Rapid and uncontrollable cell proliferation, altered metabolism, and abnormal vasculature of cancer cells make them hypoxic and result in the generation of reactive oxygen species (ROS), causing oxidative stress. Hypoxia-mediated oxidative stress represents a significant barrier to effective cancer treatment. miRNAs are emerging as a potential regulator of hypoxia-responsive genes and hypoxia-mediated oxidative stress. Based on the role of miR-140-5p in regulating a hypoxia-responsive gene, this study is aimed at understanding the miR-140-5p role in regulating hypoxia-mediated oxidative stress under breast tumor hypoxia. We found that the miR-140-5p might control the hypoxia-mediated ROS generation by regulating the Nrf2 expression. Knowing the significance of miR-140-5p in regulating hypoxia-mediated oxidative stress and breast tumor progression, targeting miR-140-5p might represent a promising strategy for anti-breast cancer therapy.
miR-140-5p Nrf2 Hypoxia Breast cancer Reactive Oxygen Species (ROS)
Birincil Dil | İngilizce |
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Konular | Biyokimya ve Hücre Biyolojisi (Diğer) |
Bölüm | Original Articles |
Yazarlar | |
Yayımlanma Tarihi | 31 Aralık 2023 |
Yayımlandığı Sayı | Yıl 2023 Cilt: 15 Sayı: 3 |