Öz
Kaynakça
- 1. Alberico S, Montico M, Barresi V, Monasta L, Businelli C, Soini V, Erenbourg A, Ronfani L, Maso G; Multicentre Study Group on Mode of Delivery in Friuli Venezia Giulia. The role of gestational diabetes, pre-pregnancy body mass index and gestational weight gain on the risk of newborn macrosomia: results from a prospective multicentre study. BMC Pregnancy Childbirth. 2014;14:23.
- 2. Pasupathy D, McCowan LM, Poston L, Kenny LC, Dekker GA, North RA; SCOPE consortium. Perinatal outcomes in large infants using customised birthweight centiles and conventional measures of high birthweight. Paediatr Perinat Epidemiol. 2012;26:543-52.
- 3. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2004;27(Suppl 1):S5–10.
- 4. Başer E, Seçkin KD, Erkılınç S, et al. The impact of parity on perinatal outcomes in pregnancies complicated by advanced maternal age. J Turk Ger Gynecol Assoc. 2013;14:205-9.
- 5. Rockhill K, Dorfman H, Srinath M, Hogue C. The Effects of Prepregnancy Body Mass Index and Gestational Weight Gain on Fetal Macrosomia Among American Indian/Alaska Native Women. Matern Child Health J. 2015;19:2480-91.
- 6. Mochhoury L, Razine R, Kasouati J, Kabiri M, Barkat A. Body mass index, gestational weight gain, and obstetric complications in Moroccan population. J Pregnancy. 2013;2013:379461.
- 7. Li Y, Liu QF, Zhang D, et al. Weight gain in pregnancy, maternal age and gestational age in relation to fetal macrosomia. Clin Nutr Res. 2015;4:104- 9.
- 8. Shi P, Yang W, Yu Q, et al. Overweight, gestational weight gain and elevated fasting plasma glucose and their association with macrosomia in chinese pregnant women. Matern Child Health J. 2014;18:10-5. 9. İnegöl Gümüş İ, Karakurt F, Kargılı A, Öztürk Turhan N, Erkmen Uyar M. Association between prepregnancy body mass index, gestational weight gain, and perinatal outcomes. Turk J Med Sci 2010; 40: 365-370. 10. Denguezli W, Faleh R, Fessi A, et al. Risk factors of fetal macrosomia: role of maternal nutrition. Tunis Med. 2009;87:564-8.
- 11. Topçu HO, Güzel Aİ, Ozgü E, Yıldız Y, Erkaya S, Uygur D. Birth weight for gestational age: a reference study in a tertiary referral hospital in the middle region of Turkey. J Chin Med Assoc. 2014;77:578-82.
- 12. Morikawa M, Cho K, Yamada T, Yamada T, Sato S, Minakami H. Fetal macrosomia in Japanese women. J Obstet Gynaecol Res. 2013;39:960-5.
- 13. Nkwabong E, Nzalli Tangho GR. Risk Factors for Macrosomia. See comment in PubMed Commons belowJ Obstet Gynaecol India. 2015;65(4):226-9.
- 14. Richardson C, Trotman H. Risk factors for the delivery of macrosomic infants at the University Hospital of the West Indies. See comment in PubMed Commons belowAm J Perinatol. 2014;31:927-32.
- 15. Mohammadbeigi A, Farhadifar F, Soufi Zadeh N, Mohammadsalehi N, Rezaiee M, Aghaei M. Fetal macrosomia: risk factors, maternal, and perinatal outcome. Ann Med Health Sci Res. 2013;3:546-50.
- 16. Gaudet L, Wen SW, Walker M. The combined effect of maternal obesity and fetal macrosomia on pregnancy outcomes. J Obstet Gynaecol Can. 2014;36:776-84.
- 17. Yumru AE, Dinçgez B, Öndeş B, Atalay N. The Relation Between Gender of Babies, Macrosomia and Cesarean Ratio in 11561 Deliveries in Our Clinic. JAREM 2011; 1: 18-20
- 18. Fuchs F, Bouyer J, Rozenberg P, Senat MV. Adverse maternal outcomes associated with fetal macrosomia: what are the risk factors beyond birthweight? BMC Pregnancy Childbirth. 2013; 13: 90.
- 19. Yildiz Y, Özgü E, Unlu SB, Salman B, Eyi EG. The relationship between third trimester maternal hemoglobin and birth weight/length; results from the tertiary center in Turkey. J Matern Fetal Neonatal Med. 2014;27:729- 32.
- 20. Al-Hashem FH. Is it necessary to consider obesity when constructing norms for hemoglobin or when screening for anemia using hemoglobin levels? Saudi Med J. 2007;28: 41-5.
- 21. Rasmussen S, Bergsjo P, Jacobsen G, Haram K, Bakketeig LS. Haemoglobin and serum ferritin in pregnancy–correlation with smoking and body mass index. Eur J Obstet Gynecol Reprod Biol 2005; 123: 27– 34.
- 22. Fay RA, Hughes AO, Farron NT. Platelets in pregnancy: hyperdestruction in pregnancy. Obstet Gynecol 1983; 61: 238-40.
- 23. Erikçi AA, Muhçu M, Dündar O, Oztürk A. Could mean platelet volume be a predictive marker for gestational diabetes mellitus? See comment in PubMed Commons belowHematology. 2008; 13: 46-8.
- 24. Pitkin R, Witte D. Platelet and leukocyte counts in pregnancy. JAMA 1979; 242: 2696 .
- 25. Coban E, Yilmaz A, Sari R. The effect of weight loss on the mean platelet volume in obese patients. Platelets. 2007; 18: 212-6.
- 26. Tarim E, Cok T. Macrosomia prediction using different maternal and fetal parameters in women with 50 g glucose challenge test between 130 and 140 mg/dl. Arch Gynecol Obstet. 2011; 284: 1081-5. 27. Biri A, Korucuoglu U, Ozcan P, Aksakal N, Turan O, Himmetoglu O. Effect of different degrees of glucose intolerance on maternal and perinatal outcomes. J Matern Fetal Neonat Med 2009; 22: 473–478. 28. Opati P, Zheng R, Wang J, Xin Y, Zhao H, Bi D. Comparison of neonatal outcomes in macrosomic infants of diabetic and non-diabetic mothers. J Neonatal Perinatal Med. 2015 Mar 10. [Epub ahead of print] DOI: 10.3233/NPM-15814037.
Öz
ÖZET
Amaç: Fetal makrozomi,
maternal, fetal ve neonatal sağlığı etkileyen önemli bir faktördür.
Çalışmamızın amacı, fetal makrozomiye yol açan maternal faktörleri ve gebelik
sonuçlarını irdelemekti.
Hastalar ve Yöntemler: Üçüncü
basamak referans merkezi olan hastanemize miadında doğum için belirgin bir risk
faktörü olmadan başvuran, makrozomik bebek doğuran 348 kadın hasta çalışma
grubu, makrozomik olmayan bebek doğuran 474 hasta da kontrol grubu olarak
araştırmamıza dahil edildi. Gruplar arasında kişisel özellikler, laboratuvar
özellikleri ve yenidoğan sağlığı açısından retrospektif olarak karşılaştırma
yapıldı.
Bulgular: Çalışma
grubundaki kadınların, yaşı, gebelik öncesi ve gebelik sonu vücut kitle
endeksleri, gebelikte ağırlık artışı, önceki doğum sayısı kontrol grubuna göre
belirgin olarak yüksekti. Bebeklerin doğum ağırlıkları, doğumun gerçekleştiği
gebelik haftasıyla ve geçmiş doğum sayısı ile anlamlı pozitif korelasyon
göstermekteydi. Açlık kan glukozu makrozomik bebek doğuran grupta belirgin
yüksekti.
Sonuç: Makrozomik bebek
doğuran kadınlar, makrozomik doğurmayanlara göre daha ileri yaşta, daha obez,
gebelikte daha fazla kilo almış, daha fazla sayıda doğum yapmış ve daha ileri
gebelik haftasında doğurmuş kadınlardır. Diyabetik olmayan gebelerde de olsa,
açlık glisemi düzeyi arttıkça bebek doğum ağırlığı artmaktadır. Neonatal
hipoglisemi, hiperbilirubinemi riskleri ve yenidoğan yoğun bakım ihtiyacı
makrozomi ile artmaktadır.
ABSTRACT
Objective: Fetal macrosomia is an important entity that effects
maternal, fetal and neonatal well-being. Our aim was to investigate the
maternal factors which cause fetal macrosomia and to investigate the pregnancy
outcomes.
Patients and
Methods: Three hundred
forty-eight low-risk women who attended to our tertiary care institution for
delivery and gave birth to a macrosomic infant were recruited as the study
group, and 474 low-risk women who gave birth to a non-macrosomic infant were
recruited as the control group. Individual, laboratorial characteristics, and
neonatal health variables were compared between two groups.
Results: Maternal age, prepregnancy and peripartum body mass
indices, weight gain during pregnancy and parity values in the study group were
more than the control group. Birth weights of the babies correlated
significantly with gestational age at birth and parity values. Fasting blood
glucose levels of the mothers in the macrosomia group were significantly higher
than the control group.
Conclusions: Women who gave birth to a macrosomic infant were
older, more obese, gained more weight in the pregnancy period, had more parity,
delivered at a later gestational age than women who gave birth to a
non-macrosomic infant. Birth weight of the baby increases with increasing
fasting blood glucose levels, even if the pregnant woman does not have any type
of diabetes in pregnancy. The risks of neonatal hypoglycemia and
hyperbilirubinemia, and the need for neonatal intensive care unit were more
frequent in macrosomic infants.
Anahtar Kelimeler
Kaynakça
- 1. Alberico S, Montico M, Barresi V, Monasta L, Businelli C, Soini V, Erenbourg A, Ronfani L, Maso G; Multicentre Study Group on Mode of Delivery in Friuli Venezia Giulia. The role of gestational diabetes, pre-pregnancy body mass index and gestational weight gain on the risk of newborn macrosomia: results from a prospective multicentre study. BMC Pregnancy Childbirth. 2014;14:23.
- 2. Pasupathy D, McCowan LM, Poston L, Kenny LC, Dekker GA, North RA; SCOPE consortium. Perinatal outcomes in large infants using customised birthweight centiles and conventional measures of high birthweight. Paediatr Perinat Epidemiol. 2012;26:543-52.
- 3. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2004;27(Suppl 1):S5–10.
- 4. Başer E, Seçkin KD, Erkılınç S, et al. The impact of parity on perinatal outcomes in pregnancies complicated by advanced maternal age. J Turk Ger Gynecol Assoc. 2013;14:205-9.
- 5. Rockhill K, Dorfman H, Srinath M, Hogue C. The Effects of Prepregnancy Body Mass Index and Gestational Weight Gain on Fetal Macrosomia Among American Indian/Alaska Native Women. Matern Child Health J. 2015;19:2480-91.
- 6. Mochhoury L, Razine R, Kasouati J, Kabiri M, Barkat A. Body mass index, gestational weight gain, and obstetric complications in Moroccan population. J Pregnancy. 2013;2013:379461.
- 7. Li Y, Liu QF, Zhang D, et al. Weight gain in pregnancy, maternal age and gestational age in relation to fetal macrosomia. Clin Nutr Res. 2015;4:104- 9.
- 8. Shi P, Yang W, Yu Q, et al. Overweight, gestational weight gain and elevated fasting plasma glucose and their association with macrosomia in chinese pregnant women. Matern Child Health J. 2014;18:10-5. 9. İnegöl Gümüş İ, Karakurt F, Kargılı A, Öztürk Turhan N, Erkmen Uyar M. Association between prepregnancy body mass index, gestational weight gain, and perinatal outcomes. Turk J Med Sci 2010; 40: 365-370. 10. Denguezli W, Faleh R, Fessi A, et al. Risk factors of fetal macrosomia: role of maternal nutrition. Tunis Med. 2009;87:564-8.
- 11. Topçu HO, Güzel Aİ, Ozgü E, Yıldız Y, Erkaya S, Uygur D. Birth weight for gestational age: a reference study in a tertiary referral hospital in the middle region of Turkey. J Chin Med Assoc. 2014;77:578-82.
- 12. Morikawa M, Cho K, Yamada T, Yamada T, Sato S, Minakami H. Fetal macrosomia in Japanese women. J Obstet Gynaecol Res. 2013;39:960-5.
- 13. Nkwabong E, Nzalli Tangho GR. Risk Factors for Macrosomia. See comment in PubMed Commons belowJ Obstet Gynaecol India. 2015;65(4):226-9.
- 14. Richardson C, Trotman H. Risk factors for the delivery of macrosomic infants at the University Hospital of the West Indies. See comment in PubMed Commons belowAm J Perinatol. 2014;31:927-32.
- 15. Mohammadbeigi A, Farhadifar F, Soufi Zadeh N, Mohammadsalehi N, Rezaiee M, Aghaei M. Fetal macrosomia: risk factors, maternal, and perinatal outcome. Ann Med Health Sci Res. 2013;3:546-50.
- 16. Gaudet L, Wen SW, Walker M. The combined effect of maternal obesity and fetal macrosomia on pregnancy outcomes. J Obstet Gynaecol Can. 2014;36:776-84.
- 17. Yumru AE, Dinçgez B, Öndeş B, Atalay N. The Relation Between Gender of Babies, Macrosomia and Cesarean Ratio in 11561 Deliveries in Our Clinic. JAREM 2011; 1: 18-20
- 18. Fuchs F, Bouyer J, Rozenberg P, Senat MV. Adverse maternal outcomes associated with fetal macrosomia: what are the risk factors beyond birthweight? BMC Pregnancy Childbirth. 2013; 13: 90.
- 19. Yildiz Y, Özgü E, Unlu SB, Salman B, Eyi EG. The relationship between third trimester maternal hemoglobin and birth weight/length; results from the tertiary center in Turkey. J Matern Fetal Neonatal Med. 2014;27:729- 32.
- 20. Al-Hashem FH. Is it necessary to consider obesity when constructing norms for hemoglobin or when screening for anemia using hemoglobin levels? Saudi Med J. 2007;28: 41-5.
- 21. Rasmussen S, Bergsjo P, Jacobsen G, Haram K, Bakketeig LS. Haemoglobin and serum ferritin in pregnancy–correlation with smoking and body mass index. Eur J Obstet Gynecol Reprod Biol 2005; 123: 27– 34.
- 22. Fay RA, Hughes AO, Farron NT. Platelets in pregnancy: hyperdestruction in pregnancy. Obstet Gynecol 1983; 61: 238-40.
- 23. Erikçi AA, Muhçu M, Dündar O, Oztürk A. Could mean platelet volume be a predictive marker for gestational diabetes mellitus? See comment in PubMed Commons belowHematology. 2008; 13: 46-8.
- 24. Pitkin R, Witte D. Platelet and leukocyte counts in pregnancy. JAMA 1979; 242: 2696 .
- 25. Coban E, Yilmaz A, Sari R. The effect of weight loss on the mean platelet volume in obese patients. Platelets. 2007; 18: 212-6.
- 26. Tarim E, Cok T. Macrosomia prediction using different maternal and fetal parameters in women with 50 g glucose challenge test between 130 and 140 mg/dl. Arch Gynecol Obstet. 2011; 284: 1081-5. 27. Biri A, Korucuoglu U, Ozcan P, Aksakal N, Turan O, Himmetoglu O. Effect of different degrees of glucose intolerance on maternal and perinatal outcomes. J Matern Fetal Neonat Med 2009; 22: 473–478. 28. Opati P, Zheng R, Wang J, Xin Y, Zhao H, Bi D. Comparison of neonatal outcomes in macrosomic infants of diabetic and non-diabetic mothers. J Neonatal Perinatal Med. 2015 Mar 10. [Epub ahead of print] DOI: 10.3233/NPM-15814037.
Ayrıntılar
| Konular | Sağlık Kurumları Yönetimi |
|---|---|
| Bölüm | Araştırma Yazısı |
| Yazarlar | |
| Yayımlanma Tarihi | 29 Aralık 2017 |
| Yayımlandığı Sayı | Yıl 2017 Cilt: 8 Sayı: 4 |