UYUZ HASTALIĞI (SKABİYES), TEDAVİSİ VE UYUZ HASTALIĞI TEDAVİSİNDE KULLANILAN BİTKİLER

Jale Akgöl; Ayşegül Köroğlu

doi:10.33483/jfpau.1085681

Derleme

UYUZ HASTALIĞI (SKABİYES), TEDAVİSİ VE UYUZ HASTALIĞI TEDAVİSİNDE KULLANILAN BİTKİLER

Yıl 2022, Cilt: 46 Sayı: 2, 600 - 618, 29.05.2022

Jale Akgöl Ayşegül Köroğlu

https://doi.org/10.33483/jfpau.1085681

Öz

Amaç: Uyuz hastalığı (Skabiyes) dünyada yaygın olarak görülen kaşıntılı, döküntülü ve bulaşıcı ektoparaziter bir hastalıktır. Etken Sarcoptes scabiei var. hominis adı verilen mikroskobik bir eklem bacaklıdır. Her yaş, cinsiyet, coğrafya ve kültürden insanı etkileyebilir. Gelişmekte olan ülkeler, tropikal ve subtropikal ülkelerde endemik olan parazit nedenli bu hastalık, büyük kalabalıklar ve hijyenin korunamadığı ortamlarda salgınlar yapabilir. Tedavide topikal ve oral olarak kullanılan seçenekler kısıtlı sayıdadır. Permetrin, Benzil Benzoat, Kükürtlü merhemler, Lindan, İvermektin gibi ilaçların birçoğu toksik etkilerinden dolayı bebek, çocuk, gebe ve laktasyon ile ilgili kısıtlılıklar nedeniyle risk altındaki tüm popülasyonlara uygulanamamaktadır. Scabiyes tedavi edilmediğinde, özellikle pediyatrik yaş grubunda görülen piyoderma, impetigo gibi sekonder enfeksiyonların da tabloya eklenmesi, hastalığın yükünü artırmaktadır. Bu nedenle daha az toksik etkileri olan ilaç arayışları halihazırda kullanılagelen bitkilere olan ilgiyi de canlı tutmaktadır.

Sonuç ve Tartışma: Sporadik ya da epidemik tüm vakalarda, yayılımı önlemek için skabiyesin etkin tedavisi şarttır. Başarılı bir tedavi, ilaç uygulamasının doğru yapılmasına, tedavinin komplikasyonlar ve semptomları kontrol etmeye yönelik ek yaklaşımları içermesine ve beraberinde koruyucu önlemlerin alınmasına bağlıdır. Bu derlemede skabiyes, tedavisi, kullanılan ilaçlar, kullanılma potansiyeli olan yeni ilaçlar ve geleneksel olarak kullanılan bitkiler incelenmiştir. Ülkemizde yetişen, tanınan ve yetişme potansiyeli olan 49 taksonun uyuz hastalığı tedavisinde kullanıldığı belirlenmiştir.

Anahtar Kelimeler

Skabiyes, Skabiyes tedavisi, Tıbbi bitkiler, Uyuz hastalığı

Kaynakça

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3. Jackson, R. (2004). Scabies by Kenneth Mellanby. J Cutan Med Surg, 8 (2) 73-76. [CrossRef]
4. Organization, W. H. Web cite (2020). From https://www.who.int/news-room/fact-sheets/detail/scabie Erişim Tarihi: 10.09.2020 5. Wang, C. H., Lee, S. C., Huang, S. S., Kao, Y. C., See, L. C. and Yang, S. H. (2012). Risk factors for scabies in Taiwan. J Microbiol Immunol Infect, 45 (4) 276-280. [CrossRef]
6. Ciftci, I. H., Karaca, S., Dogru, O., Cetinkaya, Z. and Kulac, M. (2006). Prevalence of pediculosis and scabies in preschool nursery children of Afyon, Turkey. Korean J Parasitol, 44 (1) 95-98. [CrossRef]
7. Çetinkaya, Ü., Şahin, S. and Ulutabanca, R. (2018). The Epidemiology of Scabies and Pediculosis in Kayseri. Turkiye Parazitol Derg, 42 (2) 134-137. [CrossRef]
8. Thomas, J., Peterson, G. M., Walton, S. F., Carson, C. F., Naunton, M. and Baby, K. E. (2015). Scabies: an ancient global disease with a need for new therapies. BMC Infectious Diseases, 15 (1) 250. [CrossRef]
9. GBD. (2017). Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 390 (10100) 1211-1259. [CrossRef]
10. Cinotti, E., Perrot, J. L., Labeille, B., Maguet, H., Couzan, C., Flori, P. and Cambazard, F. (2015). Inefficacy of alcohol-based hand rub on mites in a patient with hyperkeratotic scabies. Clin Exp Dermatol, 40 (2) 177-181. [CrossRef]
11. Hicks, M. I. and Elston, D. M. (2009). Scabies. Dermatol Ther, 22 (4) 279-292. [CrossRef]
12. Kazan, D. and Demirsoy, E. O. SKABİYES; KLİNİK BULGULAR, TANI VE TEDAVİ. Acta Medica Nicomedia, 3 (2) 80-87,
13. Şimşek, E., Keskin, A. and Dağcıoğlu, B. F. (2019). Sık Rastlanan ve Sık Atlanan Hastalık Uyuz: Olgu Sunumu. Ankara Medical Journal, 19 (1) 205-209. [CrossRef]
14. Shimose, L. and Munoz-Price, L. S. (2013). Diagnosis, prevention, and treatment of scabies. Curr Infect Dis Rep, 15 (5) 426-431. [CrossRef]
15. Tai, D. B. G., Abu Saleh, O. and Miest, R. (2020). Genital nodular scabies. IDCases, 22 e00947. [CrossRef]
16. Çetin, B. Ş. (2017). Uyuz Hastalığına Yaklaşım (Güncel Kılavuz Değerlendirmesi). Cocuk Enfeksiyon Dergisi, 11 (2) 107-109. [CrossRef]
17. Leung, A. K. C., Lam, J. M. and Leong, K. F. (2020). Scabies: A Neglected Global Disease. Curr Pediatr Rev, 16 (1) 33-42. [CrossRef]
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SCABIES, SCABIES TREATMENT AND PLANTS USED IN THE TREATMENT OF SCABIES

Yıl 2022, Cilt: 46 Sayı: 2, 600 - 618, 29.05.2022

Jale Akgöl Ayşegül Köroğlu

https://doi.org/10.33483/jfpau.1085681

Öz

Objective: Scabies are an itch and contagious ectoparasite that is common around the World. There is the causative Sarcoptes scabiei var. hominis. It can affect people of all ages, sexes, geographies and cultures. It is endemic in developing countries, tropical and subtropical countries. It can cause epidemics in large crowds and environments where hygiene cannot be maintained. Topical and oral options for treatment are limited. Drugs such as Permethrin, Benzyl Benzoate, Sulfur Ointments, Lindan, Ivermectin cannot be applied to all populations at risk due to their toxic effects, infants, children, pregnant women, and lactation-related restrictions. When scabies are not treated, the addition of secondary infections such as pyoderma and impetigo, which are seen especially in the pediatric age group, increases the burden of the disease. For that reason, the search for drugs with less toxic effects keeps the interest in plants still alive.

Result and Discussion: In all cases of sporadic or epidemic, effective treatment of scabies is essential to prevent to spread. Successful treatment depends on the correct administration of the medication, the inclusion of additional approaches to control complications and symptoms and the taking of preventive measures. In this review, scabies, their treatment, drugs used, new drugs with the potential to be used and traditionally used plants were examined. It has been determined that 49 taxa that are grown, known and have the potential to grow in our country are used in the treatment of scabies.

Anahtar Kelimeler

Human scabies, Medicinal plant, Scabies, Scabies treatment

Kaynakça

1. Ramos-e-Silva, M. (1998). Giovan Cosimo Bonomo (1663-1696): discoverer of the etiology of scabies. Int J Dermatol, 37 (8) 625-630.[CrossRef]
2. Thomas, C., Coates, S. J., Engelman, D., Chosidow, O. and Chang, A. Y. (2020). Ectoparasites: Scabies. J Am Acad Dermatol, 82 (3) 533-548. [CrossRef]
3. Jackson, R. (2004). Scabies by Kenneth Mellanby. J Cutan Med Surg, 8 (2) 73-76. [CrossRef]
4. Organization, W. H. Web cite (2020). From https://www.who.int/news-room/fact-sheets/detail/scabie Erişim Tarihi: 10.09.2020 5. Wang, C. H., Lee, S. C., Huang, S. S., Kao, Y. C., See, L. C. and Yang, S. H. (2012). Risk factors for scabies in Taiwan. J Microbiol Immunol Infect, 45 (4) 276-280. [CrossRef]
6. Ciftci, I. H., Karaca, S., Dogru, O., Cetinkaya, Z. and Kulac, M. (2006). Prevalence of pediculosis and scabies in preschool nursery children of Afyon, Turkey. Korean J Parasitol, 44 (1) 95-98. [CrossRef]
7. Çetinkaya, Ü., Şahin, S. and Ulutabanca, R. (2018). The Epidemiology of Scabies and Pediculosis in Kayseri. Turkiye Parazitol Derg, 42 (2) 134-137. [CrossRef]
8. Thomas, J., Peterson, G. M., Walton, S. F., Carson, C. F., Naunton, M. and Baby, K. E. (2015). Scabies: an ancient global disease with a need for new therapies. BMC Infectious Diseases, 15 (1) 250. [CrossRef]
9. GBD. (2017). Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 390 (10100) 1211-1259. [CrossRef]
10. Cinotti, E., Perrot, J. L., Labeille, B., Maguet, H., Couzan, C., Flori, P. and Cambazard, F. (2015). Inefficacy of alcohol-based hand rub on mites in a patient with hyperkeratotic scabies. Clin Exp Dermatol, 40 (2) 177-181. [CrossRef]
11. Hicks, M. I. and Elston, D. M. (2009). Scabies. Dermatol Ther, 22 (4) 279-292. [CrossRef]
12. Kazan, D. and Demirsoy, E. O. SKABİYES; KLİNİK BULGULAR, TANI VE TEDAVİ. Acta Medica Nicomedia, 3 (2) 80-87,
13. Şimşek, E., Keskin, A. and Dağcıoğlu, B. F. (2019). Sık Rastlanan ve Sık Atlanan Hastalık Uyuz: Olgu Sunumu. Ankara Medical Journal, 19 (1) 205-209. [CrossRef]
14. Shimose, L. and Munoz-Price, L. S. (2013). Diagnosis, prevention, and treatment of scabies. Curr Infect Dis Rep, 15 (5) 426-431. [CrossRef]
15. Tai, D. B. G., Abu Saleh, O. and Miest, R. (2020). Genital nodular scabies. IDCases, 22 e00947. [CrossRef]
16. Çetin, B. Ş. (2017). Uyuz Hastalığına Yaklaşım (Güncel Kılavuz Değerlendirmesi). Cocuk Enfeksiyon Dergisi, 11 (2) 107-109. [CrossRef]
17. Leung, A. K. C., Lam, J. M. and Leong, K. F. (2020). Scabies: A Neglected Global Disease. Curr Pediatr Rev, 16 (1) 33-42. [CrossRef]
18. Micali, G., Lacarrubba, F., Verzì, A. E., Chosidow, O. and Schwartz, R. A. (2016). Scabies: Advances in Noninvasive Diagnosis. PLoS Negl Trop Dis, 10 (6) e0004691. [CrossRef]
19. Roncalli, R. A. (1987). The history of scabies in veterinary and human medicine from biblical to modern times. Vet Parasitol, 25 (2) 193-198. [CrossRef]
20. Johnstone, P. and Strong, M. (2014). Scabies. BMJ Clin Evid, 2014. [CrossRef]
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38. Nolan, K., Kamrath, J. and Levitt, J. (2012). Lindane toxicity: a comprehensive review of the medical literature. Pediatr Dermatol, 29 (2) 141-146. [CrossRef]
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40. Akram, M., Riaz, M., Noreen, S., Shariati, M. A., Shaheen, G., Akhter, N., Parveen, F., Akhtar, N., Zafar, S., Owais Ghauri, A., Riaz, Z., Khan, F. S., Kausar, S. and Zainab, R. (2020). Therapeutic potential of medicinal plants for the management of scabies. Dermatol Ther, 33 (1) e13186. [CrossRef]
41. Thomas, J., Carson, C. F., Peterson, G. M., Walton, S. F., Hammer, K. A., Naunton, M., Davey, R. C., Spelman, T., Dettwiller, P., Kyle, G., Cooper, G. M. and Baby, K. E. (2016). Therapeutic Potential of Tea Tree Oil for Scabies. Am J Trop Med Hyg, 94 (2) 258-266. [CrossRef]
42. Goodman, L. S., Gilman, A., Brunton, L. L., Lazo, J. S., & Parker, K. L. (2009). Tedavinin Farmakolojik Temeli (J. S. L. Laurence L.Brunton, Keith L Parker, Ed.). Nobel Tıp Kitabevleri Ltd.Şti. Ss: 1084-87
43. Strong, M. and Johnstone, P. (2007). Interventions for treating scabies. Cochrane Database Syst Rev, 2007 (3) Cd000320. [CrossRef]
44. Hay, R. J., Steer, A. C., Engelman, D. and Walton, S. (2012). Scabies in the developing world--its prevalence, complications, and management. Clin Microbiol Infect, 18 (4) 313-323. [CrossRef]
45. Mounsey, K. E., McCarthy, J. S. and Walton, S. F. (2013). Scratching the itch: new tools to advance understanding of scabies. Trends Parasitol, 29 (1) 35-42. [CrossRef]
46. Thomas, J., Peterson, G. M., Walton, S. F., Carson, C. F., Naunton, M. and Baby, K. E. (2015). Scabies: an ancient global disease with a need for new therapies. BMC Infect Dis, 15 250. [CrossRef]
47. Mounsey, K. E., Bernigaud, C., Chosidow, O. and McCarthy, J. S. (2016). Prospects for Moxidectin as a New Oral Treatment for Human Scabies. PLoS Negl Trop Dis, 10 (3) e0004389. [CrossRef]
48. Prichard, R., Ménez, C. and Lespine, A. (2012). Moxidectin and the avermectins: Consanguinity but not identity. Int J Parasitol Drugs Drug Resist, 2 134-153. [CrossRef]
49. Talaga-Ćwiertnia, K. (2021). Sarcoptes Infestation. What Is Already Known, and What Is New about Scabies at the Beginning of the Third Decade of the 21st Century? Pathogens, 10 (7). [CrossRef]
50. Pasay, C., Rothwell, J., Mounsey, K., Kelly, A., Hutchinson, B., Miezler, A. and McCarthy, J. (2012). An exploratory study to assess the activity of the acarine growth inhibitor, fluazuron, against Sarcoptes scabei infestation in pigs. Parasit Vectors, 5 40. [CrossRef]
51. Mumcuoglu, K. Y. and Gilead, L. (2008). Treatment of scabies infestations. Parasite, 15 (3) 248-251. [CrossRef]
52. Seebaluck, R., Gurib-Fakim, A. and Mahomoodally, F. (2015). Medicinal plants from the genus Acalypha (Euphorbiaceae)--a review of their ethnopharmacology and phytochemistry. J Ethnopharmacol, 159 137-157. [CrossRef]
53. Riebenbauer, K., Weber, P. B., Haitel, A., Walochnik, J., Valencak, J., Meyersburg, D., Kinaciyan, T. and Handisurya, A. (2022). Comparison of permethrin-based treatment strategies against scabies in infants and young children. J Pediatr. [CrossRef]
54. CORRIGENDUM to "Therapeutic potential of medicinal plants for the management of scabies". (2021). Dermatol Ther, 34 (4) e15027. [CrossRef]
55. Company, M. E. (2000). PDR for Herbal Medicines. Medical Economics Company 56. Sezik, E., Yeşilada, E., Honda, G., Takaishi, Y., Takeda, Y. and Tanaka, T. (2001). Traditional medicine in Turkey X. Folk medicine in central Anatolia. Journal of Ethnopharmacology, 75 (2-3) 95-115. [CrossRef]
57. GÜNBATAN, T., GÜRBÜZ, İ. and ÖZKAN, A. M. G. (2016). The current status of ethnopharmacobotanical knowledge in Çamlıdere (Ankara, Turkey). Turkish Journal of Botany, 40 (3) 241-249. [CrossRef]
58. Saikia, A. P., Ryakala, V. K., Sharma, P., Goswami, P. and Bora, U. (2006). Ethnobotany of medicinal plants used by Assamese people for various skin ailments and cosmetics. Journal of Ethnopharmacology, 106 (2) 149-157. [CrossRef]
59. Tabassum, N. and Hamdani, M. (2014). Plants used to treat skin diseases. Pharmacogn Rev, 8 (15) 52-60. [CrossRef] 60. Khan, N., Khushtar, M., Ahmad, N., Hasan, N., Khan, Z., Idris, S., Ahmad, A. and Zishan, M. (2017). Nutritional importance and pharmacological activity of Mangifera indica. World Journal of Pharmacy and Pharmaceutical Sciences, 6 258-273. [CrossRef]
61. Kumalasari, M., Marwing, A., Kususmawati, E., Mustika, I., Lusiana, N., Widayanti, L., Andiarna, F., Andyarini, E. and Hidayati, S. (2020). Development of Extract of Herbal Plants as Anti-Scabies in Pesantren. [CrossRef]
62. Alamgeer, Sharif, A., Asif, H., Younis, W., Riaz, H., Bukhari, I. A. and Assiri, A. M. (2018). Indigenous medicinal plants of Pakistan used to treat skin diseases: a review. Chin Med, 13 52. [CrossRef]
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65. ÇAKIR, E. A. (2017). A comprehensive review on Ethnomedicinal utilization of gymnosperms in Turkey. Eurasian Journal of Forest Science, 5 (1) 35-47. [CrossRef]
66. Nigussie, G. (2021). A review on traditionally used medicinal plants for scabies therapy in Ethiopia. Advances in Traditional Medicine, 21 (2) 199-208. [CrossRef]
67. Kingston, C., Jeeva, S., Jeeva, G., Kiruba, S., Mishra, B. and Kannan, D. (2009). Indigenous knowledge of using medicinal plants in treating skin diseases in Kanyakumari district, Southern India. http://nopr.niscair.res.in/handle/123456789/3966 Erişim Tarihi:10.02.2022
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Toplam 71 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Konular	Eczacılık ve İlaç Bilimleri
Bölüm	Derleme
Yazarlar	Jale Akgöl 0000-0002-9163-3991 Ayşegül Köroğlu 0000-0002-8450-1376
Yayımlanma Tarihi	29 Mayıs 2022
Gönderilme Tarihi	10 Mart 2022
Kabul Tarihi	15 Nisan 2022
Yayımlandığı Sayı	Yıl 2022 Cilt: 46 Sayı: 2

Kaynak Göster

APA	Akgöl, J., & Köroğlu, A. (2022). UYUZ HASTALIĞI (SKABİYES), TEDAVİSİ VE UYUZ HASTALIĞI TEDAVİSİNDE KULLANILAN BİTKİLER. Journal of Faculty of Pharmacy of Ankara University, 46(2), 600-618. https://doi.org/10.33483/jfpau.1085681
AMA	Akgöl J, Köroğlu A. UYUZ HASTALIĞI (SKABİYES), TEDAVİSİ VE UYUZ HASTALIĞI TEDAVİSİNDE KULLANILAN BİTKİLER. Ankara Ecz. Fak. Derg. Mayıs 2022;46(2):600-618. doi:10.33483/jfpau.1085681
Chicago	Akgöl, Jale, ve Ayşegül Köroğlu. “UYUZ HASTALIĞI (SKABİYES), TEDAVİSİ VE UYUZ HASTALIĞI TEDAVİSİNDE KULLANILAN BİTKİLER”. Journal of Faculty of Pharmacy of Ankara University 46, sy. 2 (Mayıs 2022): 600-618. https://doi.org/10.33483/jfpau.1085681.
EndNote	Akgöl J, Köroğlu A (01 Mayıs 2022) UYUZ HASTALIĞI (SKABİYES), TEDAVİSİ VE UYUZ HASTALIĞI TEDAVİSİNDE KULLANILAN BİTKİLER. Journal of Faculty of Pharmacy of Ankara University 46 2 600–618.
IEEE	J. Akgöl ve A. Köroğlu, “UYUZ HASTALIĞI (SKABİYES), TEDAVİSİ VE UYUZ HASTALIĞI TEDAVİSİNDE KULLANILAN BİTKİLER”, Ankara Ecz. Fak. Derg., c. 46, sy. 2, ss. 600–618, 2022, doi: 10.33483/jfpau.1085681.
ISNAD	Akgöl, Jale - Köroğlu, Ayşegül. “UYUZ HASTALIĞI (SKABİYES), TEDAVİSİ VE UYUZ HASTALIĞI TEDAVİSİNDE KULLANILAN BİTKİLER”. Journal of Faculty of Pharmacy of Ankara University 46/2 (Mayıs 2022), 600-618. https://doi.org/10.33483/jfpau.1085681.
JAMA	Akgöl J, Köroğlu A. UYUZ HASTALIĞI (SKABİYES), TEDAVİSİ VE UYUZ HASTALIĞI TEDAVİSİNDE KULLANILAN BİTKİLER. Ankara Ecz. Fak. Derg. 2022;46:600–618.
MLA	Akgöl, Jale ve Ayşegül Köroğlu. “UYUZ HASTALIĞI (SKABİYES), TEDAVİSİ VE UYUZ HASTALIĞI TEDAVİSİNDE KULLANILAN BİTKİLER”. Journal of Faculty of Pharmacy of Ankara University, c. 46, sy. 2, 2022, ss. 600-18, doi:10.33483/jfpau.1085681.
Vancouver	Akgöl J, Köroğlu A. UYUZ HASTALIĞI (SKABİYES), TEDAVİSİ VE UYUZ HASTALIĞI TEDAVİSİNDE KULLANILAN BİTKİLER. Ankara Ecz. Fak. Derg. 2022;46(2):600-18.

Kapak Resmi İndir

Makale Dosyaları

Tam Metin

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.