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30 Years of Wilms Tumor Experience at One Center in Türkiye’s Central Anatolia Region

Yıl 2024, Cilt: 23 Sayı: 4, 344 - 348, 20.02.2024

Şefika Akyol Gül Pelin Odabaş Alper Özcan Ebru Yılmaz Zehra Filiz Karaman Figen Öztürk Hülya Akgün Ahmet Burak Doğan Celalettin Eroğlu Ekrem Ünal Musa Karakükçü

https://doi.org/10.26650/jchild.2023.1308863

Öz

Objective: The current study aims to evaluate the clinical presentation, treatment, and follow-up of children with Wilms Tumor (WT) who had been admitted to Erciyes University, Faculty of Medicine Department of Pediatric Hematology and Oncology hospital, a tertiary center in the central Anatolia region of Türkiye. The study assesses the survival data and features that have had an impact on survival.
Materials and Methods: The current study has been planned as a retrospective observational evaluation of patients admitted to the Pediatric Hematology and Oncology Center between 1991-2021.
Results: The study retrospectively evaluated a total of 48 patients in terms of demographic characteristics, presentation findings, tumor stages, histopathologies, and survival rates. Patients with an unfavorable histology had a 66.7% chance of both event-free survival (EFS) and overall survival (OS), which is lower than the respective 85.2% and 92.1% odds of EFS and OS for the favorable histology group. However, this is not statistically significant (p = 0.20 for EFS and p = 0.05 for OS). Regarding the impact of stage on survival rates, the EFS and OS for patients with the low-stage disease were 88% and 95.7%, respectively. These rates were significantly superior to those at an advanced stage of the disease, whose EFS and OS were 63.1% and 60.9%, respectively (p = 0.042 for EFS, p = 0.005 for OS).
Conclusion: Wilms tumor at an advanced stage and with an unfavorable histology are the major factors resulting in poor survival rates.

Anahtar Kelimeler

Wilms Tumor Event-Free Survival Overall Survival Unfavorable Histology

Destekleyen Kurum

no

Proje Numarası

no

Teşekkür

no

Kaynakça

  • Fernandez CV, Geller JI, Ehrlich PF, et al. Renal Tumors, in Pizzo&Poplack’s Pediatric Oncology.2021, Philadelphia.pp 525-540. google scholar
  • Özyörük D, Emir S. The management of bilateral Wilms tumor. Transl Pediatr. 2014;3(1):34-38. google scholar
  • Akyuz C, Yalcin B, Yildiz I, et al. Treatment of Wilms tumor: a report from the Turkish Pediatric Oncology Group (TPOG). Pediatr Hematol Oncol, 27(3): p. 161-178, 2010. google scholar
  • Aydın B, Akyüz C, Yalçın B, Ekinci S, Oğuz B, Akçören Z, Yıldız F, Varan A, Kurucu N, Büyükpamukçu M, Kutluk T. Bilateral Wilms tumors: Treatment results from a single center. Turk J Pediatr. 2019;61(1):44-51. google scholar
  • Dome JS, Graf N, Geller JI, et al. Advances in Wilms Tumor Treatment and Biology: Progress Through International Collaboration. J Clin Oncol. 2015 Sep 20;33(27):2999-3007. google scholar
  • Kara B, Sarıkaya M, Ertan K, Uğraş NS, Çiftçi İ, Yavaş G, et al. Çocuklarda primer böbrek tümörlerinin klinik özellikleri, tedavi yaklaşımları ve tedavi sonuçları. Genel Tıp Dergisi. 2021; 31(4): 375-379. google scholar
  • Libes J, Hol J, Neto JCA, et al. Pediatric renal tumor epidemiology: Global perspectives, progress, and challenges. Pediatr Blood Cancer. 2023;70(1):e30006. google scholar
  • Ünal E, Yilmaz E, Özcan A, Işik B, Karakükcü M, Turan C, et al. Twenty children with non-Wilms renal tumors from a reference center in Central Anatolia, Turkey. Turk J Med Sci. 2020 Feb 13;50(1):18-24. google scholar
  • Brok J, Treger TD, Gooskens SL, et al. Biology and treatment of renal tumours in childhood. Eur J Cancer 2016;68:179-195. google scholar
  • Jeffrey S. Dome EAM, Pedram Argani, Pediatric Renal Tumors, in Nathan and Oski’s Hematology and Oncology of Infancy and Childhood. 2015, Saunders: Philadelphia. p. 1714-1746. google scholar
  • Vujanic GM, Gessler M, Ooms AHAG, et al; International Society of Paediatric Oncology-Renal Tumour Study Group (SIOP-RTSG). The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol. Nat Rev Urol. 2018 Nov;15(11):693-701. google scholar
  • Turner JT, Brzezinski J, Dome JS. Wilms Tumor Predisposition. In: Adam MP, Mirzaa GM, Pagon RA, et al., eds. GeneReviews®. Seattle (WA): University of Washington, Seattle; December 19, 2003. google scholar
  • Richard H. Scott NR, Genetic Predisposition to Wilms Tumor, in Renal Tumors of Childhood, J.S.D. Kathy Pritchard-Jones, Editor. 2014, Springer: Berlin. p. 19-38. google scholar
  • Pater L, Melchior P, Rübe C, et al. Wilms tumor. Pediatr Blood Cancer. 2021;68 Suppl 2:e28257. google scholar
  • Perlman EJ, Grundy PE, Anderson JR, et al.WT1 mutation and 11p15 loss of heterozygosity predict relapse in very low-risk Wilms tumors treated with surgery alone: a Children’s Oncology Group study. J Clin Oncol. 2011;29:698-703. google scholar
  • Grundy PE, Breslow NE, Li S, et al. Loss of heterozygosity for chromosomes 1p and 16q is an adverse prognostic factor in favorable histology Wilms tumor: a report from the National Wilms Tumor Study Group. J Clin Oncol. 2005;23:7312-7321. google scholar
  • Vujanic GM, Sandstedt B, Harms D, et al. Revised International Society of Paediatric Oncology (SIOP) working classification of renal tumors of childhood. Med Pediatr Oncol. 2002; 38(2):79-82. google scholar
  • D’Angio GJ. The National Wilms Tumor Study: a 40 year perspective. Lifetime Data Anal. 2007;13(4):463-470. google scholar
  • Kieran K, Anderson JR, DomeJS, et al. Is adrenalectomy necessary during unilateral nephrectomy for Wilms tumor? A report from the Children’s Oncology Group. J Pediatr Surg. 2013;48:1598-1603. google scholar
  • Fernandez CV, Perlman EJ, Mullen EA, et al. Clinical outcome and biologic predictors of relapse after nephrectomy only for very low risk Wilms tumor: a report from the Children’s Oncology Group AREN0532. Ann Surg. 2017;265:835-840. google scholar
  • Kalapurakal JA, Li SM, Breslow NE, et al. Influence of radiation therapy delay on abdominal tumor recurrence in patients with favorable histology Wilms’ tumor treated on NWTS-3 and NWTS-4: a report from the National Wilms Tumor Study group. Int J Radiat Oncol Biol Phys. 2003;57:495-499. google scholar
  • Pritchard-Jones K, Bergeron C, de Camargo B, et al. Omission of doxorubicin from the treatment of stage II-III, intermediate-risk Wilms’ tumour (SIOP WT 2001): an open-label, non-inferiority, randomised controlled trial. Lancet. 2015;386:1156-1164. google scholar
  • SIOP Renal Tumour Study Group. Paediatric renal tumours: perspectives from the SIOP-RTSG. Nat Rev Urol. 2017;14:3-4. google scholar
  • Elmalı A, Sarı SY, Akyüz C, Gültekin M, Yalçın B, Ayrın B, et al. De-escalated Radiotherapy for Advanced Stage Wilms’ Tumor. Turk J Oncol 2023;38(1):66—74 google scholar
  • Stokes CL, StokesWA, Kalapurakal JA, et al. Timing of radiation therapy in pediatric Wilms tumor: a report from the National Cancer Database. Int J Radiat Oncol Biol Phys. 2018;101:453-461. google scholar

Yıl 2024, Cilt: 23 Sayı: 4, 344 - 348, 20.02.2024

Şefika Akyol Gül Pelin Odabaş Alper Özcan Ebru Yılmaz Zehra Filiz Karaman Figen Öztürk Hülya Akgün Ahmet Burak Doğan Celalettin Eroğlu Ekrem Ünal Musa Karakükçü

https://doi.org/10.26650/jchild.2023.1308863

Öz

Proje Numarası

no

Kaynakça

  • Fernandez CV, Geller JI, Ehrlich PF, et al. Renal Tumors, in Pizzo&Poplack’s Pediatric Oncology.2021, Philadelphia.pp 525-540. google scholar
  • Özyörük D, Emir S. The management of bilateral Wilms tumor. Transl Pediatr. 2014;3(1):34-38. google scholar
  • Akyuz C, Yalcin B, Yildiz I, et al. Treatment of Wilms tumor: a report from the Turkish Pediatric Oncology Group (TPOG). Pediatr Hematol Oncol, 27(3): p. 161-178, 2010. google scholar
  • Aydın B, Akyüz C, Yalçın B, Ekinci S, Oğuz B, Akçören Z, Yıldız F, Varan A, Kurucu N, Büyükpamukçu M, Kutluk T. Bilateral Wilms tumors: Treatment results from a single center. Turk J Pediatr. 2019;61(1):44-51. google scholar
  • Dome JS, Graf N, Geller JI, et al. Advances in Wilms Tumor Treatment and Biology: Progress Through International Collaboration. J Clin Oncol. 2015 Sep 20;33(27):2999-3007. google scholar
  • Kara B, Sarıkaya M, Ertan K, Uğraş NS, Çiftçi İ, Yavaş G, et al. Çocuklarda primer böbrek tümörlerinin klinik özellikleri, tedavi yaklaşımları ve tedavi sonuçları. Genel Tıp Dergisi. 2021; 31(4): 375-379. google scholar
  • Libes J, Hol J, Neto JCA, et al. Pediatric renal tumor epidemiology: Global perspectives, progress, and challenges. Pediatr Blood Cancer. 2023;70(1):e30006. google scholar
  • Ünal E, Yilmaz E, Özcan A, Işik B, Karakükcü M, Turan C, et al. Twenty children with non-Wilms renal tumors from a reference center in Central Anatolia, Turkey. Turk J Med Sci. 2020 Feb 13;50(1):18-24. google scholar
  • Brok J, Treger TD, Gooskens SL, et al. Biology and treatment of renal tumours in childhood. Eur J Cancer 2016;68:179-195. google scholar
  • Jeffrey S. Dome EAM, Pedram Argani, Pediatric Renal Tumors, in Nathan and Oski’s Hematology and Oncology of Infancy and Childhood. 2015, Saunders: Philadelphia. p. 1714-1746. google scholar
  • Vujanic GM, Gessler M, Ooms AHAG, et al; International Society of Paediatric Oncology-Renal Tumour Study Group (SIOP-RTSG). The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol. Nat Rev Urol. 2018 Nov;15(11):693-701. google scholar
  • Turner JT, Brzezinski J, Dome JS. Wilms Tumor Predisposition. In: Adam MP, Mirzaa GM, Pagon RA, et al., eds. GeneReviews®. Seattle (WA): University of Washington, Seattle; December 19, 2003. google scholar
  • Richard H. Scott NR, Genetic Predisposition to Wilms Tumor, in Renal Tumors of Childhood, J.S.D. Kathy Pritchard-Jones, Editor. 2014, Springer: Berlin. p. 19-38. google scholar
  • Pater L, Melchior P, Rübe C, et al. Wilms tumor. Pediatr Blood Cancer. 2021;68 Suppl 2:e28257. google scholar
  • Perlman EJ, Grundy PE, Anderson JR, et al.WT1 mutation and 11p15 loss of heterozygosity predict relapse in very low-risk Wilms tumors treated with surgery alone: a Children’s Oncology Group study. J Clin Oncol. 2011;29:698-703. google scholar
  • Grundy PE, Breslow NE, Li S, et al. Loss of heterozygosity for chromosomes 1p and 16q is an adverse prognostic factor in favorable histology Wilms tumor: a report from the National Wilms Tumor Study Group. J Clin Oncol. 2005;23:7312-7321. google scholar
  • Vujanic GM, Sandstedt B, Harms D, et al. Revised International Society of Paediatric Oncology (SIOP) working classification of renal tumors of childhood. Med Pediatr Oncol. 2002; 38(2):79-82. google scholar
  • D’Angio GJ. The National Wilms Tumor Study: a 40 year perspective. Lifetime Data Anal. 2007;13(4):463-470. google scholar
  • Kieran K, Anderson JR, DomeJS, et al. Is adrenalectomy necessary during unilateral nephrectomy for Wilms tumor? A report from the Children’s Oncology Group. J Pediatr Surg. 2013;48:1598-1603. google scholar
  • Fernandez CV, Perlman EJ, Mullen EA, et al. Clinical outcome and biologic predictors of relapse after nephrectomy only for very low risk Wilms tumor: a report from the Children’s Oncology Group AREN0532. Ann Surg. 2017;265:835-840. google scholar
  • Kalapurakal JA, Li SM, Breslow NE, et al. Influence of radiation therapy delay on abdominal tumor recurrence in patients with favorable histology Wilms’ tumor treated on NWTS-3 and NWTS-4: a report from the National Wilms Tumor Study group. Int J Radiat Oncol Biol Phys. 2003;57:495-499. google scholar
  • Pritchard-Jones K, Bergeron C, de Camargo B, et al. Omission of doxorubicin from the treatment of stage II-III, intermediate-risk Wilms’ tumour (SIOP WT 2001): an open-label, non-inferiority, randomised controlled trial. Lancet. 2015;386:1156-1164. google scholar
  • SIOP Renal Tumour Study Group. Paediatric renal tumours: perspectives from the SIOP-RTSG. Nat Rev Urol. 2017;14:3-4. google scholar
  • Elmalı A, Sarı SY, Akyüz C, Gültekin M, Yalçın B, Ayrın B, et al. De-escalated Radiotherapy for Advanced Stage Wilms’ Tumor. Turk J Oncol 2023;38(1):66—74 google scholar
  • Stokes CL, StokesWA, Kalapurakal JA, et al. Timing of radiation therapy in pediatric Wilms tumor: a report from the National Cancer Database. Int J Radiat Oncol Biol Phys. 2018;101:453-461. google scholar
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Çocuk Sağlığı ve Hastalıkları (Diğer)
Bölüm Araştırma Makaleleri
Yazarlar

Şefika Akyol 0000-0003-0051-4274

Gül Pelin Odabaş 0000-0003-4242-1789

Alper Özcan 0000-0002-6100-1205

Ebru Yılmaz 0000-0003-4802-0986

Zehra Filiz Karaman 0000-0003-4552-8098

Figen Öztürk 0000-0001-6180-5716

Hülya Akgün 0000-0002-0513-0045

Ahmet Burak Doğan Bu kişi benim 0000-0003-1544-4598

Celalettin Eroğlu 0000-0002-5743-2440

Ekrem Ünal 0000-0002-2691-4826

Musa Karakükçü 0000-0003-2015-3541

Proje Numarası no
Yayımlanma Tarihi 20 Şubat 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 23 Sayı: 4

Kaynak Göster

APA Akyol, Ş., Odabaş, G. P., Özcan, A., Yılmaz, E., vd. (2024). 30 Years of Wilms Tumor Experience at One Center in Türkiye’s Central Anatolia Region. Journal of Child, 23(4), 344-348. https://doi.org/10.26650/jchild.2023.1308863
AMA Akyol Ş, Odabaş GP, Özcan A, Yılmaz E, Karaman ZF, Öztürk F, Akgün H, Doğan AB, Eroğlu C, Ünal E, Karakükçü M. 30 Years of Wilms Tumor Experience at One Center in Türkiye’s Central Anatolia Region. Journal of Child. Şubat 2024;23(4):344-348. doi:10.26650/jchild.2023.1308863
Chicago Akyol, Şefika, Gül Pelin Odabaş, Alper Özcan, Ebru Yılmaz, Zehra Filiz Karaman, Figen Öztürk, Hülya Akgün, Ahmet Burak Doğan, Celalettin Eroğlu, Ekrem Ünal, ve Musa Karakükçü. “30 Years of Wilms Tumor Experience at One Center in Türkiye’s Central Anatolia Region”. Journal of Child 23, sy. 4 (Şubat 2024): 344-48. https://doi.org/10.26650/jchild.2023.1308863.
EndNote Akyol Ş, Odabaş GP, Özcan A, Yılmaz E, Karaman ZF, Öztürk F, Akgün H, Doğan AB, Eroğlu C, Ünal E, Karakükçü M (01 Şubat 2024) 30 Years of Wilms Tumor Experience at One Center in Türkiye’s Central Anatolia Region. Journal of Child 23 4 344–348.
IEEE Ş. Akyol, “30 Years of Wilms Tumor Experience at One Center in Türkiye’s Central Anatolia Region”, Journal of Child, c. 23, sy. 4, ss. 344–348, 2024, doi: 10.26650/jchild.2023.1308863.
ISNAD Akyol, Şefika vd. “30 Years of Wilms Tumor Experience at One Center in Türkiye’s Central Anatolia Region”. Journal of Child 23/4 (Şubat 2024), 344-348. https://doi.org/10.26650/jchild.2023.1308863.
JAMA Akyol Ş, Odabaş GP, Özcan A, Yılmaz E, Karaman ZF, Öztürk F, Akgün H, Doğan AB, Eroğlu C, Ünal E, Karakükçü M. 30 Years of Wilms Tumor Experience at One Center in Türkiye’s Central Anatolia Region. Journal of Child. 2024;23:344–348.
MLA Akyol, Şefika vd. “30 Years of Wilms Tumor Experience at One Center in Türkiye’s Central Anatolia Region”. Journal of Child, c. 23, sy. 4, 2024, ss. 344-8, doi:10.26650/jchild.2023.1308863.
Vancouver Akyol Ş, Odabaş GP, Özcan A, Yılmaz E, Karaman ZF, Öztürk F, Akgün H, Doğan AB, Eroğlu C, Ünal E, Karakükçü M. 30 Years of Wilms Tumor Experience at One Center in Türkiye’s Central Anatolia Region. Journal of Child. 2024;23(4):344-8.
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