; 182: 396e403. 2. Amato RJ, Jac J, Giessinger S, Saxena S, Willis JP. A phase 2 study with a daily regimen of the oral mTOR inhibitor RAD001 (everolimus) in patients with metastatic clear cell renal cell cancer. Cancer 2009; 115: 2438e46. 3. Soria JC, Shepherd FA, Douillard JY, Wolf J, Giaccone G, Crino L, et al. Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors. Ann Oncol 2009; 20: 1674e81. 4. Lee HS, Huh KH, Kim YS, Kim MS, Kim HJ, Kim SI, et al. Sirolimus-induced pneumonitis after renal transplantation: a single-center experience. Transplant Proc 2012; 44: 161e3. 5. Morelon E, Stern M, Israël-Biet D, Correas JM, Danel C, Mamzer-Bruneel MF, et al. Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patient. Transplantation 2001; 72: 787-90. 6. Haydar AA, Denton M, West A, Rees J, Goldsmith DJ. Sirolimus-induced pneumonitis: three cases and a review of the literature. Am J Transplant 2004; 4: 137-9. 7. Champion L, Stern M, Israël-Biet D, Mamzer-Bruneel MF, Peraldi MN, Kreis H, et al. Brief communication: sirolimus-associated pneumonitis: 24 cases in renal transplant recipients. Ann Intern Med 2006; 144: 505-9. 8. Cotovio P, Neves M, Santos L, Macário F, Alves R, Mota A. Conversion to everolimus in kidney transplant recipients: to believe or not believe? Transplant Proc 2012; 44: 2966-70. 9. Baas MC, Struijk GH, Moes DJ, van den Berk IA, Jonkers RE, de Fijter JW, et al. Interstitial pneumonitis caused by everolimus: a case-cohort study in renal transplant recipients. Transpl Int 2014; 27: 428-36. 10. Rehm B, Keller F, Mayer J, Stracke S. Resolution of sirolimus-induced pneumonitis after conversion to everolimus. Transplant Proc 2006; 38: 711-3. 11. Singh U. Gupta A. Jasuja S. Sirolimus-induced pneumonitis. Indian J nephrol 2009; 19: 80-1.
A Case of Everolimus Related Pneumonitis Occurred After Switching Treatment from Sirolimus in a Kidney Transplant Patient
Öz
DOI: 10.26650/cjm.2019.43.33
Pneumonitis is a reported side effect of
treatment with mammalian target of rapamycin inhibitors. In this report, we
present a case of everolimus-related pneumonitis that occurred after treatment
switching from sirolimus to everolimus. A 33-year-old female was admitted to
our clinic with fatigue, cough, night sweats, and high fever after treatment
switching from sirolimus to everolimus. Thorax CT revealed ground-glass
densities and acinar nodules. After withdrawal of everolimus, complete
remission was observed. Pneumonitis after treatment switching from sirolimus to
everolimus has not been observed before. In patients with pulmonary symptoms
during everolimus treatment, drug-related pneumonitis should be considered.
Cite this article as: Kaya E, Karakoç A,
Velidedeoğlu M, Pekmezci S, Trabulus S, Seyahi N. A Case of Everolimus Related
Pneumonitis Occurred After Switching Treatment from Sirolimus in a Kidney
Transplant Patient. Cerrahpasa Med J 2019; 43(1): 37-39.
Anahtar Kelimeler
Everolimus sirolimus mTOR inhibitors drug-related pneumonitis kidney transplantation
Kaynakça
- 1. White DA, Camus P, Endo M, Escudier B, Calvo E, Akaza H, et al. Noninfectious pneumonitis after everolimus therapy for advanced renal cell carcinoma. Am J Respir Crit Care Med 2010; 182: 396e403. 2. Amato RJ, Jac J, Giessinger S, Saxena S, Willis JP. A phase 2 study with a daily regimen of the oral mTOR inhibitor RAD001 (everolimus) in patients with metastatic clear cell renal cell cancer. Cancer 2009; 115: 2438e46. 3. Soria JC, Shepherd FA, Douillard JY, Wolf J, Giaccone G, Crino L, et al. Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors. Ann Oncol 2009; 20: 1674e81. 4. Lee HS, Huh KH, Kim YS, Kim MS, Kim HJ, Kim SI, et al. Sirolimus-induced pneumonitis after renal transplantation: a single-center experience. Transplant Proc 2012; 44: 161e3. 5. Morelon E, Stern M, Israël-Biet D, Correas JM, Danel C, Mamzer-Bruneel MF, et al. Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patient. Transplantation 2001; 72: 787-90. 6. Haydar AA, Denton M, West A, Rees J, Goldsmith DJ. Sirolimus-induced pneumonitis: three cases and a review of the literature. Am J Transplant 2004; 4: 137-9. 7. Champion L, Stern M, Israël-Biet D, Mamzer-Bruneel MF, Peraldi MN, Kreis H, et al. Brief communication: sirolimus-associated pneumonitis: 24 cases in renal transplant recipients. Ann Intern Med 2006; 144: 505-9. 8. Cotovio P, Neves M, Santos L, Macário F, Alves R, Mota A. Conversion to everolimus in kidney transplant recipients: to believe or not believe? Transplant Proc 2012; 44: 2966-70. 9. Baas MC, Struijk GH, Moes DJ, van den Berk IA, Jonkers RE, de Fijter JW, et al. Interstitial pneumonitis caused by everolimus: a case-cohort study in renal transplant recipients. Transpl Int 2014; 27: 428-36. 10. Rehm B, Keller F, Mayer J, Stracke S. Resolution of sirolimus-induced pneumonitis after conversion to everolimus. Transplant Proc 2006; 38: 711-3. 11. Singh U. Gupta A. Jasuja S. Sirolimus-induced pneumonitis. Indian J nephrol 2009; 19: 80-1.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Olgu Sunumları |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Temmuz 2019 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 43 Sayı: 1 |
