Öz
Kaynakça
- Jones MW, Lopez RA, Deppen JG. Appendicitis. In: StatPearls. Treasure Island; 2021.
- Bhangu A, Søreide K, Di Saverio S, Assarsson JH, Drake FT. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet 2015; 386: 1278-87.
- National Surgical Research Collaborative. Multicentre observational study of performance variation in provision and outcome of emergency appendicectomy. Br J Surg 2013; 100: 1240-52.
- Bailey H. The Ochsner-Sherren (delayed) treatment of acute appendicitis: indications and technique. Br Med J 1930; 1: 140.
- Mason RJ, Moazzez A, Sohn H, Katkhouda N. Meta-analysis of randomized trials comparing antibiotic therapy with appendectomy for acute uncomplicated (no abscess or phlegmon) appendicitis. Surg Infect (Larchmt) 2012; 13: 74-84.
- Gorter RR, Eker HH, Gorter-Stam MA, et al. Diagnosis and management of acute appendicitis. EAES consensus development conference 2015. Surg Endosc 2016; 30: 4668-90.
- Carr NJ. The pathology of acute appendicitis. Ann Diagn Pathol 2000; 4: 46-58.
- Sippola S, Grönroos J, Tuominen R, et al. Economic evaluation of antibiotic therapy versus appendicectomy for the treatment of uncomplicated acute appendicitis from the APPAC randomized clinical trial. Br J Surg 2017; 104: 1355-61.
- Atema JJ, van Rossem CC, Leeuwenburgh MM, Stoker J, Boermeester MA. Scoring system to distinguish uncomplicated from complicated acute appendicitis. Br J Surg 2015; 102: 979-90.
- Eddama M, Fragkos KC, Renshaw S, et al. Logistic regression model to predict acute uncomplicated and complicated appendicitis. Ann R Coll Surg Engl 2019; 101: 107-18.
- Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 1990; 132: 910-25.
- Malagon AM, Arteaga-Gonzalez I, Rodriguez-Ballester L. Outcomes after laparoscopic treatment of complicated versus uncomplicated acute appendicitis: a prospective, comparative trial. J Laparoendosc Adv Surg Tech A 2009; 19: 721-5.
- Yu CW, Juan LI, Wu MH, Shen CJ, Wu JY, Lee CC. Systematic review and meta‐analysis of the diagnostic accuracy of procalcitonin, C‐reactive protein and white blood cell count for suspected acute appendicitis. Br J Surg 2013; 100: 322-9.
- Noh H, Chang S-J, Han A. The diagnostic values of preoperative laboratory markers in children with complicated appendicitis. J Korean Surg Soc 2012; 83: 237.
- Vanker N, Ipp H. Large unstained cells: a potentially valuable parameter in the assessment of immune activation levels in HIV infection. Acta Haematol 2014; 131: 208-12.
- Buttarello M, Plebani M. Automated blood cell counts: state of the art. Am J Clin Pathol 2008; 130: 104-16.
The predictors of complicated acute appendicitis: large unstained cells, gamma-glutamyl transferase, monocyte to platelet ratio, age and gender
Öz
Aim: In this study, we sought to investigate possible biomarkers markers that can preoperatively distinguish complicated and non-complicated acute appendicitis.
Material and Method: Patients who underwent appendectomy between February and December 2019 were screened retrospectively. Patients with pathology findings other than appendicitis were excluded. Patients with a confirmed diagnosis of acute appendicitis were categorized as complicated and non-complicated appendicitis for analysis of sociodemographic characteristics, comorbidities and preoperative laboratory parameters.
Results: A total of 575 patients were included in the study. Among these, 432 (75.1%) were diagnosed with non-complicated appendicitis and 143 (24.9%) were diagnosed with complicated appendicitis. The mean (SD) age was 34.2±14.2 years. Hypertension, diabetes mellitus and hypothyroidism were the most frequent comorbidities. Age (OR, 1.026; p=0.010), male gender (OR, 1.837; p=0.044), LUC (OR: 19.868; p=0.034) and GGT (OR: 1.013; p=0.013) were associated with a higher risk of complicated appendicitis. An increase in monocyte to platelet ratio (MPR) (OR: 0.920; p=0.047) was associated with a lower risk of complicated appendicitis.
Conclusion: In patients with acute appendicitis, parameters including age, gender, as well as LUC, GGT and MPR, which are easily available and relatively cheap biomarkers, can be useful to distinguish non-complicated and complicated cases preoperatively.
Anahtar Kelimeler
Kaynakça
- Jones MW, Lopez RA, Deppen JG. Appendicitis. In: StatPearls. Treasure Island; 2021.
- Bhangu A, Søreide K, Di Saverio S, Assarsson JH, Drake FT. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet 2015; 386: 1278-87.
- National Surgical Research Collaborative. Multicentre observational study of performance variation in provision and outcome of emergency appendicectomy. Br J Surg 2013; 100: 1240-52.
- Bailey H. The Ochsner-Sherren (delayed) treatment of acute appendicitis: indications and technique. Br Med J 1930; 1: 140.
- Mason RJ, Moazzez A, Sohn H, Katkhouda N. Meta-analysis of randomized trials comparing antibiotic therapy with appendectomy for acute uncomplicated (no abscess or phlegmon) appendicitis. Surg Infect (Larchmt) 2012; 13: 74-84.
- Gorter RR, Eker HH, Gorter-Stam MA, et al. Diagnosis and management of acute appendicitis. EAES consensus development conference 2015. Surg Endosc 2016; 30: 4668-90.
- Carr NJ. The pathology of acute appendicitis. Ann Diagn Pathol 2000; 4: 46-58.
- Sippola S, Grönroos J, Tuominen R, et al. Economic evaluation of antibiotic therapy versus appendicectomy for the treatment of uncomplicated acute appendicitis from the APPAC randomized clinical trial. Br J Surg 2017; 104: 1355-61.
- Atema JJ, van Rossem CC, Leeuwenburgh MM, Stoker J, Boermeester MA. Scoring system to distinguish uncomplicated from complicated acute appendicitis. Br J Surg 2015; 102: 979-90.
- Eddama M, Fragkos KC, Renshaw S, et al. Logistic regression model to predict acute uncomplicated and complicated appendicitis. Ann R Coll Surg Engl 2019; 101: 107-18.
- Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 1990; 132: 910-25.
- Malagon AM, Arteaga-Gonzalez I, Rodriguez-Ballester L. Outcomes after laparoscopic treatment of complicated versus uncomplicated acute appendicitis: a prospective, comparative trial. J Laparoendosc Adv Surg Tech A 2009; 19: 721-5.
- Yu CW, Juan LI, Wu MH, Shen CJ, Wu JY, Lee CC. Systematic review and meta‐analysis of the diagnostic accuracy of procalcitonin, C‐reactive protein and white blood cell count for suspected acute appendicitis. Br J Surg 2013; 100: 322-9.
- Noh H, Chang S-J, Han A. The diagnostic values of preoperative laboratory markers in children with complicated appendicitis. J Korean Surg Soc 2012; 83: 237.
- Vanker N, Ipp H. Large unstained cells: a potentially valuable parameter in the assessment of immune activation levels in HIV infection. Acta Haematol 2014; 131: 208-12.
- Buttarello M, Plebani M. Automated blood cell counts: state of the art. Am J Clin Pathol 2008; 130: 104-16.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Orijinal Makale |
| Yazarlar | |
| Yayımlanma Tarihi | 15 Temmuz 2021 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 4 Sayı: 4 |
Cited By
The relationship between oral and dental health and appendicitis
Anatolian Current Medical Journal
https://doi.org/10.38053/acmj.1318825
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