Öz
Kaynakça
- 1. Evoy KE, Morrison MD, Saklad RS. Abuse and Misuse of Pregabalin and Gabapentin. Drugs .2017;77:403–426
- 2. Rudd RA, Aleshire N, Zibbell JE, Gladden RM. Centers for disease control. Increase in drug and opioid overdose deaths—USA, 2000–2014. Morbid Mortal Wkly Rep. 2016;64(50):1378–82.
- 3. Freynhagen R, Serpell M, Emir B, Ed whalen,Parsons B, Clair A, Latymer M. A comprehensive drug safety evaluation of pregabalin in peripheral neuropathic pain. Pain Pract 2015;15(1):47–57.
- 4. Toth C. Pregabalin: latest safety evidence and clinical implications for the management of neuropathic pain. Therapeutic Advances in Drug Safety. 2014;5(1): 38–56.
- 5. Martinez JA, Kasamatsu M, Rosales-Hernandez A, Hanson LR, Frey WH, Toth CC. Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states. Mol Pain 2012;8:3.
- 6. Baidya DK, Agarwal A, Khanna P, Arora MK. Pregabalin in acute and chronic pain. J Anaesthesiol Clin Pharmacol 2011;27(3):307-14.
- 7. Grosshans M, Mutschler J, Hermann D, Klein O, Dressing H, Kiefer F, et al. Pregabalin abuse, dependence, and withdrawal: a case report. Am J Psychiatry 2010;167(7):869.
- 8. Wood DM, Berry DJ, Glover G, Eastwood J, Dargan PI. Significant pregabalin toxicity managed with supportive care alone. J Med Toxicol 2010;6(4):435-7.
- 9. Blum A, Simsolo C, Tatour I. Hyponatremia and confusion caused by pregabalin. Isr Med Assoc J 2009;11(11):699-700.
- 10. Erdoğan G, Ceyhan D, Güleç S. Possible heart failure associated with pregabalin use: case report. Agri 2011;23(2):80-3.
- 11. Sendra JM, Junyent TT, Pellicer MJ. Pregabalin-induced hepatotoxicity. Ann Pharmacother 2011;45(6):32.
- 12. Parekh M, Dash GK, Ahamed I. Pregabalin Toxicity Manifesting as Reversible Encephalopathy With Continuous Triphasic Waves in Electroencephalogram. Clinical Neuropharmacology. 2017;40(5):226-228
- 13. Belli E, Erkalp K, Yangın Z, Fadıllıoğlu S, Alagöl A. A new analgesic drug: pregabalin; and the first intoxications. AĞRI 2013;25(4):187-189
Öz
Although it was originally
developed for the treatment of epilepsy, pregabalin has also been used
frequently in the management of neuropathic pain and anxiety disorders
recently. Owing to its widespread use in this regard, number of the cases
reported with regard to both its side-effects and overdose has been escalating
dramatically. More specifically, facial rash, dizziness, drowsiness, peripheral
edema and weigh gain, hyponatremia and increase in systolic dysfunction
especially in the elderly, hepatotoxicity and transient encephalopathy were
reported with increasing incidence in the literature. We hereby reported a case
of seizure and metabolic acidosis incited by pregabalin overdose, and our aim
is to constitute an appeal for the fact that implementation of hemodialysis is
a rapid and effective method in the treatment of seizure and metabolic acidosis
in case of pregabalin intoxication.
Anahtar Kelimeler
Pregabalin Intoxication Hemodialysis Generalized tonic-clonic seizure Metabolic Acidosis
Kaynakça
- 1. Evoy KE, Morrison MD, Saklad RS. Abuse and Misuse of Pregabalin and Gabapentin. Drugs .2017;77:403–426
- 2. Rudd RA, Aleshire N, Zibbell JE, Gladden RM. Centers for disease control. Increase in drug and opioid overdose deaths—USA, 2000–2014. Morbid Mortal Wkly Rep. 2016;64(50):1378–82.
- 3. Freynhagen R, Serpell M, Emir B, Ed whalen,Parsons B, Clair A, Latymer M. A comprehensive drug safety evaluation of pregabalin in peripheral neuropathic pain. Pain Pract 2015;15(1):47–57.
- 4. Toth C. Pregabalin: latest safety evidence and clinical implications for the management of neuropathic pain. Therapeutic Advances in Drug Safety. 2014;5(1): 38–56.
- 5. Martinez JA, Kasamatsu M, Rosales-Hernandez A, Hanson LR, Frey WH, Toth CC. Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states. Mol Pain 2012;8:3.
- 6. Baidya DK, Agarwal A, Khanna P, Arora MK. Pregabalin in acute and chronic pain. J Anaesthesiol Clin Pharmacol 2011;27(3):307-14.
- 7. Grosshans M, Mutschler J, Hermann D, Klein O, Dressing H, Kiefer F, et al. Pregabalin abuse, dependence, and withdrawal: a case report. Am J Psychiatry 2010;167(7):869.
- 8. Wood DM, Berry DJ, Glover G, Eastwood J, Dargan PI. Significant pregabalin toxicity managed with supportive care alone. J Med Toxicol 2010;6(4):435-7.
- 9. Blum A, Simsolo C, Tatour I. Hyponatremia and confusion caused by pregabalin. Isr Med Assoc J 2009;11(11):699-700.
- 10. Erdoğan G, Ceyhan D, Güleç S. Possible heart failure associated with pregabalin use: case report. Agri 2011;23(2):80-3.
- 11. Sendra JM, Junyent TT, Pellicer MJ. Pregabalin-induced hepatotoxicity. Ann Pharmacother 2011;45(6):32.
- 12. Parekh M, Dash GK, Ahamed I. Pregabalin Toxicity Manifesting as Reversible Encephalopathy With Continuous Triphasic Waves in Electroencephalogram. Clinical Neuropharmacology. 2017;40(5):226-228
- 13. Belli E, Erkalp K, Yangın Z, Fadıllıoğlu S, Alagöl A. A new analgesic drug: pregabalin; and the first intoxications. AĞRI 2013;25(4):187-189
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Case Report |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Ekim 2019 |
| Gönderilme Tarihi | 4 Mart 2019 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 10 Sayı: 4 |