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Retrospective analysis of histopathological findings of benign sinonasal masses

Yıl 2018, Cilt: 1 Sayı: 4, 50 - 84, 30.12.2018

Ceyhun Aksakal

https://doi.org/10.32322/jhsm.463894

Öz

Introduction:
Nasal polyps are the most common types of benign
sinonasal masses. In addition, some histopathological diagnoses like rare
sinonasal papilloma, hemangioma and Respiratory Epithelial Adenomatous
Hamartoma (REAH) are also observed. The purpose of the present study is to
examine the distribution of the masses seen in sinonasal area in terms of
histopathological types, and to determine the distribution according to age and
gender.

Material
and Method: A total of 203 patients, who were operated due to
benign nasal mass between January 2008 and January 2018 in Tokat State Hospital
and whose histopathological diagnoses were obtained, were included in the
study. The patients were divided in terms of their histopathological types.
These histopathological types were analyzed according to the gender and age
range.

Results:
A total of 128 of the patients were male and 75 were female. The mean age was
found as 42.23 (Males: 41.96±18.9,
Females: 42.68±19.1).
The most common sinonasal mass was nasal polyp (89.1%), and the other
histopathological diagnoses were sinonasal papilloma (4%), REAH (2.4%), lobular
capillary hemangioma (LKH) (2.9%) and fungal rhinosinusitis (0.9%).







Conclusion:
The histopathological findings of benign sinonasal masses vary according to age
and gender. Antrochoanal polyps are seen mostly at younger ages, nasal polyps,
which are associated with chronic sinusitis, are seen in middle age, and
inverted papilloma and REAH are detected in advanced age ranges.

Anahtar Kelimeler

Benign nasal polyp sinonasal mass

Kaynakça

  • 1. Soler ZM, Wittenberg E, Schlosser RJ, Mace JC, Smith TL. Health state utility values in patients undergoing endoscopic sinus surgery. Laryngoscope 2011;121:2672–78. doi: 10.1002/lary.21847.
  • 2. Bugter O, Monserez DA, van Zijl FVWJ, Baatenburg de Jong RJ, Hardillo JA.Surgical management of inverted papilloma; a single-center analysis of 247 patients with long follow-up. J Otolaryngol Head Neck Surg.2017; 20;46:67. doi: 10.1186/s40463-017-0246-7.
  • 3. Agarwal P, Panigrahi R .Sinonasal Mass-a Recent Study of Its Clinicopathological Profile. Indian J Surg Oncol. 2017 ;8:123-7. doi: 10.1007/s13193-016-0570-9.
  • 4. Kizil Y, Aydil U, Ceylan A, Uslu S, Baştürk V, İleri F. Analysis of Choanal Polyps. J Craniofac Surg. 2014 ;25:1082-4. doi: 10.1097/SCS.0000000000000543.
  • 5. Wang MJ, Noel JE. Etiology of sinonasal inverted papilloma: A narrative. World J Otorhinolaryngol Head Neck Surg. 2016 Dec 21;3(1):54-58. doi: 10.1016/j.wjorl.2016.11.004.
  • 6. Takaishi S, Asaka D, Nakayama T, et al. Features of sinonasal hemangioma: A retrospective study of 31 cases. Auris Nasus Larynx. 2017 ;44:719-23. doi: 10.1016/j.anl.2017.01.012.
  • 7. Tatekawa H, Shimono T, Ohsawa M, Doishita S, Sakamoto S, Miki Y. Imaging features of benign mass lesions in the nasal cavity and paranasal sinuses according to the 2017 WHO classifcation. Jpn J Radiol. 2018 ;36:361-81. doi: 10.1007/s11604-018-0739-y.
  • 8. Fokkens WJ, Lund VJ, Mullol J, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl. 2012; 3:1–298.
  • 9. Braakman I, Verest O, Pijning T, Meijer DK, Groothuis GM. Zonal distribution of the cation lucigenin in rat liver: influence of taurocholate. Mol Pharmacol. 1989; 36:532–6. doi: 10.1002/alr.20025.
  • 10. Tan BK, Zirkle W, Chandra RK, et al. Atopic profile of patients failing medical therapy for chronic rhinosinusitis. Int Forum Allergy Rhinol. 2011; 1:88–94. doi: 10.1002/alr.20025.
  • 11. Lee DH, Yoon TM, Lee JK, Lim SC. Difference of antrochoanal polyp between children and adults. Int J Pediatr Otorhinolaryngol. 2016 ;84:143-6. doi: 10.1016/j.ijporl.2016.03.004.
  • 12. Gupta R, Moupachi SS, Poorey VK. Sinonasal Masses: A Retrospective Analysis. 2013 ;65:52-6. doi: 10.1007/s12070-012-0602-x.
  • 13. Guven M, Karabay O, Akidil O, Yilmaz MS, Yildirim M. Detection of Staphylococcal Exotoxins in Antrochoanal Polyps and Chronic Rhinosinusitis with Nasal Polyps. Otolaryngol Head Neck Surg. 2013;148:302-7. doi: 10.1177/0194599812465586.
  • 14. Melroy CT, Senior BA. Benign sinonasal neoplasms: a focus on inverting papilloma. Otolaryngol Clin N Am. 2006;39(3):601–17. doi: 10.1016/j.otc.2006.01.005.
  • 15. Govindaraj S, Wang H. Does human papilloma virus play a role in sinonasal inverted papilloma? Curr Opin Otolaryngol Head Neck Surg. 2014;22:47–51. doi: 10.1097/MOO.0000000000000017.
  • 16. Strojan P, Ferlito A, Lund VJ, et al. Sinonasal inverted papilloma associated with malignancy: the role of human papillomavirus infection and its implications for radiotherapy. Oral Oncol. 2012;48:216–8. doi: 10.1016/j.oraloncology.2011.10.009.
  • 17. Lisan Q, Laccourreye O, Bonfils P. Sinonasal inverted papilloma: From diagnosis to treatment. Eur Ann Otorhinolaryngol Head Neck Dis. 2016 ;133:337-41. doi: 10.1016/j.anorl.2016.03.006.
  • 18. Wenig BM, Heffner DK: Respiratory epithelial adenomatoid hamartomas of the sinonasal tract and nasopharynx: a clinicopathologic study of 31 cases. Ann Otol Rhinol Laryngol. 1995;104:639-645. 10.1177/000348949510400809.
  • 19. Hawley KA, Pabon S, Hoschar AP, Sindwani R. The presentation and clinical significance of sinonasal respiratory epithelial adenomatoid hamartoma (REAH). Int Forum Allergy Rhinol. 2013; 3:248-253. doi: 10.1002/alr.21083.
  • 20. Vira D, Bhuta S, Wang MB. Respiratory epithelial adenomatoid hamartomas. Laryngoscope. 2011; 121:2706-09. doi: 10.1002/lary.22399.
  • 21. Mills SE, Cooper PH, Fechner RE. Lobular capillary hemangioma: the underlying lesion of pyogenic granuloma. A study of 73 cases from the oral and nasal mucous membranes. Am J Surg Pathol 1980;4:470–9.
  • 22. Kim JS, Kwon SH. Sinonasal Hemangioma: Diagnosis, Treatment, and Follow-Up of 37 Patients at a Single Center. J Oral Maxillofac Surg. 2017 ;75:1775-83. doi: 10.1016/j.joms.2016.12.044.

Benign sinonazal kitlelerin histopatolojik bulgularının retrospektif analizi

Yıl 2018, Cilt: 1 Sayı: 4, 50 - 84, 30.12.2018

Ceyhun Aksakal

https://doi.org/10.32322/jhsm.463894

Öz

Amaç: Benign sinonazal kitleler içinde
en sık görülen tür nazal poliptir. Bunun yanında nadiren sinonazal papillom,
hemanjiyom, respiratuvar epitelyal adenomatöz hamartom (REAH) gibi
histopatolojik tanılara rastlanmaktadır. Bu çalışmanın amacı sinonazal bölgede
görülen kitleleri histopatolojik tiplerine göre ayırarak cinsiyete ve yaş
aralığına göre dağılımını araştırmaktır.

Gereç ve Yöntem: Tokat Devlet Hastanesi’nde Ocak
2008 ile Ocak 2018 arasında benign nazal kitle ile opere edilmiş ve
histopatolojik tanılarına ulaşılmış 203 hasta çalışmaya dahil edilmiştir.
Hastaların histopatolojik tipleri türlerine göre ayrılmıştır. Histopatolojik
tipler cinsiyet ve yaş aralıklarına göre ayrılarak analiz edilmiştir.

Bulgular: Hastaların 128’i erkek, 75’i
kadınlardan oluşmaktadır. Ortalama yaş 42,23 (Erkek: 41,96±18,9, Kadın:
42,68±19,1) olarak bulunmuştur.  En sık
sinonazal kitle olarak nazal polip (%89,1) bulunurken elde edilen diğer
histopatolojik tanılar sinonazal papillom (%4), REAH (%2,4), lobüler kapiller
hemanjiyom (LKH) (%2,9) ve fungal rinosinüzit (%0,9) olmuştur.







Sonuç: Benign sinonazal kitlelerin
histopatolojik bulguları yaş ve cinsiyete göre farklılık göstermektedir.  Antrokoanal polip daha çok genç yaşta
görülürken, daha çok kronik sinüzitle ilişkili olan nazal polip orta yaşlarda,
inverted papillom ve REAH ise ileri yaş aralıklarında tespit edilmiştir. 

Anahtar Kelimeler

Benign nazal polip sinonazal kitle

Kaynakça

  • 1. Soler ZM, Wittenberg E, Schlosser RJ, Mace JC, Smith TL. Health state utility values in patients undergoing endoscopic sinus surgery. Laryngoscope 2011;121:2672–78. doi: 10.1002/lary.21847.
  • 2. Bugter O, Monserez DA, van Zijl FVWJ, Baatenburg de Jong RJ, Hardillo JA.Surgical management of inverted papilloma; a single-center analysis of 247 patients with long follow-up. J Otolaryngol Head Neck Surg.2017; 20;46:67. doi: 10.1186/s40463-017-0246-7.
  • 3. Agarwal P, Panigrahi R .Sinonasal Mass-a Recent Study of Its Clinicopathological Profile. Indian J Surg Oncol. 2017 ;8:123-7. doi: 10.1007/s13193-016-0570-9.
  • 4. Kizil Y, Aydil U, Ceylan A, Uslu S, Baştürk V, İleri F. Analysis of Choanal Polyps. J Craniofac Surg. 2014 ;25:1082-4. doi: 10.1097/SCS.0000000000000543.
  • 5. Wang MJ, Noel JE. Etiology of sinonasal inverted papilloma: A narrative. World J Otorhinolaryngol Head Neck Surg. 2016 Dec 21;3(1):54-58. doi: 10.1016/j.wjorl.2016.11.004.
  • 6. Takaishi S, Asaka D, Nakayama T, et al. Features of sinonasal hemangioma: A retrospective study of 31 cases. Auris Nasus Larynx. 2017 ;44:719-23. doi: 10.1016/j.anl.2017.01.012.
  • 7. Tatekawa H, Shimono T, Ohsawa M, Doishita S, Sakamoto S, Miki Y. Imaging features of benign mass lesions in the nasal cavity and paranasal sinuses according to the 2017 WHO classifcation. Jpn J Radiol. 2018 ;36:361-81. doi: 10.1007/s11604-018-0739-y.
  • 8. Fokkens WJ, Lund VJ, Mullol J, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl. 2012; 3:1–298.
  • 9. Braakman I, Verest O, Pijning T, Meijer DK, Groothuis GM. Zonal distribution of the cation lucigenin in rat liver: influence of taurocholate. Mol Pharmacol. 1989; 36:532–6. doi: 10.1002/alr.20025.
  • 10. Tan BK, Zirkle W, Chandra RK, et al. Atopic profile of patients failing medical therapy for chronic rhinosinusitis. Int Forum Allergy Rhinol. 2011; 1:88–94. doi: 10.1002/alr.20025.
  • 11. Lee DH, Yoon TM, Lee JK, Lim SC. Difference of antrochoanal polyp between children and adults. Int J Pediatr Otorhinolaryngol. 2016 ;84:143-6. doi: 10.1016/j.ijporl.2016.03.004.
  • 12. Gupta R, Moupachi SS, Poorey VK. Sinonasal Masses: A Retrospective Analysis. 2013 ;65:52-6. doi: 10.1007/s12070-012-0602-x.
  • 13. Guven M, Karabay O, Akidil O, Yilmaz MS, Yildirim M. Detection of Staphylococcal Exotoxins in Antrochoanal Polyps and Chronic Rhinosinusitis with Nasal Polyps. Otolaryngol Head Neck Surg. 2013;148:302-7. doi: 10.1177/0194599812465586.
  • 14. Melroy CT, Senior BA. Benign sinonasal neoplasms: a focus on inverting papilloma. Otolaryngol Clin N Am. 2006;39(3):601–17. doi: 10.1016/j.otc.2006.01.005.
  • 15. Govindaraj S, Wang H. Does human papilloma virus play a role in sinonasal inverted papilloma? Curr Opin Otolaryngol Head Neck Surg. 2014;22:47–51. doi: 10.1097/MOO.0000000000000017.
  • 16. Strojan P, Ferlito A, Lund VJ, et al. Sinonasal inverted papilloma associated with malignancy: the role of human papillomavirus infection and its implications for radiotherapy. Oral Oncol. 2012;48:216–8. doi: 10.1016/j.oraloncology.2011.10.009.
  • 17. Lisan Q, Laccourreye O, Bonfils P. Sinonasal inverted papilloma: From diagnosis to treatment. Eur Ann Otorhinolaryngol Head Neck Dis. 2016 ;133:337-41. doi: 10.1016/j.anorl.2016.03.006.
  • 18. Wenig BM, Heffner DK: Respiratory epithelial adenomatoid hamartomas of the sinonasal tract and nasopharynx: a clinicopathologic study of 31 cases. Ann Otol Rhinol Laryngol. 1995;104:639-645. 10.1177/000348949510400809.
  • 19. Hawley KA, Pabon S, Hoschar AP, Sindwani R. The presentation and clinical significance of sinonasal respiratory epithelial adenomatoid hamartoma (REAH). Int Forum Allergy Rhinol. 2013; 3:248-253. doi: 10.1002/alr.21083.
  • 20. Vira D, Bhuta S, Wang MB. Respiratory epithelial adenomatoid hamartomas. Laryngoscope. 2011; 121:2706-09. doi: 10.1002/lary.22399.
  • 21. Mills SE, Cooper PH, Fechner RE. Lobular capillary hemangioma: the underlying lesion of pyogenic granuloma. A study of 73 cases from the oral and nasal mucous membranes. Am J Surg Pathol 1980;4:470–9.
  • 22. Kim JS, Kwon SH. Sinonasal Hemangioma: Diagnosis, Treatment, and Follow-Up of 37 Patients at a Single Center. J Oral Maxillofac Surg. 2017 ;75:1775-83. doi: 10.1016/j.joms.2016.12.044.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Orijinal Makale
Yazarlar

Ceyhun Aksakal

Yayımlanma Tarihi 30 Aralık 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 1 Sayı: 4

Kaynak Göster

AMA Aksakal C. Benign sinonazal kitlelerin histopatolojik bulgularının retrospektif analizi. J Health Sci Med /JHSM /jhsm. Aralık 2018;1(4):50-84. doi:10.32322/jhsm.463894
 Kapak Resmi İndir

Üniversitelerarası Kurul (ÜAK) Eşdeğerliği:  Ulakbim TR Dizin'de olan dergilerde yayımlanan makale [10 PUAN] ve 1a, b, c hariç  uluslararası indekslerde (1d) olan dergilerde yayımlanan makale [5 PUAN]

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Not: Dergimiz WOS indeksli değildir ve bu nedenle Q olarak sınıflandırılmamıştır.

Yüksek Öğretim Kurumu (YÖK) kriterlerine göre yağmacı/şüpheli dergiler hakkındaki kararları ile yazar aydınlatma metni ve dergi ücretlendirme politikasını tarayıcınızdan indirebilirsiniz. https://dergipark.org.tr/tr/journal/2316/file/4905/show 


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