Öz
Objective: In some patient groups, special vaccination protocols need to be followed for vaccine preventable diseases like Hepatitis B (HB). We aimed to evaluate the antibody response against the HB vaccine in Inflammatory Bowel Disease (IBD) and Celiac Disease (CD) patients, emphasizing the efficiency of the routine vaccine protocol for these patient groups. Material and Methods: We included 219 patients (CD and IBD) and 125 in the healthy control group (HCG). The patients who had received only 3 doses of HB vaccine were included. The design of the study is retrospective in manner. Results: The patients age with positive antibody (anti-HBs titers) were lower than in patients with negative anti-HBs titers. In patients having positive anti-HBs titers, both the serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT) values were found to be significantly higher. Result: Following periodic control measures and administering an additional dose of the HB vaccine is required because the antibody protection decreases as the illness continues to progress with the increasing age of the patients.
Anahtar Kelimeler
Celiac disease (CD) Hepatitis B (HB) vaccine antibody (AntiHBs titers) inflammatory bowel disease (IBD) pediatric
Destekleyen Kurum
No one
Kaynakça
- 1. Di Sabatino A, Brunetti L, Carnevale MG, Giuffrida P, Corazza GR. Is it worth investigating splenic function in patients with celiac disease? World J Gastroenterol 2013;19:2313-18. google scholar
- 2. Di Sabatino A, Rosado MM, Ciccocioppo R, Cazzola P, Morera R, Corazza GR, et al. Depletion of immunoglobulin M memory B cells is associated with splenic hypofunction in inflammatory bowel disease. Am J Gastroenterol 2005;100:1788-95. google scholar
- 3. Gisbert JP, Chaparro M, Esteve M. Review article: prevention and management of hepatitis B and C infection in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2011; 33:619-33. google scholar
- 4. Carrera E, Manzano R, Garrido E. Efficacy of the vaccination in inflammatory bowel disease. World J Gastroenterol 2013;19:1349-53. google scholar
- 5. Husby S, Koletzko S, Korponay-Szabo IR, Mearin ML, Phillips A, Shamir R, et al. European society for pediatric gastroenterology, hepatology, and nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr. 2012:54:136-60. google scholar
- 6. Hepatitis B vaccines: WHO position paper—recommendations. Vaccine.2009;28:589-90. google scholar
- 7. Zifman E, Zevit N, Heshin-Bekenstein M. Turner D, Shamir R, Silbermintz A. Efect of a Gluten Free Diet on Hepatitis B Surface Antibody Concentration in Previously Immunized Pediatric Celiac Patients. Pediatr. Gastroenterol. Hepatol. Nutr. 2020;23:132-6. google scholar
- 8. Verso MG, Costantino C, Marrella A, Immordino P, Vitale F, Amodio E. Kinetics of Anti-Hepatitis B Surface Antigen Titers in Nurse Students after a Two-Year Follow-Up. Vaccines 2020;8:467- 77. google scholar
- 9. John TJ, Cooksley G. Hepatitis B vaccine boosters: is there a clinical need in high endemicity populations? J Gastroenterol Hepatol. 2005;20:5-10. google scholar
- 10. Anania C, Olivero F, Spagnolo A, Chiesa C, Pacifco L. Immune response to vaccines in children with celiac disease. World J Gastroenterol. 2017;23:3205 google scholar
- 11. Ertekin V, Tosun MS, Selimoglu MA. Is there need for a new hepatitis B vaccine schedule for children with celiac disease? Hepat Mon 2011;11:634-7. google scholar
- 12. Sparks B, Salman S, Shull M, Trout A, Kiel A, Hill I, et al. A Celiac Care Index Improves Care of Pediatric Patients Newly Diagnosed with Celiac Disease. J Pediatr 2020;216:32-6. google scholar
- 13. Dipasquale V, Romano C. Vaccination strategies in pediatric inflammatory bowel disease. Vaccine 2017;35:6070-75. google scholar
- 14. Rahier JF, Ben-Horin S, Chowers Y, C Conlon, P De Munter, G D’Haens, et al. European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. J Crohn Colitis 2009;3:47-91. google scholar
- 15. Passanisi S, Dipasquale V, Romano C. Vaccinations and Immune Response in Celiac Disease. Vaccines 2020;8:273-78. google scholar
Öz
Amaç: Bazı hasta gruplarında özellikle Hepatit B virüs enfeksiyonu gibi, aşı ile önlenebilen hastalıklar açısından özel aşılama protokollerine ihtiyaç vardır. Biz çalışmamızda İnflammatuvar Bağırsak Hastalığı (İBH) ve Çölyak Hastalığında (ÇH) Hepatit B aşı cevabını değerlendirerek bu hasta gruplarında kullanılan aşı protokolünün hastaları korumadaki etkinliğini araştırmak istedik. Gereç ve Yöntem: Çalışmaya toplam 219 kronik hastalığı olan çocuk (ÇH ve İBH) ve 125 sağlıklı (kontrol grubu) çocuk dahil edildi. Tüm gruplarda sadece 3 doz Hepatit B aşısı yapılmış olan hastalar çalışmaya dahil edilerek ek doz yapılmış ya da eksik doz uygulanmış hastalar çalışma dışında bırakıldı. Çalışma retrospektif olarak tasarlanmıştır. Bulgular: Çalışmaya dahil edilen hastaların anti HBs titreleri değerlendirildiğinde tüm gruplarda Anti HBs titresi pozitif olan hastaların yaş ortalamaları Anti HBs titresi negatif olan hastalara kıyasla daha düşük idi. Hastaların Anti HBs titresi pozitif olanlar değerlendirildiğinde Aspartat aminotransferaz (AST) ve Alanin aminotransferaz (ALT) değerleri daha yüksek bulundu. Sonuç: Hastalarda antikor koruyuculuğunun zamanla azaldığı gösterilmiştir. Özellikle infeksiyon açısından risk taşıyan, immunsüpresif ilaç kullanmak zorunda olan, ÇH ve İBH, gibi hasta gruplarında aşı titresi hastalık seyri sırasında belirli aralıklar ile takip edilmeli ve gerekirse ek doz aşılama düşünülmelidir.
Anahtar Kelimeler
Çölyak Hastalığı (ÇH) Hepatit B virüs aşısı Anti HBs antikor titresi İnflammatuvar bağırsak hastalığı (İBH) çocuk
Kaynakça
- 1. Di Sabatino A, Brunetti L, Carnevale MG, Giuffrida P, Corazza GR. Is it worth investigating splenic function in patients with celiac disease? World J Gastroenterol 2013;19:2313-18. google scholar
- 2. Di Sabatino A, Rosado MM, Ciccocioppo R, Cazzola P, Morera R, Corazza GR, et al. Depletion of immunoglobulin M memory B cells is associated with splenic hypofunction in inflammatory bowel disease. Am J Gastroenterol 2005;100:1788-95. google scholar
- 3. Gisbert JP, Chaparro M, Esteve M. Review article: prevention and management of hepatitis B and C infection in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2011; 33:619-33. google scholar
- 4. Carrera E, Manzano R, Garrido E. Efficacy of the vaccination in inflammatory bowel disease. World J Gastroenterol 2013;19:1349-53. google scholar
- 5. Husby S, Koletzko S, Korponay-Szabo IR, Mearin ML, Phillips A, Shamir R, et al. European society for pediatric gastroenterology, hepatology, and nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr. 2012:54:136-60. google scholar
- 6. Hepatitis B vaccines: WHO position paper—recommendations. Vaccine.2009;28:589-90. google scholar
- 7. Zifman E, Zevit N, Heshin-Bekenstein M. Turner D, Shamir R, Silbermintz A. Efect of a Gluten Free Diet on Hepatitis B Surface Antibody Concentration in Previously Immunized Pediatric Celiac Patients. Pediatr. Gastroenterol. Hepatol. Nutr. 2020;23:132-6. google scholar
- 8. Verso MG, Costantino C, Marrella A, Immordino P, Vitale F, Amodio E. Kinetics of Anti-Hepatitis B Surface Antigen Titers in Nurse Students after a Two-Year Follow-Up. Vaccines 2020;8:467- 77. google scholar
- 9. John TJ, Cooksley G. Hepatitis B vaccine boosters: is there a clinical need in high endemicity populations? J Gastroenterol Hepatol. 2005;20:5-10. google scholar
- 10. Anania C, Olivero F, Spagnolo A, Chiesa C, Pacifco L. Immune response to vaccines in children with celiac disease. World J Gastroenterol. 2017;23:3205 google scholar
- 11. Ertekin V, Tosun MS, Selimoglu MA. Is there need for a new hepatitis B vaccine schedule for children with celiac disease? Hepat Mon 2011;11:634-7. google scholar
- 12. Sparks B, Salman S, Shull M, Trout A, Kiel A, Hill I, et al. A Celiac Care Index Improves Care of Pediatric Patients Newly Diagnosed with Celiac Disease. J Pediatr 2020;216:32-6. google scholar
- 13. Dipasquale V, Romano C. Vaccination strategies in pediatric inflammatory bowel disease. Vaccine 2017;35:6070-75. google scholar
- 14. Rahier JF, Ben-Horin S, Chowers Y, C Conlon, P De Munter, G D’Haens, et al. European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. J Crohn Colitis 2009;3:47-91. google scholar
- 15. Passanisi S, Dipasquale V, Romano C. Vaccinations and Immune Response in Celiac Disease. Vaccines 2020;8:273-78. google scholar
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Çocuk Sağlığı ve Hastalıkları |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Yayımlanma Tarihi | 27 Mart 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 23 Sayı: 1 |
