Klinik Araştırma
Yıl 2022,
Cilt: 1 Sayı: 1, 18 - 23, 25.06.2022
Öz
Aim: Hypotheses about idiopathic sudden sensorineural hearing loss (ISSNHL) have focused on inflammation and vascular etiopathogenesis. We evaluated the relationship between ISSNHL and choroidal thickness (CT), ocular pulse amplitude (OPA), and intraocular pressure (IOP) to reveal the generality of inflammation and vascular pathology.
Materials and Methods: This study was conducted on 34 ISSNHL patients who were admitted within 5 days and were considered idiopathic with no etiological cause and 34 healthy controls. The ISSNHL group and the control group were assessed in terms of CT, OPA and IOP and ISSNHL groups on both affected (ipsilateral) and non-affected (contralateral) sides. Mild-moderate hearing loss group (n=20) and severe-profound hearing loss group (n=14) were also investigated and ocular parameters were compared.
Results: CT values were increased statistically significantly in the ISSHNL group (p=0.03), but there was no significant difference between groups in terms of OPA and IOP. When the ipsilateral and contralateral sides of ISSHNL patients were compared, no statistical difference was found between the CT, OPA and IOP values (p>0.05). Choroid thickness was found to be higher in severe-profound group rather than the mild-moderate group, but it was not statistically significant.
Conclusion: Increase in CT values of the ISSNHL group supports the relationship between sudden hearing loss and inflammatory processes. The bilateral nature of the findings support that systemic inflammation rather than a local inflammatory response.
Materials and Methods: This study was conducted on 34 ISSNHL patients who were admitted within 5 days and were considered idiopathic with no etiological cause and 34 healthy controls. The ISSNHL group and the control group were assessed in terms of CT, OPA and IOP and ISSNHL groups on both affected (ipsilateral) and non-affected (contralateral) sides. Mild-moderate hearing loss group (n=20) and severe-profound hearing loss group (n=14) were also investigated and ocular parameters were compared.
Results: CT values were increased statistically significantly in the ISSHNL group (p=0.03), but there was no significant difference between groups in terms of OPA and IOP. When the ipsilateral and contralateral sides of ISSHNL patients were compared, no statistical difference was found between the CT, OPA and IOP values (p>0.05). Choroid thickness was found to be higher in severe-profound group rather than the mild-moderate group, but it was not statistically significant.
Conclusion: Increase in CT values of the ISSNHL group supports the relationship between sudden hearing loss and inflammatory processes. The bilateral nature of the findings support that systemic inflammation rather than a local inflammatory response.
Anahtar Kelimeler
Choroidal thickness Inflammation Ocular physiology Sensorineural hearing loss
Teşekkür
We wish to thank Assoc. Prof. Aydin Keskinruzgar for his assistance with the statistics used in this study.
Kaynakça
- 1. Stachler RJ, Chandrasekhar SS, Archer SM, Rosenfeld RM, Schwartz SR, Barrs DM et al. Clinical practice guideline: sudden hearing loss. Otolaryngol Head Neck Surg. 2012;146(3 Suppl):S1-35.
- 2. Chau JK, Lin JR, Atashband S, Irvine RA, Westerberg BD. Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. Laryngoscope. 2010;120:1011-21.
- 3. Dziedzic T. Systemic inflammation as a therapeutic target in acute ischemic stroke. Expert Rev Neurother. 2015;15:523-31.
- 4. Quaranta N, De Ceglie V, D'Elia A. Endothelial dysfunction in idiopathic sudden sensorineural hearing loss: A Review. Audiol Res. 2016;6:151.
- 5. Mosnier I, Stepanian A, Baron G, Bodenez C, Robier A, Meyer B et al. Cardiovascular and thromboembolic risk factors in idiopathic sudden sensorineural hearing loss: a case-control study. Audiol Neurootol. 2011;16:55-66.
- 6. Ocal R, Akın Ocal FC, Gulluev M, Alatas N. Is the C-reactive protein/albumin ratio a prognostic and predictive factor in sudden hearing loss? Braz J Otorhinolaryngol. 2020;86:180-4.
- 7. Seo YJ, Jeong JH, Choi JY, Moon IS. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Dis Markers. 2014;2014:702807.
- 8. Masuda M, Kanzaki S, Minami S, Kikuchi J, Kanzaki J, Sato H et al. Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 2012;33:1142-50.
- 9. Bill A, Sperber GO. Control of retinal and choroidal blood flow. Eye (Lond). 1990;4:319-25.
- 10. Ehrlich R, Harris A, Wentz SM, Moore NA, Siesky B A. Anatomy and regulation of the optic nerve blood flow. 2017, https://doi.org/10.1016/ B978-0-12- 809324-5.01301-8.
- 11. Williamson TH, Harris A. Ocular blood flow measurement. Br J Ophthalmol. 1994;78:939-45.
- 12. Stalmans I, Harris A, Fieuws S, Zeyen T, Vanbellinghen V, McCranor L et al. Color Doppler imaging and ocular pulse amplitude in glaucomatous and healthy eyes. Eur J Ophthalmol. 2009;19:580-7.
- 13. Çalışkan S, Acar M, Gürdal C. Choroidal Thickness in Patients with Graves' Ophthalmopathy. Curr Eye Res. 2017;42:484-90.
- 14. Türkcü FM, Şahin A, Yüksel H, Akkurt M, Uçmak D, Çınar Y et al. Evaluation of choroidal thickness in psoriasis using optical coherence tomography. Int Ophthalmol. 2016;36:851-4.
- 15. Karadag AS, Bilgin B, Soylu MB. Comparison of optical coherence tomographic findings between Behcet disease patients with and without ocular involvement and healthy subjects. Arq Bras Oftalmol. 2017;80(2):69-73.
- 16. Onal IK, Yuksel E, Bayrakceken K, Demir MM, Karaca EE, Ibis M, et al. Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease. Arq Bras Oftalmol. 2015;78:278-82.
- 17. Report of the informal working group on prevention of deafness and hearing impairment programme planning, Geneva, 18-21 June 1991. Geneva: World Health Organization; 1991. Available from: http://www.who.int/iris/handle/10665/58839
- 18. Hiramatsu M, Teranishi M, Uchida Y, Nishio N, Suzuki H, Kato K et al. Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss. J Neurogenet. 2012;26:387-96.
- 19. Crane RA, Camilon M, Nguyen S, Meyer TA. Steroids for treatment of sudden sensorineural hearing loss: a meta-analysis of randomized controlled trials. Laryngoscope. 2015;125:209-17.
- 20.Arslan Y, Arslan İB, Aydin H, Yağiz Ö, Tokuçoğlu F, Çukurova İ. The etiological relationship between migraine and sudden hearing Loss. Otol Neurotol. 2017;38:1411-4.
- 21.Hsu HT, Chen JY, Weng SF, Huang KH, Lin YS. Increased risk of erectile dysfunction in patients with sudden sensorineural hearing loss: a nationwide, population-based cohort study. Otol Neurotol. 2013;34:862-7.
- 22. Alm A. Ocular circulation. In: Hart W, ed. Adler's Physiology of the Eye: Clinical Application. St. Louis, MO: Mosby-Year Book, Inc. 1992: 199–227.
- 23.Mei X, Atturo F, Wadin K, Larsson S, Agrawal S, Ladak HM et al. Human inner ear blood supply revisited: the Uppsala collection of temporal bone-an international resource of education and collaboration. Ups J Med Sci. 2018;123:131-42.
- 24. Yoon TH, Paparella MM, Schachern PA, Alleva M. Histopathology of sudden hearing loss. Laryngoscope. 1990;100:707-15.
- 25. Dervisogullari MS, Totan Y, Gençler OS. Choroid thickness and ocular pulse amplitude in migraine during attack. Eye (Lond). 2015;29:371-5.
- 26. Dervişoğulları MS, Totan Y, Yüce A, Kulak AE. Acute effects of caffeine on choroidal thickness and ocular pulse amplitude. Cutan Ocul Toxicol. 2016;35:281-6.
- 27. Doğan S, Şimşek A, Bayraktar C, Yazıcı H, Sarıkaya Y, Karataş M et al. Ocular blood flow alterations during inferior turbinate radiofrequency reduction under local anesthesia. Am J Rhinol Allergy. 2016;30:185-8.
- 28. Steiner M, Esteban-Ortega MDM, Muñoz-Fernández S. Choroidal and retinal thickness in systemic autoimmune and inflammatory diseases: A review. Surv Ophthalmol. 2019;64:757-69.
Yıl 2022,
Cilt: 1 Sayı: 1, 18 - 23, 25.06.2022
Öz
Amaç: Ani idiyopatik sensörinöral işitme kaybı (AİSNİK) ile ilgili hipotezler, inflamasyon ve vasküler etiyopatogenez üzerine odaklanmıştır. Biz bu çalışmada AİSNİK ile koroid kalınlığı (KK), oküler pulsamplitüdü (OPA) ve göz içi basıncı (GİB) arasındaki ilişkiyi değerlendirerek, inflamasyon ve vasküler patolojilerin hastalıktaki rolünü ortaya koymayı amaçladık. Gereç ve Yöntemler: Ani işitme kaybı şikayetiyle beş gün içinde başvuran ve etiyolojik bir neden bulunma yarak idiyopatik kabul edilen 34 AİSNİK hastası ve 34 sağlıklı gönüllü çalışmaya dahil edildi. AİSNİK grubu ile kontrol grubu ve kendi içinde AİSNİK grubunun etkilenen (ipsilateral) ve etkilenmeyen (kontralateral) tarafları KK, OPA ve GİB açısından karşılaştırıldı. Ayrıca hafif-orta işitme kayıplı grup (n=20) ve ileri-çok ileri işitme kayıplı gruplar (n=14) arasındaki oküler parametreler karşılaştırıldı. Bulgular: Koroid kalınlığı, AİSNİK grubunda istatistiksel olarak anlamlı düzeyde artmış bulundu (p=0,03). Ancak OPA ve GİB açısından gruplar arasında anlamlı bir fark görülmedi. AİSNİK hastalarının, aynı taraf ve karşı tarafları karşılaştırıldığında KK, OPA ve GİB değerleri arasında istatistiksel olarak fark bulunmadı (p>0.05). Koroid kalınlığı, ileri-çok ileri işitme kaybı izlenen grupta, hafif-orta işitme kaybı izlenen gruba göre, artmıştı ancak istatistiksel olarak anlamlı değildi. Sonuç: AİSNİK grubunun KK değerlerindeki artış, ani işitme kaybı ile inflamatuar süreçler arasındaki ilişkiyi desteklemektedir. Bulguların bilateral olması, lokal bir inflamatuar yanıttan çok sistemik inflamasyonu desteklemektedir.
Anahtar Kelimeler
İnflamasyon Koroid kalınlığı Oküler fizyoloji Sensörinöral işitme kaybı
Kaynakça
- 1. Stachler RJ, Chandrasekhar SS, Archer SM, Rosenfeld RM, Schwartz SR, Barrs DM et al. Clinical practice guideline: sudden hearing loss. Otolaryngol Head Neck Surg. 2012;146(3 Suppl):S1-35.
- 2. Chau JK, Lin JR, Atashband S, Irvine RA, Westerberg BD. Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. Laryngoscope. 2010;120:1011-21.
- 3. Dziedzic T. Systemic inflammation as a therapeutic target in acute ischemic stroke. Expert Rev Neurother. 2015;15:523-31.
- 4. Quaranta N, De Ceglie V, D'Elia A. Endothelial dysfunction in idiopathic sudden sensorineural hearing loss: A Review. Audiol Res. 2016;6:151.
- 5. Mosnier I, Stepanian A, Baron G, Bodenez C, Robier A, Meyer B et al. Cardiovascular and thromboembolic risk factors in idiopathic sudden sensorineural hearing loss: a case-control study. Audiol Neurootol. 2011;16:55-66.
- 6. Ocal R, Akın Ocal FC, Gulluev M, Alatas N. Is the C-reactive protein/albumin ratio a prognostic and predictive factor in sudden hearing loss? Braz J Otorhinolaryngol. 2020;86:180-4.
- 7. Seo YJ, Jeong JH, Choi JY, Moon IS. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Dis Markers. 2014;2014:702807.
- 8. Masuda M, Kanzaki S, Minami S, Kikuchi J, Kanzaki J, Sato H et al. Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 2012;33:1142-50.
- 9. Bill A, Sperber GO. Control of retinal and choroidal blood flow. Eye (Lond). 1990;4:319-25.
- 10. Ehrlich R, Harris A, Wentz SM, Moore NA, Siesky B A. Anatomy and regulation of the optic nerve blood flow. 2017, https://doi.org/10.1016/ B978-0-12- 809324-5.01301-8.
- 11. Williamson TH, Harris A. Ocular blood flow measurement. Br J Ophthalmol. 1994;78:939-45.
- 12. Stalmans I, Harris A, Fieuws S, Zeyen T, Vanbellinghen V, McCranor L et al. Color Doppler imaging and ocular pulse amplitude in glaucomatous and healthy eyes. Eur J Ophthalmol. 2009;19:580-7.
- 13. Çalışkan S, Acar M, Gürdal C. Choroidal Thickness in Patients with Graves' Ophthalmopathy. Curr Eye Res. 2017;42:484-90.
- 14. Türkcü FM, Şahin A, Yüksel H, Akkurt M, Uçmak D, Çınar Y et al. Evaluation of choroidal thickness in psoriasis using optical coherence tomography. Int Ophthalmol. 2016;36:851-4.
- 15. Karadag AS, Bilgin B, Soylu MB. Comparison of optical coherence tomographic findings between Behcet disease patients with and without ocular involvement and healthy subjects. Arq Bras Oftalmol. 2017;80(2):69-73.
- 16. Onal IK, Yuksel E, Bayrakceken K, Demir MM, Karaca EE, Ibis M, et al. Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease. Arq Bras Oftalmol. 2015;78:278-82.
- 17. Report of the informal working group on prevention of deafness and hearing impairment programme planning, Geneva, 18-21 June 1991. Geneva: World Health Organization; 1991. Available from: http://www.who.int/iris/handle/10665/58839
- 18. Hiramatsu M, Teranishi M, Uchida Y, Nishio N, Suzuki H, Kato K et al. Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss. J Neurogenet. 2012;26:387-96.
- 19. Crane RA, Camilon M, Nguyen S, Meyer TA. Steroids for treatment of sudden sensorineural hearing loss: a meta-analysis of randomized controlled trials. Laryngoscope. 2015;125:209-17.
- 20.Arslan Y, Arslan İB, Aydin H, Yağiz Ö, Tokuçoğlu F, Çukurova İ. The etiological relationship between migraine and sudden hearing Loss. Otol Neurotol. 2017;38:1411-4.
- 21.Hsu HT, Chen JY, Weng SF, Huang KH, Lin YS. Increased risk of erectile dysfunction in patients with sudden sensorineural hearing loss: a nationwide, population-based cohort study. Otol Neurotol. 2013;34:862-7.
- 22. Alm A. Ocular circulation. In: Hart W, ed. Adler's Physiology of the Eye: Clinical Application. St. Louis, MO: Mosby-Year Book, Inc. 1992: 199–227.
- 23.Mei X, Atturo F, Wadin K, Larsson S, Agrawal S, Ladak HM et al. Human inner ear blood supply revisited: the Uppsala collection of temporal bone-an international resource of education and collaboration. Ups J Med Sci. 2018;123:131-42.
- 24. Yoon TH, Paparella MM, Schachern PA, Alleva M. Histopathology of sudden hearing loss. Laryngoscope. 1990;100:707-15.
- 25. Dervisogullari MS, Totan Y, Gençler OS. Choroid thickness and ocular pulse amplitude in migraine during attack. Eye (Lond). 2015;29:371-5.
- 26. Dervişoğulları MS, Totan Y, Yüce A, Kulak AE. Acute effects of caffeine on choroidal thickness and ocular pulse amplitude. Cutan Ocul Toxicol. 2016;35:281-6.
- 27. Doğan S, Şimşek A, Bayraktar C, Yazıcı H, Sarıkaya Y, Karataş M et al. Ocular blood flow alterations during inferior turbinate radiofrequency reduction under local anesthesia. Am J Rhinol Allergy. 2016;30:185-8.
- 28. Steiner M, Esteban-Ortega MDM, Muñoz-Fernández S. Choroidal and retinal thickness in systemic autoimmune and inflammatory diseases: A review. Surv Ophthalmol. 2019;64:757-69.
Toplam 28 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Yayımlanma Tarihi | 25 Haziran 2022 |
| Gönderilme Tarihi | 12 Mayıs 2022 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 1 Sayı: 1 |
Kaynak Göster
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