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METHANOL POISONING IN THREE CASES: DIAGNOSIS AND TREATMENT IN EMERGENCY DEPARTMENT

Yıl 2012, Cilt: 75 Sayı: 2, 25 - 27, 06.08.2012

Fatma Kukul Güven Kenan Türkdoğan Şevki Eren Hüseyin Aydın İlhan Korkmaz Abuzer Coşkun

Öz

ABSTRACT
Methanol is a very poisonous substance that is used as an industrial solvent and automotive antifreeze. Toxic dose is between 20-250 ml and causes neurological symptoms such as headache, cerebral edema and putamen necrosis within the first 12 to 14 hours. Central nervous system and visual cortex are the main areas which are damaged by methanol poisoning. Methyl alcohol is not toxic until its toxic metabolites turn into formic acid. Formic acid is especially responsible for the clinical findings. Serum half-life of methanol is 14 to 20 hours in mild and 24 to 30 hours in severe toxicity. Gastric lavage, fomepizole, ethanol and hemodialysis are used in the treatment. In this study, we aimed to review and discuss information from literature about the treatment and monitoring of methanol poisoning in three cases followed at emergency department.
Key words: Methanol poisoning, emergency, blurred vision, hemodialysis

Anahtar Kelimeler

Methanol zehirlenmesi acil bulanık görme hemodiyaliz

Kaynakça

  • Anderson IB. Methanol. In: Poisoning and Drug Overdose, Kent R. Olson (ed). 4th edition, The McGrawHill Companies, USA 260-261, 2004.
  • Barceloux GD, Bond GR, Krenzelok EP, Olson K, Watson W. American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Methanol Poisoning. Clin Toxicol 40:415-446, 2002.
  • BlancoM,CasadoR,VazquezF,PumarJM.CTandMR imaging findings in methanol intocication. Am J Neuroradiol, 27:452-4, 2006.
  • Burkhart KK, Kulig KW. The other alcohols. Methanol, ethylene glycol, and isopropanol. Emerg Med Clin North Am 8:913-928,1990.
  • Dart RC, Goldfrank LR, Chyka PA, Lotzer D, Woolf AD, McNally J, Snodgrass WR, Olson KR, Scharman E, Geller RJ, Spyker D, Kraft M, Lipsy R.Combined evidence-based ing the dialysis however; putamenal haemorrhage may be seen in patients who were literature analysis and consensus guidelines for stocking of emergency antidotes in the United States. Ann Emerg Med 36:126-132,2000.
  • Eells JT, Makar AB, Noker PE, Tephly TR. Methanol Poisoning and Formate Oxidation in Nitrous Oxide Treated Rats. J Pharmacol Exp Ther 217:57-61,1981.
  • Elmas I,Tüzün B,Imrag C. Evaluation of deaths due to methyl alcohol intoxication with respect to forensic medicine. Istanbul Med. Faculty 59:64-69, 1996.
  • Hassanian-Moghaddam H, Pajoumand A, Dadgar SM, Shadnia Sh. Prognostic factors in methanol poisoning. Hum Exp Toxicol 26:583-586, 2007.
  • IPCS,Healthy and Safety Guide No. 105. Methanol; World Healthy Organization: Geneva, 105, 1997.
  • Kruse JR. Methanole poisoning. Intensive Care Med 18:391-397, 1992.
  • Liu JJ, Daya MR, Carrasquillo O, Kales SN.Prognostic factors in patients with methanol poisoning. J Toxicol Clin Toxicol, 36:175-181, 1998.
  • Liu ,JJ, Daya, MR, Mann, NC. Methanol-Related Deaths in Ontario. Clin Toxicol 37:69-73, 1999.
  • Mittal BV, Desai AP, Khade KR. Methyl alcohol poisoning an autopsy study of 28 cases. J Post Grad-Med 37:9-13, 997.
  • Naraqi S, Dethlefs RF, Slobodniuk RA, Sairere JS. An outbreak of acute methyl alcohol intoxication. Aust N Z J Med 9:65-8, 1979.
  • Nolla-Salas J, Nogué Xarau S, Marruecos Sant L, Palomar Martínez M, Martínez Pérez J. Methanol and ethylene glycol poisoning. Study of 18 cases. Med Clin (Barc) 104:121-125 1995.
  • Oliveras Ley C,Gali,G. Parkinsonien Syndrome after Methanol Intoxication. Eur Neurol; 22:405-409,1983.
  • Rley RJ, Ilson BE, Narins RG. Acute metabolic acid-base disorder.Crit Care Clin 5:699-724, 1987. 18.Scrimgeour, EM. Outbreak of Methanol and Isopropanol Poisoning in New Britain, Papua New Guinea. Med J Aust 2:36-38, 1980.
  • Server A, Hovda KE, Nakstad PH, Jacobsen D, Dullerud R, Haakonsen M. Conventional and diffusion-weighted MRI in the evaluation of methanol poisoning. Acta Neurol 44:691- 5, 2003.
  • Sharma AN. Toxic alcohols. In: Goldfrank LR, Flomenbaum NE, Lewin NA, Weisman RS, Howland MA, Hoffman RS, eds.Goldfrank’s Toxicologic Emergencies, 7th edition, USA, The McGraw-Hill Companies 980-990, 2002.
  • Suit PF, Estes ML. Methanol intoxication: Clinical features and differential diagnosis.Cleve Clin J Med 57:464-471, 1990. 22.Teo, SK, Lo KL,Tey BH. Mass methanol poisoning: A clinico- Biochemical Analysis of 10 Cases. Singap. Med J 37:485-487, 1996.
  • Turla A,Yaycı N, Koç S. Ölümle sonuçlanan metil alkol zehirlenmeleri. Adli Tıp Derg 15:37-40, 2001. 24.Yayci N, Ağritmiş H, Turla A, Koç S.Fatalities due to methyl alcohol intoxication in Turkey: an 8 year study. Forensic Sci Int 131:36-41, 2003.
  • Yaycı N, Inanıcı MA. Methyl Alcohol (methanol) Intoxication. T Clin J Foren Med 2:101-108, 2005.

Yıl 2012, Cilt: 75 Sayı: 2, 25 - 27, 06.08.2012

Fatma Kukul Güven Kenan Türkdoğan Şevki Eren Hüseyin Aydın İlhan Korkmaz Abuzer Coşkun

Öz

Kaynakça

  • Anderson IB. Methanol. In: Poisoning and Drug Overdose, Kent R. Olson (ed). 4th edition, The McGrawHill Companies, USA 260-261, 2004.
  • Barceloux GD, Bond GR, Krenzelok EP, Olson K, Watson W. American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Methanol Poisoning. Clin Toxicol 40:415-446, 2002.
  • BlancoM,CasadoR,VazquezF,PumarJM.CTandMR imaging findings in methanol intocication. Am J Neuroradiol, 27:452-4, 2006.
  • Burkhart KK, Kulig KW. The other alcohols. Methanol, ethylene glycol, and isopropanol. Emerg Med Clin North Am 8:913-928,1990.
  • Dart RC, Goldfrank LR, Chyka PA, Lotzer D, Woolf AD, McNally J, Snodgrass WR, Olson KR, Scharman E, Geller RJ, Spyker D, Kraft M, Lipsy R.Combined evidence-based ing the dialysis however; putamenal haemorrhage may be seen in patients who were literature analysis and consensus guidelines for stocking of emergency antidotes in the United States. Ann Emerg Med 36:126-132,2000.
  • Eells JT, Makar AB, Noker PE, Tephly TR. Methanol Poisoning and Formate Oxidation in Nitrous Oxide Treated Rats. J Pharmacol Exp Ther 217:57-61,1981.
  • Elmas I,Tüzün B,Imrag C. Evaluation of deaths due to methyl alcohol intoxication with respect to forensic medicine. Istanbul Med. Faculty 59:64-69, 1996.
  • Hassanian-Moghaddam H, Pajoumand A, Dadgar SM, Shadnia Sh. Prognostic factors in methanol poisoning. Hum Exp Toxicol 26:583-586, 2007.
  • IPCS,Healthy and Safety Guide No. 105. Methanol; World Healthy Organization: Geneva, 105, 1997.
  • Kruse JR. Methanole poisoning. Intensive Care Med 18:391-397, 1992.
  • Liu JJ, Daya MR, Carrasquillo O, Kales SN.Prognostic factors in patients with methanol poisoning. J Toxicol Clin Toxicol, 36:175-181, 1998.
  • Liu ,JJ, Daya, MR, Mann, NC. Methanol-Related Deaths in Ontario. Clin Toxicol 37:69-73, 1999.
  • Mittal BV, Desai AP, Khade KR. Methyl alcohol poisoning an autopsy study of 28 cases. J Post Grad-Med 37:9-13, 997.
  • Naraqi S, Dethlefs RF, Slobodniuk RA, Sairere JS. An outbreak of acute methyl alcohol intoxication. Aust N Z J Med 9:65-8, 1979.
  • Nolla-Salas J, Nogué Xarau S, Marruecos Sant L, Palomar Martínez M, Martínez Pérez J. Methanol and ethylene glycol poisoning. Study of 18 cases. Med Clin (Barc) 104:121-125 1995.
  • Oliveras Ley C,Gali,G. Parkinsonien Syndrome after Methanol Intoxication. Eur Neurol; 22:405-409,1983.
  • Rley RJ, Ilson BE, Narins RG. Acute metabolic acid-base disorder.Crit Care Clin 5:699-724, 1987. 18.Scrimgeour, EM. Outbreak of Methanol and Isopropanol Poisoning in New Britain, Papua New Guinea. Med J Aust 2:36-38, 1980.
  • Server A, Hovda KE, Nakstad PH, Jacobsen D, Dullerud R, Haakonsen M. Conventional and diffusion-weighted MRI in the evaluation of methanol poisoning. Acta Neurol 44:691- 5, 2003.
  • Sharma AN. Toxic alcohols. In: Goldfrank LR, Flomenbaum NE, Lewin NA, Weisman RS, Howland MA, Hoffman RS, eds.Goldfrank’s Toxicologic Emergencies, 7th edition, USA, The McGraw-Hill Companies 980-990, 2002.
  • Suit PF, Estes ML. Methanol intoxication: Clinical features and differential diagnosis.Cleve Clin J Med 57:464-471, 1990. 22.Teo, SK, Lo KL,Tey BH. Mass methanol poisoning: A clinico- Biochemical Analysis of 10 Cases. Singap. Med J 37:485-487, 1996.
  • Turla A,Yaycı N, Koç S. Ölümle sonuçlanan metil alkol zehirlenmeleri. Adli Tıp Derg 15:37-40, 2001. 24.Yayci N, Ağritmiş H, Turla A, Koç S.Fatalities due to methyl alcohol intoxication in Turkey: an 8 year study. Forensic Sci Int 131:36-41, 2003.
  • Yaycı N, Inanıcı MA. Methyl Alcohol (methanol) Intoxication. T Clin J Foren Med 2:101-108, 2005.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Olgu Sunumu
Yazarlar

Fatma Kukul Güven

Kenan Türkdoğan Bu kişi benim

Şevki Eren Bu kişi benim

Hüseyin Aydın Bu kişi benim

İlhan Korkmaz Bu kişi benim

Abuzer Coşkun Bu kişi benim

Yayımlanma Tarihi 6 Ağustos 2012
Gönderilme Tarihi 6 Ağustos 2012
Yayımlandığı Sayı Yıl 2012 Cilt: 75 Sayı: 2

Kaynak Göster

APA Kukul Güven, F., Türkdoğan, K., Eren, Ş., Aydın, H., vd. (2012). METHANOL POISONING IN THREE CASES: DIAGNOSIS AND TREATMENT IN EMERGENCY DEPARTMENT. Journal of Istanbul Faculty of Medicine, 75(2), 25-27.
AMA Kukul Güven F, Türkdoğan K, Eren Ş, Aydın H, Korkmaz İ, Coşkun A. METHANOL POISONING IN THREE CASES: DIAGNOSIS AND TREATMENT IN EMERGENCY DEPARTMENT. İst Tıp Fak Derg. Ağustos 2012;75(2):25-27.
Chicago Kukul Güven, Fatma, Kenan Türkdoğan, Şevki Eren, Hüseyin Aydın, İlhan Korkmaz, ve Abuzer Coşkun. “METHANOL POISONING IN THREE CASES: DIAGNOSIS AND TREATMENT IN EMERGENCY DEPARTMENT”. Journal of Istanbul Faculty of Medicine 75, sy. 2 (Ağustos 2012): 25-27.
EndNote Kukul Güven F, Türkdoğan K, Eren Ş, Aydın H, Korkmaz İ, Coşkun A (01 Ağustos 2012) METHANOL POISONING IN THREE CASES: DIAGNOSIS AND TREATMENT IN EMERGENCY DEPARTMENT. Journal of Istanbul Faculty of Medicine 75 2 25–27.
IEEE F. Kukul Güven, K. Türkdoğan, Ş. Eren, H. Aydın, İ. Korkmaz, ve A. Coşkun, “METHANOL POISONING IN THREE CASES: DIAGNOSIS AND TREATMENT IN EMERGENCY DEPARTMENT”, İst Tıp Fak Derg, c. 75, sy. 2, ss. 25–27, 2012.
ISNAD Kukul Güven, Fatma vd. “METHANOL POISONING IN THREE CASES: DIAGNOSIS AND TREATMENT IN EMERGENCY DEPARTMENT”. Journal of Istanbul Faculty of Medicine 75/2 (Ağustos 2012), 25-27.
JAMA Kukul Güven F, Türkdoğan K, Eren Ş, Aydın H, Korkmaz İ, Coşkun A. METHANOL POISONING IN THREE CASES: DIAGNOSIS AND TREATMENT IN EMERGENCY DEPARTMENT. İst Tıp Fak Derg. 2012;75:25–27.
MLA Kukul Güven, Fatma vd. “METHANOL POISONING IN THREE CASES: DIAGNOSIS AND TREATMENT IN EMERGENCY DEPARTMENT”. Journal of Istanbul Faculty of Medicine, c. 75, sy. 2, 2012, ss. 25-27.
Vancouver Kukul Güven F, Türkdoğan K, Eren Ş, Aydın H, Korkmaz İ, Coşkun A. METHANOL POISONING IN THREE CASES: DIAGNOSIS AND TREATMENT IN EMERGENCY DEPARTMENT. İst Tıp Fak Derg. 2012;75(2):25-7.
 Kapak Resmi İndir

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